# TRPN troponin module # rates are based on Niederer et al 2006 # assuming that k_off is constant, disregarding dependency on Tension, for now i.e. let Tension = 0 import numpy as np def kinetic_parameters(M, include_all_reactions, dims, V): # Set the kinetic rate constants. # all reactions are reversible. no closed loops. num_cols = dims['num_cols'] num_rows = dims['num_rows'] # CONVERT TO fM bigNum = 1e6 fastKineticConstant = bigNum smallReverse = fastKineticConstant/(pow(bigNum,2)) k_on = 100e3 # [=] 1/mM.s k_off = 200 # [=] 1/ms k_kinetic = [k_on, k_off] # CONSTRAINTS N_cT = [] K_C = [] # volume vector W = list(np.append([1] * num_cols, [V['V_myo']] * num_rows)) return (k_kinetic, [N_cT], K_C, W)