16032015084707638m0500
type: Ontology
sem sim version: 0.2
has cell m ldocumentation: <documentation xmlns="http://cellml.org/tmp-documentation"> <articleinfo> Biophysical Characteristics of the Pig Kidney Na/Glucose Cotransporter SGLT2 Reveal a Common Mechanism for SGLT1 and SGLT2 <author> <firstname>Jonna</firstname> <surname>Terkildsen</surname> <affiliation> <shortaffil>Auckland Bioengineering Institute, University of Auckland</shortaffil> </affiliation> </author> </articleinfo> <sect1 id="sec_status"> Model Status This CellML model has been curated, the units are consistent and the model runs in COR and PCEnv. This model recreates the published results. </sect1> <sect1 id="sec_structure"> Model Structure Abstract: The Na-dependent, low affinity glucose transporter SGLT2 cloned from pig kidney is 76% identical (at the amino acid level) to its high affinity homologue SGLT1. Using two-microelectrode voltage clamp, we have characterized the presteady-state and steady-state kinetics of SGLT2 expressed in Xenopus oocytes. The kinetic properties of the steady-state sugar-evoked currents as a function of external Na and a-methyl-D-glucopyranoside (aMG) concentrations were consistent with an ordered, simultaneous transport model in which Na binds first. Na binding was voltage-dependent and saturated with hyperpolarizing voltages. Phlorizin was a potent inhibitor of the sugar-evoked currents (Ki ~10 mM) and blocked an inward Na current in the absence of sugar. SGLT2 exhibited Na-dependent presteadystate currents with time constants 3-7 ms. Charge movements were described by Boltzmann relations with apparent valence ~1 and maximal charge transfer ~11 nC, and were reduced by the addition of sugar or phlorizin. The differences between SGLT1 and SGLT2 were that (i) the apparent affinity constant (K0.5) for aMG (~3 mM) was an order of magnitude higher for SGLT2; (ii) SGLT2 excluded galactose, suggesting discrete sugar binding; (iii) K0.5 for Na was lower in SGLT2; and (iv) the Hill coefficient for Na was 1 for SGLT2 but 2 for SGLT1. Simulations of the six-stat…
has cell m lrdf markup: <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:j.0="http://www.example.org/foo/bar/" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:j.1="http://imc.org/vCard/3.0#"> <rdf:Description rdf:about="http://www.cellml.org/cellml/1.0"> <dcterms:created rdf:parseType="Resource"> <dcterms:W3CDTF>2009-10-28</dcterms:W3CDTF> </dcterms:created> <dc:creator rdf:parseType="Resource"> <vCard:ORG rdf:parseType="Resource"> <vCard:Orgname>Auckland Bioengineering Institute</vCard:Orgname> </vCard:ORG> <vCard:EMAIL> <j.1:internet> <rdf:value>j.terkildsen@auckland.ac.nz</rdf:value> </j.1:internet> </vCard:EMAIL> <vCard:N rdf:parseType="Resource"> <vCard:Given>Jonna</vCard:Given> <vCard:Family>Terkildsen</vCard:Family> </vCard:N> </dc:creator> </rdf:Description> <j.0:bazfoo/> <rdf:Description rdf:about="http://www.cellml.org/cellml/1.0#mackenzie_1996"> <bqs:reference rdf:parseType="Resource"> <bqs:JournalArticle rdf:parseType="Resource"> <bqs:last_page>32683</bqs:last_page> <bqs:first_page>32678</bqs:first_page> <bqs:volume>271</bqs:volume> <bqs:Journal rdf:parseType="Resource"> <dc:title>Journal of Biological Chemistry</dc:title> </bqs:Journal> <dc:title>Biophysical Characteristics of the Pig Kidney Na/Glucose Cotransporter SGLT2 Reveal a Common Mechanism for SGLT1 and SGLT2</dc:title> <dc:creator> <rdf:Seq> <rdf:li rdf:parseType="Resource"> <bqs:Person rdf:parseType="Resource"> <vCard:N rdf:parseType="Resource"> <vCard:Given>M</vCard:Given> <vCard:Family>Mackenzie</vCard:Family> </vCard:N> </bqs:Person> </rdf:li> <rdf:li rdf:parseType="Resource"> <bqs:Person rdf:parseType="Resource"> <vCard:N rdf:parseType="Resource"> <vCard:Other>F</vCard:Other> <vCard:Other>D</vCard:Other> <vCard:Given>D</vCard:Given> <vCard:Family>Loo</vCard:Family> </vCard:N> </bqs:Person> </rdf:li> <rdf:l…
legacy code URI: C:\Users\Christopher\Dropbox\Work Related\Annotated Models\MacKenzie_1996\mackenzie_1996.cellml
model description: Model of the pig kidney Na1/Glucose cotransporter SGLT2
model name: mackenzie_1996
model id: mackenzie_1996

Area of spatial entity
type: Class
subclass of: Reference physical property
subclass of: Restriction
  on property: refersTo
  has value: Area of spatial entity

Charge flow rate
type: Class
subclass of: Reference physical property
subclass of: Restriction
  on property: refersTo
  has value: Charge flow rate

Chemical concentration
type: Class
subclass of: Reference physical property
subclass of: Restriction
  on property: refersTo
  has value: Chemical concentration

Chemical molar amount
type: Class
subclass of: Reference physical property
subclass of: Restriction
  on property: refersTo
  has value: Chemical molar amount

Electrical potential
type: Class
subclass of: Reference physical property
subclass of: Restriction
  on property: refersTo
  has value: Electrical potential

sodium(1+)
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: sodium(1+)

methyl alpha-D-glucopyranoside
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: methyl alpha-D-glucopyranoside

sodium-glucose transport protein subtype 2 inhibitor
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: sodium-glucose transport protein subtype 2 inhibitor

oocyte
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: oocyte

Plasma membrane
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: Plasma membrane

Portion of cytosol
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: Portion of cytosol

Composite physical entity
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subclass of: Physical entity
disjoint with: Custom physical entity
disjoint with: Reference physical entity
comment: A physical entity that is defined by linking multiple physical entity terms with structural relations.

Computation
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subclass of: Computational model component
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Computational model component
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subclass of: SemSim component
disjoint with: Physical model component
comment: An element of a SemSim model that relates to the mathematical or logical representation of physical quantities or qualities.

Custom physical dependency
type: Class
subclass of: Physical dependency
disjoint with: Reference physical dependency
comment: A physical dependency defined in a specific SemSim model.

Custom physical entity
type: Class
subclass of: Physical entity
comment: A physical entity defined in a specific SemSim model.

Custom physical process
type: Class
subclass of: Physical process
comment: A physical process defined in a specific SemSim model.

Custom physical property
type: Class
subclass of: Physical property
disjoint with: Reference physical property
comment: A physical property defined in a specific SemSim model.

Data structure
type: Class
subclass of: Computational model component
comment: A computational element that stores numerical and/or logical information related to the model.

Decimal
type: Class
subclass of: Real
disjoint with: Integer
comment: A data structure whose value is limited to decimals.

Integer
type: Class
subclass of: Real
comment: A data structure whose value is limited to the whole numbers.

MMLchoice
type: Class
subclass of: Real
comment: A data structure unique to JSim's Mathematical Modeling Language (MML) used to set one or more model input values at runtime.

Physical dependency
type: Class
subclass of: Physical model component
disjoint with: Physical entity
disjoint with: Physical process
disjoint with: Physical property
comment: A quantitative relation between values of physical properties that occurs over a span of time and that determines the time-course of a physical process.

Physical entity
type: Class
subclass of: Physical model component
disjoint with: Physical process
disjoint with: Physical property
comment: A physics analytical entity that represents the material, energy, and/or information content of material or immaterial, space-occupying continuants.

Physical model component
type: Class
subclass of: SemSim component
comment: A SemSim model element used to represent, in whole or in part, the physical meaning of a computational element.

Physical process
type: Class
subclass of: Physical model component
disjoint with: Physical property
comment: A physical processural entity that is a flow, or the control of a flow, of energy and/or information amongst physical continuants that are participants in the physical process.

Physical property
type: Class
subclass of: Physical model component
comment: A physical attribute of an instance of a physical entity, an occurrence of a physical process, or a physical dependency that has a quantitative value that is measurable by a physical device or method, or is computable from such values.

Real
type: Class
subclass of: Data structure
comment: A data structure whose value is limited to the real numbers.

Reference physical dependency
type: Class
subclass of: Physical dependency
comment: A physical dependency that is defined using a term in an external knowledge resource.

Reference physical entity
type: Class
subclass of: Physical entity
comment: A physical entity that is defined using a term from an external knowledge resource.

Reference physical process
type: Class
subclass of: Physical process
comment: A physical process that is defined using a term in an external knowledge resource.

Reference physical property
type: Class
subclass of: Physical property
comment: A physical property that is defined using a term in an external knowledge resource.

Relational constraint
type: Class
subclass of: Computational model component
comment: A logical expression that constrains, but does not define, the value of a data structure. Example: x > 0.

SemSim component
type: Class
comment: A computational or physical element of a SemSim model.

Submodel
type: Class
subclass of: Physical model component
comment: A grouping of one or more data structures that comprise a computationally or physically distinct part of a model or submodel.

Unit of measurement
type: Class
subclass of: Computational model component
comment: A physical quantity chosen as a standard in terms of which other physical quantities may be expressed.

sodium(1+)
type: NamedIndividual
refers to: sodium(1+)
is index entity for: CHEBI 29101 part of Cell culture medium
part of: Cell culture medium
has physical property: Chemical concentration

sodium(1+)
type: NamedIndividual
refers to: sodium(1+)
is index entity for: CHEBI 29101 part of fma66836 part of CL 0000023
part of: Portion of cytosol
has physical property: Chemical concentration

methyl alpha-D-glucopyranoside
type: NamedIndividual
refers to: methyl alpha-D-glucopyranoside
is index entity for: CHEBI 320061 part of fma66836 part of CL 0000023
part of: Portion of cytosol
has physical property: Chemical concentration

methyl alpha-D-glucopyranoside
type: NamedIndividual
refers to: methyl alpha-D-glucopyranoside
is index entity for: CHEBI 320061 part of Cell culture medium
part of: Cell culture medium
has physical property: Chemical concentration

sodium-glucose transport protein subtype 2 inhibitor
type: NamedIndividual
refers to: sodium-glucose transport protein subtype 2 inhibitor
is index entity for: CHEBI 73273 part of fma63841 part of CL 0000023
part of: Plasma membrane
has physical property: Chemical molar amount

oocyte
type: NamedIndividual
refers to: oocyte
has part: Plasma membrane
has part: Portion of cytosol

Cell culture medium
type: NamedIndividual
type: Custom physical entity
has part: sodium(1+)
has part: methyl alpha-D-glucopyranoside

External Na Bound SGLT2 Cotransporter
type: NamedIndividual
type: sodium-glucose transport protein subtype 2 inhibitor
type: Custom physical entity
is index entity for: External Na Bound SGLT2 Cotransporter part of fma63841 part of CL 0000023
has physical property: Chemical molar amount
part of: Plasma membrane

