30012019165058021p1300
type: Ontology
sem sim version: 0.2
is described by: 12972422
has cell m ldocumentation: Modelling Beta-adrenergic Control of Cardiac Myocyte Contractility in Silico Catherine Lloyd Auckland Bioengineering Institute, The University of Auckland Model Status This CellML version of the Saucerman and McCulloch 2003 model is a translation of Jeff Saucerman's original MATLAB code. It doesn't run in COR due to the presence of differential algebraic equations (DAEs). Use of additional RDF intial condition hints allow this version to run in the head revision of OpenCell using IDA as the solver. Exporting the CellML to MATLAB using OpenCell and then running the MATLAB output also works. It recreates the results of the original published model. Units require further correction and we are continuting to work on this model. Model Structure ABSTRACT: The beta-adrenergic signaling pathway regulates cardiac myocyte contractility through a combination of feedforward and feedback mechanisms. We used systems analysis to investigate how the components and topology of this signaling network permit neurohormonal control of excitation-contraction coupling in the rat ventricular myocyte. A kinetic model integrating beta-adrenergic signaling with excitation-contraction coupling was formulated, and each subsystem was validated with independent biochemical and physiological measurements. Model analysis was used to investigate quantitatively the effects of specific molecular perturbations. 3-Fold overexpression of adenylyl cyclase in the model allowed an 85% higher rate of cyclic AMP synthesis than an equivalent overexpression of beta 1-adrenergic receptor, and manipulating the affinity of Gs alpha for adenylyl cyclase was a more potent regulator of cyclic AMP production. The model predicted that less than 40% of adenylyl cyclase molecules may be stimulated under maximal receptor activation, and an experimental protocol is suggested for validating this prediction. The model also predicted that the endogenous heat-stable protein kinase inhibitor may enhance basal cyclic AMP bufferi…
has cell m lrdf markup: <rdf:RDF xmlns:semsim="http://www.bhi.washington.edu/SemSim#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:vcard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:sh="http://www.cellml.org/metadata/simulation/solverhints/1.0#" xmlns:ro="http://www.obofoundry.org/ro/ro.owl#" xmlns:j.0="http://imc.org/vCard/3.0#"> <rdf:Description rdf:about=""> <dcterms:created dcterms:W3CDTF="2009-12-02"/> <dc:creator rdf:parseType="Resource"> <vcard:ORG rdf:parseType="Resource"> <vcard:Orgunit>Auckland Bioengineering Institute</vcard:Orgunit> <vcard:Orgname>The University of Auckland</vcard:Orgname> </vcard:ORG> <vcard:EMAIL rdf:value="gnunns1@jhu.edu" rdf:type="http://imc.org/vCard/3.0#internet"/> <vcard:N vcard:Other="Rogan" vcard:Given="Geoffrey" vcard:Family="Nunns"/> </dc:creator> </rdf:Description> <rdf:Description rdf:about="#environment.time"> <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/> </rdf:Description> <rdf:Description rdf:about="#LCC_module.time"> <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/> </rdf:Description> <rdf:Description rdf:about="#Ion_Concentrations_and_Membrane_Potential.time"> <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/> </rdf:Description> <rdf:Description rdf:about="#b1_AR_module.time"> <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/> </rdf:Description> <rdf:Description rdf:about="#Steady_State_K_Current.time"> <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/> </rdf:Description> <rdf:Description rdf:about="#Pacing.time"> <bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/> </rdf:Description> <rdf:Description rdf:about="#Transient_Outward_K_Current.time"> <bqbiol:is rdf:resource="https://identifiers.org/o…
legacy code URI: C:\Users\aram148\Documents\563\saucerman_brunton_michailova_mcculloch_2003.cellml
model name: saucerman_brunton_michailova_mcculloch_2003
model metadata ID: saucerman_brunton_michailova_mcculloch_2003
model name: testout

Charge flow rate
type: Class
subclass of: Reference physical property
subclass of: Restriction
  on property: hasPhysicalDefinition
  has value: Charge flow rate

Chemical concentration
type: Class
subclass of: Reference physical property
subclass of: Restriction
  on property: hasPhysicalDefinition
  has value: Chemical concentration

Chemical potential
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subclass of: Reference physical property
subclass of: Restriction
  on property: hasPhysicalDefinition
  has value: Chemical potential

Chemical concentration flow rate
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subclass of: Reference physical property
subclass of: Restriction
  on property: hasPhysicalDefinition
  has value: Chemical concentration flow rate

Nernst potential
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subclass of: Reference physical property
subclass of: Restriction
  on property: hasPhysicalDefinition
  has value: Nernst potential

Cytosol of cardiac myocyte
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: hasPhysicalDefinition
  has value: Cytosol of cardiac myocyte

Junctional sarcoplasmic reticulum of cardiac muscle cell
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subclass of: Reference physical entity
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  has value: Junctional sarcoplasmic reticulum of cardiac muscle cell

Sarcoplasmic reticulum of cardiac muscle cell
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: hasPhysicalDefinition
  has value: Sarcoplasmic reticulum of cardiac muscle cell

Sarcolemma of cardiac muscle cell
type: Class
subclass of: Reference physical entity
subclass of: Restriction
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  has value: Sarcolemma of cardiac muscle cell

Extracellular space
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  on property: hasPhysicalDefinition
  has value: Extracellular space

cAMP biosynthetic process
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subclass of: Reference physical entity
subclass of: Restriction
  on property: hasPhysicalDefinition
  has value: cAMP biosynthetic process

junctional sarcoplasmic reticulum membrane
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subclass of: Reference physical entity
subclass of: Restriction
  on property: hasPhysicalDefinition
  has value: junctional sarcoplasmic reticulum membrane

calcium channel complex
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subclass of: Restriction
  on property: hasPhysicalDefinition
  has value: calcium channel complex

potassium channel complex
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subclass of: Reference physical entity
subclass of: Restriction
  on property: hasPhysicalDefinition
  has value: potassium channel complex

sodium channel complex
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: hasPhysicalDefinition
  has value: sodium channel complex

sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: hasPhysicalDefinition
  has value: sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential

sodium/calcium exchanger 1
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: hasPhysicalDefinition
  has value: sodium/calcium exchanger 1

adenylate cyclase
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: hasPhysicalDefinition
  has value: adenylate cyclase

null
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  has value: null

Composite physical entity
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Computation
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Computational model component
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Custom physical dependency
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Custom physical entity
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Custom physical process
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Custom physical property
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Data structure
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subclass of: Computational model component
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Decimal
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Event
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comment: A discrete occurence in a simulation

EventAssignment
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comment: A computational assignment triggered by an Event

Integer
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subclass of: Real
comment: A data structure whose value is limited to the whole numbers.

MMLchoice
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comment: A data structure unique to JSim's Mathematical Modeling Language (MML) used to set one or more model input values at runtime.

Physical dependency
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subclass of: Physical model component
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disjoint with: Physical process
disjoint with: Physical property
comment: A quantitative relation between values of physical properties that occurs over a span of time and that determines the time-course of a physical process.

Physical entity
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comment: A physics analytical entity that represents the material, energy, and/or information content of material or immaterial, space-occupying continuants.

Physical model component
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Physical process
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disjoint with: Physical property
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Physical property
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Real
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subclass of: Data structure
comment: A data structure whose value is limited to the real numbers.

Reference physical dependency
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subclass of: Physical dependency
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Reference physical entity
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subclass of: Physical entity
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Reference physical process
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Reference physical property
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subclass of: Physical property
comment: A physical property that is defined using a term in an external knowledge resource.

Relational constraint
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SBML function output
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subclass of: Decimal
comment: The output of an SBML-style Function Definition

SemSim component
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comment: A computational or physical element of a SemSim model.

Submodel
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subclass of: Physical model component
comment: A grouping of one or more data structures that comprise a computationally or physically distinct part of a model or submodel.

Unit of measurement
type: Class
subclass of: Computational model component
comment: A physical quantity chosen as a standard in terms of which other physical quantities may be expressed.

sodium(1+)
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: hasPhysicalDefinition
  has value: sodium(1+)

potassium(1+)
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: hasPhysicalDefinition
  has value: potassium(1+)

calcium(2+)
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: hasPhysicalDefinition
  has value: calcium(2+)

forskolin
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: hasPhysicalDefinition
  has value: forskolin

3-isobutyl-1-methylxanthine
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: hasPhysicalDefinition
  has value: 3-isobutyl-1-methylxanthine

ventricular cardiac muscle cell
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: hasPhysicalDefinition
  has value: ventricular cardiac muscle cell

Beta-1 adrenergic receptor
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: hasPhysicalDefinition
  has value: Beta-1 adrenergic receptor

Background Na+ current flow
type: NamedIndividual
type: Custom physical process
has sink: sodium(1+)
has source: sodium(1+)
has mediator: sodium channel complex
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated source: Background Na+ current flow
annotated target: sodium(1+)

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated source: Background Na+ current flow
annotated target: sodium(1+)

sodium(1+)
type: NamedIndividual
has physical definition: sodium(1+)
is index entity for: CHEBI:29101 part of FMA:226050
part of: Cytosol of cardiac myocyte

sodium(1+)
type: NamedIndividual
has physical definition: sodium(1+)
is index entity for: CHEBI:29101 part of FMA:70022
part of: Extracellular space

sodium(1+)
type: NamedIndividual
has physical definition: sodium(1+)
is index entity for: CHEBI:29101 part of CL:2000046
part of: ventricular cardiac muscle cell
has physical property: Chemical concentration

potassium(1+)
type: NamedIndividual
has physical definition: potassium(1+)
is index entity for: CHEBI:29103 part of FMA:226050
part of: Cytosol of cardiac myocyte

potassium(1+)
type: NamedIndividual
has physical definition: potassium(1+)
is index entity for: CHEBI:29103 part of FMA:70022
part of: Extracellular space

potassium(1+)
type: NamedIndividual
has physical definition: potassium(1+)
is index entity for: CHEBI:29103 part of CL:2000046
part of: ventricular cardiac muscle cell
has physical property: Chemical concentration

calcium(2+)
type: NamedIndividual
has physical definition: calcium(2+)
is index entity for: CHEBI:29108 part of FMA:62387
has physical property: Chemical concentration
part of: Junctional sarcoplasmic reticulum of cardiac muscle cell

calcium(2+)
type: NamedIndividual
has physical definition: calcium(2+)
is index entity for: CHEBI:29108 part of FMA:226050
has physical property: Chemical concentration
part of: Cytosol of cardiac myocyte

calcium(2+)
type: NamedIndividual
has physical definition: calcium(2+)
is index entity for: CHEBI:29108 part of FMA:70022
part of: Extracellular space

calcium(2+)
type: NamedIndividual
has physical definition: calcium(2+)
is index entity for: CHEBI:29108 part of Network SR
part of: Network SR

calcium(2+)
type: NamedIndividual
has physical definition: calcium(2+)
is index entity for: CHEBI:29108

calcium(2+)
type: NamedIndividual
has physical definition: calcium(2+)
is index entity for: CHEBI:29108 part of FMA:62390
part of: Sarcoplasmic reticulum of cardiac muscle cell
has physical property: Chemical concentration

calcium(2+)
type: NamedIndividual
has physical definition: calcium(2+)
is index entity for: CHEBI:29108 part of GO:0014701
part of: junctional sarcoplasmic reticulum membrane

forskolin
type: NamedIndividual
has physical definition: forskolin
is index entity for: CHEBI:42471
has physical property: Chemical concentration

3-isobutyl-1-methylxanthine
type: NamedIndividual
has physical definition: 3-isobutyl-1-methylxanthine
is index entity for: CHEBI:48518
has physical property: Chemical concentration

3-isobutyl-1-methylxanthine
type: NamedIndividual
has physical definition: 3-isobutyl-1-methylxanthine
is index entity for: CHEBI:48518 part of CL:2000046
part of: ventricular cardiac muscle cell
has physical property: Chemical concentration

CICR release current
type: NamedIndividual
type: Custom physical process
has source: calcium(2+)
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: calcium(2+)
annotated source: CICR release current

ventricular cardiac muscle cell
type: NamedIndividual
has physical definition: ventricular cardiac muscle cell
has part: sodium(1+)
has part: potassium(1+)
has part: 3-isobutyl-1-methylxanthine
has part: Beta-1 adrenergic receptor

Ca2+ ion flux into the rat ventricular myocyte
type: NamedIndividual
type: Custom physical process
has sink: calcium(2+)
has source: calcium(2+)
has physical property: Charge flow rate
has mediator: calcium channel complex

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: calcium(2+)
annotated source: Ca2+ ion flux into the rat ventricular myocyte

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: calcium(2+)
annotated source: Ca2+ ion flux into the rat ventricular myocyte

Ca2+ transfer from JSR to NSR
type: NamedIndividual
type: Custom physical process
has sink: calcium(2+)
has source: calcium(2+)
has physical property: Chemical concentration flow rate

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: calcium(2+)
annotated source: Ca2+ transfer from JSR to NSR

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: calcium(2+)
annotated source: Ca2+ transfer from JSR to NSR

Ca2+ uptake into the NSR by the SR
type: NamedIndividual
type: Custom physical process
has source: calcium(2+)
has sink: calcium(2+)
has physical property: Chemical concentration flow rate

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: calcium(2+)
annotated source: Ca2+ uptake into the NSR by the SR

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: calcium(2+)
annotated source: Ca2+ uptake into the NSR by the SR

Ca Background Current
type: NamedIndividual
type: Submodel
name: Ca_Background_Current
has associated data structure: Ca Background Current.E Ca
has associated data structure: Ca Background Current.G CaB
has associated data structure: Ca Background Current.I CaB
has associated data structure: Ca Background Current.V m
has computational component: Ca Background Current computation

Ca Background Current.E Ca
type: NamedIndividual
type: Decimal
metadata ID: Ca_Background_Current.E_Ca
has cell m lpublic interface: in
comment: Calcium Nernst potential
is computational component for: Nernst potential
has unit: UNIT mV
has solution domain: Time

Nernst potential
type: NamedIndividual
has physical definition: Nernst potential
has computational component: Ca Background Current.E Ca

Ca Background Current.G CaB
type: NamedIndividual
type: Decimal
metadata ID: Ca_Background_Current.G_CaB
has cell m lpublic interface: in
has unit: UNIT uA per uF
has solution domain: Time

Ca Background Current.I CaB
type: NamedIndividual
type: Decimal
metadata ID: Ca_Background_Current.I_CaB
has cell m lpublic interface: out
comment: Background Ca current
is computational component for: Charge flow rate
mapped to: Total Membrane Currents.I CaB
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
physical property of: Ca2+ ion flux into the rat ventricular myocyte
has computational component: Ca Background Current.I CaB

Ca Background Current.V m
type: NamedIndividual
type: Decimal
metadata ID: Ca_Background_Current.V_m
has cell m lpublic interface: in
comment: Sarcoplasm membrane potential
is computational component for: Chemical potential
has unit: UNIT mV
has solution domain: Time

Chemical potential
type: NamedIndividual
has physical definition: Chemical potential
has computational component: Ca Background Current.V m

Ca Background Current computation
type: NamedIndividual
type: Computation
has math ML: <eq /> I_CaB <times /> G_CaB <minus /> V_m E_Ca
is computational component for: Ca Background Current

Calcium Induced Calcium Release
type: NamedIndividual
type: Submodel
name: Calcium_Induced_Calcium_Release
has associated data structure: Calcium Induced Calcium Release.Ca i
has associated data structure: Calcium Induced Calcium Release.Ca jsr
has associated data structure: Calcium Induced Calcium Release.G max rel
has associated data structure: Calcium Induced Calcium Release.I Ca tot
has associated data structure: Calcium Induced Calcium Release.I rel
has associated data structure: Calcium Induced Calcium Release.g rel
has associated data structure: Calcium Induced Calcium Release.ryr off
has associated data structure: Calcium Induced Calcium Release.ryr on
has associated data structure: Calcium Induced Calcium Release.t rel
has associated data structure: Calcium Induced Calcium Release.tau off
has associated data structure: Calcium Induced Calcium Release.tau on
has associated data structure: Calcium Induced Calcium Release.trel
has computational component: Calcium Induced Calcium Release computation

Calcium Induced Calcium Release.Ca i
type: NamedIndividual
type: Decimal
metadata ID: Calcium_Induced_Calcium_Release.Ca_i
has cell m lpublic interface: in
comment: Concentration of intracellular calcium in the rat ventricular myocyte
is computational component for: Chemical concentration
has unit: UNIT mM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: calcium(2+)
has computational component: Calcium Induced Calcium Release.Ca i

Calcium Induced Calcium Release.Ca jsr
type: NamedIndividual
type: Decimal
metadata ID: Calcium_Induced_Calcium_Release.Ca_jsr
has cell m lpublic interface: in
comment: Concentration of junctional SR Ca2+ ions
is computational component for: Chemical concentration
has unit: UNIT mM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: calcium(2+)
has computational component: Calcium Induced Calcium Release.Ca jsr

Calcium Induced Calcium Release.G max rel
type: NamedIndividual
type: Decimal
metadata ID: Calcium_Induced_Calcium_Release.G_max_rel
has cell m lpublic interface: in
has unit: UNIT mM per sec
has solution domain: Time

Calcium Induced Calcium Release.I Ca tot
type: NamedIndividual
type: Decimal
metadata ID: Calcium_Induced_Calcium_Release.I_Ca_tot
has cell m lpublic interface: in
is computational component for: Charge flow rate
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
has computational component: Calcium Induced Calcium Release.I Ca tot

Calcium Induced Calcium Release.I rel
type: NamedIndividual
type: Decimal
metadata ID: Calcium_Induced_Calcium_Release.I_rel
has cell m lpublic interface: out
comment: CICR release current
is computational component for: Charge flow rate
mapped to: Ion Concentrations and Membrane Potential.I rel
mapped to: Other SR Fluxes and Concentrations.I rel
has unit: UNIT mM per sec
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
physical property of: CICR release current
has computational component: Calcium Induced Calcium Release.I rel

Calcium Induced Calcium Release.g rel
type: NamedIndividual
type: Decimal
metadata ID: Calcium_Induced_Calcium_Release.g_rel
has unit: UNIT per sec
has solution domain: Time

Calcium Induced Calcium Release.ryr off
type: NamedIndividual
type: Decimal
metadata ID: Calcium_Induced_Calcium_Release.ryr_off
has unit: UNIT dimensionless
has solution domain: Time

Calcium Induced Calcium Release.ryr on
type: NamedIndividual
type: Decimal
metadata ID: Calcium_Induced_Calcium_Release.ryr_on
has unit: UNIT dimensionless
has solution domain: Time

Calcium Induced Calcium Release.t rel
type: NamedIndividual
type: Decimal
metadata ID: Calcium_Induced_Calcium_Release.t_rel
has unit: UNIT second
has solution domain: Time

Calcium Induced Calcium Release.tau off
type: NamedIndividual
type: Decimal
metadata ID: Calcium_Induced_Calcium_Release.tau_off
has cell m lpublic interface: in
has unit: UNIT second
has solution domain: Time

Calcium Induced Calcium Release.tau on
type: NamedIndividual
type: Decimal
metadata ID: Calcium_Induced_Calcium_Release.tau_on
has cell m lpublic interface: in
has unit: UNIT second
has solution domain: Time

Calcium Induced Calcium Release.trel
type: NamedIndividual
type: Decimal
metadata ID: Calcium_Induced_Calcium_Release.trel
has cell m lpublic interface: in
has unit: UNIT second
has solution domain: Time

Calcium Induced Calcium Release computation
type: NamedIndividual
type: Computation
has math ML: <eq /> t_rel <plus /> trel 2 <sep /> -3 <eq /> ryr_on <minus /> 1 <exp /> <divide /> <minus /> t_rel tau_on <eq /> ryr_off <exp /> <divide /> <minus /> t_rel tau_off <eq /> g_rel <divide /> G_max_rel <plus /> 1 <exp /> <divide /> <plus /> I_Ca_tot 5 0.9 <eq /> I_rel <times /> g_rel ryr_on ryr_off <minus /> Ca_jsr Ca_i
is computational component for: Calcium Induced Calcium Release

Concentration of Protein phosphatase-1
type: NamedIndividual
type: Custom physical entity
is index entity for: Concentration of Protein phosphatase-1
has physical property: Chemical concentration

Concentration of phosphodiesterase
type: NamedIndividual
type: Custom physical entity
is index entity for: Concentration of phosphodiesterase
has physical property: Chemical concentration

