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HumanSAN_Fabbri_Fantini_Wilders_Severi_2017.cellml
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This is the source code for the sino-atrial node (SAN) action potential (AP) mathematical model presented in :

“Computational analysis of the human sinus node action potential: model development and effects of mutations”
Fabbri A., Fantini M., Wilders R., Severi S.

The model can be run directly on COR [1] (for Windows Only)/OpenCOR [2] (for all platforms Windows/Mac/Linux) or can be automatically exported in other computational languages (matlab, c, java, python, etc.) through tools provided by COR/OpenCoR.

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Running simulations in OpenCOR :

Seconds are the OpenCOR default time unit.
To run a simulation set the “Point interval” value to 0.001 s (but you can chose also lower values) ,
otherwise a “at t = xxxx, mxstep steps taken before reaching out” will occur. 
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For more details don’t hesitate to contact us: 

Alan Fabbri : alan.fabbri3@unibo.it
Stefano Severi : stefano.severi@unibo.it 

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References for COR/OpenCOR
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[1] Garny A, Noble D, Hunter PJ & Kohl P (2009).
      Cellular Open Resource (COR): current status and future directions. 
      Philos Trans R Soc Lond Math Phys Eng Sci 367, 1885–1905.

[2] Garny A & Hunter PJ (2015). 
      OpenCOR: a modular and interoperable approach to computational biology. 
      Front Physiol; DOI: 10.3389/fphys.2015.00026.

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Web sources 
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OpenCOR is downloadable from:

http://opencor.ws (home page) 
http://opencor.ws/downloads/index.html (downloads)

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Cite us
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Fabbri A, Fantini M, Wilders R & Severi S (2017). Computational analysis of the human sinus node action potential: model development and effects of mutations. J Physiol 595, 2365–2396.