External Na and Substrate Bound SGLT2 Cotransporter
type: NamedIndividual
type: sodium-glucose transport protein subtype 2 inhibitor
type: Custom physical entity
is index entity for: External Na and Substrate Bound SGLT2 Cotransporter part of fma63841 part of CL 0000023
has physical property: Chemical molar amount
part of: Plasma membrane

External Unbound SGLT2 Cotransporter
type: NamedIndividual
type: sodium-glucose transport protein subtype 2 inhibitor
type: Custom physical entity
is index entity for: External Unbound SGLT2 Cotransporter part of fma63841 part of CL 0000023
has physical property: Chemical molar amount
part of: Plasma membrane

Glucose transport across cell membrane via SGLT2 cotransporters
type: NamedIndividual
type: Custom physical process
has source: methyl alpha-D-glucopyranoside
has sink: methyl alpha-D-glucopyranoside
has mediator: External Na Bound SGLT2 Cotransporter
has mediator: External Unbound SGLT2 Cotransporter
has mediator: Internal Unbound SGLT2 Cotransporter
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasMediator
annotated target: External Na Bound SGLT2 Cotransporter
annotated source: Glucose transport across cell membrane via SGLT2 cotransporters

Axiom
has multiplier: 1.0
annotated property: hasMediator
annotated source: Glucose transport across cell membrane via SGLT2 cotransporters
annotated target: Internal Unbound SGLT2 Cotransporter

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: methyl alpha-D-glucopyranoside
annotated source: Glucose transport across cell membrane via SGLT2 cotransporters

Axiom
has multiplier: 1.0
annotated property: hasMediator
annotated target: External Unbound SGLT2 Cotransporter
annotated source: Glucose transport across cell membrane via SGLT2 cotransporters

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: methyl alpha-D-glucopyranoside
annotated source: Glucose transport across cell membrane via SGLT2 cotransporters

Internal Na Bound SGLT2 Cotransporter
type: NamedIndividual
type: sodium-glucose transport protein subtype 2 inhibitor
type: Custom physical entity
is index entity for: Internal Na Bound SGLT2 Cotransporter part of fma63841 part of CL 0000023
has physical property: Chemical molar amount
part of: Plasma membrane

Internal Na and Substrate Bound SGLT2 Cotransporter
type: NamedIndividual
type: sodium-glucose transport protein subtype 2 inhibitor
type: Custom physical entity
is index entity for: Internal Na and Substrate Bound SGLT2 Cotransporter part of fma63841 part of CL 0000023
has physical property: Chemical molar amount
part of: Plasma membrane

Internal Unbound SGLT2 Cotransporter
type: NamedIndividual
type: sodium-glucose transport protein subtype 2 inhibitor
type: Custom physical entity
is index entity for: Internal Unbound SGLT2 Cotransporter part of fma63841 part of CL 0000023
has physical property: Chemical molar amount
part of: Plasma membrane

NBC current
type: NamedIndividual
type: Submodel
name: NBC_current
has associated data structure: NBC current.C1
has associated data structure: NBC current.C2
has associated data structure: NBC current.C3
has associated data structure: NBC current.C4
has associated data structure: NBC current.C5
has associated data structure: NBC current.C6
has associated data structure: NBC current.C 1
has associated data structure: NBC current.C 2
has associated data structure: NBC current.C 3
has associated data structure: NBC current.C 4
has associated data structure: NBC current.C 5
has associated data structure: NBC current.C 6
has associated data structure: NBC current.F
has associated data structure: NBC current.I NaGl SS
has associated data structure: NBC current.I NaGl pSS
has associated data structure: NBC current.J Na
has associated data structure: NBC current.alpha p
has associated data structure: NBC current.alpha pp
has associated data structure: NBC current.delta
has associated data structure: NBC current.k 12
has associated data structure: NBC current.k 16
has associated data structure: NBC current.k 21
has associated data structure: NBC current.k 25
has associated data structure: NBC current.k 34
has associated data structure: NBC current.k 43
has associated data structure: NBC current.k 52
has associated data structure: NBC current.k 56
has associated data structure: NBC current.k 61
has associated data structure: NBC current.k 65
has associated data structure: NBC current.n
has associated data structure: NBC current.z Na
has associated data structure: NBC current.z c
has computational component: NBC current computation

NBC current.C1
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Steady state external unbound cotransporter concentration
is computational component for: NBC current.C1 property
has unit: UNIT umol

NBC current.C2
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Steady state external Na bound cotransporter concentration
is computational component for: NBC current.C2 property
has unit: UNIT umol

NBC current.C3
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Steady state external CNaS concentration
is computational component for: NBC current.C3 property
has unit: UNIT umol

NBC current.C4
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Steady state internal CNaS concentration
is computational component for: NBC current.C4 property
has unit: UNIT umol

NBC current.C5
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Steady state internal CNa concentration
is computational component for: NBC current.C5 property
has unit: UNIT umol

NBC current.C6
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Steady state internal unbound cotransporter concentration
is computational component for: NBC current.C6 property
has unit: UNIT umol

NBC current.C 1
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Pre-steady state external unbound cotransporter concentration
is computational component for: Chemical molar amount
has unit: UNIT umol

Chemical molar amount
type: NamedIndividual
refers to: Chemical molar amount
physical property of: External Unbound SGLT2 Cotransporter
has computational component: NBC current.C 1

NBC current.C 2
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Pre-steady state external Na bound cotransporter concentration
is computational component for: Chemical molar amount
has unit: UNIT umol

Chemical molar amount
type: NamedIndividual
refers to: Chemical molar amount
physical property of: External Na Bound SGLT2 Cotransporter
has computational component: NBC current.C 2

NBC current.C 3
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Pre-steady state external CNaS concentration
is computational component for: Chemical molar amount
has unit: UNIT umol

Chemical molar amount
type: NamedIndividual
refers to: Chemical molar amount
physical property of: External Na and Substrate Bound SGLT2 Cotransporter
has computational component: NBC current.C 3

NBC current.C 4
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Steady state internal CNaS concentration
is computational component for: Chemical molar amount
has unit: UNIT umol

Chemical molar amount
type: NamedIndividual
refers to: Chemical molar amount
physical property of: Internal Na and Substrate Bound SGLT2 Cotransporter
has computational component: NBC current.C 4

NBC current.C 5
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Pre-steady state internal CNa concentration
is computational component for: Chemical molar amount
has unit: UNIT umol

Chemical molar amount
type: NamedIndividual
refers to: Chemical molar amount
physical property of: Internal Na Bound SGLT2 Cotransporter
has computational component: NBC current.C 5

NBC current.C 6
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Pre-steady state internal unbound cotransporter concentration
is computational component for: Chemical molar amount
has unit: UNIT umol

Chemical molar amount
type: NamedIndividual
refers to: Chemical molar amount
physical property of: Internal Unbound SGLT2 Cotransporter
has computational component: NBC current.C 6

NBC current.F
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Faraday constant
is computational component for: NBC current.F property
has unit: UNIT C per mol

NBC current.I NaGl SS
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Na glucose steady state current
is computational component for: NBC current.I NaGl SS property
has unit: UNIT uA

NBC current.I NaGl pSS
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Na-glucose pre-steady state current
is computational component for: Charge flow rate
has unit: UNIT uA

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Glucose transport across cell membrane via SGLT2 cotransporters
has computational component: NBC current.I NaGl pSS

NBC current.J Na
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Sodium ion flow into the cytosol
is computational component for: Charge flow rate
has unit: UNIT umol per second

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
has computational component: NBC current.J Na
physical property of: Sodium ion flow into cytosol via SGLT2 cotransporter

NBC current.alpha p
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Fraction of membrane electric field between bulk solution and external face Na binding site.
is computational component for: NBC current.alpha p property

NBC current.alpha pp
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Fraction of membrane electric field between bulk solution and internal face Na binding site.
is computational component for: NBC current.alpha pp property

NBC current.delta
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Fraction of the membrane field sensed by the empty binding on the carrier durring translocation.
is computational component for: NBC current.delta property

NBC current.k 12
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for sodium ion binding to external unbound cotransporter.
is computational component for: NBC current.k 12 property
has unit: UNIT per second

NBC current.k 16
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for external unbound transport site to internal unbound transport site reaction step
is computational component for: NBC current.k 16 property
has unit: UNIT per second

NBC current.k 21
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for sodium ion release from external bound cotransporter.
is computational component for: NBC current.k 21 property
has unit: UNIT per second

NBC current.k 25
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for external CNa to internal CNa reaction step.
is computational component for: NBC current.k 25 property
has unit: UNIT per second

NBC current.k 34
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for external CNaS to internal CNas reaction step
is computational component for: NBC current.k 34 property
has unit: UNIT per second

NBC current.k 43
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for internal CNaS to external CNaS reaction step
is computational component for: NBC current.k 43 property
has unit: UNIT per second

NBC current.k 52
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate for internal CNa to external CNa reaction step
is computational component for: NBC current.k 52 property
has unit: UNIT per second

NBC current.k 56
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for release of Sodium from internal Na bound cotransporter
is computational component for: NBC current.k 56 property
has unit: UNIT per second

NBC current.k 61
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate for internal unbound cotransporter binding site to external unbound cotransporter binding site reaction step
is computational component for: NBC current.k 61 property
has unit: UNIT per second

NBC current.k 65
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate for sodium ion release from internal Na bound cotransporter.
is computational component for: NBC current.k 65 property
has unit: UNIT per second

NBC current.n
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Sodium-glucose coupling coefficent
is computational component for: NBC current.n property

NBC current.z Na
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Na valence
is computational component for: NBC current.z Na property

NBC current.z c
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Empty transporter valence
is computational component for: NBC current.z c property