Cytoplasmic Calcium Buffering
type: NamedIndividual
type: Submodel
name: Cytoplasmic_Calcium_Buffering
has associated data structure: Cytoplasmic Calcium Buffering.B myo
has associated data structure: Cytoplasmic Calcium Buffering.CMDN bar
has associated data structure: Cytoplasmic Calcium Buffering.Ca i
has associated data structure: Cytoplasmic Calcium Buffering.INDO bar
has associated data structure: Cytoplasmic Calcium Buffering.Km CMDN
has associated data structure: Cytoplasmic Calcium Buffering.Km INDO
has associated data structure: Cytoplasmic Calcium Buffering.Km TRPN
has associated data structure: Cytoplasmic Calcium Buffering.TRPN bar
has associated data structure: Cytoplasmic Calcium Buffering.b cmdn
has associated data structure: Cytoplasmic Calcium Buffering.b indo
has associated data structure: Cytoplasmic Calcium Buffering.b trpn
has computational component: Cytoplasmic Calcium Buffering computation

Cytoplasmic Calcium Buffering.B myo
type: NamedIndividual
type: Decimal
metadata ID: Cytoplasmic_Calcium_Buffering.B_myo
has cell m lpublic interface: out
mapped to: Ion Concentrations and Membrane Potential.B myo
has unit: UNIT dimensionless
has solution domain: Time

Cytoplasmic Calcium Buffering.CMDN bar
type: NamedIndividual
type: Decimal
metadata ID: Cytoplasmic_Calcium_Buffering.CMDN_bar
has cell m lpublic interface: in
has unit: UNIT mM
has solution domain: Time

Cytoplasmic Calcium Buffering.Ca i
type: NamedIndividual
type: Decimal
metadata ID: Cytoplasmic_Calcium_Buffering.Ca_i
has cell m lpublic interface: in
comment: Concentration of intracellular calcium in the rat ventricular myocyte
is computational component for: Chemical concentration
has unit: UNIT mM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: calcium(2+)
has computational component: Cytoplasmic Calcium Buffering.Ca i

Cytoplasmic Calcium Buffering.INDO bar
type: NamedIndividual
type: Decimal
metadata ID: Cytoplasmic_Calcium_Buffering.INDO_bar
has cell m lpublic interface: in
has unit: UNIT mM
has solution domain: Time

Cytoplasmic Calcium Buffering.Km CMDN
type: NamedIndividual
type: Decimal
metadata ID: Cytoplasmic_Calcium_Buffering.Km_CMDN
has cell m lpublic interface: in
has unit: UNIT mM
has solution domain: Time

Cytoplasmic Calcium Buffering.Km INDO
type: NamedIndividual
type: Decimal
metadata ID: Cytoplasmic_Calcium_Buffering.Km_INDO
has cell m lpublic interface: in
has unit: UNIT mM
has solution domain: Time

Cytoplasmic Calcium Buffering.Km TRPN
type: NamedIndividual
type: Decimal
metadata ID: Cytoplasmic_Calcium_Buffering.Km_TRPN
has cell m lpublic interface: in
has unit: UNIT mM
has solution domain: Time

Cytoplasmic Calcium Buffering.TRPN bar
type: NamedIndividual
type: Decimal
metadata ID: Cytoplasmic_Calcium_Buffering.TRPN_bar
has cell m lpublic interface: in
has unit: UNIT mM
has solution domain: Time

Cytoplasmic Calcium Buffering.b cmdn
type: NamedIndividual
type: Decimal
metadata ID: Cytoplasmic_Calcium_Buffering.b_cmdn
has unit: UNIT dimensionless
has solution domain: Time

Cytoplasmic Calcium Buffering.b indo
type: NamedIndividual
type: Decimal
metadata ID: Cytoplasmic_Calcium_Buffering.b_indo
has unit: UNIT dimensionless
has solution domain: Time

Cytoplasmic Calcium Buffering.b trpn
type: NamedIndividual
type: Decimal
metadata ID: Cytoplasmic_Calcium_Buffering.b_trpn
has unit: UNIT dimensionless
has solution domain: Time

Cytoplasmic Calcium Buffering computation
type: NamedIndividual
type: Computation
has math ML: <eq /> b_trpn <divide /> <times /> TRPN_bar Km_TRPN <power /> <plus /> Km_TRPN Ca_i 2 <eq /> b_cmdn <divide /> <times /> CMDN_bar Km_CMDN <power /> <plus /> Km_CMDN Ca_i 2 <eq /> b_indo <divide /> <times /> INDO_bar Km_INDO <power /> <plus /> Km_INDO Ca_i 2 <eq /> B_myo <divide /> 1 <plus /> 1 b_cmdn b_trpn b_trpn b_indo
is computational component for: Cytoplasmic Calcium Buffering

EC Coupling Parameters
type: NamedIndividual
type: Submodel
name: EC_Coupling_Parameters
has associated data structure: EC Coupling Parameters.A Cap
has associated data structure: EC Coupling Parameters.CMDN bar
has associated data structure: EC Coupling Parameters.CSQN bar
has associated data structure: EC Coupling Parameters.CSQN th
has associated data structure: EC Coupling Parameters.Ca ext
has associated data structure: EC Coupling Parameters.G CaB
has associated data structure: EC Coupling Parameters.G Ki bar
has associated data structure: EC Coupling Parameters.G Kp
has associated data structure: EC Coupling Parameters.G Na
has associated data structure: EC Coupling Parameters.G NaB
has associated data structure: EC Coupling Parameters.G max rel
has associated data structure: EC Coupling Parameters.G ss
has associated data structure: EC Coupling Parameters.G to
has associated data structure: EC Coupling Parameters.INDO bar
has associated data structure: EC Coupling Parameters.I Ca05
has associated data structure: EC Coupling Parameters.I bar NaK
has associated data structure: EC Coupling Parameters.I bar PCa
has associated data structure: EC Coupling Parameters.I up bar
has associated data structure: EC Coupling Parameters.K ext
has associated data structure: EC Coupling Parameters.Km CMDN
has associated data structure: EC Coupling Parameters.Km CSQN
has associated data structure: EC Coupling Parameters.Km Ca
has associated data structure: EC Coupling Parameters.Km INDO
has associated data structure: EC Coupling Parameters.Km Ko
has associated data structure: EC Coupling Parameters.Km NS
has associated data structure: EC Coupling Parameters.Km Na
has associated data structure: EC Coupling Parameters.Km Nai
has associated data structure: EC Coupling Parameters.Km PCa
has associated data structure: EC Coupling Parameters.Km TRPN
has associated data structure: EC Coupling Parameters.Km rel
has associated data structure: EC Coupling Parameters.Km up0
has associated data structure: EC Coupling Parameters.NSR bar
has associated data structure: EC Coupling Parameters.N lcc
has associated data structure: EC Coupling Parameters.Na ext
has associated data structure: EC Coupling Parameters.Pns
has associated data structure: EC Coupling Parameters.TRPN bar
has associated data structure: EC Coupling Parameters.Temp
has associated data structure: EC Coupling Parameters.V jsr
has associated data structure: EC Coupling Parameters.V myo
has associated data structure: EC Coupling Parameters.V nsr
has associated data structure: EC Coupling Parameters.d Cai th
has associated data structure: EC Coupling Parameters.eta
has associated data structure: EC Coupling Parameters.f
has associated data structure: EC Coupling Parameters.g
has associated data structure: EC Coupling Parameters.gamma o
has associated data structure: EC Coupling Parameters.k NaCa
has associated data structure: EC Coupling Parameters.k sat
has associated data structure: EC Coupling Parameters.omega
has associated data structure: EC Coupling Parameters.p Ca
has associated data structure: EC Coupling Parameters.p K
has associated data structure: EC Coupling Parameters.tau off
has associated data structure: EC Coupling Parameters.tau on
has associated data structure: EC Coupling Parameters.tau tr
has computational component: EC Coupling Parameters computation

EC Coupling Parameters.A Cap
type: NamedIndividual
type: Decimal
has cell m linitial value: 1.534e-4
metadata ID: EC_Coupling_Parameters.A_Cap
has cell m lpublic interface: out
mapped to: Ion Concentrations and Membrane Potential.A Cap
has unit: UNIT cm2
has solution domain: Time

EC Coupling Parameters.CMDN bar
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.05
metadata ID: EC_Coupling_Parameters.CMDN_bar
has cell m lpublic interface: out
mapped to: Cytoplasmic Calcium Buffering.CMDN bar
has unit: UNIT mM
has solution domain: Time

EC Coupling Parameters.CSQN bar
type: NamedIndividual
type: Decimal
has cell m linitial value: 15
metadata ID: EC_Coupling_Parameters.CSQN_bar
has cell m lpublic interface: out
mapped to: Other SR Fluxes and Concentrations.CSQN bar
has unit: UNIT mM
has solution domain: Time

EC Coupling Parameters.CSQN th
type: NamedIndividual
type: Decimal
has cell m linitial value: 8.75
metadata ID: EC_Coupling_Parameters.CSQN_th
has cell m lpublic interface: out
has unit: UNIT mM
has solution domain: Time

EC Coupling Parameters.Ca ext
type: NamedIndividual
type: Decimal
has cell m linitial value: 1.8
metadata ID: EC_Coupling_Parameters.Ca_ext
has cell m lpublic interface: out
mapped to: L Type Calcium Current.Ca ext
mapped to: Na Ca Exchanger Current.Ca ext
mapped to: Nernst Potentials.Ca ext
has unit: UNIT mM
has solution domain: Time

EC Coupling Parameters.G CaB
type: NamedIndividual
type: Decimal
has cell m linitial value: 2.8e-3
metadata ID: EC_Coupling_Parameters.G_CaB
has cell m lpublic interface: out
mapped to: Ca Background Current.G CaB
has unit: UNIT uA per uF
has solution domain: Time

EC Coupling Parameters.G Ki bar
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.24
metadata ID: EC_Coupling_Parameters.G_Ki_bar
has cell m lpublic interface: out
mapped to: Time Independent K Current.G Ki bar
has unit: UNIT mS per uF
has solution domain: Time

EC Coupling Parameters.G Kp
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.008
metadata ID: EC_Coupling_Parameters.G_Kp
has cell m lpublic interface: out
mapped to: Plateau K Current.G Kp
has unit: UNIT mS per uF
has solution domain: Time

EC Coupling Parameters.G Na
type: NamedIndividual
type: Decimal
has cell m linitial value: 8
metadata ID: EC_Coupling_Parameters.G_Na
has cell m lpublic interface: out
mapped to: Fast Na Current.G Na
has unit: UNIT mS per uF
has solution domain: Time

EC Coupling Parameters.G NaB
type: NamedIndividual
type: Decimal
has cell m linitial value: 1.18e-3
metadata ID: EC_Coupling_Parameters.G_NaB
has cell m lpublic interface: out
mapped to: Na Background Current.G NaB
has unit: UNIT uA per uF
has solution domain: Time

EC Coupling Parameters.G max rel
type: NamedIndividual
type: Decimal
has cell m linitial value: 60e3
metadata ID: EC_Coupling_Parameters.G_max_rel
has cell m lpublic interface: out
mapped to: Calcium Induced Calcium Release.G max rel
has unit: UNIT mM per sec
has solution domain: Time

EC Coupling Parameters.G ss
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.07
metadata ID: EC_Coupling_Parameters.G_ss
has cell m lpublic interface: out
mapped to: Steady State K Current.G ss
has unit: UNIT mS per uF
has solution domain: Time

EC Coupling Parameters.G to
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.35
metadata ID: EC_Coupling_Parameters.G_to
has cell m lpublic interface: out
mapped to: Transient Outward K Current.G to
has unit: UNIT mS per uF
has solution domain: Time

EC Coupling Parameters.INDO bar
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.07
metadata ID: EC_Coupling_Parameters.INDO_bar
has cell m lpublic interface: out
mapped to: Cytoplasmic Calcium Buffering.INDO bar
has unit: UNIT mM
has solution domain: Time

EC Coupling Parameters.I Ca05
type: NamedIndividual
type: Decimal
has cell m linitial value: -0.458
metadata ID: EC_Coupling_Parameters.I_Ca05
has cell m lpublic interface: out
mapped to: L Type Calcium Current.I Ca05
has unit: UNIT uA per uF
has solution domain: Time

EC Coupling Parameters.I bar NaK
type: NamedIndividual
type: Decimal
has cell m linitial value: 1.1
metadata ID: EC_Coupling_Parameters.I_bar_NaK
has cell m lpublic interface: out
mapped to: Na K Pump Current.I bar NaK
has unit: UNIT uA per uF
has solution domain: Time

EC Coupling Parameters.I bar PCa
type: NamedIndividual
type: Decimal
has cell m linitial value: 1.15
metadata ID: EC_Coupling_Parameters.I_bar_PCa
has cell m lpublic interface: out
mapped to: Sarcolemmal Ca Pump Current.I bar PCa
has unit: UNIT uA per uF
has solution domain: Time

EC Coupling Parameters.I up bar
type: NamedIndividual
type: Decimal
has cell m linitial value: 4.7
metadata ID: EC_Coupling_Parameters.I_up_bar
has cell m lpublic interface: out
mapped to: Other SR Fluxes and Concentrations.I up bar
has unit: UNIT mM per sec
has solution domain: Time

EC Coupling Parameters.K ext
type: NamedIndividual
type: Decimal
has cell m linitial value: 5.4
metadata ID: EC_Coupling_Parameters.K_ext
has cell m lpublic interface: out
mapped to: L Type Calcium Current.K ext
mapped to: Na K Pump Current.K ext
mapped to: Nernst Potentials.K ext
mapped to: Time Independent K Current.K ext
has unit: UNIT mM
has solution domain: Time

EC Coupling Parameters.Km CMDN
type: NamedIndividual
type: Decimal
has cell m linitial value: 2.38e-3
metadata ID: EC_Coupling_Parameters.Km_CMDN
has cell m lpublic interface: out
mapped to: Cytoplasmic Calcium Buffering.Km CMDN
has unit: UNIT mM
has solution domain: Time

EC Coupling Parameters.Km CSQN
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.8
metadata ID: EC_Coupling_Parameters.Km_CSQN
has cell m lpublic interface: out
mapped to: Other SR Fluxes and Concentrations.Km CSQN
has unit: UNIT mM
has solution domain: Time

EC Coupling Parameters.Km Ca
type: NamedIndividual
type: Decimal
has cell m linitial value: 1.38
metadata ID: EC_Coupling_Parameters.Km_Ca
has cell m lpublic interface: out
mapped to: Na Ca Exchanger Current.Km Ca
has unit: UNIT mM
has solution domain: Time

EC Coupling Parameters.Km INDO
type: NamedIndividual
type: Decimal
has cell m linitial value: 8.44e-4
metadata ID: EC_Coupling_Parameters.Km_INDO
has cell m lpublic interface: out
mapped to: Cytoplasmic Calcium Buffering.Km INDO
has unit: UNIT mM
has solution domain: Time

EC Coupling Parameters.Km Ko
type: NamedIndividual
type: Decimal
has cell m linitial value: 1.5
metadata ID: EC_Coupling_Parameters.Km_Ko
has cell m lpublic interface: out
mapped to: Na K Pump Current.Km Ko
has unit: UNIT mM
has solution domain: Time

EC Coupling Parameters.Km NS
type: NamedIndividual
type: Decimal
has cell m linitial value: 1.2e-3
metadata ID: EC_Coupling_Parameters.Km_NS
has cell m lpublic interface: out
has unit: UNIT mM
has solution domain: Time

EC Coupling Parameters.Km Na
type: NamedIndividual
type: Decimal
has cell m linitial value: 87.5
metadata ID: EC_Coupling_Parameters.Km_Na
has cell m lpublic interface: out
mapped to: Na Ca Exchanger Current.Km Na
has unit: UNIT mM
has solution domain: Time

EC Coupling Parameters.Km Nai
type: NamedIndividual
type: Decimal
has cell m linitial value: 10
metadata ID: EC_Coupling_Parameters.Km_Nai
has cell m lpublic interface: out
mapped to: Na K Pump Current.Km Nai
has unit: UNIT mM
has solution domain: Time

EC Coupling Parameters.Km PCa
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.5e-3
metadata ID: EC_Coupling_Parameters.Km_PCa
has cell m lpublic interface: out
mapped to: Sarcolemmal Ca Pump Current.Km PCa
has unit: UNIT mM
has solution domain: Time

EC Coupling Parameters.Km TRPN
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.5128e-3
metadata ID: EC_Coupling_Parameters.Km_TRPN
has cell m lpublic interface: out
mapped to: Cytoplasmic Calcium Buffering.Km TRPN
has unit: UNIT mM
has solution domain: Time

EC Coupling Parameters.Km rel
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.8e-3
metadata ID: EC_Coupling_Parameters.Km_rel
has cell m lpublic interface: out
has unit: UNIT mM
has solution domain: Time

EC Coupling Parameters.Km up0
type: NamedIndividual
type: Decimal
has cell m linitial value: 3e-4
metadata ID: EC_Coupling_Parameters.Km_up0
has cell m lpublic interface: out
mapped to: Other SR Fluxes and Concentrations.Km up0
has unit: UNIT mM
has solution domain: Time

EC Coupling Parameters.NSR bar
type: NamedIndividual
type: Decimal
has cell m linitial value: 15
metadata ID: EC_Coupling_Parameters.NSR_bar
has cell m lpublic interface: out
mapped to: Other SR Fluxes and Concentrations.NSR bar
has unit: UNIT mM
has solution domain: Time

EC Coupling Parameters.N lcc
type: NamedIndividual
type: Decimal
has cell m linitial value: 3e5
metadata ID: EC_Coupling_Parameters.N_lcc
has cell m lpublic interface: out
mapped to: L Type Calcium Current.N lcc
has unit: UNIT dimensionless
has solution domain: Time

EC Coupling Parameters.Na ext
type: NamedIndividual
type: Decimal
has cell m linitial value: 140
metadata ID: EC_Coupling_Parameters.Na_ext
has cell m lpublic interface: out
mapped to: Na Ca Exchanger Current.Na ext
mapped to: Na K Pump Current.Na ext
mapped to: Nernst Potentials.Na ext
has unit: UNIT mM
has solution domain: Time

EC Coupling Parameters.Pns
type: NamedIndividual
type: Decimal
has cell m linitial value: 0
metadata ID: EC_Coupling_Parameters.Pns
has cell m lpublic interface: out
has unit: UNIT dimensionless
has solution domain: Time

EC Coupling Parameters.TRPN bar
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.07
metadata ID: EC_Coupling_Parameters.TRPN_bar
has cell m lpublic interface: out
mapped to: Cytoplasmic Calcium Buffering.TRPN bar
has unit: UNIT mM
has solution domain: Time

EC Coupling Parameters.Temp
type: NamedIndividual
type: Decimal
has cell m linitial value: 310
metadata ID: EC_Coupling_Parameters.Temp
has cell m lpublic interface: out
mapped to: Nernst Potentials.Temp
has unit: UNIT kelvin
has solution domain: Time

EC Coupling Parameters.V jsr
type: NamedIndividual
type: Decimal
has cell m linitial value: 9.3e-8
metadata ID: EC_Coupling_Parameters.V_jsr
has cell m lpublic interface: out
mapped to: Ion Concentrations and Membrane Potential.V jsr
mapped to: Other SR Fluxes and Concentrations.V jsr
has unit: UNIT uL
has solution domain: Time

EC Coupling Parameters.V myo
type: NamedIndividual
type: Decimal
has cell m linitial value: 20.8e-6
metadata ID: EC_Coupling_Parameters.V_myo
has cell m lpublic interface: out
mapped to: Ion Concentrations and Membrane Potential.V myo
mapped to: Other SR Fluxes and Concentrations.V myo
has unit: UNIT uL
has solution domain: Time

EC Coupling Parameters.V nsr
type: NamedIndividual
type: Decimal
has cell m linitial value: 9.88e-7
metadata ID: EC_Coupling_Parameters.V_nsr
has cell m lpublic interface: out
mapped to: Ion Concentrations and Membrane Potential.V nsr
mapped to: Other SR Fluxes and Concentrations.V nsr
has unit: UNIT uL
has solution domain: Time

EC Coupling Parameters.d Cai th
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.18e-3
metadata ID: EC_Coupling_Parameters.d_Cai_th
has cell m lpublic interface: out
has unit: UNIT mM
has solution domain: Time

