Files:

Parameter fit n find

	matlab routines to fit the Tong, 2011 PMCA data

		pmca_fun1p1.m  <- script that generates PMCA data to fit, assembles the Higgins 6-state kinetic model parameters from Higgins, 2006 SERCA model, and fits the k’s
			fitting routines
			higgins_serc_fit_ktilde_phosph_s_v1.m 
			higgins_serc_fit_ktilde_v1.m 
			higgins_pmca_v1.m 			
			higgins_pmca_s1p5_v1.m

		plot file shows original data from Tong, 2011 PMCA (Sigmoidal function), original Higgins, 6-state SERCA, and fit of kinetic model to PMCA
			note: two fits presented with Hille coefficient of ‘2’ that fails and ‘1.5’ that fits
			higgins_6state_fit_tong_usmc_pmca_ncomp1.png

		BG schematic
			serca_pmca_map_electrogenic_t1p2.001.png

CELLML File: 

	Higgins_SERCA_to_PMCA_wVm_v1.cellml

	Run above out to ~t = 100k to see solution approach expected steady-state moles of Ca2+ (inside/outside) as predicted by analytical steady-state flux