NBC current computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>I_NaGl_pSS</ci> <apply> <times /> <apply> <minus /> <ci>F</ci> </apply> <apply> <plus /> <apply> <times /> <ci>n</ci> <ci>z_Na</ci> <ci>alpha_p</ci> <apply> <minus /> <apply> <times /> <ci>k_12</ci> <ci>C_1</ci> </apply> <apply> <times /> <ci>k_21</ci> <ci>C_2</ci> </apply> </apply> </apply> <apply> <times /> <ci>z_c</ci> <ci>delta</ci> <apply> <minus /> <apply> <times /> <ci>k_16</ci> <ci>C_1</ci> </apply> <apply> <times /> <ci>k_61</ci> <ci>C_6</ci> </apply> </apply> </apply> <apply> <times /> <ci>n</ci> <ci>z_Na</ci> <ci>alpha_pp</ci> <apply> <minus /> <apply> <times /> <ci>k_56</ci> <ci>C_5</ci> </apply> <apply> <times /> <ci>k_65</ci> <ci>C_6</ci> </apply> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>I_NaGl_SS</ci> <apply> <times /> <apply> <minus /> <ci>F</ci> </apply> <apply> <plus /> <apply> <times /> <ci>z_c</ci> <apply> <minus /> <apply> <times /> <ci>k_16</ci> <ci>C1</ci> </apply> <apply> <times /> <ci>k_61</ci> <ci>C6</ci> </apply> </apply> </apply> <apply> <times /> <apply> <plus /> <ci>z_c</ci> <apply> <times /> <ci>z_Na</ci> <ci>n</ci> </apply> </apply> <apply> <minus /> <apply> <times /> <ci>k_25</ci> <ci>C2</ci> </apply> <apply> <times /> <ci>k_52</ci> <ci>C5</ci> </apply> </apply> </apply> <apply> <times /> <apply> <plus /> <ci>z_c</ci> <apply> <times /> <ci>z_Na</ci> <ci>n</ci> </apply> </apply> <apply> <minus /> <apply> <times /> <ci>k_34</ci> <ci>C3</ci> </apply> <apply> <times /> <ci>k_43</ci> <ci>C4</ci> </apply> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>J_Na</ci> <apply> <plus /> <apply> <minus /> <apply> <times /> <ci>k_25</ci> <ci>C2</ci> </apply> <apply> <times /> <ci>k_52</ci> <ci>C5</ci> </apply> </apply> <apply> <minus /> <apply> <times /> <ci>k_34</ci> <ci>C3</ci> </apply> <apply> <times /> <ci>k_43</ci> <ci>C4</ci> </apply> </apply> </apply> </apply>
is computational component for: NBC current

Sodium ion flow into cytosol via SGLT2 cotransporter
type: NamedIndividual
type: Custom physical process
has source: sodium(1+)
has sink: sodium(1+)
has mediator: External Na Bound SGLT2 Cotransporter
has mediator: External Na and Substrate Bound SGLT2 Cotransporter
has mediator: Internal Na Bound SGLT2 Cotransporter
has mediator: Internal Na and Substrate Bound SGLT2 Cotransporter
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasMediator
annotated target: External Na and Substrate Bound SGLT2 Cotransporter
annotated source: Sodium ion flow into cytosol via SGLT2 cotransporter

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: sodium(1+)
annotated source: Sodium ion flow into cytosol via SGLT2 cotransporter

Axiom
has multiplier: 1.0
annotated property: hasMediator
annotated target: External Na Bound SGLT2 Cotransporter
annotated source: Sodium ion flow into cytosol via SGLT2 cotransporter

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: sodium(1+)
annotated source: Sodium ion flow into cytosol via SGLT2 cotransporter

Axiom
has multiplier: 1.0
annotated property: hasMediator
annotated target: Internal Na and Substrate Bound SGLT2 Cotransporter
annotated source: Sodium ion flow into cytosol via SGLT2 cotransporter

Axiom
has multiplier: 1.0
annotated property: hasMediator
annotated target: Internal Na Bound SGLT2 Cotransporter
annotated source: Sodium ion flow into cytosol via SGLT2 cotransporter

UNIT C per mol
type: NamedIndividual
type: Unit of measurement
has computational code: C_per_mol
unit for: NBC current.F
has unit factor: UNIT coulomb
has unit factor: UNIT mole
unit for: parameters.F
unit for: phenomonological constants.F

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT C per mol
annotated target: UNIT mole

UNIT J per K per mol
type: NamedIndividual
type: Unit of measurement
has computational code: J_per_K_per_mol
has unit factor: UNIT joule
has unit factor: UNIT kelvin
has unit factor: UNIT mole
unit for: parameters.R

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT J per K per mol
annotated target: UNIT kelvin

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT J per K per mol
annotated target: UNIT mole

UNIT M
type: NamedIndividual
type: Unit of measurement
has computational code: M
unit factor for: UNIT M2
unit factor for: UNIT M2 per second
unit factor for: UNIT M per second
has unit factor: UNIT litre
has unit factor: UNIT mole
unit factor for: UNIT per M2 per second5
unit factor for: UNIT per M per second
unit for: ion concentrations.Na i
unit for: ion concentrations.Na o
unit for: ion concentrations.glucose i
unit for: ion concentrations.glucose o
unit for: phenomonological constants.Khalf Na
unit for: phenomonological constants.Khalf gluc
unit for: phenomonological constants.Na o
unit for: phenomonological constants.beta
unit for: phenomonological constants.chi
unit for: phenomonological constants.glucose o
unit for: rate constants.Na i
unit for: rate constants.Na o
unit for: rate constants.glucose i
unit for: rate constants.glucose o

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT M
annotated target: UNIT litre

UNIT M2
type: NamedIndividual
type: Unit of measurement
has computational code: M2
has unit factor: UNIT M
unit for: phenomonological constants.alpha

Axiom
has unit factor exponent: 2.0
annotated property: hasUnitFactor
annotated target: UNIT M
annotated source: UNIT M2

UNIT M2 per second
type: NamedIndividual
type: Unit of measurement
has computational code: M2_per_second
has unit factor: UNIT M
has unit factor: UNIT second
unit for: phenomonological constants.gamma

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT M2 per second
annotated target: UNIT second

Axiom
has unit factor exponent: 2.0
annotated property: hasUnitFactor
annotated target: UNIT M
annotated source: UNIT M2 per second

UNIT M per second
type: NamedIndividual
type: Unit of measurement
has computational code: M_per_second
has unit factor: UNIT M
has unit factor: UNIT second
unit for: phenomonological constants.phi

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT M per second
annotated target: UNIT second

UNIT ampere
type: NamedIndividual
type: Unit of measurement
has computational code: ampere
is fundamental unit: true
unit factor for: UNIT uA

UNIT coulomb
type: NamedIndividual
type: Unit of measurement
has computational code: coulomb
is fundamental unit: true
unit factor for: UNIT C per mol

UNIT joule
type: NamedIndividual
type: Unit of measurement
has computational code: joule
is fundamental unit: true
unit factor for: UNIT J per K per mol

UNIT kelvin
type: NamedIndividual
type: Unit of measurement
has computational code: kelvin
is fundamental unit: true
unit factor for: UNIT J per K per mol
unit for: parameters.T

UNIT litre
type: NamedIndividual
type: Unit of measurement
has computational code: litre
is fundamental unit: true
unit factor for: UNIT M

UNIT metre
type: NamedIndividual
type: Unit of measurement
has computational code: metre
is fundamental unit: true
unit factor for: UNIT um2

UNIT mole
type: NamedIndividual
type: Unit of measurement
has computational code: mole
is fundamental unit: true
unit factor for: UNIT C per mol
unit factor for: UNIT J per K per mol
unit factor for: UNIT M
unit factor for: UNIT per mol
unit factor for: UNIT umol

UNIT per M2 per second5
type: NamedIndividual
type: Unit of measurement
has computational code: per_M2_per_second5
has unit factor: UNIT M
has unit factor: UNIT second
unit for: phenomonological constants.lambda

Axiom
has unit factor exponent: -2.0
annotated property: hasUnitFactor
annotated target: UNIT M
annotated source: UNIT per M2 per second5

Axiom
has unit factor exponent: -5.0
annotated property: hasUnitFactor
annotated source: UNIT per M2 per second5
annotated target: UNIT second

UNIT per M per second
type: NamedIndividual
type: Unit of measurement
has computational code: per_M_per_second
has unit factor: UNIT M
has unit factor: UNIT second
unit for: parameters.k0 12
unit for: parameters.k0 23
unit for: parameters.k0 54
unit for: parameters.k0 65
unit for: phenomonological constants.k0 23
unit for: phenomonological constants.ks 12
unit for: rate constants.k0 12
unit for: rate constants.k0 23
unit for: rate constants.k0 54
unit for: rate constants.k0 54 temp
unit for: rate constants.k0 65
unit for: rate constants.ks 12

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated target: UNIT M
annotated source: UNIT per M per second

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT per M per second
annotated target: UNIT second

UNIT per mol
type: NamedIndividual
type: Unit of measurement
has computational code: per_mol
has unit factor: UNIT mole
unit for: parameters.N Avo

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated target: UNIT mole
annotated source: UNIT per mol

UNIT per second
type: NamedIndividual
type: Unit of measurement
has computational code: per_second
unit for: NBC current.k 12
unit for: NBC current.k 16
unit for: NBC current.k 21
unit for: NBC current.k 25
unit for: NBC current.k 34
unit for: NBC current.k 43
unit for: NBC current.k 52
unit for: NBC current.k 56
unit for: NBC current.k 61
unit for: NBC current.k 65
has unit factor: UNIT second
unit for: kinetic equations.k 12
unit for: kinetic equations.k 16
unit for: kinetic equations.k 21
unit for: kinetic equations.k 23
unit for: kinetic equations.k 25
unit for: kinetic equations.k 32
unit for: kinetic equations.k 34
unit for: kinetic equations.k 43
unit for: kinetic equations.k 45
unit for: kinetic equations.k 52
unit for: kinetic equations.k 54
unit for: kinetic equations.k 56
unit for: kinetic equations.k 61
unit for: kinetic equations.k 65
unit for: king altman states.k 12
unit for: king altman states.k 16
unit for: king altman states.k 21
unit for: king altman states.k 23
unit for: king altman states.k 25
unit for: king altman states.k 32
unit for: king altman states.k 34
unit for: king altman states.k 43
unit for: king altman states.k 45
unit for: king altman states.k 52
unit for: king altman states.k 54
unit for: king altman states.k 56
unit for: king altman states.k 61
unit for: king altman states.k 65
unit for: parameters.k0 16
unit for: parameters.k0 21
unit for: parameters.k0 25
unit for: parameters.k0 32
unit for: parameters.k0 34
unit for: parameters.k0 43
unit for: parameters.k0 45
unit for: parameters.k0 52
unit for: parameters.k0 56
unit for: parameters.k0 61
unit for: phenomonological constants.epsilon
unit for: phenomonological constants.k 12
unit for: phenomonological constants.k 16
unit for: phenomonological constants.k 21
unit for: phenomonological constants.k 23
unit for: phenomonological constants.k 25
unit for: phenomonological constants.k 32
unit for: phenomonological constants.k 34
unit for: phenomonological constants.k 43
unit for: phenomonological constants.k 45
unit for: phenomonological constants.k 52
unit for: phenomonological constants.k 54
unit for: phenomonological constants.k 56
unit for: phenomonological constants.k 61
unit for: phenomonological constants.k 65
unit for: rate constants.k0 16
unit for: rate constants.k0 21
unit for: rate constants.k0 25
unit for: rate constants.k0 32
unit for: rate constants.k0 34
unit for: rate constants.k0 43
unit for: rate constants.k0 45
unit for: rate constants.k0 52
unit for: rate constants.k0 56
unit for: rate constants.k0 61
unit for: rate constants.k 12
unit for: rate constants.k 16
unit for: rate constants.k 21

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT per second
annotated target: UNIT second

