# To reproduce the data needed for Figure 3 in associated original paper,
# execute this script in the Python console in OpenCOR. This can be done
# with the following commands at the prompt in the OpenCOR Python console:
#
#     In [1]: cd path/to/folder_this_file_is_in
#     In [2]: run Fig3_sim.py

import opencor as oc
import numpy as np

# Load the simulation file
simfile='../Single_stim_experiment.sedml'
simulation = oc.open_simulation(simfile)
# The data object houses all the relevant information
# and pointers to the OpenCOR internal data representations
data = simulation.data()
# Set the experiments
Vholding, t_ss = -50, 0
duration = 0.2
#Nai=16.55
Nai=[ 2.9836,16.55]
Cai_init = 123e-6
# Define the interval of interest for this simulation experiment
start, pointInterval = 0, 0.001
data.set_starting_point(start)
data.set_point_interval(pointInterval)
# Data to save
varName = np.array(["time", "Cai", "V"])
vars = np.reshape(varName, (1, len(varName)))
# start to save when the test voltage returns to holding
rows=int((duration+3.5)/pointInterval+1)
r = np.zeros((rows,len(varName)))
# The prefix of the saved output file name 
prefilenames = ['simFig3A','simFig3B','simFig3C']
inhPump=1
Vtest = [0, 10, -10]
for j, prefilename in enumerate(prefilenames):
   data.set_ending_point(t_ss+duration+3.5)
   for k, iNai in enumerate(Nai):
       # Reset states and parameters
       simulation.reset(True)
       # Set constant parameter values
       data.constants()['Vstim_para/V_actHolding'] = Vholding
       data.constants()['Vstim_para/V_actTest'] = Vtest[j]
       data.constants()['Vstim_para/t_act'] = duration
       data.constants()['Vstim_para/t_ss'] = t_ss
       data.constants()['control_para/Nai'] = iNai
       data.states()['outputs/Cai'] = Cai_init
       data.constants()['control_para/inhPump'] = inhPump
       simulation.run()
       # Access simulation results
       results = simulation.results()
       # Grab a specific algebraic variable results 
       r[:,0] = results.voi().values()[-rows:]
       r[:,1] = results.states()['outputs/Cai'].values()[-rows:]
       r[:,2] = results.algebraic()['outputs/V'].values()[-rows:]
       # clear the results except the last run
       simulation.clear_results() 
       # Save the simulation result of the last run
       filename='../simulatedData/%s_%d.csv' % (prefilename,k)
       np.savetxt(filename, vars, fmt='%s',delimiter=",")
       with open(filename, "ab") as f:
           np.savetxt(f, r, delimiter=",")
       f.close