EC Coupling Parameters.eta
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.35
metadata ID: EC_Coupling_Parameters.eta
has cell m lpublic interface: out
mapped to: Na Ca Exchanger Current.eta
has unit: UNIT dimensionless
has solution domain: Time

EC Coupling Parameters.f
type: NamedIndividual
type: Decimal
has cell m linitial value: 300
metadata ID: EC_Coupling_Parameters.f
has cell m lpublic interface: out
mapped to: L Type Calcium Current.f
has unit: UNIT per sec
has solution domain: Time

EC Coupling Parameters.g
type: NamedIndividual
type: Decimal
has cell m linitial value: 2e3
metadata ID: EC_Coupling_Parameters.g
has cell m lpublic interface: out
mapped to: L Type Calcium Current.g
has unit: UNIT per sec
has solution domain: Time

EC Coupling Parameters.gamma o
type: NamedIndividual
type: Decimal
has cell m linitial value: 5187.5
metadata ID: EC_Coupling_Parameters.gamma_o
has cell m lpublic interface: out
mapped to: L Type Calcium Current.gamma o
has unit: UNIT per mM per sec
has solution domain: Time

EC Coupling Parameters.k NaCa
type: NamedIndividual
type: Decimal
has cell m linitial value: 1483
metadata ID: EC_Coupling_Parameters.k_NaCa
has cell m lpublic interface: out
mapped to: Na Ca Exchanger Current.k NaCa
has unit: UNIT uA per uF
has solution domain: Time

EC Coupling Parameters.k sat
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.1
metadata ID: EC_Coupling_Parameters.k_sat
has cell m lpublic interface: out
mapped to: Na Ca Exchanger Current.k sat
has unit: UNIT dimensionless
has solution domain: Time

EC Coupling Parameters.omega
type: NamedIndividual
type: Decimal
has cell m linitial value: 10
metadata ID: EC_Coupling_Parameters.omega
has cell m lpublic interface: out
mapped to: L Type Calcium Current.omega
has unit: UNIT per sec
has solution domain: Time

EC Coupling Parameters.p Ca
type: NamedIndividual
type: Decimal
has cell m linitial value: 1.7469e-8
metadata ID: EC_Coupling_Parameters.p_Ca
has cell m lpublic interface: out
mapped to: L Type Calcium Current.p Ca
has unit: UNIT cm per sec
has solution domain: Time

EC Coupling Parameters.p K
type: NamedIndividual
type: Decimal
has cell m linitial value: 3.234e-11
metadata ID: EC_Coupling_Parameters.p_K
has cell m lpublic interface: out
mapped to: L Type Calcium Current.p K
has unit: UNIT cm per sec
has solution domain: Time

EC Coupling Parameters.tau off
type: NamedIndividual
type: Decimal
has cell m linitial value: 2e-3
metadata ID: EC_Coupling_Parameters.tau_off
has cell m lpublic interface: out
mapped to: Calcium Induced Calcium Release.tau off
has unit: UNIT second
has solution domain: Time

EC Coupling Parameters.tau on
type: NamedIndividual
type: Decimal
has cell m linitial value: 2e-3
metadata ID: EC_Coupling_Parameters.tau_on
has cell m lpublic interface: out
mapped to: Calcium Induced Calcium Release.tau on
has unit: UNIT second
has solution domain: Time

EC Coupling Parameters.tau tr
type: NamedIndividual
type: Decimal
has cell m linitial value: 5.7e-4
metadata ID: EC_Coupling_Parameters.tau_tr
has cell m lpublic interface: out
mapped to: Other SR Fluxes and Concentrations.tau tr
has unit: UNIT second
has solution domain: Time

Cytosol of cardiac myocyte
type: NamedIndividual
has physical definition: Cytosol of cardiac myocyte
has part: sodium(1+)
has part: potassium(1+)
has part: calcium(2+)
has part: adenylate cyclase

Junctional sarcoplasmic reticulum of cardiac muscle cell
type: NamedIndividual
has physical definition: Junctional sarcoplasmic reticulum of cardiac muscle cell
has part: calcium(2+)

Sarcoplasmic reticulum of cardiac muscle cell
type: NamedIndividual
has physical definition: Sarcoplasmic reticulum of cardiac muscle cell
has part: calcium(2+)

Sarcolemma of cardiac muscle cell
type: NamedIndividual
has physical definition: Sarcolemma of cardiac muscle cell
has part: sodium channel complex

Extracellular space
type: NamedIndividual
has physical definition: Extracellular space
has part: sodium(1+)
has part: potassium(1+)
has part: calcium(2+)

Fast Na Current
type: NamedIndividual
type: Submodel
name: Fast_Na_Current
has associated data structure: Fast Na Current.E Na
has associated data structure: Fast Na Current.G Na
has associated data structure: Fast Na Current.I Na
has associated data structure: Fast Na Current.V m
has associated data structure: Fast Na Current.ah
has associated data structure: Fast Na Current.aj
has associated data structure: Fast Na Current.am
has associated data structure: Fast Na Current.bh
has associated data structure: Fast Na Current.bj
has associated data structure: Fast Na Current.bm
has associated data structure: Fast Na Current.h
has associated data structure: Fast Na Current.j
has associated data structure: Fast Na Current.m
has associated data structure: Time
has computational component: Fast Na Current computation

Fast Na Current.E Na
type: NamedIndividual
type: Decimal
metadata ID: Fast_Na_Current.E_Na
has cell m lpublic interface: in
comment: Sodium nernst potential
is computational component for: Nernst potential
has unit: UNIT mV
has solution domain: Time

Nernst potential
type: NamedIndividual
has physical definition: Nernst potential
has computational component: Fast Na Current.E Na

Fast Na Current.G Na
type: NamedIndividual
type: Decimal
metadata ID: Fast_Na_Current.G_Na
has cell m lpublic interface: in
has unit: UNIT mS per uF
has solution domain: Time

Fast Na Current.I Na
type: NamedIndividual
type: Decimal
metadata ID: Fast_Na_Current.I_Na
has cell m lpublic interface: out
comment: Na+ flux across sarcolemma of rat ventricular myocyte
is computational component for: Charge flow rate
mapped to: Total Membrane Currents.I Na
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
has computational component: Fast Na Current.I Na
physical property of: Sodium flux across sarcolemma of rat ventricular myocyte

Fast Na Current.V m
type: NamedIndividual
type: Decimal
metadata ID: Fast_Na_Current.V_m
has cell m lpublic interface: in
comment: Sarcoplasm membrane potential
is computational component for: Chemical potential
has unit: UNIT mV
has solution domain: Time

Chemical potential
type: NamedIndividual
has physical definition: Chemical potential
has computational component: Fast Na Current.V m

Fast Na Current.ah
type: NamedIndividual
type: Decimal
metadata ID: Fast_Na_Current.ah
has unit: UNIT per sec
has solution domain: Time

Fast Na Current.aj
type: NamedIndividual
type: Decimal
metadata ID: Fast_Na_Current.aj
has unit: UNIT per sec
has solution domain: Time

Fast Na Current.am
type: NamedIndividual
type: Decimal
metadata ID: Fast_Na_Current.am
has unit: UNIT per sec
has solution domain: Time

Fast Na Current.bh
type: NamedIndividual
type: Decimal
metadata ID: Fast_Na_Current.bh
has unit: UNIT per sec
has solution domain: Time

Fast Na Current.bj
type: NamedIndividual
type: Decimal
metadata ID: Fast_Na_Current.bj
has unit: UNIT per sec
has solution domain: Time

Fast Na Current.bm
type: NamedIndividual
type: Decimal
metadata ID: Fast_Na_Current.bm
has unit: UNIT per sec
has solution domain: Time

Fast Na Current.h
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.99
metadata ID: Fast_Na_Current.h
has unit: UNIT dimensionless
has solution domain: Time

Fast Na Current.j
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.99
metadata ID: Fast_Na_Current.j
has unit: UNIT dimensionless
has solution domain: Time

Fast Na Current.m
type: NamedIndividual
type: Decimal
has cell m linitial value: 1.4e-3
metadata ID: Fast_Na_Current.m
has unit: UNIT dimensionless
has solution domain: Time

Time
type: NamedIndividual
type: Decimal
metadata ID: Fast_Na_Current.time
has physical definition: https://identifiers.org/opb/OPB_01023
has cell m lpublic interface: in
has unit: UNIT second
has solution domain: Time

Fast Na Current computation
type: NamedIndividual
type: Computation
has math ML: <eq /> am <divide /> <times /> 0.32 <plus /> V_m 47.13 <minus /> 1 <exp /> <times /> <minus /> 0.1 <plus /> V_m 47.13 <eq /> bm <times /> 0.08 <exp /> <divide /> <minus /> V_m 11 <eq /> ah 0 <geq /> V_m <minus /> 40 <times /> 0.135 <exp /> <divide /> <plus /> 80 V_m <minus /> 6.8 <eq /> aj 0 <geq /> V_m <minus /> 40 <divide /> <times /> <minus /> <times /> <minus /> 1.2714 <sep /> 5 <exp /> <times /> 0.2444 V_m <times /> 3.474 <sep /> -5 <exp /> <times /> <minus /> 0.04391 V_m <plus /> V_m 37.78 <plus /> 1 <exp /> <times /> 0.311 <plus /> V_m 79.23 <eq /> bh <divide /> 1 <times /> 0.13 <plus /> 1 <exp /> <divide /> <minus /> <plus /> V_m 10.66 11.1 <geq /> V_m <minus /> 40 <plus /> <times /> 3.56 <exp /> <times /> 0.079 V_m <times /> 3.1 <sep /> 5 <exp /> <times /> 0.35 V_m <eq /> bj <divide /> <times /> 0.3 <exp /> <times /> <minus /> 2.575 <sep /> -7 V_m <plus /> 1 <exp /> <times /> <minus /> 0.1 <plus /> V_m 32 <geq /> V_m <minus /> 40 <divide /> <times /> 0.1212 <exp /> <times /> <minus /> 0.01052 V_m <plus /> 1 <exp /> <times /> <minus /> 0.1378 <plus /> V_m 40.14 <eq /> <diff /> time m <times /> 1 <sep /> 3 <minus /> <times /> am <minus /> 1 m <times /> bm m <eq /> <diff /> time h <times /> 1 <sep /> 3 <minus /> <times /> ah <minus /> 1 h <times /> bh h <eq /> <diff /> time j <times /> 1 <sep /> 3 <minus /> <times /> aj <minus /> 1 j <times /> bj j <eq /> I_Na <times /> G_Na <power /> m 3 h j <minus /> V_m E_Na
is computational component for: Fast Na Current

cAMP biosynthetic process
type: NamedIndividual
has physical definition: cAMP biosynthetic process
is index entity for: GO:0006171
has physical property: Chemical concentration

junctional sarcoplasmic reticulum membrane
type: NamedIndividual
has physical definition: junctional sarcoplasmic reticulum membrane
has part: calcium(2+)

calcium channel complex
type: NamedIndividual
has physical definition: calcium channel complex
is index entity for: GO:0034704

potassium channel complex
type: NamedIndividual
has physical definition: potassium channel complex
is index entity for: GO:0034705

sodium channel complex
type: NamedIndividual
has physical definition: sodium channel complex
part of: Sarcolemma of cardiac muscle cell
is index entity for: GO:0034706 part of FMA:67964

sodium channel complex
type: NamedIndividual
has physical definition: sodium channel complex
is index entity for: GO:0034706

sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential
type: NamedIndividual
has physical definition: sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential
is index entity for: GO:0086037

Ion Concentrations and Membrane Potential
type: NamedIndividual
type: Submodel
name: Ion_Concentrations_and_Membrane_Potential
has associated data structure: Ion Concentrations and Membrane Potential.A Cap
has associated data structure: Ion Concentrations and Membrane Potential.B myo
has associated data structure: Ion Concentrations and Membrane Potential.Ca i
has associated data structure: Ion Concentrations and Membrane Potential.Frdy
has associated data structure: Ion Concentrations and Membrane Potential.I Ca tot
has associated data structure: Ion Concentrations and Membrane Potential.I K tot
has associated data structure: Ion Concentrations and Membrane Potential.I Na tot
has associated data structure: Ion Concentrations and Membrane Potential.I app
has associated data structure: Ion Concentrations and Membrane Potential.I leak
has associated data structure: Ion Concentrations and Membrane Potential.I pace
has associated data structure: Ion Concentrations and Membrane Potential.I rel
has associated data structure: Ion Concentrations and Membrane Potential.I up
has associated data structure: Ion Concentrations and Membrane Potential.K i
has associated data structure: Ion Concentrations and Membrane Potential.Na i
has associated data structure: Ion Concentrations and Membrane Potential.R clamp
has associated data structure: Ion Concentrations and Membrane Potential.V clamp
has associated data structure: Ion Concentrations and Membrane Potential.V hold
has associated data structure: Ion Concentrations and Membrane Potential.V jsr
has associated data structure: Ion Concentrations and Membrane Potential.V m
has associated data structure: Ion Concentrations and Membrane Potential.V myo
has associated data structure: Ion Concentrations and Membrane Potential.V nsr
has associated data structure: Ion Concentrations and Membrane Potential.V test
has associated data structure: Ion Concentrations and Membrane Potential.protocol
has associated data structure: Time
has associated data structure: Ion Concentrations and Membrane Potential.trel
has associated data structure: Ion Concentrations and Membrane Potential.z Ca
has associated data structure: Ion Concentrations and Membrane Potential.z K
has associated data structure: Ion Concentrations and Membrane Potential.z Na
has computational component: Ion Concentrations and Membrane Potential computation

Ion Concentrations and Membrane Potential.A Cap
type: NamedIndividual
type: Decimal
metadata ID: Ion_Concentrations_and_Membrane_Potential.A_Cap
has cell m lpublic interface: in
has unit: UNIT cm2
has solution domain: Time

Ion Concentrations and Membrane Potential.B myo
type: NamedIndividual
type: Decimal
metadata ID: Ion_Concentrations_and_Membrane_Potential.B_myo
has cell m lpublic interface: in
has unit: UNIT dimensionless
has solution domain: Time

Ion Concentrations and Membrane Potential.Ca i
type: NamedIndividual
type: Decimal
has cell m linitial value: 1.58e-4
metadata ID: Ion_Concentrations_and_Membrane_Potential.Ca_i
has cell m lpublic interface: out
comment: Concentration of intracellular calcium in the rat ventricular myocyte
mapped to: Calcium Induced Calcium Release.Ca i
mapped to: Cytoplasmic Calcium Buffering.Ca i
is computational component for: Chemical concentration
mapped to: L Type Calcium Current.Ca i
mapped to: Na Ca Exchanger Current.Ca i
mapped to: Nernst Potentials.Ca i
mapped to: Other SR Fluxes and Concentrations.Ca i
mapped to: Sarcolemmal Ca Pump Current.Ca i
has unit: UNIT mM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: calcium(2+)
has computational component: Ion Concentrations and Membrane Potential.Ca i

Ion Concentrations and Membrane Potential.Frdy
type: NamedIndividual
type: Decimal
metadata ID: Ion_Concentrations_and_Membrane_Potential.Frdy
has cell m lpublic interface: in
has unit: UNIT coulombs per mole
has solution domain: Time

Ion Concentrations and Membrane Potential.I Ca tot
type: NamedIndividual
type: Decimal
metadata ID: Ion_Concentrations_and_Membrane_Potential.I_Ca_tot
has cell m lpublic interface: in
is computational component for: Charge flow rate
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
has computational component: Ion Concentrations and Membrane Potential.I Ca tot

Ion Concentrations and Membrane Potential.I K tot
type: NamedIndividual
type: Decimal
metadata ID: Ion_Concentrations_and_Membrane_Potential.I_K_tot
has cell m lpublic interface: in
comment: Total K+ current
is computational component for: Charge flow rate
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
has computational component: Ion Concentrations and Membrane Potential.I K tot
physical property of: Total K+ current

Ion Concentrations and Membrane Potential.I Na tot
type: NamedIndividual
type: Decimal
metadata ID: Ion_Concentrations_and_Membrane_Potential.I_Na_tot
has cell m lpublic interface: in
comment: Total membrane Na+ current
is computational component for: Charge flow rate
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
has computational component: Ion Concentrations and Membrane Potential.I Na tot
physical property of: Total membrane Na+ current

Ion Concentrations and Membrane Potential.I app
type: NamedIndividual
type: Decimal
metadata ID: Ion_Concentrations_and_Membrane_Potential.I_app
has unit: UNIT uA per uF
has solution domain: Time

Ion Concentrations and Membrane Potential.I leak
type: NamedIndividual
type: Decimal
metadata ID: Ion_Concentrations_and_Membrane_Potential.I_leak
has cell m lpublic interface: in
is computational component for: Chemical concentration flow rate
has unit: UNIT mM per sec
has solution domain: Time

Chemical concentration flow rate
type: NamedIndividual
has physical definition: Chemical concentration flow rate
has computational component: Ion Concentrations and Membrane Potential.I leak

Ion Concentrations and Membrane Potential.I pace
type: NamedIndividual
type: Decimal
metadata ID: Ion_Concentrations_and_Membrane_Potential.I_pace
has cell m lpublic interface: in
has unit: UNIT uA per uF
has solution domain: Time

Ion Concentrations and Membrane Potential.I rel
type: NamedIndividual
type: Decimal
metadata ID: Ion_Concentrations_and_Membrane_Potential.I_rel
has cell m lpublic interface: in
comment: CICR release current
is computational component for: Charge flow rate
has unit: UNIT mM per sec
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
physical property of: CICR release current
has computational component: Ion Concentrations and Membrane Potential.I rel

Ion Concentrations and Membrane Potential.I up
type: NamedIndividual
type: Decimal
metadata ID: Ion_Concentrations_and_Membrane_Potential.I_up
has cell m lpublic interface: in
comment: Ca2+ uptake into the NSR by the SR
is computational component for: Chemical concentration flow rate
has unit: UNIT mM per sec
has solution domain: Time

Chemical concentration flow rate
type: NamedIndividual
has physical definition: Chemical concentration flow rate
physical property of: Ca2+ uptake into the NSR by the SR
has computational component: Ion Concentrations and Membrane Potential.I up

Ion Concentrations and Membrane Potential.K i
type: NamedIndividual
type: Decimal
has cell m linitial value: 145
metadata ID: Ion_Concentrations_and_Membrane_Potential.K_i
has cell m lpublic interface: out
comment: Concentration of intracellular potassium in the rat ventricular myocyte.
is computational component for: Chemical concentration
mapped to: L Type Calcium Current.K i
mapped to: Nernst Potentials.K i
has unit: UNIT mM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: potassium(1+)
has computational component: Ion Concentrations and Membrane Potential.K i

Ion Concentrations and Membrane Potential.Na i
type: NamedIndividual
type: Decimal
has cell m linitial value: 16
metadata ID: Ion_Concentrations_and_Membrane_Potential.Na_i
has cell m lpublic interface: out
comment: Concentration of intracellular sodium in the rat ventricular myocyte
is computational component for: Chemical concentration
mapped to: Na Ca Exchanger Current.Na i
mapped to: Na K Pump Current.Na i
mapped to: Nernst Potentials.Na i
has unit: UNIT mM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: sodium(1+)
has computational component: Ion Concentrations and Membrane Potential.Na i

Ion Concentrations and Membrane Potential.R clamp
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.02
metadata ID: Ion_Concentrations_and_Membrane_Potential.R_clamp
has unit: UNIT dimensionless
has solution domain: Time

Ion Concentrations and Membrane Potential.V clamp
type: NamedIndividual
type: Decimal
metadata ID: Ion_Concentrations_and_Membrane_Potential.V_clamp
has unit: UNIT mV
has solution domain: Time

Ion Concentrations and Membrane Potential.V hold
type: NamedIndividual
type: Decimal
has cell m linitial value: -40
metadata ID: Ion_Concentrations_and_Membrane_Potential.V_hold
has unit: UNIT mV
has solution domain: Time

Ion Concentrations and Membrane Potential.V jsr
type: NamedIndividual
type: Decimal
metadata ID: Ion_Concentrations_and_Membrane_Potential.V_jsr
has cell m lpublic interface: in
has unit: UNIT uL
has solution domain: Time