UNIT per second5
type: NamedIndividual
type: Unit of measurement
has computational code: per_second5
has unit factor: UNIT second
unit for: king altman states.C1 sum
unit for: king altman states.C2 sum
unit for: king altman states.C3 sum
unit for: king altman states.C4 sum
unit for: king altman states.C5 sum
unit for: king altman states.C6 sum
unit for: king altman states.C sum

Axiom
has unit factor exponent: -5.0
annotated property: hasUnitFactor
annotated source: UNIT per second5
annotated target: UNIT second

UNIT second
type: NamedIndividual
type: Unit of measurement
has computational code: second
is fundamental unit: true
unit factor for: UNIT M2 per second
unit factor for: UNIT M per second
unit factor for: UNIT per M2 per second5
unit factor for: UNIT per M per second
unit factor for: UNIT per second
unit factor for: UNIT per second5
unit factor for: UNIT umol per second
unit for: environment.time
unit for: ion concentrations.time
unit for: kinetic equations.time

UNIT uA
type: NamedIndividual
type: Unit of measurement
has computational code: uA
unit for: NBC current.I NaGl SS
unit for: NBC current.I NaGl pSS
has unit factor: UNIT ampere
unit for: phenomonological constants.Imax Na
unit for: phenomonological constants.Imax gluc

Axiom
has unit factor prefix: micro
annotated property: hasUnitFactor
annotated target: UNIT ampere
annotated source: UNIT uA

UNIT um2
type: NamedIndividual
type: Unit of measurement
has computational code: um2
has unit factor: UNIT metre
unit for: parameters.area

Axiom
has unit factor exponent: 2.0
has unit factor prefix: micro
annotated property: hasUnitFactor
annotated target: UNIT metre
annotated source: UNIT um2

UNIT umol
type: NamedIndividual
type: Unit of measurement
has computational code: umol
unit for: NBC current.C1
unit for: NBC current.C2
unit for: NBC current.C3
unit for: NBC current.C4
unit for: NBC current.C5
unit for: NBC current.C6
unit for: NBC current.C 1
unit for: NBC current.C 2
unit for: NBC current.C 3
unit for: NBC current.C 4
unit for: NBC current.C 5
unit for: NBC current.C 6
has unit factor: UNIT mole
unit factor for: UNIT umol per second
unit for: kinetic equations.C 1
unit for: kinetic equations.C 2
unit for: kinetic equations.C 3
unit for: kinetic equations.C 4
unit for: kinetic equations.C 5
unit for: kinetic equations.C 6
unit for: kinetic equations.C 6 temp
unit for: kinetic equations.C T
unit for: king altman states.C1
unit for: king altman states.C2
unit for: king altman states.C3
unit for: king altman states.C4
unit for: king altman states.C5
unit for: king altman states.C6
unit for: king altman states.C T
unit for: parameters.C T
unit for: phenomonological constants.C T
unit for: rate constants.C T

Axiom
has unit factor prefix: micro
annotated property: hasUnitFactor
annotated target: UNIT mole
annotated source: UNIT umol

UNIT umol per second
type: NamedIndividual
type: Unit of measurement
has computational code: umol_per_second
unit for: NBC current.J Na
has unit factor: UNIT second
has unit factor: UNIT umol

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated target: UNIT second
annotated source: UNIT umol per second

UNIT volt
type: NamedIndividual
type: Unit of measurement
is fundamental unit: true
has computational code: volt
unit for: ion concentrations.V
unit for: parameters.V

environment
type: NamedIndividual
type: Submodel
name: environment
has associated data structure: environment.time
has computational component: environment computation

environment.time
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Time - Solution Domain
has unit: UNIT second
is computational component for: environment.time property
mapped to: ion concentrations.time
mapped to: kinetic equations.time

Plasma membrane
type: NamedIndividual
refers to: Plasma membrane
has part: sodium-glucose transport protein subtype 2 inhibitor
part of: oocyte
has part: External Na Bound SGLT2 Cotransporter
has part: External Na and Substrate Bound SGLT2 Cotransporter
has part: External Unbound SGLT2 Cotransporter
has part: Internal Na Bound SGLT2 Cotransporter
has part: Internal Na and Substrate Bound SGLT2 Cotransporter
has part: Internal Unbound SGLT2 Cotransporter
is index entity for: fma63841 part of CL 0000023
has physical property: Electrical potential

Portion of cytosol
type: NamedIndividual
refers to: Portion of cytosol
has part: sodium(1+)
has part: methyl alpha-D-glucopyranoside
part of: oocyte
is index entity for: fma66836 part of CL 0000023

ion concentrations
type: NamedIndividual
type: Submodel
name: ion_concentrations
has associated data structure: ion concentrations.Na i
has associated data structure: ion concentrations.Na o
has associated data structure: ion concentrations.V
has associated data structure: ion concentrations.glucose i
has associated data structure: ion concentrations.glucose o
has associated data structure: ion concentrations.time
has computational component: ion concentrations computation

ion concentrations.Na i
type: NamedIndividual
type: Decimal
has start value: 10e-3
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Intracellular sodium concentration
has unit: UNIT M
is computational component for: Chemical concentration
mapped to: rate constants.Na i

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: ion concentrations.Na i

ion concentrations.Na o
type: NamedIndividual
type: Decimal
has start value: 100e-3
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Sodium concentration in cell culture medium
has unit: UNIT M
is computational component for: Chemical concentration
mapped to: phenomonological constants.Na o
mapped to: rate constants.Na o

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: ion concentrations.Na o

ion concentrations.V
type: NamedIndividual
type: Decimal
has start value: -150e-3
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Electrical potential of the cell membrane
has unit: UNIT volt
is computational component for: Electrical potential
mapped to: parameters.V

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: ion concentrations.V

ion concentrations.glucose i
type: NamedIndividual
type: Decimal
has start value: 0e-3
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Intracellular glucose concentration
has unit: UNIT M
is computational component for: Chemical concentration
mapped to: rate constants.glucose i

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: methyl alpha-D-glucopyranoside
has computational component: ion concentrations.glucose i

ion concentrations.glucose o
type: NamedIndividual
type: Decimal
has start value: 1e-3
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Glucose concentration in experimental medium
has unit: UNIT M
is computational component for: Chemical concentration
mapped to: phenomonological constants.glucose o
mapped to: rate constants.glucose o

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: methyl alpha-D-glucopyranoside
has computational component: ion concentrations.glucose o

ion concentrations.time
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Time - Solution Domain
has unit: UNIT second
is computational component for: ion concentrations.time property

ion concentrations computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>V</ci> </apply> <cn type="e-notation" xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="volt_per_second"> 100 <sep /> -6 </cn> </apply>
is computational component for: ion concentrations

kinetic equations
type: NamedIndividual
type: Submodel
name: kinetic_equations
has associated data structure: kinetic equations.C 1
has associated data structure: kinetic equations.C 2
has associated data structure: kinetic equations.C 3
has associated data structure: kinetic equations.C 4
has associated data structure: kinetic equations.C 5
has associated data structure: kinetic equations.C 6
has associated data structure: kinetic equations.C 6 temp
has associated data structure: kinetic equations.C T
has associated data structure: kinetic equations.k 12
has associated data structure: kinetic equations.k 16
has associated data structure: kinetic equations.k 21
has associated data structure: kinetic equations.k 23
has associated data structure: kinetic equations.k 25
has associated data structure: kinetic equations.k 32
has associated data structure: kinetic equations.k 34
has associated data structure: kinetic equations.k 43
has associated data structure: kinetic equations.k 45
has associated data structure: kinetic equations.k 52
has associated data structure: kinetic equations.k 54
has associated data structure: kinetic equations.k 56
has associated data structure: kinetic equations.k 61
has associated data structure: kinetic equations.k 65
has associated data structure: kinetic equations.time
has computational component: kinetic equations computation

kinetic equations.C 1
type: NamedIndividual
type: Decimal
has start value: 3.923e-9
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
mapped to: NBC current.C 1
has unit: UNIT umol
is computational component for: Chemical molar amount

Chemical molar amount
type: NamedIndividual
refers to: Chemical molar amount
has computational component: kinetic equations.C 1

kinetic equations.C 2
type: NamedIndividual
type: Decimal
has start value: 1.016e-7
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Pre-steady state external Na bound cotransporter concentration
mapped to: NBC current.C 2
has unit: UNIT umol
is computational component for: Chemical molar amount

Chemical molar amount
type: NamedIndividual
refers to: Chemical molar amount
physical property of: External Na Bound SGLT2 Cotransporter
has computational component: kinetic equations.C 2

kinetic equations.C 3
type: NamedIndividual
type: Decimal
has start value: 1.515e-8
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Pre-steady state external CNaS concentration
mapped to: NBC current.C 3
has unit: UNIT umol
is computational component for: Chemical molar amount

Chemical molar amount
type: NamedIndividual
refers to: Chemical molar amount
physical property of: External Na and Substrate Bound SGLT2 Cotransporter
has computational component: kinetic equations.C 3

kinetic equations.C 4
type: NamedIndividual
type: Decimal
has start value: 8.912e-10
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Steady state internal CNaS concentration
mapped to: NBC current.C 4
has unit: UNIT umol
is computational component for: Chemical molar amount

Chemical molar amount
type: NamedIndividual
refers to: Chemical molar amount
physical property of: Internal Na and Substrate Bound SGLT2 Cotransporter
has computational component: kinetic equations.C 4

kinetic equations.C 5
type: NamedIndividual
type: Decimal
has start value: 1.485e-8
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Pre-steady state internal CNa concentration
mapped to: NBC current.C 5
has unit: UNIT umol
is computational component for: Chemical molar amount

Chemical molar amount
type: NamedIndividual
refers to: Chemical molar amount
physical property of: Internal Na Bound SGLT2 Cotransporter
has computational component: kinetic equations.C 5

kinetic equations.C 6
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Pre-steady state internal unbound cotransporter concentration
mapped to: NBC current.C 6
has unit: UNIT umol
is computational component for: Chemical molar amount

Chemical molar amount
type: NamedIndividual
refers to: Chemical molar amount
physical property of: Internal Unbound SGLT2 Cotransporter
has computational component: kinetic equations.C 6

kinetic equations.C 6 temp
type: NamedIndividual
type: Decimal
has start value: 3.06798e-9
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
has unit: UNIT umol
is computational component for: Chemical molar amount

Chemical molar amount
type: NamedIndividual
refers to: Chemical molar amount
has computational component: kinetic equations.C 6 temp

kinetic equations.C T
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Density of functional SGLT2 carriers in the oocyte membrane
has unit: UNIT umol
is computational component for: Chemical molar amount

