Encoded in CellML by Dennis Ogiermann
Chair of Continuum Mechanics, Ruhr University Bochum
Several experiment files on channel and cell level have been added to reproduce Figure 3-5 from the publication. The model is known to run and integrate in OpenCOR. The units have been checked and they are consistent.
Piezo1 ion channels are voltage-modulated, stretch-activated ion channels involved in a variety of important physiological and pathophysiological processes, as for example cardiovascular development and homeostasis. Since its discovery, it has been known that this type of ion channel desensitizes when exposed to stretch. However, recent experiments on Piezo1 ion channels have uncovered that their stretch response is qualitatively different when exposed to positive electrochemical driving forces, where the desensitization is reset. In this work, we propose a novel voltage-modulated mathematical model of Piezo1 based on a continuous-time Markov chain. We show that our Piezo1 model is able to quantitatively reproduce a wide range of experimental observations. Furthermore, we integrate our new ion channel model into the Mahajan-Shiferaw ventricular cardiomyocyte model to study the effect of electromechanical pacing at the cellular scale. This integrated cell model is able to qualitatively reproduce some aspects of the experimental observations regarding the rate-dependence of electromechanical pacing protocols. Our studies suggest that the Piezo1 ion channel is an important component that significantly contributes to the electromechanical coupled response of cardiomyocytes.
The complete original paper reference is cited below:
A Simple Voltage-Modulated Markov Chain Model for the Piezo1 Ion Channel to Investigate Electromechanical Pacing, Ogiermann, D., Mohamed, A., Perotti, L.E. and Balzani D. 2025. Submitted to Journal of Physiology. Preprint at https://doi.org/10.48550/arXiv.2501.19366
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| A schematic diagram describing the currents and ionic flows across the cell membrane that are captured in the modified Mahajan-Shiferaw model. The flows associated with the new Piezo1 channel are boxed. |