Ion Concentrations and Membrane Potential.V m
type: NamedIndividual
type: Decimal
has cell m linitial value: -85.66
metadata ID: Ion_Concentrations_and_Membrane_Potential.V_m
has cell m lpublic interface: out
comment: Sarcoplasm membrane potential
mapped to: Ca Background Current.V m
mapped to: Fast Na Current.V m
is computational component for: Chemical potential
mapped to: L Type Calcium Current.V m
mapped to: Na Background Current.V m
mapped to: Na Ca Exchanger Current.V m
mapped to: Na K Pump Current.V m
mapped to: Plateau K Current.V m
mapped to: Steady State K Current.V m
mapped to: Time Independent K Current.V m
mapped to: Transient Outward K Current.V m
has unit: UNIT mV
has solution domain: Time

Chemical potential
type: NamedIndividual
has physical definition: Chemical potential
has computational component: Ion Concentrations and Membrane Potential.V m

Ion Concentrations and Membrane Potential.V myo
type: NamedIndividual
type: Decimal
metadata ID: Ion_Concentrations_and_Membrane_Potential.V_myo
has cell m lpublic interface: in
has unit: UNIT uL
has solution domain: Time

Ion Concentrations and Membrane Potential.V nsr
type: NamedIndividual
type: Decimal
metadata ID: Ion_Concentrations_and_Membrane_Potential.V_nsr
has cell m lpublic interface: in
has unit: UNIT uL
has solution domain: Time

Ion Concentrations and Membrane Potential.V test
type: NamedIndividual
type: Decimal
has cell m linitial value: -10
metadata ID: Ion_Concentrations_and_Membrane_Potential.V_test
has unit: UNIT mV
has solution domain: Time

Ion Concentrations and Membrane Potential.protocol
type: NamedIndividual
type: Decimal
metadata ID: Ion_Concentrations_and_Membrane_Potential.protocol
has cell m lpublic interface: in
has unit: UNIT dimensionless
has solution domain: Time

Time
type: NamedIndividual
type: Decimal
metadata ID: Ion_Concentrations_and_Membrane_Potential.time
has physical definition: https://identifiers.org/opb/OPB_01023
has cell m lpublic interface: in
has unit: UNIT second
has solution domain: Time

Ion Concentrations and Membrane Potential.trel
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.9
metadata ID: Ion_Concentrations_and_Membrane_Potential.trel
has cell m lpublic interface: out
mapped to: Calcium Induced Calcium Release.trel
has unit: UNIT second
has solution domain: Time

Ion Concentrations and Membrane Potential.z Ca
type: NamedIndividual
type: Decimal
metadata ID: Ion_Concentrations_and_Membrane_Potential.z_Ca
has cell m lpublic interface: in
has unit: UNIT dimensionless
has solution domain: Time

Ion Concentrations and Membrane Potential.z K
type: NamedIndividual
type: Decimal
metadata ID: Ion_Concentrations_and_Membrane_Potential.z_K
has cell m lpublic interface: in
has unit: UNIT dimensionless
has solution domain: Time

Ion Concentrations and Membrane Potential.z Na
type: NamedIndividual
type: Decimal
metadata ID: Ion_Concentrations_and_Membrane_Potential.z_Na
has cell m lpublic interface: in
has unit: UNIT dimensionless
has solution domain: Time

Ion Concentrations and Membrane Potential computation
type: NamedIndividual
type: Computation
has math ML: <eq /> V_clamp V_test <and /> <gt /> time 59.1 <lt /> time 59.5 V_hold <eq /> I_app 0 <eq /> protocol 0 I_pace <eq /> protocol 1 <divide /> <minus /> V_clamp V_m 0.02 <eq /> <diff /> time Na_i <divide /> <times /> <minus /> 1 <sep /> 3 I_Na_tot A_Cap <times /> V_myo z_Na Frdy <eq /> <diff /> time K_i <divide /> <times /> <minus /> 1 <sep /> 3 I_K_tot A_Cap <times /> V_myo z_K Frdy <eq /> <diff /> time Ca_i <times /> <minus /> B_myo <minus /> <plus /> <divide /> <times /> 1 <sep /> 3 I_Ca_tot A_Cap <times /> V_myo z_Ca Frdy <divide /> <times /> <minus /> I_up I_leak V_nsr V_myo <divide /> <times /> I_rel V_jsr V_myo <eq /> <diff /> time V_m <times /> <minus /> 1 <sep /> 3 <minus /> <plus /> I_Ca_tot I_K_tot I_Na_tot I_app <eq /> <diff /> time trel <minus /> 1 <times /> 1 <sep /> 4 trel <gt /> <times /> <minus /> 1 <sep /> 3 <minus /> <plus /> I_Ca_tot I_K_tot I_Na_tot I_app 30 <sep /> 3 1
is computational component for: Ion Concentrations and Membrane Potential

LCC module
type: NamedIndividual
type: Submodel
name: LCC_module
has associated data structure: LCC module.Km pka lcc
has associated data structure: LCC module.Km pp1 lcc
has associated data structure: LCC module.Km pp2a lcc
has associated data structure: LCC module.LCC tot
has associated data structure: LCC module.LCCa
has associated data structure: LCC module.LCCa DEPHOSPH
has associated data structure: LCC module.LCCa PHOSPH
has associated data structure: LCC module.LCCa p
has associated data structure: LCC module.LCCb
has associated data structure: LCC module.LCCb DEPHOSPH
has associated data structure: LCC module.LCCb PHOSPH
has associated data structure: LCC module.LCCb p
has associated data structure: LCC module.PKAC II
has associated data structure: LCC module.PP1 lcc tot
has associated data structure: LCC module.PP2A lcc tot
has associated data structure: LCC module.epsilon
has associated data structure: LCC module.frac LCCa p
has associated data structure: LCC module.frac LCCa po
has associated data structure: LCC module.frac LCCb p
has associated data structure: LCC module.frac LCCb po
has associated data structure: LCC module.k pka lcc
has associated data structure: LCC module.k pp1 lcc
has associated data structure: LCC module.k pp2a lcc
has associated data structure: Time
has computational component: LCC module computation

LCC module.Km pka lcc
type: NamedIndividual
type: Decimal
metadata ID: LCC_module.Km_pka_lcc
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

LCC module.Km pp1 lcc
type: NamedIndividual
type: Decimal
metadata ID: LCC_module.Km_pp1_lcc
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

LCC module.Km pp2a lcc
type: NamedIndividual
type: Decimal
metadata ID: LCC_module.Km_pp2a_lcc
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

LCC module.LCC tot
type: NamedIndividual
type: Decimal
metadata ID: LCC_module.LCC_tot
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

LCC module.LCCa
type: NamedIndividual
type: Decimal
metadata ID: LCC_module.LCCa
is computational component for: Chemical concentration
has unit: UNIT uM
has solution domain: Time

LCC module.LCCa DEPHOSPH
type: NamedIndividual
type: Decimal
metadata ID: LCC_module.LCCa_DEPHOSPH
is computational component for: Chemical concentration flow rate
has unit: UNIT uM per sec
has solution domain: Time

Chemical concentration flow rate
type: NamedIndividual
has physical definition: Chemical concentration flow rate
has computational component: LCC module.LCCa DEPHOSPH

LCC module.LCCa PHOSPH
type: NamedIndividual
type: Decimal
metadata ID: LCCa_PHOSPH
is computational component for: Charge flow rate
has unit: UNIT uM per sec
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
has computational component: LCC module.LCCa PHOSPH

LCC module.LCCa p
type: NamedIndividual
type: Decimal
has cell m linitial value: 5.103e-3
metadata ID: LCC_module.LCCa_p
is computational component for: Chemical concentration
has unit: UNIT uM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: LCC module.LCCa p

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: LCC module.LCCa

LCC module.LCCb
type: NamedIndividual
type: Decimal
metadata ID: LCC_module.LCCb
is computational component for: Chemical concentration
has unit: UNIT uM
has solution domain: Time

LCC module.LCCb DEPHOSPH
type: NamedIndividual
type: Decimal
metadata ID: LCC_module.LCCb_DEPHOSPH
is computational component for: Chemical concentration flow rate
has unit: UNIT uM per sec
has solution domain: Time

Chemical concentration flow rate
type: NamedIndividual
has physical definition: Chemical concentration flow rate
has computational component: LCC module.LCCb DEPHOSPH

LCC module.LCCb PHOSPH
type: NamedIndividual
type: Decimal
metadata ID: LCCb_PHOSPH
is computational component for: Chemical concentration flow rate
has unit: UNIT uM per sec
has solution domain: Time

Chemical concentration flow rate
type: NamedIndividual
has physical definition: Chemical concentration flow rate
has computational component: LCC module.LCCb PHOSPH

LCC module.LCCb p
type: NamedIndividual
type: Decimal
has cell m linitial value: 5.841e-3
metadata ID: LCC_module.LCCb_p
is computational component for: Chemical concentration
has unit: UNIT uM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: LCC module.LCCb p

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: LCC module.LCCb

LCC module.PKAC II
type: NamedIndividual
type: Decimal
metadata ID: LCC_module.PKAC_II
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

LCC module.PP1 lcc tot
type: NamedIndividual
type: Decimal
metadata ID: LCC_module.PP1_lcc_tot
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

LCC module.PP2A lcc tot
type: NamedIndividual
type: Decimal
metadata ID: LCC_module.PP2A_lcc_tot
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

LCC module.epsilon
type: NamedIndividual
type: Decimal
metadata ID: LCC_module.epsilon
has cell m lpublic interface: in
has unit: UNIT dimensionless
has solution domain: Time

LCC module.frac LCCa p
type: NamedIndividual
type: Decimal
metadata ID: LCC_module.frac_LCCa_p
has cell m lpublic interface: out
mapped to: L Type Calcium Current.frac LCCa p
has unit: UNIT dimensionless
has solution domain: Time

LCC module.frac LCCa po
type: NamedIndividual
type: Decimal
metadata ID: LCC_module.frac_LCCa_po
has cell m lpublic interface: out
mapped to: L Type Calcium Current.frac LCCa po
has unit: UNIT dimensionless
has solution domain: Time

LCC module.frac LCCb p
type: NamedIndividual
type: Decimal
metadata ID: LCC_module.frac_LCCb_p
has cell m lpublic interface: out
mapped to: L Type Calcium Current.frac LCCb p
has unit: UNIT dimensionless
has solution domain: Time

LCC module.frac LCCb po
type: NamedIndividual
type: Decimal
metadata ID: LCC_module.frac_LCCb_po
has cell m lpublic interface: out
mapped to: L Type Calcium Current.frac LCCb po
has unit: UNIT dimensionless
has solution domain: Time

LCC module.k pka lcc
type: NamedIndividual
type: Decimal
metadata ID: LCC_module.k_pka_lcc
has cell m lpublic interface: in
has unit: UNIT per sec
has solution domain: Time

LCC module.k pp1 lcc
type: NamedIndividual
type: Decimal
metadata ID: LCC_module.k_pp1_lcc
has cell m lpublic interface: in
has unit: UNIT per sec
has solution domain: Time

LCC module.k pp2a lcc
type: NamedIndividual
type: Decimal
metadata ID: LCC_module.k_pp2a_lcc
has cell m lpublic interface: in
has unit: UNIT per sec
has solution domain: Time

Time
type: NamedIndividual
type: Decimal
metadata ID: LCC_module.time
has physical definition: https://identifiers.org/opb/OPB_01023
has cell m lpublic interface: in
has unit: UNIT second
has solution domain: Time

LCC module computation
type: NamedIndividual
type: Computation
has math ML: <eq /> LCCa <minus /> LCC_tot LCCa_p <eq /> LCCa_PHOSPH <divide /> <times /> epsilon k_pka_lcc PKAC_II LCCa <plus /> Km_pka_lcc <times /> epsilon LCCa <eq /> LCCa_DEPHOSPH <divide /> <times /> epsilon k_pp2a_lcc PP2A_lcc_tot LCCa_p <plus /> Km_pp2a_lcc <times /> epsilon LCCa_p <eq /> LCCb <minus /> LCC_tot LCCb_p <eq /> LCCb_PHOSPH <divide /> <times /> epsilon k_pka_lcc PKAC_II LCCb <plus /> Km_pka_lcc <times /> epsilon LCCb <eq /> LCCb_DEPHOSPH <divide /> <times /> epsilon k_pp1_lcc PP1_lcc_tot LCCb_p <plus /> Km_pp1_lcc <times /> epsilon LCCb_p <eq /> <diff /> time LCCa_p <minus /> LCCa_PHOSPH LCCa_DEPHOSPH <eq /> <diff /> time LCCb_p <minus /> LCCb_PHOSPH LCCb_DEPHOSPH <eq /> frac_LCCa_p <divide /> LCCa_p LCC_tot <eq /> frac_LCCa_po 0.2041 <eq /> frac_LCCb_p <divide /> LCCb_p LCC_tot <eq /> frac_LCCb_po 0.2336
is computational component for: LCC module

LCC parameters
type: NamedIndividual
type: Submodel
name: LCC_parameters
has associated data structure: LCC parameters.Km pka lcc
has associated data structure: LCC parameters.Km pp1 lcc
has associated data structure: LCC parameters.Km pp2a lcc
has associated data structure: LCC parameters.LCC tot
has associated data structure: LCC parameters.PP1 lcc tot
has associated data structure: LCC parameters.PP2A lcc tot
has associated data structure: LCC parameters.epsilon
has associated data structure: LCC parameters.k pka lcc
has associated data structure: LCC parameters.k pp1 lcc
has associated data structure: LCC parameters.k pp2a lcc
has computational component: LCC parameters computation

LCC parameters.Km pka lcc
type: NamedIndividual
type: Decimal
has cell m linitial value: 21
metadata ID: LCC_parameters.Km_pka_lcc
has cell m lpublic interface: out
mapped to: LCC module.Km pka lcc
has unit: UNIT uM
has solution domain: Time

LCC parameters.Km pp1 lcc
type: NamedIndividual
type: Decimal
has cell m linitial value: 3
metadata ID: LCC_parameters.Km_pp1_lcc
has cell m lpublic interface: out
mapped to: LCC module.Km pp1 lcc
has unit: UNIT uM
has solution domain: Time

LCC parameters.Km pp2a lcc
type: NamedIndividual
type: Decimal
has cell m linitial value: 3
metadata ID: LCC_parameters.Km_pp2a_lcc
has cell m lpublic interface: out
mapped to: LCC module.Km pp2a lcc
has unit: UNIT uM
has solution domain: Time

LCC parameters.LCC tot
type: NamedIndividual
type: Decimal
has cell m linitial value: 25e-3
metadata ID: LCC_parameters.LCC_tot
has cell m lpublic interface: out
mapped to: LCC module.LCC tot
has unit: UNIT uM
has solution domain: Time

LCC parameters.PP1 lcc tot
type: NamedIndividual
type: Decimal
has cell m linitial value: 25e-3
metadata ID: LCC_parameters.PP1_lcc_tot
has cell m lpublic interface: out
mapped to: LCC module.PP1 lcc tot
has unit: UNIT uM
has solution domain: Time

LCC parameters.PP2A lcc tot
type: NamedIndividual
type: Decimal
has cell m linitial value: 25e-3
metadata ID: LCC_parameters.PP2A_lcc_tot
has cell m lpublic interface: out
mapped to: LCC module.PP2A lcc tot
has unit: UNIT uM
has solution domain: Time

LCC parameters.epsilon
type: NamedIndividual
type: Decimal
has cell m linitial value: 10
metadata ID: LCC_parameters.epsilon
has cell m lpublic interface: out
mapped to: LCC module.epsilon
has unit: UNIT dimensionless
has solution domain: Time

LCC parameters.k pka lcc
type: NamedIndividual
type: Decimal
has cell m linitial value: 54
metadata ID: LCC_parameters.k_pka_lcc
has cell m lpublic interface: out
mapped to: LCC module.k pka lcc
has unit: UNIT per sec
has solution domain: Time

LCC parameters.k pp1 lcc
type: NamedIndividual
type: Decimal
has cell m linitial value: 8.52
metadata ID: LCC_parameters.k_pp1_lcc
has cell m lpublic interface: out
mapped to: LCC module.k pp1 lcc
has unit: UNIT per sec
has solution domain: Time

LCC parameters.k pp2a lcc
type: NamedIndividual
type: Decimal
has cell m linitial value: 10.1
metadata ID: LCC_parameters.k_pp2a_lcc
has cell m lpublic interface: out
mapped to: LCC module.k pp2a lcc
has unit: UNIT per sec
has solution domain: Time

L Type Calcium Current
type: NamedIndividual
type: Submodel
name: L_Type_Calcium_Current
has associated data structure: L Type Calcium Current.Ca ext
has associated data structure: L Type Calcium Current.Ca i
has associated data structure: L Type Calcium Current.FoRT
has associated data structure: L Type Calcium Current.Frdy
has associated data structure: L Type Calcium Current.I Ca
has associated data structure: L Type Calcium Current.I Ca05
has associated data structure: L Type Calcium Current.I CaK
has associated data structure: L Type Calcium Current.I Ca tot
has associated data structure: L Type Calcium Current.K ext
has associated data structure: L Type Calcium Current.K i
has associated data structure: L Type Calcium Current.N lcc
has associated data structure: L Type Calcium Current.V m
has associated data structure: L Type Calcium Current.a lcc
has associated data structure: L Type Calcium Current.b lcc
has associated data structure: L Type Calcium Current.f
has associated data structure: L Type Calcium Current.f avail
has associated data structure: L Type Calcium Current.f lcc
has associated data structure: L Type Calcium Current.frac LCCa p
has associated data structure: L Type Calcium Current.frac LCCa po
has associated data structure: L Type Calcium Current.frac LCCb p
has associated data structure: L Type Calcium Current.frac LCCb po
has associated data structure: L Type Calcium Current.g
has associated data structure: L Type Calcium Current.gamma
has associated data structure: L Type Calcium Current.gamma o
has associated data structure: L Type Calcium Current.i bar Ca
has associated data structure: L Type Calcium Current.i bar K
has associated data structure: L Type Calcium Current.omega
has associated data structure: L Type Calcium Current.p Ca
has associated data structure: L Type Calcium Current.p K
has associated data structure: L Type Calcium Current.tau y lcc
has associated data structure: Time
has associated data structure: L Type Calcium Current.v
has associated data structure: L Type Calcium Current.v gamma
has associated data structure: L Type Calcium Current.v omega
has associated data structure: L Type Calcium Current.w
has associated data structure: L Type Calcium Current.x
has associated data structure: L Type Calcium Current.y
has associated data structure: L Type Calcium Current.y lcc inf
has associated data structure: L Type Calcium Current.z
has computational component: L Type Calcium Current computation

L Type Calcium Current.Ca ext
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.Ca_ext
has cell m lpublic interface: in
has unit: UNIT mM
has solution domain: Time

L Type Calcium Current.Ca i
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.Ca_i
has cell m lpublic interface: in
comment: Concentration of intracellular calcium in the rat ventricular myocyte
is computational component for: Chemical concentration
has unit: UNIT mM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: calcium(2+)
has computational component: L Type Calcium Current.Ca i

L Type Calcium Current.FoRT
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.FoRT
has cell m lpublic interface: in
has unit: UNIT per mV
has solution domain: Time

L Type Calcium Current.Frdy
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.Frdy
has cell m lpublic interface: in
has unit: UNIT coulombs per mole
has solution domain: Time

L Type Calcium Current.I Ca
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.I_Ca
has cell m lpublic interface: out
comment: L-Type calcium current
is computational component for: Charge flow rate
mapped to: Total Membrane Currents.I Ca
has unit: UNIT uA per uF
has solution domain: Time

L Type Calcium Current.I Ca05
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.I_Ca05
has cell m lpublic interface: in
has unit: UNIT uA per uF
has solution domain: Time

L Type Calcium Current.I CaK
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.I_CaK
has cell m lpublic interface: out
comment: Potassium current through the channel
is computational component for: Charge flow rate
mapped to: Total Membrane Currents.I CaK
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
has computational component: L Type Calcium Current.I CaK

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
has computational component: L Type Calcium Current.I Ca

L Type Calcium Current.I Ca tot
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.I_Ca_tot
has cell m lpublic interface: out
comment: Total L-type Ca2+ current
is computational component for: Charge flow rate
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
has computational component: L Type Calcium Current.I Ca tot

L Type Calcium Current.K ext
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.K_ext
has cell m lpublic interface: in
has unit: UNIT mM
has solution domain: Time

L Type Calcium Current.K i
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.K_i
has cell m lpublic interface: in
comment: Concentration of intracellular potassium in the rat ventricular myocyte.
is computational component for: Chemical concentration
has unit: UNIT mM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: potassium(1+)
has computational component: L Type Calcium Current.K i