Chemical molar amount
type: NamedIndividual
refers to: Chemical molar amount
physical property of: sodium-glucose transport protein subtype 2 inhibitor
has computational component: kinetic equations.C T

kinetic equations.k 12
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for sodium ion binding to external unbound cotransporter.
has unit: UNIT per second
is computational component for: kinetic equations.k 12 property

kinetic equations.k 16
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for external unbound transport site to internal unbound transport site reaction step
has unit: UNIT per second
is computational component for: kinetic equations.k 16 property

kinetic equations.k 21
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for sodium ion release from external bound cotransporter.
has unit: UNIT per second
is computational component for: kinetic equations.k 21 property

kinetic equations.k 23
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for binding of glucose to external CNa binding site
has unit: UNIT per second
is computational component for: kinetic equations.k 23 property

kinetic equations.k 25
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate for external CNa to internal CNa reaction step.
has unit: UNIT per second
is computational component for: kinetic equations.k 25 property

kinetic equations.k 32
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for release of glucose from external CNaS
has unit: UNIT per second
is computational component for: kinetic equations.k 32 property

kinetic equations.k 34
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for external CNaS to internal CNas reaction step
has unit: UNIT per second
is computational component for: kinetic equations.k 34 property

kinetic equations.k 43
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for internal CNaS to external CNaS reaction step
has unit: UNIT per second
is computational component for: kinetic equations.k 43 property

kinetic equations.k 45
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate constant for release of glucose from internal CNaS
has unit: UNIT per second
is computational component for: kinetic equations.k 45 property

kinetic equations.k 52
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for internal CNa to external CNa reaction step
has unit: UNIT per second
is computational component for: kinetic equations.k 52 property

kinetic equations.k 54
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for binding of glucose to internal CNa binding site
has unit: UNIT per second
is computational component for: kinetic equations.k 54 property

kinetic equations.k 56
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for release of Sodium from internal Na bound cotransporter
has unit: UNIT per second
is computational component for: kinetic equations.k 56 property

kinetic equations.k 61
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for internal unbound cotransporter binding site to external unbound cotransporter binding site reaction step
has unit: UNIT per second
is computational component for: kinetic equations.k 61 property

kinetic equations.k 65
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for sodium ion release from internal Na bound cotransporter.
has unit: UNIT per second
is computational component for: kinetic equations.k 65 property

kinetic equations.time
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Time - Solution Domain
has unit: UNIT second
is computational component for: kinetic equations.time property

kinetic equations computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>C_1</ci> </apply> <apply> <minus /> <apply> <plus /> <apply> <times /> <ci>k_21</ci> <ci>C_2</ci> </apply> <apply> <times /> <ci>k_61</ci> <ci>C_6</ci> </apply> </apply> <apply> <times /> <apply> <plus /> <ci>k_12</ci> <ci>k_16</ci> </apply> <ci>C_1</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>C_2</ci> </apply> <apply> <minus /> <apply> <plus /> <apply> <times /> <ci>k_12</ci> <ci>C_1</ci> </apply> <apply> <times /> <ci>k_32</ci> <ci>C_3</ci> </apply> <apply> <times /> <ci>k_52</ci> <ci>C_5</ci> </apply> </apply> <apply> <times /> <apply> <plus /> <ci>k_21</ci> <ci>k_23</ci> <ci>k_25</ci> </apply> <ci>C_2</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>C_3</ci> </apply> <apply> <minus /> <apply> <plus /> <apply> <times /> <ci>k_23</ci> <ci>C_2</ci> </apply> <apply> <times /> <ci>k_43</ci> <ci>C_4</ci> </apply> </apply> <apply> <times /> <apply> <plus /> <ci>k_32</ci> <ci>k_34</ci> </apply> <ci>C_3</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>C_4</ci> </apply> <apply> <minus /> <apply> <plus /> <apply> <times /> <ci>k_34</ci> <ci>C_3</ci> </apply> <apply> <times /> <ci>k_54</ci> <ci>C_5</ci> </apply> </apply> <apply> <times /> <apply> <plus /> <ci>k_45</ci> <ci>k_43</ci> </apply> <ci>C_4</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>C_5</ci> </apply> <apply> <minus /> <apply> <plus /> <apply> <times /> <ci>k_45</ci> <ci>C_4</ci> </apply> <apply> <times /> <ci>k_65</ci> <ci>C_6</ci> </apply> <apply> <times /> <ci>k_25</ci> <ci>C_2</ci> </apply> </apply> <apply> <times /> <apply> <plus /> <ci>k_54</ci> <ci>k_52</ci> <ci>k_56</ci> </apply> <ci>C_5</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>C_6_temp</ci> </apply> <apply> <minus /> <apply> <plus /> <apply…
is computational component for: kinetic equations

king altman states
type: NamedIndividual
type: Submodel
name: king_altman_states
has associated data structure: king altman states.C1
has associated data structure: king altman states.C1 sum
has associated data structure: king altman states.C2
has associated data structure: king altman states.C2 sum
has associated data structure: king altman states.C3
has associated data structure: king altman states.C3 sum
has associated data structure: king altman states.C4
has associated data structure: king altman states.C4 sum
has associated data structure: king altman states.C5
has associated data structure: king altman states.C5 sum
has associated data structure: king altman states.C6
has associated data structure: king altman states.C6 sum
has associated data structure: king altman states.C T
has associated data structure: king altman states.C sum
has associated data structure: king altman states.k 12
has associated data structure: king altman states.k 16
has associated data structure: king altman states.k 21
has associated data structure: king altman states.k 23
has associated data structure: king altman states.k 25
has associated data structure: king altman states.k 32
has associated data structure: king altman states.k 34
has associated data structure: king altman states.k 43
has associated data structure: king altman states.k 45
has associated data structure: king altman states.k 52
has associated data structure: king altman states.k 54
has associated data structure: king altman states.k 56
has associated data structure: king altman states.k 61
has associated data structure: king altman states.k 65
has computational component: king altman states computation

king altman states.C1
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
mapped to: NBC current.C1
has unit: UNIT umol
is computational component for: Chemical molar amount

Chemical molar amount
type: NamedIndividual
refers to: Chemical molar amount
has computational component: king altman states.C1

king altman states.C1 sum
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
has unit: UNIT per second5
is computational component for: king altman states.C1 sum property

king altman states.C2
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Steady state external Na bound cotransporter concentration
mapped to: NBC current.C2
has unit: UNIT umol
is computational component for: king altman states.C2 property

king altman states.C2 sum
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
has unit: UNIT per second5
is computational component for: king altman states.C2 sum property

king altman states.C3
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Steady state external CNaS concentration
mapped to: NBC current.C3
has unit: UNIT umol
is computational component for: king altman states.C3 property

king altman states.C3 sum
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
is declared: true
has unit: UNIT per second5
is computational component for: king altman states.C3 sum property

king altman states.C4
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Steady state internal CNaS concentration
mapped to: NBC current.C4
has unit: UNIT umol
is computational component for: king altman states.C4 property

king altman states.C4 sum
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
is declared: true
has unit: UNIT per second5
is computational component for: king altman states.C4 sum property

king altman states.C5
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Steady state internal CNa concentration
mapped to: NBC current.C5
has unit: UNIT umol
is computational component for: king altman states.C5 property

king altman states.C5 sum
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
has unit: UNIT per second5
is computational component for: king altman states.C5 sum property

king altman states.C6
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Steady state internal unbound cotransporter concentration
mapped to: NBC current.C6
has unit: UNIT umol
is computational component for: king altman states.C6 property

king altman states.C6 sum
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
is declared: true
has unit: UNIT per second5
is computational component for: king altman states.C6 sum property

king altman states.C T
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Density of functional SGLT2 carriers in the oocyte membrane
has unit: UNIT umol
is computational component for: Chemical molar amount

Chemical molar amount
type: NamedIndividual
refers to: Chemical molar amount
physical property of: sodium-glucose transport protein subtype 2 inhibitor
has computational component: king altman states.C T

king altman states.C sum
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
has unit: UNIT per second5
is computational component for: king altman states.C sum property

king altman states.k 12
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate for sodium ion binding to external unbound cotransporter.
has unit: UNIT per second
is computational component for: king altman states.k 12 property

king altman states.k 16
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate for external unbound transport site to internal unbound transport site reaction step
has unit: UNIT per second
is computational component for: king altman states.k 16 property

king altman states.k 21
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for sodium ion release from external bound cotransporter.
has unit: UNIT per second
is computational component for: king altman states.k 21 property

king altman states.k 23
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate for binding of glucose to external CNa binding site
has unit: UNIT per second
is computational component for: king altman states.k 23 property

king altman states.k 25
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate for external CNa to internal CNa reaction step.
has unit: UNIT per second
is computational component for: king altman states.k 25 property

king altman states.k 32
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for release of glucose from external CNaS
has unit: UNIT per second
is computational component for: king altman states.k 32 property

king altman states.k 34
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate for external CNaS to internal CNas reaction step
has unit: UNIT per second
is computational component for: king altman states.k 34 property

king altman states.k 43
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for internal CNaS to external CNaS reaction step
has unit: UNIT per second
is computational component for: king altman states.k 43 property

king altman states.k 45
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate constant for release of glucose from internal CNaS
has unit: UNIT per second
is computational component for: king altman states.k 45 property

king altman states.k 52
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for internal CNa to external CNa reaction step
has unit: UNIT per second
is computational component for: king altman states.k 52 property

king altman states.k 54
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for binding of glucose to internal CNa binding site
has unit: UNIT per second
is computational component for: king altman states.k 54 property

king altman states.k 56
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate for release of Sodium from internal Na bound cotransporter
has unit: UNIT per second
is computational component for: king altman states.k 56 property

king altman states.k 61
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for internal unbound cotransporter binding site to external unbound cotransporter binding site reaction step
has unit: UNIT per second
is computational component for: king altman states.k 61 property

king altman states.k 65
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for sodium ion release from internal Na bound cotransporter.
has unit: UNIT per second
is computational component for: king altman states.k 65 property

