# fast Na module # Return kinetic parameters, constraints, and vector of volumes in each # compartment (pL) (1 if gating variable, or in element corresponding to # kappa) # Translated from Pan 2018 cardiac AP import numpy as np def kinetic_parameters(M, include_type2_reactions, dims, V): # Set the kinetic rate constants num_cols = dims['num_cols'] num_rows = dims['num_rows'] # constants are stored in V F = V['F'] N_A = V['N_A'] x_Nab_channel = 10000*725 / N_A * 1e15 #unit fmol x_Nab_channel = V['numChannels']/N_A*1e15 # unit fmol G_GHK = 1.622987611682678e-11 # convert to permeability P_Cab = G_GHK / F * 1e12 #Unit pL / s channel_k = P_Cab #/ x_Nab_channel kf =[channel_k] kr =[channel_k] k_kinetic = kf + kr # CONSTRAINTS N_cT = [] K_C = [] # volume vector # W = list(np.append([1] * num_cols, [V['V_myo']] * num_rows)) W = [1] * num_cols + [V['V_myo'], V['V_o']] return (k_kinetic, N_cT, K_C, W)