L Type Calcium Current.N lcc
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.N_lcc
has cell m lpublic interface: in
has unit: UNIT dimensionless
has solution domain: Time

L Type Calcium Current.V m
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.V_m
has cell m lpublic interface: in
comment: Sarcoplasm membrane potential
is computational component for: Chemical potential
has unit: UNIT mV
has solution domain: Time

Chemical potential
type: NamedIndividual
has physical definition: Chemical potential
has computational component: L Type Calcium Current.V m

L Type Calcium Current.a lcc
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.a_lcc
has unit: UNIT per sec
has solution domain: Time

L Type Calcium Current.b lcc
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.b_lcc
has unit: UNIT per sec
has solution domain: Time

L Type Calcium Current.f
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.f
has cell m lpublic interface: in
has unit: UNIT per sec
has solution domain: Time

L Type Calcium Current.f avail
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.f_avail
has unit: UNIT dimensionless
has solution domain: Time

L Type Calcium Current.f lcc
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.f_lcc
has unit: UNIT dimensionless
has solution domain: Time

L Type Calcium Current.frac LCCa p
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.frac_LCCa_p
has cell m lpublic interface: in
has unit: UNIT dimensionless
has solution domain: Time

L Type Calcium Current.frac LCCa po
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.frac_LCCa_po
has cell m lpublic interface: in
has unit: UNIT dimensionless
has solution domain: Time

L Type Calcium Current.frac LCCb p
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.frac_LCCb_p
has cell m lpublic interface: in
has unit: UNIT dimensionless
has solution domain: Time

L Type Calcium Current.frac LCCb po
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.frac_LCCb_po
has cell m lpublic interface: in
has unit: UNIT dimensionless
has solution domain: Time

L Type Calcium Current.g
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.g
has cell m lpublic interface: in
has unit: UNIT per sec
has solution domain: Time

L Type Calcium Current.gamma
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.gamma
has unit: UNIT per mM per sec
has solution domain: Time

L Type Calcium Current.gamma o
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.gamma_o
has cell m lpublic interface: in
has unit: UNIT per mM per sec
has solution domain: Time

L Type Calcium Current.i bar Ca
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.i_bar_Ca
has unit: UNIT dimensionless
has solution domain: Time

L Type Calcium Current.i bar K
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.i_bar_K
has unit: UNIT dimensionless
has solution domain: Time

L Type Calcium Current.omega
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.omega
has cell m lpublic interface: in
has unit: UNIT per sec
has solution domain: Time

L Type Calcium Current.p Ca
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.p_Ca
has cell m lpublic interface: in
has unit: UNIT cm per sec
has solution domain: Time

L Type Calcium Current.p K
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.p_K
has cell m lpublic interface: in
has unit: UNIT cm per sec
has solution domain: Time

L Type Calcium Current.tau y lcc
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.tau_y_lcc
has unit: UNIT second
has solution domain: Time

Time
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.time
has physical definition: https://identifiers.org/opb/OPB_01023
has cell m lpublic interface: in
has unit: UNIT second
has solution domain: Time

L Type Calcium Current.v
type: NamedIndividual
type: Decimal
has cell m linitial value: 0
metadata ID: L_Type_Calcium_Current.v
has unit: UNIT dimensionless
has solution domain: Time

L Type Calcium Current.v gamma
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.v_gamma
has unit: UNIT per mM per sec
has solution domain: Time

L Type Calcium Current.v omega
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.v_omega
has unit: UNIT dimensionless
has solution domain: Time

L Type Calcium Current.w
type: NamedIndividual
type: Decimal
has cell m linitial value: 0
metadata ID: L_Type_Calcium_Current.w
has unit: UNIT dimensionless
has solution domain: Time

L Type Calcium Current.x
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.13
metadata ID: L_Type_Calcium_Current.x
has unit: UNIT dimensionless
has solution domain: Time

L Type Calcium Current.y
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.96
metadata ID: L_Type_Calcium_Current.y
has unit: UNIT dimensionless
has solution domain: Time

L Type Calcium Current.y lcc inf
type: NamedIndividual
type: Decimal
metadata ID: L_Type_Calcium_Current.y_lcc_inf
has unit: UNIT dimensionless
has solution domain: Time

L Type Calcium Current.z
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.92
metadata ID: L_Type_Calcium_Current.z
has unit: UNIT dimensionless
has solution domain: Time

L Type Calcium Current computation
type: NamedIndividual
type: Computation
has math ML: <eq /> a_lcc <times /> 400 <exp /> <divide /> <plus /> V_m 2 10 <eq /> b_lcc <times /> 50 <exp /> <divide /> <times /> <minus /> 1 <plus /> V_m 2 13 <eq /> f_lcc <times /> f <plus /> <divide /> <times /> 0.375 frac_LCCa_p frac_LCCa_po 0.625 <eq /> y_lcc_inf <plus /> <divide /> 1 <plus /> 1 <exp /> <divide /> <plus /> V_m 55 7.5 <divide /> 0.1 <plus /> 1 <exp /> <divide /> <plus /> <minus /> V_m 21 6 <eq /> tau_y_lcc <plus /> 0.02 <divide /> 0.3 <plus /> 1 <exp /> <divide /> <plus /> V_m 30 9.5 <eq /> gamma <times /> gamma_o Ca_i <eq /> v_gamma <times /> gamma <plus /> <power /> <minus /> 1 v 4 <times /> 2 v <power /> <minus /> 1 v 3 <times /> 4 <power /> v 2 <power /> <minus /> 1 v 2 <times /> 8 <power /> v 3 <minus /> 1 v <times /> 16 <power /> v 4 <minus /> 1 <divide /> f_lcc g <eq /> v_omega <times /> omega <plus /> <power /> <minus /> 1 w 4 <times /> 0.5 w <power /> <minus /> 1 w 3 <times /> 0.25 <power /> w 2 <power /> <minus /> 1 w 2 <times /> 0.125 <power /> w 3 <minus /> 1 w <times /> 0.0625 <power /> w 4 <eq /> <diff /> time v <minus /> <times /> a_lcc <minus /> 1 v <times /> b_lcc v <eq /> <diff /> time w <minus /> <times /> 2 a_lcc <minus /> 1 w <times /> <divide /> b_lcc 2 w <eq /> <diff /> time x <minus /> <times /> f_lcc <minus /> 1 x <times /> g x <eq /> <diff /> time y <divide /> <minus /> y_lcc_inf y tau_y_lcc <eq /> <diff /> time z <minus /> <times /> v_omega <minus /> 1 z <times /> v_gamma z <eq /> i_bar_Ca <divide /> <times /> p_Ca 4 V_m Frdy FoRT <minus /> <times /> 1 <sep /> -3 <exp /> <times /> 2 V_m FoRT <times /> 0.341 Ca_ext <minus /> <exp /> <times /> 2 V_m FoRT 1 <eq /> i_bar_K <divide /> <times /> p_K V_m Frdy FoRT <minus /> <times /> K_i <exp /> <times /> V_m FoRT K_ext <minus /> <exp /> <times /> V_m FoRT 1 <eq /> f_avail <times /> 0.5 <plus /> <divide /> <times /> 0.4 frac_LCCb_p frac_LCCb_po 0.6 <eq /> I_Ca <times /> i_bar_Ca N_lcc f_avail <power /> v 4 x y z <eq /> I_CaK <times /> <divide /> i_bar_K <plus /> 1 <divide /> I_Ca I_Ca05…
is computational component for: L Type Calcium Current

Na+ - Ca2+ current exchanger across sarcolemma
type: NamedIndividual
type: Custom physical process
has sink: sodium(1+)
has source: sodium(1+)
has source: calcium(2+)
has sink: calcium(2+)
has physical property: Charge flow rate
has mediator: sodium/calcium exchanger 1

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: calcium(2+)
annotated source: Na+ - Ca2+ current exchanger across sarcolemma

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: sodium(1+)
annotated source: Na+ - Ca2+ current exchanger across sarcolemma

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: sodium(1+)
annotated source: Na+ - Ca2+ current exchanger across sarcolemma

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: calcium(2+)
annotated source: Na+ - Ca2+ current exchanger across sarcolemma

Na+ - K+ pump current across sarcolemma
type: NamedIndividual
type: Custom physical process
has source: sodium(1+)
has sink: sodium(1+)
has sink: potassium(1+)
has source: potassium(1+)
has mediator: sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: potassium(1+)
annotated source: Na+ - K+ pump current across sarcolemma

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: sodium(1+)
annotated source: Na+ - K+ pump current across sarcolemma

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: sodium(1+)
annotated source: Na+ - K+ pump current across sarcolemma

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: potassium(1+)
annotated source: Na+ - K+ pump current across sarcolemma

Na Background Current
type: NamedIndividual
type: Submodel
name: Na_Background_Current
has associated data structure: Na Background Current.E Na
has associated data structure: Na Background Current.G NaB
has associated data structure: Na Background Current.I NaB
has associated data structure: Na Background Current.V m
has computational component: Na Background Current computation

Na Background Current.E Na
type: NamedIndividual
type: Decimal
metadata ID: Na_Background_Current.E_Na
has cell m lpublic interface: in
comment: Sodium nernst potential
is computational component for: Nernst potential
has unit: UNIT mV
has solution domain: Time

Nernst potential
type: NamedIndividual
has physical definition: Nernst potential
has computational component: Na Background Current.E Na

Na Background Current.G NaB
type: NamedIndividual
type: Decimal
metadata ID: Na_Background_Current.G_NaB
has cell m lpublic interface: in
has unit: UNIT uA per uF
has solution domain: Time

Na Background Current.I NaB
type: NamedIndividual
type: Decimal
metadata ID: Na_Background_Current.I_NaB
has cell m lpublic interface: out
comment: Background Na+ current
is computational component for: Charge flow rate
mapped to: Total Membrane Currents.I NaB
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
physical property of: Background Na+ current flow
has computational component: Na Background Current.I NaB

Na Background Current.V m
type: NamedIndividual
type: Decimal
metadata ID: Na_Background_Current.V_m
has cell m lpublic interface: in
comment: Sarcoplasm membrane potential
is computational component for: Chemical potential
has unit: UNIT mV
has solution domain: Time

Chemical potential
type: NamedIndividual
has physical definition: Chemical potential
has computational component: Na Background Current.V m

Na Background Current computation
type: NamedIndividual
type: Computation
has math ML: <eq /> I_NaB <times /> G_NaB <minus /> V_m E_Na
is computational component for: Na Background Current

Na Ca Exchanger Current
type: NamedIndividual
type: Submodel
name: Na_Ca_Exchanger_Current
has associated data structure: Na Ca Exchanger Current.Ca ext
has associated data structure: Na Ca Exchanger Current.Ca i
has associated data structure: Na Ca Exchanger Current.FoRT
has associated data structure: Na Ca Exchanger Current.I NCX
has associated data structure: Na Ca Exchanger Current.Km Ca
has associated data structure: Na Ca Exchanger Current.Km Na
has associated data structure: Na Ca Exchanger Current.Na ext
has associated data structure: Na Ca Exchanger Current.Na i
has associated data structure: Na Ca Exchanger Current.V m
has associated data structure: Na Ca Exchanger Current.eta
has associated data structure: Na Ca Exchanger Current.k NaCa
has associated data structure: Na Ca Exchanger Current.k sat
has associated data structure: Na Ca Exchanger Current.s4
has associated data structure: Na Ca Exchanger Current.s5
has computational component: Na Ca Exchanger Current computation

Na Ca Exchanger Current.Ca ext
type: NamedIndividual
type: Decimal
metadata ID: Na_Ca_Exchanger_Current.Ca_ext
has cell m lpublic interface: in
has unit: UNIT mM
has solution domain: Time

Na Ca Exchanger Current.Ca i
type: NamedIndividual
type: Decimal
metadata ID: Na_Ca_Exchanger_Current.Ca_i
has cell m lpublic interface: in
comment: Concentration of intracellular calcium in the rat ventricular myocyte
is computational component for: Chemical concentration
has unit: UNIT mM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: calcium(2+)
has computational component: Na Ca Exchanger Current.Ca i

Na Ca Exchanger Current.FoRT
type: NamedIndividual
type: Decimal
metadata ID: Na_Ca_Exchanger_Current.FoRT
has cell m lpublic interface: in
has unit: UNIT per mV
has solution domain: Time

Na Ca Exchanger Current.I NCX
type: NamedIndividual
type: Decimal
metadata ID: Na_Ca_Exchanger_Current.I_NCX
has cell m lpublic interface: out
comment: Na+ - Ca2+ current exchanger across sarcolemma
is computational component for: Charge flow rate
mapped to: Total Membrane Currents.I NCX
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
physical property of: Na+ - Ca2+ current exchanger across sarcolemma
has computational component: Na Ca Exchanger Current.I NCX

Na Ca Exchanger Current.Km Ca
type: NamedIndividual
type: Decimal
metadata ID: Na_Ca_Exchanger_Current.Km_Ca
has cell m lpublic interface: in
has unit: UNIT mM
has solution domain: Time

Na Ca Exchanger Current.Km Na
type: NamedIndividual
type: Decimal
metadata ID: Na_Ca_Exchanger_Current.Km_Na
has cell m lpublic interface: in
has unit: UNIT mM
has solution domain: Time

Na Ca Exchanger Current.Na ext
type: NamedIndividual
type: Decimal
metadata ID: Na_Ca_Exchanger_Current.Na_ext
has cell m lpublic interface: in
has unit: UNIT mM
has solution domain: Time

Na Ca Exchanger Current.Na i
type: NamedIndividual
type: Decimal
metadata ID: Na_Ca_Exchanger_Current.Na_i
has cell m lpublic interface: in
comment: Concentration of intracellular sodium in the rat ventricular myocyte
is computational component for: Chemical concentration
has unit: UNIT mM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: sodium(1+)
has computational component: Na Ca Exchanger Current.Na i

Na Ca Exchanger Current.V m
type: NamedIndividual
type: Decimal
metadata ID: Na_Ca_Exchanger_Current.V_m
has cell m lpublic interface: in
comment: Sarcoplasm membrane potential
is computational component for: Chemical potential
has unit: UNIT mV
has solution domain: Time

Chemical potential
type: NamedIndividual
has physical definition: Chemical potential
has computational component: Na Ca Exchanger Current.V m

Na Ca Exchanger Current.eta
type: NamedIndividual
type: Decimal
metadata ID: Na_Ca_Exchanger_Current.eta
has cell m lpublic interface: in
has unit: UNIT dimensionless
has solution domain: Time

Na Ca Exchanger Current.k NaCa
type: NamedIndividual
type: Decimal
metadata ID: Na_Ca_Exchanger_Current.k_NaCa
has cell m lpublic interface: in
has unit: UNIT uA per uF
has solution domain: Time

Na Ca Exchanger Current.k sat
type: NamedIndividual
type: Decimal
metadata ID: Na_Ca_Exchanger_Current.k_sat
has cell m lpublic interface: in
has unit: UNIT dimensionless
has solution domain: Time

Na Ca Exchanger Current.s4
type: NamedIndividual
type: Decimal
metadata ID: Na_Ca_Exchanger_Current.s4
has unit: UNIT dimensionless
has solution domain: Time

Na Ca Exchanger Current.s5
type: NamedIndividual
type: Decimal
metadata ID: Na_Ca_Exchanger_Current.s5
has unit: UNIT dimensionless
has solution domain: Time

Na Ca Exchanger Current computation
type: NamedIndividual
type: Computation
has math ML: <eq /> s4 <times /> <exp /> <times /> eta V_m FoRT <power /> Na_i 3 Ca_ext <eq /> s5 <times /> <exp /> <times /> <minus /> eta 1 V_m FoRT <power /> Na_ext 3 Ca_i <eq /> I_NCX <times /> <divide /> k_NaCa <times /> <plus /> <power /> Km_Na 3 <power /> Na_ext 3 <plus /> Km_Ca Ca_ext <plus /> 1 <times /> k_sat <exp /> <times /> <minus /> eta 1 V_m FoRT <minus /> s4 s5
is computational component for: Na Ca Exchanger Current

Na K Pump Current
type: NamedIndividual
type: Submodel
name: Na_K_Pump_Current
has associated data structure: Na K Pump Current.FoRT
has associated data structure: Na K Pump Current.I NaK
has associated data structure: Na K Pump Current.I bar NaK
has associated data structure: Na K Pump Current.K ext
has associated data structure: Na K Pump Current.Km Ko
has associated data structure: Na K Pump Current.Km Nai
has associated data structure: Na K Pump Current.Na ext
has associated data structure: Na K Pump Current.Na i
has associated data structure: Na K Pump Current.V m
has associated data structure: Na K Pump Current.f NaK
has associated data structure: Na K Pump Current.sigma
has computational component: Na K Pump Current computation

Na K Pump Current.FoRT
type: NamedIndividual
type: Decimal
metadata ID: Na_K_Pump_Current.FoRT
has cell m lpublic interface: in
has unit: UNIT per mV
has solution domain: Time

Na K Pump Current.I NaK
type: NamedIndividual
type: Decimal
metadata ID: Na_K_Pump_Current.I_NaK
has cell m lpublic interface: out
comment: Na+ - K+ pump current across sarcolemma
is computational component for: Charge flow rate
mapped to: Total Membrane Currents.I NaK
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
physical property of: Na+ - K+ pump current across sarcolemma
has computational component: Na K Pump Current.I NaK

Na K Pump Current.I bar NaK
type: NamedIndividual
type: Decimal
metadata ID: Na_K_Pump_Current.I_bar_NaK
has cell m lpublic interface: in
has unit: UNIT uA per uF
has solution domain: Time

Na K Pump Current.K ext
type: NamedIndividual
type: Decimal
metadata ID: Na_K_Pump_Current.K_ext
has cell m lpublic interface: in
has unit: UNIT mM
has solution domain: Time

Na K Pump Current.Km Ko
type: NamedIndividual
type: Decimal
metadata ID: Na_K_Pump_Current.Km_Ko
has cell m lpublic interface: in
has unit: UNIT mM
has solution domain: Time

Na K Pump Current.Km Nai
type: NamedIndividual
type: Decimal
metadata ID: Na_K_Pump_Current.Km_Nai
has cell m lpublic interface: in
has unit: UNIT mM
has solution domain: Time

Na K Pump Current.Na ext
type: NamedIndividual
type: Decimal
metadata ID: Na_K_Pump_Current.Na_ext
has cell m lpublic interface: in
has unit: UNIT mM
has solution domain: Time

Na K Pump Current.Na i
type: NamedIndividual
type: Decimal
metadata ID: Na_K_Pump_Current.Na_i
has cell m lpublic interface: in
comment: Concentration of intracellular sodium in the rat ventricular myocyte
is computational component for: Chemical concentration
has unit: UNIT mM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: sodium(1+)
has computational component: Na K Pump Current.Na i

Na K Pump Current.V m
type: NamedIndividual
type: Decimal
metadata ID: Na_K_Pump_Current.V_m
has cell m lpublic interface: in
comment: Sarcoplasm membrane potential
is computational component for: Chemical potential
has unit: UNIT mV
has solution domain: Time

Chemical potential
type: NamedIndividual
has physical definition: Chemical potential
has computational component: Na K Pump Current.V m

Na K Pump Current.f NaK
type: NamedIndividual
type: Decimal
metadata ID: Na_K_Pump_Current.f_NaK
has unit: UNIT dimensionless
has solution domain: Time

Na K Pump Current.sigma
type: NamedIndividual
type: Decimal
metadata ID: Na_K_Pump_Current.sigma
has unit: UNIT dimensionless
has solution domain: Time

Na K Pump Current computation
type: NamedIndividual
type: Computation
has math ML: <eq /> sigma <divide /> <minus /> <exp /> <divide /> Na_ext 67.3 1 7 <eq /> f_NaK <divide /> 1 <plus /> 1 <times /> 0.1245 <exp /> <times /> <minus /> 0.1 V_m FoRT <times /> 0.0365 sigma <exp /> <times /> <minus /> V_m FoRT <eq /> I_NaK <divide /> <times /> <divide /> <times /> I_bar_NaK f_NaK <plus /> 1 <power /> <divide /> Km_Nai Na_i 1.5 K_ext <plus /> K_ext Km_Ko
is computational component for: Na K Pump Current