king altman states computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>C1_sum</ci> <apply> <plus /> <apply> <times /> <ci>k_21</ci> <ci>k_32</ci> <ci>k_43</ci> <ci>k_54</ci> <ci>k_65</ci> </apply> <apply> <times /> <ci>k_21</ci> <ci>k_34</ci> <ci>k_45</ci> <ci>k_52</ci> <ci>k_65</ci> </apply> <apply> <times /> <ci>k_21</ci> <ci>k_32</ci> <ci>k_45</ci> <ci>k_52</ci> <ci>k_65</ci> </apply> <apply> <times /> <ci>k_21</ci> <ci>k_32</ci> <ci>k_43</ci> <ci>k_52</ci> <ci>k_65</ci> </apply> <apply> <times /> <ci>k_25</ci> <ci>k_34</ci> <ci>k_45</ci> <ci>k_56</ci> <ci>k_61</ci> </apply> <apply> <times /> <ci>k_23</ci> <ci>k_34</ci> <ci>k_45</ci> <ci>k_56</ci> <ci>k_61</ci> </apply> <apply> <times /> <ci>k_21</ci> <ci>k_34</ci> <ci>k_45</ci> <ci>k_56</ci> <ci>k_61</ci> </apply> <apply> <times /> <ci>k_25</ci> <ci>k_32</ci> <ci>k_45</ci> <ci>k_56</ci> <ci>k_61</ci> </apply> <apply> <times /> <ci>k_21</ci> <ci>k_32</ci> <ci>k_45</ci> <ci>k_56</ci> <ci>k_61</ci> </apply> <apply> <times /> <ci>k_25</ci> <ci>k_32</ci> <ci>k_43</ci> <ci>k_56</ci> <ci>k_61</ci> </apply> <apply> <times /> <ci>k_21</ci> <ci>k_32</ci> <ci>k_43</ci> <ci>k_56</ci> <ci>k_61</ci> </apply> <apply> <times /> <ci>k_21</ci> <ci>k_32</ci> <ci>k_43</ci> <ci>k_54</ci> <ci>k_61</ci> </apply> <apply> <times /> <ci>k_21</ci> <ci>k_34</ci> <ci>k_45</ci> <ci>k_52</ci> <ci>k_61</ci> </apply> <apply> <times /> <ci>k_21</ci> <ci>k_32</ci> <ci>k_45</ci> <ci>k_52</ci> <ci>k_61</ci> </apply> <apply> <times /> <ci>k_21</ci> <ci>k_32</ci> <ci>k_43</ci> <ci>k_52</ci> <ci>k_61</ci> </apply> </apply> </apply> <apply> <eq /> <ci>C2_sum</ci> <apply> <plus /> <apply> <times /> <ci>k_16</ci> <ci>k_32</ci> <ci>k_43</ci> <ci>k_54</ci> <ci>k_65</ci> </apply> <apply> <times /> <ci>k_12</ci> <ci>k_32</ci> <ci>k_43</ci> <ci>k_54</ci> <ci>k_65</ci> </apply> <apply> <times /> <ci>k_16</ci> <ci>k_34</ci> <ci>k_45</ci> <ci>k_52</ci> <ci>k_65</ci> </apply> <apply> <times /> <ci>k_12</ci> <ci>k_34</ci> <ci>k_45</ci> <ci>k_52</ci> <ci>k_65</ci> </apply> <apply> <times /> <ci>k_16</ci> <ci>k_32</c…
is computational component for: king altman states

parameters
type: NamedIndividual
type: Submodel
name: parameters
has associated data structure: parameters.C T
has associated data structure: parameters.F
has associated data structure: parameters.N Avo
has associated data structure: parameters.N C
has associated data structure: parameters.R
has associated data structure: parameters.T
has associated data structure: parameters.V
has associated data structure: parameters.alpha p
has associated data structure: parameters.alpha pp
has associated data structure: parameters.area
has associated data structure: parameters.delta
has associated data structure: parameters.k0 12
has associated data structure: parameters.k0 16
has associated data structure: parameters.k0 21
has associated data structure: parameters.k0 23
has associated data structure: parameters.k0 25
has associated data structure: parameters.k0 32
has associated data structure: parameters.k0 34
has associated data structure: parameters.k0 43
has associated data structure: parameters.k0 45
has associated data structure: parameters.k0 52
has associated data structure: parameters.k0 54
has associated data structure: parameters.k0 56
has associated data structure: parameters.k0 61
has associated data structure: parameters.k0 65
has associated data structure: parameters.mu
has associated data structure: parameters.n
has associated data structure: parameters.z Na
has associated data structure: parameters.z c
has computational component: parameters computation

parameters.C T
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Density of functional SGLT2 carriers in the oocyte membrane
has unit: UNIT umol
mapped to: kinetic equations.C T
mapped to: king altman states.C T
is computational component for: Chemical molar amount
mapped to: phenomonological constants.C T
mapped to: rate constants.C T

Chemical molar amount
type: NamedIndividual
refers to: Chemical molar amount
physical property of: sodium-glucose transport protein subtype 2 inhibitor
has computational component: parameters.C T

parameters.F
type: NamedIndividual
type: Decimal
has start value: 96485.34
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Faraday constant
mapped to: NBC current.F
has unit: UNIT C per mol
is computational component for: parameters.F property
mapped to: phenomonological constants.F

parameters.N Avo
type: NamedIndividual
type: Decimal
has start value: 6.022e23
is solution domain: false
is discrete: false
is declared: true
comment: Avogadro's number
has unit: UNIT per mol
is computational component for: parameters.N Avo property

parameters.N C
type: NamedIndividual
type: Decimal
has start value: 8.4e10
is discrete: false
is solution domain: false
is declared: true
is computational component for: parameters.N C property

parameters.R
type: NamedIndividual
type: Decimal
has start value: 8.314
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Boltzmann constant
has unit: UNIT J per K per mol
is computational component for: parameters.R property

parameters.T
type: NamedIndividual
type: Decimal
has start value: 310
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Temperature
has unit: UNIT kelvin
is computational component for: parameters.T property

parameters.V
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Electrical potential of the cell membrane
has unit: UNIT volt
is computational component for: Electrical potential

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: parameters.V

parameters.alpha p
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Fraction of membrane electric field between bulk solution and external face Na binding site.
mapped to: NBC current.alpha p
is computational component for: parameters.alpha p property
mapped to: rate constants.alpha p

parameters.alpha pp
type: NamedIndividual
type: Decimal
has start value: 0
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Fraction of membrane electric field between bulk solution and internal face Na binding site.
mapped to: NBC current.alpha pp
is computational component for: parameters.alpha pp property
mapped to: rate constants.alpha pp

parameters.area
type: NamedIndividual
type: Decimal
has start value: 1e6
is solution domain: false
is discrete: false
is declared: true
has unit: UNIT um2
is computational component for: Area of spatial entity

Area of spatial entity
type: NamedIndividual
refers to: Area of spatial entity
has computational component: parameters.area

parameters.delta
type: NamedIndividual
type: Decimal
has start value: 0.7
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Fraction of the membrane field sensed by the empty binding on the carrier durring translocation.
mapped to: NBC current.delta
is computational component for: parameters.delta property
mapped to: rate constants.delta

parameters.k0 12
type: NamedIndividual
type: Decimal
has start value: 20000
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Rate constant for sodium ion binding to external unbound cotransporter.
has unit: UNIT per M per second
is computational component for: parameters.k0 12 property
mapped to: rate constants.k0 12

parameters.k0 16
type: NamedIndividual
type: Decimal
has start value: 100
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Rate constant for external unbound transport site to internal unbound transport site reaction step
has unit: UNIT per second
is computational component for: parameters.k0 16 property
mapped to: rate constants.k0 16

parameters.k0 21
type: NamedIndividual
type: Decimal
has start value: 400
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Rate constant for sodium ion release from external bound cotransporter.
has unit: UNIT per second
is computational component for: parameters.k0 21 property
mapped to: rate constants.k0 21

parameters.k0 23
type: NamedIndividual
type: Decimal
has start value: 1e4
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Rate constant for binding of glucose to external CNa binding site
has unit: UNIT per M per second
is computational component for: parameters.k0 23 property
mapped to: phenomonological constants.k0 23
mapped to: rate constants.k0 23

parameters.k0 25
type: NamedIndividual
type: Decimal
has start value: 0.01
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Rate constant for external CNa to internal CNa reaction step.
has unit: UNIT per second
is computational component for: parameters.k0 25 property
mapped to: rate constants.k0 25

parameters.k0 32
type: NamedIndividual
type: Decimal
has start value: 20
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Rate constant for release of glucose from external CNaS
has unit: UNIT per second
is computational component for: parameters.k0 32 property
mapped to: rate constants.k0 32

parameters.k0 34
type: NamedIndividual
type: Decimal
has start value: 50
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Rate constant for external CNaS to internal CNas reaction step
has unit: UNIT per second
is computational component for: parameters.k0 34 property
mapped to: rate constants.k0 34

parameters.k0 43
type: NamedIndividual
type: Decimal
has start value: 50
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Rate constant for internal CNaS to external CNaS reaction step
has unit: UNIT per second
is computational component for: parameters.k0 43 property
mapped to: rate constants.k0 43

parameters.k0 45
type: NamedIndividual
type: Decimal
has start value: 800
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Rate constant for release of glucose from internal CNaS
has unit: UNIT per second
is computational component for: parameters.k0 45 property
mapped to: rate constants.k0 45

parameters.k0 52
type: NamedIndividual
type: Decimal
has start value: 0.17
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Rate constant for internal CNa to external CNa reaction step
has unit: UNIT per second
is computational component for: parameters.k0 52 property
mapped to: rate constants.k0 52

parameters.k0 54
type: NamedIndividual
type: Decimal
has start value: 6.7e6
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Rate constant for binding of glucose to internal CNa binding site
has unit: UNIT per M per second
is computational component for: parameters.k0 54 property
mapped to: rate constants.k0 54

parameters.k0 56
type: NamedIndividual
type: Decimal
has start value: 48
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
has unit: UNIT per second
is computational component for: parameters.k0 56 property
mapped to: rate constants.k0 56

parameters.k0 61
type: NamedIndividual
type: Decimal
has start value: 35
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Rate constant for internal unbound cotransporter binding site to external unbound cotransporter binding site reaction step
has unit: UNIT per second
is computational component for: parameters.k0 61 property
mapped to: rate constants.k0 61

parameters.k0 65
type: NamedIndividual
type: Decimal
has start value: 50
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Rate constant for sodium ion release from internal Na bound cotransporter.
has unit: UNIT per M per second
is computational component for: parameters.k0 65 property
mapped to: rate constants.k0 65

parameters.mu
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Relationship between membrane voltage and F*R/T.
is computational component for: parameters.mu property
mapped to: rate constants.mu

parameters.n
type: NamedIndividual
type: Decimal
has start value: 1
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Sodium-glucose coupling coefficent
mapped to: NBC current.n
is computational component for: parameters.n property
mapped to: rate constants.n

parameters.z Na
type: NamedIndividual
type: Decimal
has start value: 1
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Na valence
mapped to: NBC current.z Na
is computational component for: parameters.z Na property
mapped to: rate constants.z Na

parameters.z c
type: NamedIndividual
type: Decimal
has start value: -1
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Empty transporter valence
mapped to: NBC current.z c
is computational component for: parameters.z c property
mapped to: rate constants.z c

parameters computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>alpha_p</ci> <apply> <minus /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <ci>delta</ci> </apply> <ci>alpha_pp</ci> </apply> </apply> <apply> <eq /> <ci>C_T</ci> <apply> <divide /> <apply> <times /> <cn type="e-notation" xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="umol_per_mol"> 1 <sep /> 6 </cn> <ci>N_C</ci> </apply> <ci>N_Avo</ci> </apply> </apply> <apply> <eq /> <ci>mu</ci> <apply> <divide /> <apply> <times /> <ci>F</ci> <ci>V</ci> </apply> <apply> <times /> <ci>R</ci> <ci>T</ci> </apply> </apply> </apply>
is computational component for: parameters

phenomonological constants
type: NamedIndividual
type: Submodel
name: phenomonological_constants
has associated data structure: phenomonological constants.C T
has associated data structure: phenomonological constants.F
has associated data structure: phenomonological constants.Imax Na
has associated data structure: phenomonological constants.Imax gluc
has associated data structure: phenomonological constants.Khalf Na
has associated data structure: phenomonological constants.Khalf gluc
has associated data structure: phenomonological constants.Na o
has associated data structure: phenomonological constants.alpha
has associated data structure: phenomonological constants.beta
has associated data structure: phenomonological constants.chi
has associated data structure: phenomonological constants.epsilon
has associated data structure: phenomonological constants.gamma
has associated data structure: phenomonological constants.glucose o
has associated data structure: phenomonological constants.k0 23
has associated data structure: phenomonological constants.k 12
has associated data structure: phenomonological constants.k 16
has associated data structure: phenomonological constants.k 21
has associated data structure: phenomonological constants.k 23
has associated data structure: phenomonological constants.k 25
has associated data structure: phenomonological constants.k 32
has associated data structure: phenomonological constants.k 34
has associated data structure: phenomonological constants.k 43
has associated data structure: phenomonological constants.k 45
has associated data structure: phenomonological constants.k 52
has associated data structure: phenomonological constants.k 54
has associated data structure: phenomonological constants.k 56
has associated data structure: phenomonological constants.k 61
has associated data structure: phenomonological constants.k 65
has associated data structure: phenomonological constants.ks 12
has associated data structure: phenomonological constants.lambda
has associated data structure: phenomonological constants.phi
has computational component: phenomonological constants computation

phenomonological constants.C T
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Density of functional SGLT2 carriers in the oocyte membrane
has unit: UNIT umol
is computational component for: Chemical molar amount

Chemical molar amount
type: NamedIndividual
refers to: Chemical molar amount
physical property of: sodium-glucose transport protein subtype 2 inhibitor
has computational component: phenomonological constants.C T

phenomonological constants.F
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Faraday constant
has unit: UNIT C per mol
is computational component for: phenomonological constants.F property

phenomonological constants.Imax Na
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Maximum sodium current across cell membrane
has unit: UNIT uA
is computational component for: phenomonological constants.Imax Na property

phenomonological constants.Imax gluc
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Maximum glucose current across cell membrane
has unit: UNIT uA
is computational component for: phenomonological constants.Imax gluc property

phenomonological constants.Khalf Na
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Experimental substrate sodium concentration for half maximal current.
has unit: UNIT M
is computational component for: phenomonological constants.Khalf Na property

phenomonological constants.Khalf gluc
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Experimental substrate glucose concentration for half maximal current.
has unit: UNIT M
is computational component for: phenomonological constants.Khalf gluc property

phenomonological constants.Na o
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Sodium concentration in cell culture medium
has unit: UNIT M
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: phenomonological constants.Na o

phenomonological constants.alpha
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
has unit: UNIT M2
is computational component for: phenomonological constants.alpha property

phenomonological constants.beta
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
has unit: UNIT M
is computational component for: phenomonological constants.beta property

phenomonological constants.chi
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
has unit: UNIT M
is computational component for: phenomonological constants.chi property

phenomonological constants.epsilon
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
has unit: UNIT per second
is computational component for: phenomonological constants.epsilon property

phenomonological constants.gamma
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Membrane dislocation
has unit: UNIT M2 per second
is computational component for: phenomonological constants.gamma property

phenomonological constants.glucose o
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Glucose concentration in experimental medium
has unit: UNIT M
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: methyl alpha-D-glucopyranoside
has computational component: phenomonological constants.glucose o

phenomonological constants.k0 23
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate constant for binding of glucose to external CNa binding site
has unit: UNIT per M per second
is computational component for: phenomonological constants.k0 23 property

phenomonological constants.k 12
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for sodium ion binding to external unbound cotransporter.
has unit: UNIT per second
is computational component for: phenomonological constants.k 12 property

phenomonological constants.k 16
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for external unbound transport site to internal unbound transport site reaction step
has unit: UNIT per second
is computational component for: phenomonological constants.k 16 property

phenomonological constants.k 21
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for sodium ion release from external bound cotransporter.
has unit: UNIT per second
is computational component for: phenomonological constants.k 21 property

phenomonological constants.k 23
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate for binding of glucose to external CNa binding site
has unit: UNIT per second
is computational component for: phenomonological constants.k 23 property

phenomonological constants.k 25
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate for external CNa to internal CNa reaction step.
has unit: UNIT per second
is computational component for: phenomonological constants.k 25 property

phenomonological constants.k 32
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for release of glucose from external CNaS
has unit: UNIT per second
is computational component for: phenomonological constants.k 32 property

phenomonological constants.k 34
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate for external CNaS to internal CNas reaction step
has unit: UNIT per second
is computational component for: phenomonological constants.k 34 property

phenomonological constants.k 43
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for internal CNaS to external CNaS reaction step
has unit: UNIT per second
is computational component for: phenomonological constants.k 43 property

phenomonological constants.k 45
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate constant for release of glucose from internal CNaS
has unit: UNIT per second
is computational component for: phenomonological constants.k 45 property

phenomonological constants.k 52
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for internal CNa to external CNa reaction step
has unit: UNIT per second
is computational component for: phenomonological constants.k 52 property

phenomonological constants.k 54
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for binding of glucose to internal CNa binding site
has unit: UNIT per second
is computational component for: phenomonological constants.k 54 property

phenomonological constants.k 56
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate for release of Sodium from internal Na bound cotransporter
has unit: UNIT per second
is computational component for: phenomonological constants.k 56 property

phenomonological constants.k 61
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate for internal unbound cotransporter binding site to external unbound cotransporter binding site reaction step
has unit: UNIT per second
is computational component for: phenomonological constants.k 61 property

phenomonological constants.k 65
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate for sodium ion release from internal Na bound cotransporter.
has unit: UNIT per second
is computational component for: phenomonological constants.k 65 property

phenomonological constants.ks 12
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Sodium concentration independent rate for sodium ion binding to external unbound cotransporter.
has unit: UNIT per M per second
is computational component for: phenomonological constants.ks 12 property

phenomonological constants.lambda
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Sum of all enzymes.
has unit: UNIT per M2 per second5
is computational component for: phenomonological constants.lambda property

phenomonological constants.phi
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
has unit: UNIT M per second
is computational component for: phenomonological constants.phi property

phenomonological constants computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>lambda</ci> <apply> <plus /> <apply> <times /> <ci>ks_12</ci> <ci>k0_23</ci> <ci>k_43</ci> <ci>k_54</ci> <ci>k_65</ci> </apply> <apply> <times /> <ci>ks_12</ci> <ci>k0_23</ci> <ci>k_34</ci> <ci>k_54</ci> <ci>k_65</ci> </apply> <apply> <times /> <ci>ks_12</ci> <ci>k0_23</ci> <ci>k_45</ci> <ci>k_52</ci> <ci>k_65</ci> </apply> <apply> <times /> <ci>ks_12</ci> <ci>k0_23</ci> <ci>k_43</ci> <ci>k_52</ci> <ci>k_65</ci> </apply> <apply> <times /> <ci>ks_12</ci> <ci>k0_23</ci> <ci>k_34</ci> <ci>k_52</ci> <ci>k_65</ci> </apply> <apply> <times /> <ci>ks_12</ci> <ci>k0_23</ci> <ci>k_34</ci> <ci>k_45</ci> <ci>k_65</ci> </apply> <apply> <times /> <ci>ks_12</ci> <ci>k0_23</ci> <ci>k_45</ci> <ci>k_56</ci> <ci>k_61</ci> </apply> <apply> <times /> <ci>ks_12</ci> <ci>k0_23</ci> <ci>k_43</ci> <ci>k_56</ci> <ci>k_61</ci> </apply> <apply> <times /> <ci>ks_12</ci> <ci>k0_23</ci> <ci>k_34</ci> <ci>k_56</ci> <ci>k_61</ci> </apply> <apply> <times /> <ci>ks_12</ci> <ci>k0_23</ci> <ci>k_43</ci> <ci>k_54</ci> <ci>k_61</ci> </apply> <apply> <times /> <ci>ks_12</ci> <ci>k0_23</ci> <ci>k_34</ci> <ci>k_54</ci> <ci>k_61</ci> </apply> <apply> <times /> <ci>ks_12</ci> <ci>k0_23</ci> <ci>k_45</ci> <ci>k_52</ci> <ci>k_61</ci> </apply> <apply> <times /> <ci>ks_12</ci> <ci>k0_23</ci> <ci>k_43</ci> <ci>k_52</ci> <ci>k_61</ci> </apply> <apply> <times /> <ci>ks_12</ci> <ci>k0_23</ci> <ci>k_34</ci> <ci>k_52</ci> <ci>k_61</ci> </apply> <apply> <times /> <ci>ks_12</ci> <ci>k0_23</ci> <ci>k_34</ci> <ci>k_45</ci> <ci>k_61</ci> </apply> <apply> <times /> <ci>ks_12</ci> <ci>k0_23</ci> <ci>k_34</ci> <ci>k_45</ci> <ci>k_56</ci> </apply> </apply> </apply> <apply> <eq /> <ci>chi</ci> <apply> <times /> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <ci>lambda</ci> </apply> <apply> <plus /> <apply> <times /> <ci>ks_12</ci> <ci>k_32</ci> <ci>k_43</ci> <ci>k_54</ci> <ci>k_65</ci> </apply> <apply> <times /> <ci>ks_12</ci> <ci>k_25</ci> <ci>k_43<…
is computational component for: phenomonological constants

rate constants
type: NamedIndividual
type: Submodel
name: rate_constants
has associated data structure: rate constants.C T
has associated data structure: rate constants.Na i
has associated data structure: rate constants.Na o
has associated data structure: rate constants.alpha p
has associated data structure: rate constants.alpha pp
has associated data structure: rate constants.delta
has associated data structure: rate constants.glucose i
has associated data structure: rate constants.glucose o
has associated data structure: rate constants.k0 12
has associated data structure: rate constants.k0 16
has associated data structure: rate constants.k0 21
has associated data structure: rate constants.k0 23
has associated data structure: rate constants.k0 25
has associated data structure: rate constants.k0 32
has associated data structure: rate constants.k0 34
has associated data structure: rate constants.k0 43
has associated data structure: rate constants.k0 45
has associated data structure: rate constants.k0 52
has associated data structure: rate constants.k0 54
has associated data structure: rate constants.k0 54 temp
has associated data structure: rate constants.k0 56
has associated data structure: rate constants.k0 61
has associated data structure: rate constants.k0 65
has associated data structure: rate constants.k 12
has associated data structure: rate constants.k 16
has associated data structure: rate constants.k 21
has associated data structure: rate constants.k 23
has associated data structure: rate constants.k 25
has associated data structure: rate constants.k 32
has associated data structure: rate constants.k 34
has associated data structure: rate constants.k 43
has associated data structure: rate constants.k 45
has associated data structure: rate constants.k 52
has associated data structure: rate constants.k 52 temp
has associated data structure: rate constants.k 54
has associated data structure: rate constants.k 56
has associated data structure: rate constants.k 61
has associated data structure: rate constants.k 65
has associated data structure: rate constants.ks 12
has associated data structure: rate constants.mu
has associated data structure: rate constants.n
has associated data structure: rate constants.z Na
has associated data structure: rate constants.z c
has computational component: rate constants computation

rate constants.C T
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Density of functional SGLT2 carriers in the oocyte membrane
has unit: UNIT umol
is computational component for: Chemical molar amount