Nernst Potentials
type: NamedIndividual
type: Submodel
name: Nernst_Potentials
has associated data structure: Nernst Potentials.Ca ext
has associated data structure: Nernst Potentials.Ca i
has associated data structure: Nernst Potentials.E Ca
has associated data structure: Nernst Potentials.E Cl
has associated data structure: Nernst Potentials.E K
has associated data structure: Nernst Potentials.E Na
has associated data structure: Nernst Potentials.FoRT
has associated data structure: Nernst Potentials.Frdy
has associated data structure: Nernst Potentials.K ext
has associated data structure: Nernst Potentials.K i
has associated data structure: Nernst Potentials.Na ext
has associated data structure: Nernst Potentials.Na i
has associated data structure: Nernst Potentials.R
has associated data structure: Nernst Potentials.Temp
has associated data structure: Nernst Potentials.z Ca
has associated data structure: Nernst Potentials.z K
has associated data structure: Nernst Potentials.z Na
has computational component: Nernst Potentials computation

Nernst Potentials.Ca ext
type: NamedIndividual
type: Decimal
metadata ID: Nernst_Potentials.Ca_ext
has cell m lpublic interface: in
has unit: UNIT mM
has solution domain: Time

Nernst Potentials.Ca i
type: NamedIndividual
type: Decimal
metadata ID: Nernst_Potentials.Ca_i
has cell m lpublic interface: in
comment: Concentration of intracellular calcium in the rat ventricular myocyte
is computational component for: Chemical concentration
has unit: UNIT mM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: calcium(2+)
has computational component: Nernst Potentials.Ca i

Nernst Potentials.E Ca
type: NamedIndividual
type: Decimal
metadata ID: Nernst_Potentials.E_Ca
has cell m lpublic interface: out
comment: Calcium Nernst potential
mapped to: Ca Background Current.E Ca
is computational component for: Nernst potential
has unit: UNIT mV
has solution domain: Time

Nernst potential
type: NamedIndividual
has physical definition: Nernst potential
has computational component: Nernst Potentials.E Ca

Nernst Potentials.E Cl
type: NamedIndividual
type: Decimal
metadata ID: Nernst_Potentials.E_Cl
has cell m lpublic interface: out
has unit: UNIT mV
has solution domain: Time

Nernst Potentials.E K
type: NamedIndividual
type: Decimal
metadata ID: Nernst_Potentials.E_K
has cell m lpublic interface: out
comment: Potassium nernst potentials
is computational component for: Nernst potential
mapped to: Plateau K Current.E K
mapped to: Steady State K Current.E K
mapped to: Time Independent K Current.E K
mapped to: Transient Outward K Current.E K
has unit: UNIT mV
has solution domain: Time

Nernst potential
type: NamedIndividual
has physical definition: Nernst potential
has computational component: Nernst Potentials.E K

Nernst Potentials.E Na
type: NamedIndividual
type: Decimal
metadata ID: Nernst_Potentials.E_Na
has cell m lpublic interface: out
comment: Sodium nernst potential
mapped to: Fast Na Current.E Na
mapped to: Na Background Current.E Na
is computational component for: Nernst potential
has unit: UNIT mV
has solution domain: Time

Nernst potential
type: NamedIndividual
has physical definition: Nernst potential
has computational component: Nernst Potentials.E Na

Nernst Potentials.FoRT
type: NamedIndividual
type: Decimal
metadata ID: Nernst_Potentials.FoRT
has cell m lpublic interface: out
mapped to: L Type Calcium Current.FoRT
mapped to: Na Ca Exchanger Current.FoRT
mapped to: Na K Pump Current.FoRT
has unit: UNIT per mV
has solution domain: Time

Nernst Potentials.Frdy
type: NamedIndividual
type: Decimal
has cell m linitial value: 96485
metadata ID: Nernst_Potentials.Frdy
has cell m lpublic interface: out
mapped to: Ion Concentrations and Membrane Potential.Frdy
mapped to: L Type Calcium Current.Frdy
has unit: UNIT coulombs per mole
has solution domain: Time

Nernst Potentials.K ext
type: NamedIndividual
type: Decimal
metadata ID: Nernst_Potentials.K_ext
has cell m lpublic interface: in
has unit: UNIT mM
has solution domain: Time

Nernst Potentials.K i
type: NamedIndividual
type: Decimal
metadata ID: Nernst_Potentials.K_i
has cell m lpublic interface: in
comment: Concentration of intracellular potassium in the rat ventricular myocyte.
is computational component for: Chemical concentration
has unit: UNIT mM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: potassium(1+)
has computational component: Nernst Potentials.K i

Nernst Potentials.Na ext
type: NamedIndividual
type: Decimal
metadata ID: Nernst_Potentials.Na_ext
has cell m lpublic interface: in
has unit: UNIT mM
has solution domain: Time

Nernst Potentials.Na i
type: NamedIndividual
type: Decimal
metadata ID: Nernst_Potentials.Na_i
has cell m lpublic interface: in
comment: Concentration of intracellular sodium in the rat ventricular myocyte
is computational component for: Chemical concentration
has unit: UNIT mM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: sodium(1+)
has computational component: Nernst Potentials.Na i

Nernst Potentials.R
type: NamedIndividual
type: Decimal
has cell m linitial value: 8314
metadata ID: Nernst_Potentials.R
has unit: UNIT joules per mole kelvin
has solution domain: Time

Nernst Potentials.Temp
type: NamedIndividual
type: Decimal
metadata ID: Nernst_Potentials.Temp
has cell m lpublic interface: in
has unit: UNIT kelvin
has solution domain: Time

Nernst Potentials.z Ca
type: NamedIndividual
type: Decimal
has cell m linitial value: 2
metadata ID: Nernst_Potentials.z_Ca
has cell m lpublic interface: out
mapped to: Ion Concentrations and Membrane Potential.z Ca
has unit: UNIT dimensionless
has solution domain: Time

Nernst Potentials.z K
type: NamedIndividual
type: Decimal
has cell m linitial value: 1
metadata ID: Nernst_Potentials.z_K
has cell m lpublic interface: out
mapped to: Ion Concentrations and Membrane Potential.z K
has unit: UNIT dimensionless
has solution domain: Time

Nernst Potentials.z Na
type: NamedIndividual
type: Decimal
has cell m linitial value: 1
metadata ID: Nernst_Potentials.z_Na
has cell m lpublic interface: out
mapped to: Ion Concentrations and Membrane Potential.z Na
has unit: UNIT dimensionless
has solution domain: Time

Nernst Potentials computation
type: NamedIndividual
type: Computation
has math ML: <eq /> FoRT <divide /> <divide /> Frdy R Temp <eq /> E_Na <times /> <divide /> 1 <times /> FoRT z_Na <ln /> <divide /> Na_ext Na_i <eq /> E_K <times /> <divide /> 1 <times /> FoRT z_K <ln /> <divide /> K_ext K_i <eq /> E_Ca <times /> <divide /> 1 <times /> FoRT z_Ca <ln /> <divide /> Ca_ext Ca_i <eq /> E_Cl <minus /> 40
is computational component for: Nernst Potentials

Network SR
type: NamedIndividual
type: Custom physical entity
has part: calcium(2+)

Other SR Fluxes and Concentrations
type: NamedIndividual
type: Submodel
name: Other_SR_Fluxes_and_Concentrations
has associated data structure: Other SR Fluxes and Concentrations.B jsr
has associated data structure: Other SR Fluxes and Concentrations.CSQN bar
has associated data structure: Other SR Fluxes and Concentrations.Ca i
has associated data structure: Other SR Fluxes and Concentrations.Ca jsr
has associated data structure: Other SR Fluxes and Concentrations.Ca nsr
has associated data structure: Other SR Fluxes and Concentrations.I leak
has associated data structure: Other SR Fluxes and Concentrations.I rel
has associated data structure: Other SR Fluxes and Concentrations.I tr
has associated data structure: Other SR Fluxes and Concentrations.I up
has associated data structure: Other SR Fluxes and Concentrations.I up bar
has associated data structure: Other SR Fluxes and Concentrations.Km CSQN
has associated data structure: Other SR Fluxes and Concentrations.Km up
has associated data structure: Other SR Fluxes and Concentrations.Km up0
has associated data structure: Other SR Fluxes and Concentrations.NSR bar
has associated data structure: Other SR Fluxes and Concentrations.SR content
has associated data structure: Other SR Fluxes and Concentrations.V jsr
has associated data structure: Other SR Fluxes and Concentrations.V myo
has associated data structure: Other SR Fluxes and Concentrations.V nsr
has associated data structure: Other SR Fluxes and Concentrations.frac PLB
has associated data structure: Other SR Fluxes and Concentrations.frac PLB o
has associated data structure: Other SR Fluxes and Concentrations.tau tr
has associated data structure: Time
has computational component: Other SR Fluxes and Concentrations computation

Other SR Fluxes and Concentrations.B jsr
type: NamedIndividual
type: Decimal
metadata ID: Other_SR_Fluxes_and_Concentrations.B_jsr
has unit: UNIT dimensionless
has solution domain: Time

Other SR Fluxes and Concentrations.CSQN bar
type: NamedIndividual
type: Decimal
metadata ID: Other_SR_Fluxes_and_Concentrations.CSQN_bar
has cell m lpublic interface: in
has unit: UNIT mM
has solution domain: Time

Other SR Fluxes and Concentrations.Ca i
type: NamedIndividual
type: Decimal
metadata ID: Other_SR_Fluxes_and_Concentrations.Ca_i
has cell m lpublic interface: in
comment: Concentration of intracellular calcium in the rat ventricular myocyte
is computational component for: Chemical concentration
has unit: UNIT mM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: calcium(2+)
has computational component: Other SR Fluxes and Concentrations.Ca i

Other SR Fluxes and Concentrations.Ca jsr
type: NamedIndividual
type: Decimal
has cell m linitial value: 1.92
metadata ID: Other_SR_Fluxes_and_Concentrations.Ca_jsr
has cell m lpublic interface: out
comment: Concentration of junctional SR Ca2+ ions
mapped to: Calcium Induced Calcium Release.Ca jsr
is computational component for: Chemical concentration
has unit: UNIT mM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: calcium(2+)
has computational component: Other SR Fluxes and Concentrations.Ca jsr

Other SR Fluxes and Concentrations.Ca nsr
type: NamedIndividual
type: Decimal
has cell m linitial value: 1.92
metadata ID: Other_SR_Fluxes_and_Concentrations.Ca_nsr
has cell m lpublic interface: out
comment: Network SR Ca2+ concentration
is computational component for: Chemical concentration
has unit: UNIT mM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: calcium(2+)
has computational component: Other SR Fluxes and Concentrations.Ca nsr

Other SR Fluxes and Concentrations.I leak
type: NamedIndividual
type: Decimal
metadata ID: Other_SR_Fluxes_and_Concentrations.I_leak
has cell m lpublic interface: out
mapped to: Ion Concentrations and Membrane Potential.I leak
is computational component for: Chemical concentration flow rate
has unit: UNIT mM per sec
has solution domain: Time

Chemical concentration flow rate
type: NamedIndividual
has physical definition: Chemical concentration flow rate
has computational component: Other SR Fluxes and Concentrations.I leak

Other SR Fluxes and Concentrations.I rel
type: NamedIndividual
type: Decimal
metadata ID: Other_SR_Fluxes_and_Concentrations.I_rel
has cell m lpublic interface: in
comment: CICR release current
is computational component for: Charge flow rate
has unit: UNIT mM per sec
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
physical property of: CICR release current
has computational component: Other SR Fluxes and Concentrations.I rel

Other SR Fluxes and Concentrations.I tr
type: NamedIndividual
type: Decimal
metadata ID: Other_SR_Fluxes_and_Concentrations.I_tr
comment: Transfer flux of Ca2+ from the JSR to the NSR
is computational component for: Chemical concentration flow rate
has unit: UNIT mM per sec
has solution domain: Time

Chemical concentration flow rate
type: NamedIndividual
has physical definition: Chemical concentration flow rate
physical property of: Ca2+ transfer from JSR to NSR
has computational component: Other SR Fluxes and Concentrations.I tr

Other SR Fluxes and Concentrations.I up
type: NamedIndividual
type: Decimal
metadata ID: Other_SR_Fluxes_and_Concentrations.I_up
has cell m lpublic interface: out
comment: Ca2+ uptake into the NSR by the SR
mapped to: Ion Concentrations and Membrane Potential.I up
is computational component for: Chemical concentration flow rate
has unit: UNIT mM per sec
has solution domain: Time

Other SR Fluxes and Concentrations.I up bar
type: NamedIndividual
type: Decimal
metadata ID: Other_SR_Fluxes_and_Concentrations.I_up_bar
has cell m lpublic interface: in
has unit: UNIT mM per sec
has solution domain: Time

Chemical concentration flow rate
type: NamedIndividual
has physical definition: Chemical concentration flow rate
physical property of: Ca2+ uptake into the NSR by the SR
has computational component: Other SR Fluxes and Concentrations.I up

Other SR Fluxes and Concentrations.Km CSQN
type: NamedIndividual
type: Decimal
metadata ID: Other_SR_Fluxes_and_Concentrations.Km_CSQN
has cell m lpublic interface: in
has unit: UNIT mM
has solution domain: Time

Other SR Fluxes and Concentrations.Km up
type: NamedIndividual
type: Decimal
metadata ID: Other_SR_Fluxes_and_Concentrations.Km_up
is computational component for: Chemical concentration
has unit: UNIT mM
has solution domain: Time

Other SR Fluxes and Concentrations.Km up0
type: NamedIndividual
type: Decimal
metadata ID: Other_SR_Fluxes_and_Concentrations.Km_up0
has cell m lpublic interface: in
has unit: UNIT mM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: Other SR Fluxes and Concentrations.Km up

Other SR Fluxes and Concentrations.NSR bar
type: NamedIndividual
type: Decimal
metadata ID: Other_SR_Fluxes_and_Concentrations.NSR_bar
has cell m lpublic interface: in
has unit: UNIT mM
has solution domain: Time

Other SR Fluxes and Concentrations.SR content
type: NamedIndividual
type: Decimal
metadata ID: Other_SR_Fluxes_and_Concentrations.SR_content
is computational component for: Chemical concentration
has unit: UNIT uM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: Other SR Fluxes and Concentrations.SR content

Other SR Fluxes and Concentrations.V jsr
type: NamedIndividual
type: Decimal
metadata ID: Other_SR_Fluxes_and_Concentrations.V_jsr
has cell m lpublic interface: in
has unit: UNIT uL
has solution domain: Time

Other SR Fluxes and Concentrations.V myo
type: NamedIndividual
type: Decimal
metadata ID: Other_SR_Fluxes_and_Concentrations.V_myo
has cell m lpublic interface: in
has unit: UNIT uL
has solution domain: Time

Other SR Fluxes and Concentrations.V nsr
type: NamedIndividual
type: Decimal
metadata ID: Other_SR_Fluxes_and_Concentrations.V_nsr
has cell m lpublic interface: in
has unit: UNIT uL
has solution domain: Time

Other SR Fluxes and Concentrations.frac PLB
type: NamedIndividual
type: Decimal
metadata ID: Other_SR_Fluxes_and_Concentrations.frac_PLB
has cell m lpublic interface: in
has unit: UNIT dimensionless
has solution domain: Time

Other SR Fluxes and Concentrations.frac PLB o
type: NamedIndividual
type: Decimal
metadata ID: Other_SR_Fluxes_and_Concentrations.frac_PLB_o
has cell m lpublic interface: in
has unit: UNIT dimensionless
has solution domain: Time

Other SR Fluxes and Concentrations.tau tr
type: NamedIndividual
type: Decimal
metadata ID: Other_SR_Fluxes_and_Concentrations.tau_tr
has cell m lpublic interface: in
has unit: UNIT second
has solution domain: Time

Time
type: NamedIndividual
type: Decimal
metadata ID: Other_SR_Fluxes_and_Concentrations.time
has physical definition: https://identifiers.org/opb/OPB_01023
has cell m lpublic interface: in
has unit: UNIT second
has solution domain: Time

Other SR Fluxes and Concentrations computation
type: NamedIndividual
type: Computation
has math ML: <eq /> Km_up <divide /> <times /> Km_up0 <plus /> 1 <times /> 2 frac_PLB <plus /> 1 <times /> 2 frac_PLB_o <eq /> I_up <divide /> <times /> I_up_bar <power /> Ca_i 2 <plus /> <power /> Km_up 2 <power /> Ca_i 2 <eq /> I_leak <divide /> <times /> I_up_bar Ca_nsr NSR_bar <eq /> I_tr <divide /> <minus /> Ca_nsr Ca_jsr tau_tr <eq /> B_jsr <divide /> 1 <plus /> 1 <divide /> <times /> CSQN_bar Km_CSQN <power /> <plus /> Km_CSQN Ca_jsr 2 <eq /> <diff /> time Ca_nsr <minus /> <minus /> I_up I_leak <divide /> <times /> I_tr V_jsr V_nsr <eq /> <diff /> time Ca_jsr <times /> B_jsr <minus /> I_tr I_rel <eq /> SR_content <times /> 1 <sep /> 3 <plus /> <divide /> <times /> <plus /> Ca_jsr <divide /> Ca_jsr B_jsr V_jsr V_myo <divide /> <times /> Ca_nsr V_nsr V_myo
is computational component for: Other SR Fluxes and Concentrations

Beta-1 adrenergic receptor
type: NamedIndividual
has physical definition: Beta-1 adrenergic receptor
part of: ventricular cardiac muscle cell
is index entity for: P18090 part of CL:2000046
has physical property: Chemical concentration

PKA module
type: NamedIndividual
type: Submodel
name: PKA_module
has associated data structure: PKA module.A2RC I
has associated data structure: PKA module.A2RC II
has associated data structure: PKA module.A2R I
has associated data structure: PKA module.A2R II
has associated data structure: PKA module.ARC I
has associated data structure: PKA module.ARC II
has associated data structure: PKA module.K a
has associated data structure: PKA module.K b
has associated data structure: PKA module.K d
has associated data structure: PKA module.Ki pki
has associated data structure: PKA module.PKAC I
has associated data structure: PKA module.PKAC II
has associated data structure: PKA module.PKAII tot
has associated data structure: PKA module.PKAI tot
has associated data structure: PKA module.PKA temp
has associated data structure: PKA module.PKI
has associated data structure: PKA module.PKI tot
has associated data structure: PKA module.cAMP
has associated data structure: PKA module.cAMP tot
has associated data structure: PKA module.zed
has associated data structure: PKA module.zed1
has computational component: PKA module computation

PKA module.A2RC I
type: NamedIndividual
type: Decimal
metadata ID: A2RC_I
is computational component for: Chemical concentration
has unit: UNIT uM
has solution domain: Time

PKA module.A2RC II
type: NamedIndividual
type: Decimal
metadata ID: A2RC_II
is computational component for: Chemical concentration
has unit: UNIT uM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: PKA module.A2RC II

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: PKA module.A2RC I

PKA module.A2R I
type: NamedIndividual
type: Decimal
metadata ID: A2R_I
is computational component for: Chemical concentration
has unit: UNIT uM
has solution domain: Time

PKA module.A2R II
type: NamedIndividual
type: Decimal
metadata ID: A2R_II
is computational component for: Chemical concentration
has unit: UNIT uM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: PKA module.A2R II

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: PKA module.A2R I

PKA module.ARC I
type: NamedIndividual
type: Decimal
metadata ID: ARC_I
is computational component for: Chemical concentration
has unit: UNIT uM
has solution domain: Time

PKA module.ARC II
type: NamedIndividual
type: Decimal
metadata ID: ARC_II
is computational component for: Chemical concentration
has unit: UNIT uM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: PKA module.ARC II

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: PKA module.ARC I

PKA module.K a
type: NamedIndividual
type: Decimal
metadata ID: PKA_module.K_a
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

PKA module.K b
type: NamedIndividual
type: Decimal
metadata ID: PKA_module.K_b
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

PKA module.K d
type: NamedIndividual
type: Decimal
metadata ID: PKA_module.K_d
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

PKA module.Ki pki
type: NamedIndividual
type: Decimal
metadata ID: PKA_module.Ki_pki
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

PKA module.PKAC I
type: NamedIndividual
type: Decimal
metadata ID: PKAC_I
has cell m lpublic interface: out
mapped to: PLB module.PKAC I
has unit: UNIT uM
mapped to: b1 AR module.PKAC I
has solution domain: Time

PKA module.PKAC II
type: NamedIndividual
type: Decimal
metadata ID: PKAC_II
has cell m lpublic interface: out
mapped to: LCC module.PKAC II
has unit: UNIT uM
has solution domain: Time

PKA module.PKAII tot
type: NamedIndividual
type: Decimal
metadata ID: PKA_module.PKAII_tot
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

PKA module.PKAI tot
type: NamedIndividual
type: Decimal
metadata ID: PKA_module.PKAI_tot
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

PKA module.PKA temp
type: NamedIndividual
type: Decimal
metadata ID: PKA_temp
is computational component for: Chemical concentration
has unit: UNIT uM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: PKA module.PKA temp

PKA module.PKI
type: NamedIndividual
type: Decimal
metadata ID: PKI
is computational component for: Chemical concentration
has unit: UNIT uM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: PKA module.PKI

PKA module.PKI tot
type: NamedIndividual
type: Decimal
metadata ID: PKA_module.PKI_tot
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

PKA module.cAMP
type: NamedIndividual
type: Decimal
metadata ID: cAMP
has cell m lpublic interface: out
is computational component for: Chemical concentration
has unit: UNIT uM
mapped to: cAMP module.cAMP
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: cAMP biosynthetic process
has computational component: PKA module.cAMP

PKA module.cAMP tot
type: NamedIndividual
type: Decimal
metadata ID: PKA_module.cAMP_tot
has cell m lpublic interface: in
comment: Concentration of cyclic AMP
is computational component for: Chemical concentration
has unit: UNIT uM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: cAMP biosynthetic process
has computational component: PKA module.cAMP tot

PKA module.zed
type: NamedIndividual
type: Decimal
has cell m linitial value: 0
metadata ID: PKA_module.zed
has unit: UNIT dimensionless
has solution domain: Time

PKA module.zed1
type: NamedIndividual
type: Decimal
has cell m linitial value: 0
metadata ID: PKA_module.zed1
has unit: UNIT dimensionless
has solution domain: Time

PKA module computation
type: NamedIndividual
type: Computation
has math ML: <eq /> PKI <divide /> <times /> PKI_tot Ki_pki <plus /> Ki_pki PKAC_I PKAC_II <eq /> A2RC_I <times /> <divide /> PKAC_I K_d PKAC_I <plus /> 1 <divide /> PKI Ki_pki <eq /> A2R_I <times /> PKAC_I <plus /> 1 <divide /> PKI Ki_pki <eq /> A2RC_II <times /> <divide /> PKAC_II K_d PKAC_II <plus /> 1 <divide /> PKI Ki_pki <eq /> A2R_II <times /> PKAC_II <plus /> 1 <divide /> PKI Ki_pki <eq /> ARC_I <times /> <divide /> K_a cAMP A2RC_I <eq /> ARC_II <times /> <divide /> K_a cAMP A2RC_II <eq /> PKA_temp <plus /> <divide /> <times /> K_a K_b K_d <divide /> <times /> K_a cAMP K_d <divide /> <power /> cAMP 2 K_d <eq /> cAMP <minus /> <minus /> cAMP_tot <plus /> ARC_I <times /> 2 A2RC_I <times /> 2 A2R_I <plus /> ARC_II <times /> 2 A2RC_II <times /> 2 A2R_II <eq /> zed <minus /> <times /> 2 PKAI_tot <power /> cAMP 2 <times /> PKAC_I <plus /> 1 <divide /> PKI Ki_pki <plus /> <times /> PKA_temp PKAC_I <power /> cAMP 2 <eq /> zed1 <minus /> <times /> 2 PKAII_tot <power /> cAMP 2 <times /> PKAC_II <plus /> 1 <divide /> PKI Ki_pki <plus /> <times /> PKA_temp PKAC_II <power /> cAMP 2
is computational component for: PKA module

PKA parameters
type: NamedIndividual
type: Submodel
name: PKA_parameters
has associated data structure: PKA parameters.K a
has associated data structure: PKA parameters.K b
has associated data structure: PKA parameters.K d
has associated data structure: PKA parameters.Ki pki
has associated data structure: PKA parameters.PKAII tot
has associated data structure: PKA parameters.PKAI tot
has associated data structure: PKA parameters.PKI tot
has computational component: PKA parameters computation

PKA parameters.K a
type: NamedIndividual
type: Decimal
has cell m linitial value: 9.14
metadata ID: PKA_parameters.K_a
has cell m lpublic interface: out
mapped to: PKA module.K a
has unit: UNIT uM
has solution domain: Time

PKA parameters.K b
type: NamedIndividual
type: Decimal
has cell m linitial value: 1.64
metadata ID: PKA_parameters.K_b
has cell m lpublic interface: out
mapped to: PKA module.K b
has unit: UNIT uM
has solution domain: Time

PKA parameters.K d
type: NamedIndividual
type: Decimal
has cell m linitial value: 4.375
metadata ID: PKA_parameters.K_d
has cell m lpublic interface: out
mapped to: PKA module.K d
has unit: UNIT uM
has solution domain: Time

PKA parameters.Ki pki
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.2e-3
metadata ID: PKA_parameters.Ki_pki
has cell m lpublic interface: out
mapped to: PKA module.Ki pki
has unit: UNIT uM
has solution domain: Time

PKA parameters.PKAII tot
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.025
metadata ID: PKA_parameters.PKAII_tot
has cell m lpublic interface: out
mapped to: PKA module.PKAII tot
has unit: UNIT uM
has solution domain: Time

PKA parameters.PKAI tot
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.59
metadata ID: PKA_parameters.PKAI_tot
has cell m lpublic interface: out
mapped to: PKA module.PKAI tot
has unit: UNIT uM
has solution domain: Time

PKA parameters.PKI tot
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.18
metadata ID: PKA_parameters.PKI_tot
has cell m lpublic interface: out
mapped to: PKA module.PKI tot
has unit: UNIT uM
has solution domain: Time

PLB module
type: NamedIndividual
type: Submodel
name: PLB_module
has associated data structure: PLB module.Inhib1
has associated data structure: PLB module.Inhib1 DEPHOSPH
has associated data structure: PLB module.Inhib1 PHOSPH
has associated data structure: PLB module.Inhib1 tot
has associated data structure: PLB module.Inhib1p
has associated data structure: PLB module.Inhib1p PP1
has associated data structure: PLB module.Inhib1p tot
has associated data structure: PLB module.Ki inhib1
has associated data structure: PLB module.Km pka i1
has associated data structure: PLB module.Km pka plb
has associated data structure: PLB module.Km pp1 plb
has associated data structure: PLB module.Km pp2a i1
has associated data structure: PLB module.PKAC I
has associated data structure: PLB module.PLB
has associated data structure: PLB module.PLB DEPHOSPH
has associated data structure: PLB module.PLB PHOSPH
has associated data structure: PLB module.PLB p
has associated data structure: PLB module.PLB tot
has associated data structure: PLB module.PP1
has associated data structure: PLB module.PP1 tot
has associated data structure: PLB module.Vmax pp2a i1
has associated data structure: PLB module.frac PLB
has associated data structure: PLB module.frac PLB o
has associated data structure: PLB module.frac PLB p
has associated data structure: PLB module.k pka i1
has associated data structure: PLB module.k pka plb
has associated data structure: PLB module.k pp1 plb
has associated data structure: Time
has computational component: PLB module computation

PLB module.Inhib1
type: NamedIndividual
type: Decimal
metadata ID: PLB_module.Inhib1
is computational component for: Chemical concentration
has unit: UNIT uM
has solution domain: Time

PLB module.Inhib1 DEPHOSPH
type: NamedIndividual
type: Decimal
metadata ID: PLB_module.Inhib1_DEPHOSPH
is computational component for: Chemical concentration flow rate
has unit: UNIT uM per sec
has solution domain: Time

Chemical concentration flow rate
type: NamedIndividual
has physical definition: Chemical concentration flow rate
has computational component: PLB module.Inhib1 DEPHOSPH

PLB module.Inhib1 PHOSPH
type: NamedIndividual
type: Decimal
metadata ID: Inhib1_PHOSPH
is computational component for: Chemical concentration flow rate
has unit: UNIT uM per sec
has solution domain: Time

Chemical concentration flow rate
type: NamedIndividual
has physical definition: Chemical concentration flow rate
has computational component: PLB module.Inhib1 PHOSPH

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: PLB module.Inhib1

PLB module.Inhib1 tot
type: NamedIndividual
type: Decimal
metadata ID: PLB_module.Inhib1_tot
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

PLB module.Inhib1p
type: NamedIndividual
type: Decimal
metadata ID: Inhib1p
is computational component for: Chemical concentration flow rate
has unit: UNIT uM
has solution domain: Time

PLB module.Inhib1p PP1
type: NamedIndividual
type: Decimal
metadata ID: Inhib1p_PP1
is computational component for: Chemical concentration
has unit: UNIT uM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: PLB module.Inhib1p PP1

Chemical concentration flow rate
type: NamedIndividual
has physical definition: Chemical concentration flow rate
has computational component: PLB module.Inhib1p

PLB module.Inhib1p tot
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.0526
metadata ID: PLB_module.Inhib1p_tot
is computational component for: Chemical concentration
has unit: UNIT uM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: PLB module.Inhib1p tot

PLB module.Ki inhib1
type: NamedIndividual
type: Decimal
metadata ID: PLB_module.Ki_inhib1
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

PLB module.Km pka i1
type: NamedIndividual
type: Decimal
metadata ID: PLB_module.Km_pka_i1
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

PLB module.Km pka plb
type: NamedIndividual
type: Decimal
metadata ID: PLB_module.Km_pka_plb
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

PLB module.Km pp1 plb
type: NamedIndividual
type: Decimal
metadata ID: PLB_module.Km_pp1_plb
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

PLB module.Km pp2a i1
type: NamedIndividual
type: Decimal
metadata ID: PLB_module.Km_pp2a_i1
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

PLB module.PKAC I
type: NamedIndividual
type: Decimal
metadata ID: PLB_module.PKAC_I
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

PLB module.PLB
type: NamedIndividual
type: Decimal
metadata ID: PLB_module.PLB
comment: Concentration of phospholamban
is computational component for: Chemical concentration
has unit: UNIT uM
has solution domain: Time

PLB module.PLB DEPHOSPH
type: NamedIndividual
type: Decimal
metadata ID: PLB_DEPHOSPH
is computational component for: Chemical concentration flow rate
has unit: UNIT uM per sec
has solution domain: Time

Chemical concentration flow rate
type: NamedIndividual
has physical definition: Chemical concentration flow rate
has computational component: PLB module.PLB DEPHOSPH

PLB module.PLB PHOSPH
type: NamedIndividual
type: Decimal
metadata ID: PLB_PHOSPH
is computational component for: Chemical concentration flow rate
has unit: UNIT uM per sec
has solution domain: Time

Chemical concentration flow rate
type: NamedIndividual
has physical definition: Chemical concentration flow rate
has computational component: PLB module.PLB PHOSPH

PLB module.PLB p
type: NamedIndividual
type: Decimal
has cell m linitial value: 4.105
metadata ID: PLB_module.PLB_p
is computational component for: Chemical concentration
has unit: UNIT uM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: PLB module.PLB p

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: PLB module.PLB
physical property of: null

PLB module.PLB tot
type: NamedIndividual
type: Decimal
metadata ID: PLB_module.PLB_tot
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

PLB module.PP1
type: NamedIndividual
type: Decimal
metadata ID: PP1
comment: Concentration of Protein phosphatase-1
is computational component for: Chemical concentration
has unit: UNIT uM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: Concentration of Protein phosphatase-1
has computational component: PLB module.PP1

PLB module.PP1 tot
type: NamedIndividual
type: Decimal
metadata ID: PLB_module.PP1_tot
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

PLB module.Vmax pp2a i1
type: NamedIndividual
type: Decimal
metadata ID: PLB_module.Vmax_pp2a_i1
has cell m lpublic interface: in
has unit: UNIT uM per sec
has solution domain: Time

PLB module.frac PLB
type: NamedIndividual
type: Decimal
metadata ID: PLB_module.frac_PLB
has cell m lpublic interface: out
mapped to: Other SR Fluxes and Concentrations.frac PLB
has unit: UNIT dimensionless
has solution domain: Time

PLB module.frac PLB o
type: NamedIndividual
type: Decimal
metadata ID: PLB_module.frac_PLB_o
has cell m lpublic interface: out
mapped to: Other SR Fluxes and Concentrations.frac PLB o
has unit: UNIT dimensionless
has solution domain: Time

PLB module.frac PLB p
type: NamedIndividual
type: Decimal
metadata ID: PLB_module.frac_PLB_p
has unit: UNIT dimensionless
has solution domain: Time

PLB module.k pka i1
type: NamedIndividual
type: Decimal
metadata ID: PLB_module.k_pka_i1
has cell m lpublic interface: in
has unit: UNIT per sec
has solution domain: Time

PLB module.k pka plb
type: NamedIndividual
type: Decimal
metadata ID: PLB_module.k_pka_plb
has cell m lpublic interface: in
has unit: UNIT per sec
has solution domain: Time

PLB module.k pp1 plb
type: NamedIndividual
type: Decimal
metadata ID: PLB_module.k_pp1_plb
has cell m lpublic interface: in
has unit: UNIT per sec
has solution domain: Time

Time
type: NamedIndividual
type: Decimal
metadata ID: PLB_module.time
has physical definition: https://identifiers.org/opb/OPB_01023
has cell m lpublic interface: in
has unit: UNIT second
has solution domain: Time

PLB module computation
type: NamedIndividual
type: Computation
has math ML: <eq /> PLB <minus /> PLB_tot PLB_p <eq /> PLB_PHOSPH <divide /> <times /> k_pka_plb PKAC_I PLB <plus /> Km_pka_plb PLB <eq /> PLB_DEPHOSPH <divide /> <times /> k_pp1_plb PP1 PLB_p <plus /> Km_pp1_plb PLB_p <eq /> Inhib1 <minus /> Inhib1_tot Inhib1p_tot <eq /> Inhib1p_PP1 <divide /> <times /> Inhib1p PP1 Ki_inhib1 <eq /> Inhib1_PHOSPH <divide /> <times /> k_pka_i1 PKAC_I Inhib1 <plus /> Km_pka_i1 Inhib1 <eq /> Inhib1_DEPHOSPH <divide /> <times /> Vmax_pp2a_i1 Inhib1p_tot <plus /> Km_pp2a_i1 Inhib1p_tot <eq /> <diff /> time PLB_p <minus /> PLB_PHOSPH PLB_DEPHOSPH <eq /> <diff /> time Inhib1p_tot <minus /> Inhib1_PHOSPH Inhib1_DEPHOSPH <eq /> Inhib1p <minus /> Inhib1p_tot Inhib1p_PP1 <eq /> PP1 <minus /> PP1_tot Inhib1p_PP1 <eq /> frac_PLB_p <divide /> PLB_p PLB_tot <eq /> frac_PLB <divide /> PLB PLB_tot <eq /> frac_PLB_o 0.9613
is computational component for: PLB module

PLB parameters
type: NamedIndividual
type: Submodel
name: PLB_parameters
has associated data structure: PLB parameters.Inhib1 tot
has associated data structure: PLB parameters.Ki inhib1
has associated data structure: PLB parameters.Km pka i1
has associated data structure: PLB parameters.Km pka plb
has associated data structure: PLB parameters.Km pp1 plb
has associated data structure: PLB parameters.Km pp2a i1
has associated data structure: PLB parameters.PLB tot
has associated data structure: PLB parameters.PP1 tot
has associated data structure: PLB parameters.Vmax pp2a i1
has associated data structure: PLB parameters.k pka i1
has associated data structure: PLB parameters.k pka plb
has associated data structure: PLB parameters.k pp1 plb
has computational component: PLB parameters computation

PLB parameters.Inhib1 tot
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.3
metadata ID: PLB_parameters.Inhib1_tot
has cell m lpublic interface: out
mapped to: PLB module.Inhib1 tot
has unit: UNIT uM
has solution domain: Time

PLB parameters.Ki inhib1
type: NamedIndividual
type: Decimal
has cell m linitial value: 1e-3
metadata ID: PLB_parameters.Ki_inhib1
has cell m lpublic interface: out
mapped to: PLB module.Ki inhib1
has unit: UNIT uM
has solution domain: Time

PLB parameters.Km pka i1
type: NamedIndividual
type: Decimal
has cell m linitial value: 1
metadata ID: PLB_parameters.Km_pka_i1
has cell m lpublic interface: out
mapped to: PLB module.Km pka i1
has unit: UNIT uM
has solution domain: Time

PLB parameters.Km pka plb
type: NamedIndividual
type: Decimal
has cell m linitial value: 21
metadata ID: PLB_parameters.Km_pka_plb
has cell m lpublic interface: out
mapped to: PLB module.Km pka plb
has unit: UNIT uM
has solution domain: Time

PLB parameters.Km pp1 plb
type: NamedIndividual
type: Decimal
has cell m linitial value: 7
metadata ID: PLB_parameters.Km_pp1_plb
has cell m lpublic interface: out
mapped to: PLB module.Km pp1 plb
has unit: UNIT uM
has solution domain: Time

PLB parameters.Km pp2a i1
type: NamedIndividual
type: Decimal
has cell m linitial value: 1
metadata ID: PLB_parameters.Km_pp2a_i1
has cell m lpublic interface: out
mapped to: PLB module.Km pp2a i1
has unit: UNIT uM
has solution domain: Time

PLB parameters.PLB tot
type: NamedIndividual
type: Decimal
has cell m linitial value: 106
metadata ID: PLB_parameters.PLB_tot
has cell m lpublic interface: out
mapped to: PLB module.PLB tot
has unit: UNIT uM
has solution domain: Time

PLB parameters.PP1 tot
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.89
metadata ID: PLB_parameters.PP1_tot
has cell m lpublic interface: out
mapped to: PLB module.PP1 tot
has unit: UNIT uM
has solution domain: Time

PLB parameters.Vmax pp2a i1
type: NamedIndividual
type: Decimal
has cell m linitial value: 14
metadata ID: PLB_parameters.Vmax_pp2a_i1
has cell m lpublic interface: out
mapped to: PLB module.Vmax pp2a i1
has unit: UNIT uM per sec
has solution domain: Time

PLB parameters.k pka i1
type: NamedIndividual
type: Decimal
has cell m linitial value: 60
metadata ID: PLB_parameters.k_pka_i1
has cell m lpublic interface: out
mapped to: PLB module.k pka i1
has unit: UNIT per sec
has solution domain: Time

PLB parameters.k pka plb
type: NamedIndividual
type: Decimal
has cell m linitial value: 54
metadata ID: PLB_parameters.k_pka_plb
has cell m lpublic interface: out
mapped to: PLB module.k pka plb
has unit: UNIT per sec
has solution domain: Time

PLB parameters.k pp1 plb
type: NamedIndividual
type: Decimal
has cell m linitial value: 8.5
metadata ID: PLB_parameters.k_pp1_plb
has cell m lpublic interface: out
mapped to: PLB module.k pp1 plb
has unit: UNIT per sec
has solution domain: Time

sodium/calcium exchanger 1
type: NamedIndividual
has physical definition: sodium/calcium exchanger 1
is index entity for: PR_000015207

adenylate cyclase
type: NamedIndividual
has physical definition: adenylate cyclase
part of: Cytosol of cardiac myocyte
is index entity for: PR 000022358 part of FMA:226050
has physical property: Chemical concentration

null
type: NamedIndividual
has physical definition: null
has physical property: Chemical concentration
is index entity for: PR P61016

Pacing
type: NamedIndividual
type: Submodel
name: Pacing
has associated data structure: Pacing.I pace
has associated data structure: Time
has computational component: Pacing computation

Pacing.I pace
type: NamedIndividual
type: Decimal
metadata ID: Pacing.I_pace
has cell m lpublic interface: out
mapped to: Ion Concentrations and Membrane Potential.I pace
has unit: UNIT uA per uF
has solution domain: Time

Time
type: NamedIndividual
type: Decimal
metadata ID: Pacing.time
has physical definition: https://identifiers.org/opb/OPB_01023
has cell m lpublic interface: in
has unit: UNIT second
has solution domain: Time

Pacing computation
type: NamedIndividual
type: Computation
has math ML: <eq /> I_pace 10 <and /> <geq /> time 0 <leq /> time 10 <leq /> <minus /> <minus /> time 0 <times /> <floor /> <divide /> <minus /> time 0 1 1 0.003 0
is computational component for: Pacing

Plateau K+ current
type: NamedIndividual
type: Custom physical process
has physical property: Charge flow rate