Chemical molar amount
type: NamedIndividual
refers to: Chemical molar amount
physical property of: sodium-glucose transport protein subtype 2 inhibitor
has computational component: rate constants.C T

rate constants.Na i
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Intracellular sodium concentration
has unit: UNIT M
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: rate constants.Na i

rate constants.Na o
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Sodium concentration in cell culture medium
has unit: UNIT M
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: rate constants.Na o

rate constants.alpha p
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Fraction of membrane electric field between bulk solution and external face Na binding site.
is computational component for: rate constants.alpha p property

rate constants.alpha pp
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Fraction of membrane electric field between bulk solution and internal face Na binding site.
is computational component for: rate constants.alpha pp property

rate constants.delta
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Fraction of the membrane field sensed by the empty binding on the carrier durring translocation.
is computational component for: rate constants.delta property

rate constants.glucose i
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Intracellular glucose concentration
has unit: UNIT M
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: methyl alpha-D-glucopyranoside
has computational component: rate constants.glucose i

rate constants.glucose o
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Glucose concentration in experimental medium
has unit: UNIT M
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: methyl alpha-D-glucopyranoside
has computational component: rate constants.glucose o

rate constants.k0 12
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate constant for sodium ion binding to external unbound cotransporter.
has unit: UNIT per M per second
is computational component for: rate constants.k0 12 property

rate constants.k0 16
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate constant for external unbound transport site to internal unbound transport site reaction step
has unit: UNIT per second
is computational component for: rate constants.k0 16 property

rate constants.k0 21
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate constant for sodium ion release from external bound cotransporter.
has unit: UNIT per second
is computational component for: rate constants.k0 21 property

rate constants.k0 23
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate constant for binding of glucose to external CNa binding site
has unit: UNIT per M per second
is computational component for: rate constants.k0 23 property

rate constants.k0 25
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate constant for external CNa to internal CNa reaction step.
has unit: UNIT per second
is computational component for: rate constants.k0 25 property

rate constants.k0 32
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate constant for release of glucose from external CNaS
has unit: UNIT per second
is computational component for: rate constants.k0 32 property

rate constants.k0 34
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate constant for external CNaS to internal CNas reaction step
has unit: UNIT per second
is computational component for: rate constants.k0 34 property

rate constants.k0 43
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate constant for internal CNaS to external CNaS reaction step
has unit: UNIT per second
is computational component for: rate constants.k0 43 property

rate constants.k0 45
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate constant for release of glucose from internal CNaS
has unit: UNIT per second
is computational component for: rate constants.k0 45 property

rate constants.k0 52
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate constant for internal CNa to external CNa reaction step
has unit: UNIT per second
is computational component for: rate constants.k0 52 property

rate constants.k0 54
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate constant for binding of glucose to internal CNa binding site
has unit: UNIT per M per second
is computational component for: rate constants.k0 54 property

rate constants.k0 54 temp
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Glucose independent rate constant for binding of glucose to internal CNa binding site
has unit: UNIT per M per second
is computational component for: rate constants.k0 54 temp property

rate constants.k0 56
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate constant for release of Sodium from internal Na bound cotransporter
has unit: UNIT per second
is computational component for: rate constants.k0 56 property

rate constants.k0 61
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Rate constant for internal unbound cotransporter binding site to external unbound cotransporter binding site reaction step
has unit: UNIT per second
is computational component for: rate constants.k0 61 property

rate constants.k0 65
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Rate constant for sodium ion release from internal Na bound cotransporter.
has unit: UNIT per M per second
is computational component for: rate constants.k0 65 property

rate constants.k 12
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Rate for sodium ion binding to external unbound cotransporter.
mapped to: NBC current.k 12
has unit: UNIT per second
mapped to: kinetic equations.k 12
mapped to: king altman states.k 12
mapped to: phenomonological constants.k 12
is computational component for: rate constants.k 12 property

rate constants.k 16
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Rate for external unbound transport site to internal unbound transport site reaction step
mapped to: NBC current.k 16
has unit: UNIT per second
mapped to: kinetic equations.k 16
mapped to: king altman states.k 16
mapped to: phenomonological constants.k 16
is computational component for: rate constants.k 16 property

rate constants.k 21
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Rate for sodium ion release from external bound cotransporter.
mapped to: NBC current.k 21
has unit: UNIT per second
mapped to: kinetic equations.k 21
mapped to: king altman states.k 21
mapped to: phenomonological constants.k 21
is computational component for: rate constants.k 21 property

rate constants.k 23
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Rate for binding of glucose to external CNa binding site
has unit: UNIT per second
mapped to: kinetic equations.k 23
mapped to: king altman states.k 23
mapped to: phenomonological constants.k 23
is computational component for: rate constants.k 23 property

rate constants.k 25
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Rate for external CNa to internal CNa reaction step.
mapped to: NBC current.k 25
has unit: UNIT per second
mapped to: kinetic equations.k 25
mapped to: king altman states.k 25
mapped to: phenomonological constants.k 25
is computational component for: rate constants.k 25 property

rate constants.k 32
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Rate for release of glucose from external CNaS
has unit: UNIT per second
mapped to: kinetic equations.k 32
mapped to: king altman states.k 32
mapped to: phenomonological constants.k 32
is computational component for: rate constants.k 32 property

rate constants.k 34
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Rate for external CNaS to internal CNas reaction step
mapped to: NBC current.k 34
has unit: UNIT per second
mapped to: kinetic equations.k 34
mapped to: king altman states.k 34
mapped to: phenomonological constants.k 34
is computational component for: rate constants.k 34 property

rate constants.k 43
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Rate for internal CNaS to external CNaS reaction step
mapped to: NBC current.k 43
has unit: UNIT per second
mapped to: kinetic equations.k 43
mapped to: king altman states.k 43
mapped to: phenomonological constants.k 43
is computational component for: rate constants.k 43 property

rate constants.k 45
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Rate for release of glucose from internal CNaS
has unit: UNIT per second
mapped to: kinetic equations.k 45
mapped to: king altman states.k 45
mapped to: phenomonological constants.k 45
is computational component for: rate constants.k 45 property

rate constants.k 52
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Rate for internal CNa to external CNa reaction step
mapped to: NBC current.k 52
has unit: UNIT per second
mapped to: kinetic equations.k 52
mapped to: king altman states.k 52
mapped to: phenomonological constants.k 52
is computational component for: rate constants.k 52 property

rate constants.k 52 temp
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Glucose concentration independent rate for internal CNa to external CNa reaction step
has unit: UNIT per second
is computational component for: rate constants.k 52 temp property

rate constants.k 54
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Rate for binding of glucose to internal CNa binding site
has unit: UNIT per second
mapped to: kinetic equations.k 54
mapped to: king altman states.k 54
mapped to: phenomonological constants.k 54
is computational component for: rate constants.k 54 property

rate constants.k 56
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Rate for release of Sodium from internal Na bound cotransporter
mapped to: NBC current.k 56
has unit: UNIT per second
mapped to: kinetic equations.k 56
mapped to: king altman states.k 56
mapped to: phenomonological constants.k 56
is computational component for: rate constants.k 56 property

rate constants.k 61
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Rate for internal unbound cotransporter binding site to external unbound cotransporter binding site reaction step
mapped to: NBC current.k 61
has unit: UNIT per second
mapped to: kinetic equations.k 61
mapped to: king altman states.k 61
mapped to: phenomonological constants.k 61
is computational component for: rate constants.k 61 property

rate constants.k 65
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Rate for sodium ion release from internal Na bound cotransporter.
mapped to: NBC current.k 65
has unit: UNIT per second
mapped to: kinetic equations.k 65
mapped to: king altman states.k 65
mapped to: phenomonological constants.k 65
is computational component for: rate constants.k 65 property

rate constants.ks 12
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Sodium concentration independent rate for sodium ion binding to external unbound cotransporter.
has unit: UNIT per M per second
mapped to: phenomonological constants.ks 12
is computational component for: rate constants.ks 12 property

rate constants.mu
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Relationship between membrane voltage and F*R/T.
is computational component for: rate constants.mu property

rate constants.n
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Sodium-glucose coupling coefficent
is computational component for: rate constants.n property

rate constants.z Na
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Na valence
is computational component for: rate constants.z Na property

rate constants.z c
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Empty transporter valence
is computational component for: rate constants.z c property

rate constants computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>ks_12</ci> <apply> <times /> <ci>k0_12</ci> <apply> <exp /> <apply> <divide /> <apply> <times /> <apply> <minus /> <ci>n</ci> </apply> <ci>alpha_p</ci> <ci>mu</ci> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>k_12</ci> <apply> <times /> <ci>ks_12</ci> <apply> <power /> <ci>Na_o</ci> <ci>n</ci> </apply> </apply> </apply> <apply> <eq /> <ci>k_21</ci> <apply> <times /> <ci>k0_21</ci> <apply> <exp /> <apply> <divide /> <apply> <times /> <ci>n</ci> <ci>z_Na</ci> <ci>alpha_p</ci> <ci>mu</ci> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>k_23</ci> <apply> <times /> <ci>k0_23</ci> <ci>glucose_o</ci> </apply> </apply> <apply> <eq /> <ci>k_32</ci> <ci>k0_32</ci> </apply> <apply> <eq /> <ci>k_34</ci> <apply> <times /> <ci>k0_34</ci> <apply> <exp /> <apply> <divide /> <apply> <times /> <apply> <minus /> <apply> <plus /> <ci>z_c</ci> <ci>n</ci> </apply> </apply> <ci>delta</ci> <ci>mu</ci> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>k_43</ci> <apply> <times /> <ci>k0_43</ci> <apply> <exp /> <apply> <divide /> <apply> <times /> <apply> <plus /> <ci>z_c</ci> <ci>n</ci> </apply> <ci>delta</ci> <ci>mu</ci> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>k_45</ci> <ci>k0_45</ci> </apply> <apply> <eq /> <ci>k_54</ci> <apply> <times /> <ci>k0_54_temp</ci> <ci>glucose_i</ci> </apply> </apply> <apply> <eq /> <ci>k_25</ci> <apply> <times /> <ci>k0_25</ci> <apply> <exp /> <apply> <divide /> <apply> <times /> <apply> <minus /> <apply> <plus /> <ci>z_c</ci> <ci>n</ci> </apply> </apply> <ci>delta</ci> <ci>mu</ci> </apply> <cn xmlns:cellml="http://www.cel…
is computational component for: rate constants