Plateau K Current
type: NamedIndividual
type: Submodel
name: Plateau_K_Current
has associated data structure: Plateau K Current.E K
has associated data structure: Plateau K Current.G Kp
has associated data structure: Plateau K Current.I Kp
has associated data structure: Plateau K Current.Kp
has associated data structure: Plateau K Current.V m
has computational component: Plateau K Current computation

Plateau K Current.E K
type: NamedIndividual
type: Decimal
metadata ID: Plateau_K_Current.E_K
has cell m lpublic interface: in
comment: Potassium nernst potentials
is computational component for: Nernst potential
has unit: UNIT mV
has solution domain: Time

Nernst potential
type: NamedIndividual
has physical definition: Nernst potential
has computational component: Plateau K Current.E K

Plateau K Current.G Kp
type: NamedIndividual
type: Decimal
metadata ID: Plateau_K_Current.G_Kp
has cell m lpublic interface: in
has unit: UNIT mS per uF
has solution domain: Time

Plateau K Current.I Kp
type: NamedIndividual
type: Decimal
metadata ID: Plateau_K_Current.I_Kp
has cell m lpublic interface: out
comment: Plateau K+ current
is computational component for: Charge flow rate
mapped to: Total Membrane Currents.I Kp
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
physical property of: Plateau K+ current
has computational component: Plateau K Current.I Kp

Plateau K Current.Kp
type: NamedIndividual
type: Decimal
metadata ID: Plateau_K_Current.Kp
has unit: UNIT dimensionless
has solution domain: Time

Plateau K Current.V m
type: NamedIndividual
type: Decimal
metadata ID: Plateau_K_Current.V_m
has cell m lpublic interface: in
comment: Sarcoplasm membrane potential
is computational component for: Chemical potential
has unit: UNIT mV
has solution domain: Time

Chemical potential
type: NamedIndividual
has physical definition: Chemical potential
has computational component: Plateau K Current.V m

Plateau K Current computation
type: NamedIndividual
type: Computation
has math ML: <eq /> Kp <divide /> 1 <plus /> 1 <exp /> <divide /> <minus /> 7.488 V_m 5.98 <eq /> I_Kp <times /> G_Kp Kp <minus /> V_m E_K
is computational component for: Plateau K Current

Sarcolemmal Ca2+ pump current
type: NamedIndividual
type: Custom physical process
has source: calcium(2+)
has sink: calcium(2+)
has mediator: calcium channel complex
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: calcium(2+)
annotated source: Sarcolemmal Ca2+ pump current

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: calcium(2+)
annotated source: Sarcolemmal Ca2+ pump current

Sarcolemmal Ca Pump Current
type: NamedIndividual
type: Submodel
name: Sarcolemmal_Ca_Pump_Current
has associated data structure: Sarcolemmal Ca Pump Current.Ca i
has associated data structure: Sarcolemmal Ca Pump Current.I PCa
has associated data structure: Sarcolemmal Ca Pump Current.I bar PCa
has associated data structure: Sarcolemmal Ca Pump Current.Km PCa
has computational component: Sarcolemmal Ca Pump Current computation

Sarcolemmal Ca Pump Current.Ca i
type: NamedIndividual
type: Decimal
metadata ID: Sarcolemmal_Ca_Pump_Current.Ca_i
has cell m lpublic interface: in
comment: Concentration of intracellular calcium in the rat ventricular myocyte
is computational component for: Chemical concentration
has unit: UNIT mM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: calcium(2+)
has computational component: Sarcolemmal Ca Pump Current.Ca i

Sarcolemmal Ca Pump Current.I PCa
type: NamedIndividual
type: Decimal
metadata ID: Sarcolemmal_Ca_Pump_Current.I_PCa
has cell m lpublic interface: out
comment: Sarcolemmal Ca2+ pump current
is computational component for: Charge flow rate
mapped to: Total Membrane Currents.I PCa
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
physical property of: Sarcolemmal Ca2+ pump current
has computational component: Sarcolemmal Ca Pump Current.I PCa

Sarcolemmal Ca Pump Current.I bar PCa
type: NamedIndividual
type: Decimal
metadata ID: Sarcolemmal_Ca_Pump_Current.I_bar_PCa
has cell m lpublic interface: in
has unit: UNIT uA per uF
has solution domain: Time

Sarcolemmal Ca Pump Current.Km PCa
type: NamedIndividual
type: Decimal
metadata ID: Sarcolemmal_Ca_Pump_Current.Km_PCa
has cell m lpublic interface: in
has unit: UNIT mM
has solution domain: Time

Sarcolemmal Ca Pump Current computation
type: NamedIndividual
type: Computation
has math ML: <eq /> I_PCa <divide /> <times /> I_bar_PCa Ca_i <plus /> Km_PCa Ca_i
is computational component for: Sarcolemmal Ca Pump Current

Sodium flux across sarcolemma of rat ventricular myocyte
type: NamedIndividual
type: Custom physical process
has sink: sodium(1+)
has source: sodium(1+)
has physical property: Charge flow rate
has mediator: sodium channel complex

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: sodium(1+)
annotated source: Sodium flux across sarcolemma of rat ventricular myocyte

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: sodium(1+)
annotated source: Sodium flux across sarcolemma of rat ventricular myocyte

Steady State K Current
type: NamedIndividual
type: Submodel
name: Steady_State_K_Current
has associated data structure: Steady State K Current.E K
has associated data structure: Steady State K Current.G ss
has associated data structure: Steady State K Current.I ss
has associated data structure: Steady State K Current.V m
has associated data structure: Steady State K Current.r ss
has associated data structure: Steady State K Current.r ss inf
has associated data structure: Steady State K Current.s ss
has associated data structure: Steady State K Current.s ss inf
has associated data structure: Steady State K Current.tau r ss
has associated data structure: Steady State K Current.tau s ss
has associated data structure: Time
has computational component: Steady State K Current computation

Steady State K Current.E K
type: NamedIndividual
type: Decimal
metadata ID: Steady_State_K_Current.E_K
has cell m lpublic interface: in
comment: Potassium nernst potentials
is computational component for: Nernst potential
has unit: UNIT mV
has solution domain: Time

Nernst potential
type: NamedIndividual
has physical definition: Nernst potential
has computational component: Steady State K Current.E K

Steady State K Current.G ss
type: NamedIndividual
type: Decimal
metadata ID: Steady_State_K_Current.G_ss
has cell m lpublic interface: in
has unit: UNIT mS per uF
has solution domain: Time

Steady State K Current.I ss
type: NamedIndividual
type: Decimal
metadata ID: Steady_State_K_Current.I_ss
has cell m lpublic interface: out
comment: Subspace steady state current across sarcolemma
is computational component for: Charge flow rate
mapped to: Total Membrane Currents.I ss
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
has computational component: Steady State K Current.I ss

Steady State K Current.V m
type: NamedIndividual
type: Decimal
metadata ID: Steady_State_K_Current.V_m
has cell m lpublic interface: in
comment: Sarcoplasm membrane potential
is computational component for: Chemical potential
has unit: UNIT mV
has solution domain: Time

Chemical potential
type: NamedIndividual
has physical definition: Chemical potential
has computational component: Steady State K Current.V m

Steady State K Current.r ss
type: NamedIndividual
type: Decimal
has cell m linitial value: 198e-3
metadata ID: Steady_State_K_Current.r_ss
has unit: UNIT dimensionless
has solution domain: Time

Steady State K Current.r ss inf
type: NamedIndividual
type: Decimal
metadata ID: Steady_State_K_Current.r_ss_inf
has unit: UNIT dimensionless
has solution domain: Time

Steady State K Current.s ss
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.43
metadata ID: Steady_State_K_Current.s_ss
has unit: UNIT dimensionless
has solution domain: Time

Steady State K Current.s ss inf
type: NamedIndividual
type: Decimal
metadata ID: Steady_State_K_Current.s_ss_inf
has unit: UNIT dimensionless
has solution domain: Time

Steady State K Current.tau r ss
type: NamedIndividual
type: Decimal
metadata ID: Steady_State_K_Current.tau_r_ss
has unit: UNIT second
has solution domain: Time

Steady State K Current.tau s ss
type: NamedIndividual
type: Decimal
metadata ID: Steady_State_K_Current.tau_s_ss
has unit: UNIT second
has solution domain: Time

Time
type: NamedIndividual
type: Decimal
metadata ID: Steady_State_K_Current.time
has physical definition: https://identifiers.org/opb/OPB_01023
has cell m lpublic interface: in
has unit: UNIT second
has solution domain: Time

Steady State K Current computation
type: NamedIndividual
type: Computation
has math ML: <eq /> r_ss_inf <divide /> 1 <plus /> 1 <exp /> <divide /> <plus /> V_m 11.5 <minus /> 11.82 <eq /> tau_r_ss <divide /> 10 <plus /> <times /> 45.16 <exp /> <times /> 0.03577 <plus /> V_m 50 <times /> 98.9 <exp /> <times /> <minus /> 0.1 <plus /> V_m 38 <eq /> s_ss_inf <divide /> 1 <plus /> 1 <exp /> <divide /> <plus /> V_m 87.5 10.3 <eq /> tau_s_ss 2.1 <eq /> <diff /> time r_ss <divide /> <minus /> r_ss_inf r_ss tau_r_ss <eq /> <diff /> time s_ss <divide /> <minus /> s_ss_inf s_ss tau_s_ss <eq /> I_ss <times /> G_ss r_ss s_ss <minus /> V_m E_K
is computational component for: Steady State K Current

Time Independent K Current
type: NamedIndividual
type: Submodel
name: Time_Independent_K_Current
has associated data structure: Time Independent K Current.E K
has associated data structure: Time Independent K Current.G Ki bar
has associated data structure: Time Independent K Current.I Ki
has associated data structure: Time Independent K Current.K ext
has associated data structure: Time Independent K Current.Ki ss
has associated data structure: Time Independent K Current.V m
has associated data structure: Time Independent K Current.a Ki
has associated data structure: Time Independent K Current.b Ki
has computational component: Time Independent K Current computation

Time Independent K Current.E K
type: NamedIndividual
type: Decimal
metadata ID: Time_Independent_K_Current.E_K
has cell m lpublic interface: in
comment: Potassium nernst potentials
is computational component for: Nernst potential
has unit: UNIT mV
has solution domain: Time

Nernst potential
type: NamedIndividual
has physical definition: Nernst potential
has computational component: Time Independent K Current.E K

Time Independent K Current.G Ki bar
type: NamedIndividual
type: Decimal
metadata ID: Time_Independent_K_Current.G_Ki_bar
has cell m lpublic interface: in
has unit: UNIT mS per uF
has solution domain: Time

Time Independent K Current.I Ki
type: NamedIndividual
type: Decimal
metadata ID: Time_Independent_K_Current.I_Ki
has cell m lpublic interface: out
comment: Time independent K+ current across sarcolemma
is computational component for: Charge flow rate
mapped to: Total Membrane Currents.I Ki
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
has computational component: Time Independent K Current.I Ki
physical property of: Time independent K current

Time Independent K Current.K ext
type: NamedIndividual
type: Decimal
metadata ID: Time_Independent_K_Current.K_ext
has cell m lpublic interface: in
has unit: UNIT mM
has solution domain: Time

Time Independent K Current.Ki ss
type: NamedIndividual
type: Decimal
metadata ID: Time_Independent_K_Current.Ki_ss
has unit: UNIT dimensionless
has solution domain: Time

Time Independent K Current.V m
type: NamedIndividual
type: Decimal
metadata ID: Time_Independent_K_Current.V_m
has cell m lpublic interface: in
comment: Sarcoplasm membrane potential
is computational component for: Chemical potential
has unit: UNIT mV
has solution domain: Time

Chemical potential
type: NamedIndividual
has physical definition: Chemical potential
has computational component: Time Independent K Current.V m

Time Independent K Current.a Ki
type: NamedIndividual
type: Decimal
metadata ID: Time_Independent_K_Current.a_Ki
has unit: UNIT dimensionless
has solution domain: Time

Time Independent K Current.b Ki
type: NamedIndividual
type: Decimal
metadata ID: Time_Independent_K_Current.b_Ki
has unit: UNIT dimensionless
has solution domain: Time

Time Independent K Current computation
type: NamedIndividual
type: Computation
has math ML: <eq /> a_Ki <divide /> 1.02 <plus /> 1 <exp /> <times /> 0.2385 <minus /> <minus /> V_m E_K 59.215 <eq /> b_Ki <divide /> <plus /> <times /> 0.49124 <exp /> <times /> 0.08032 <minus /> <plus /> V_m 5.476 E_K <exp /> <times /> 0.06175 <minus /> <minus /> V_m E_K 594.31 <plus /> 1 <exp /> <times /> <minus /> 0.5143 <plus /> <minus /> V_m E_K 4.753 <eq /> Ki_ss <divide /> a_Ki <plus /> a_Ki b_Ki <eq /> I_Ki <times /> G_Ki_bar <root /> <divide /> K_ext 5.4 Ki_ss <minus /> V_m E_K
is computational component for: Time Independent K Current

Time independent K current
type: NamedIndividual
type: Custom physical process
has source: potassium(1+)
has sink: potassium(1+)
has mediator: potassium channel complex
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: potassium(1+)
annotated source: Time independent K current

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: potassium(1+)
annotated source: Time independent K current

Total K+ current
type: NamedIndividual
type: Custom physical process
has physical property: Charge flow rate

Total Membrane Currents
type: NamedIndividual
type: Submodel
name: Total_Membrane_Currents
has associated data structure: Total Membrane Currents.I Ca
has associated data structure: Total Membrane Currents.I CaB
has associated data structure: Total Membrane Currents.I CaK
has associated data structure: Total Membrane Currents.I Ca tot
has associated data structure: Total Membrane Currents.I K tot
has associated data structure: Total Membrane Currents.I Ki
has associated data structure: Total Membrane Currents.I Kp
has associated data structure: Total Membrane Currents.I NCX
has associated data structure: Total Membrane Currents.I Na
has associated data structure: Total Membrane Currents.I NaB
has associated data structure: Total Membrane Currents.I NaK
has associated data structure: Total Membrane Currents.I Na tot
has associated data structure: Total Membrane Currents.I PCa
has associated data structure: Total Membrane Currents.I ss
has associated data structure: Total Membrane Currents.I to
has computational component: Total Membrane Currents computation

Total Membrane Currents.I Ca
type: NamedIndividual
type: Decimal
metadata ID: Total_Membrane_Currents.I_Ca
has cell m lpublic interface: in
comment: L-Type calcium current
is computational component for: Charge flow rate
has unit: UNIT uA per uF
has solution domain: Time

Total Membrane Currents.I CaB
type: NamedIndividual
type: Decimal
metadata ID: Total_Membrane_Currents.I_CaB
has cell m lpublic interface: in
comment: Background Ca current
is computational component for: Charge flow rate
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
physical property of: Ca2+ ion flux into the rat ventricular myocyte
has computational component: Total Membrane Currents.I CaB

Total Membrane Currents.I CaK
type: NamedIndividual
type: Decimal
metadata ID: Total_Membrane_Currents.I_CaK
has cell m lpublic interface: in
comment: Potassium current through the channel
is computational component for: Charge flow rate
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
has computational component: Total Membrane Currents.I CaK

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
has computational component: Total Membrane Currents.I Ca

Total Membrane Currents.I Ca tot
type: NamedIndividual
type: Decimal
metadata ID: Total_Membrane_Currents.I_Ca_tot
has cell m lpublic interface: out
mapped to: Calcium Induced Calcium Release.I Ca tot
mapped to: Ion Concentrations and Membrane Potential.I Ca tot
is computational component for: Charge flow rate
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
has computational component: Total Membrane Currents.I Ca tot

Total Membrane Currents.I K tot
type: NamedIndividual
type: Decimal
metadata ID: Total_Membrane_Currents.I_K_tot
has cell m lpublic interface: out
comment: Total K+ current
mapped to: Ion Concentrations and Membrane Potential.I K tot
is computational component for: Charge flow rate
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
physical property of: Total K+ current
has computational component: Total Membrane Currents.I K tot

Total Membrane Currents.I Ki
type: NamedIndividual
type: Decimal
metadata ID: Total_Membrane_Currents.I_Ki
has cell m lpublic interface: in
comment: Time independent K+ current across sarcolemma
is computational component for: Charge flow rate
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
physical property of: Time independent K current
has computational component: Total Membrane Currents.I Ki

Total Membrane Currents.I Kp
type: NamedIndividual
type: Decimal
metadata ID: Total_Membrane_Currents.I_Kp
has cell m lpublic interface: in
comment: Plateau K+ current
is computational component for: Charge flow rate
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
physical property of: Plateau K+ current
has computational component: Total Membrane Currents.I Kp

Total Membrane Currents.I NCX
type: NamedIndividual
type: Decimal
metadata ID: Total_Membrane_Currents.I_NCX
has cell m lpublic interface: in
comment: Na+ - Ca2+ current exchanger across sarcolemma
is computational component for: Charge flow rate
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
physical property of: Na+ - Ca2+ current exchanger across sarcolemma
has computational component: Total Membrane Currents.I NCX

Total Membrane Currents.I Na
type: NamedIndividual
type: Decimal
metadata ID: Total_Membrane_Currents.I_Na
has cell m lpublic interface: in
comment: Na+ flux across sarcolemma of rat ventricular myocyte
is computational component for: Charge flow rate
has unit: UNIT uA per uF
has solution domain: Time

Total Membrane Currents.I NaB
type: NamedIndividual
type: Decimal
metadata ID: Total_Membrane_Currents.I_NaB
has cell m lpublic interface: in
comment: Background Na+ current
is computational component for: Charge flow rate
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
physical property of: Background Na+ current flow
has computational component: Total Membrane Currents.I NaB

Total Membrane Currents.I NaK
type: NamedIndividual
type: Decimal
metadata ID: Total_Membrane_Currents.I_NaK
has cell m lpublic interface: in
comment: Na+ - K+ pump current across sarcolemma
is computational component for: Charge flow rate
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
physical property of: Na+ - K+ pump current across sarcolemma
has computational component: Total Membrane Currents.I NaK

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
physical property of: Sodium flux across sarcolemma of rat ventricular myocyte
has computational component: Total Membrane Currents.I Na

Total Membrane Currents.I Na tot
type: NamedIndividual
type: Decimal
metadata ID: Total_Membrane_Currents.I_Na_tot
has cell m lpublic interface: out
comment: Total membrane Na+ current
mapped to: Ion Concentrations and Membrane Potential.I Na tot
is computational component for: Charge flow rate
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
has computational component: Total Membrane Currents.I Na tot
physical property of: Total membrane Na+ current

Total Membrane Currents.I PCa
type: NamedIndividual
type: Decimal
metadata ID: Total_Membrane_Currents.I_PCa
has cell m lpublic interface: in
comment: Sarcolemmal Ca2+ pump current
is computational component for: Charge flow rate
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
physical property of: Sarcolemmal Ca2+ pump current
has computational component: Total Membrane Currents.I PCa

Total Membrane Currents.I ss
type: NamedIndividual
type: Decimal
metadata ID: Total_Membrane_Currents.I_ss
has cell m lpublic interface: in
comment: Subspace steady state current across sarcolemma
is computational component for: Charge flow rate
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
has computational component: Total Membrane Currents.I ss

Total Membrane Currents.I to
type: NamedIndividual
type: Decimal
metadata ID: Total_Membrane_Currents.I_to
has cell m lpublic interface: in
comment: Transient Outward K+ current
is computational component for: Charge flow rate
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
has computational component: Total Membrane Currents.I to
physical property of: Transient Outward K+ current

Total Membrane Currents computation
type: NamedIndividual
type: Computation
has math ML: <eq /> I_Na_tot <plus /> I_Na I_NaB <times /> 3 I_NCX <times /> 3 I_NaK <eq /> I_K_tot <plus /> <minus /> <plus /> I_to I_ss I_Ki I_Kp <times /> 2 I_NaK I_CaK <eq /> I_Ca_tot <minus /> <plus /> I_Ca I_CaB I_PCa <times /> 2 I_NCX
is computational component for: Total Membrane Currents

Total membrane Na+ current
type: NamedIndividual
type: Custom physical process
has physical property: Charge flow rate

Transient Outward K+ current
type: NamedIndividual
type: Custom physical process
has physical property: Charge flow rate

Transient Outward K Current
type: NamedIndividual
type: Submodel
name: Transient_Outward_K_Current
has associated data structure: Transient Outward K Current.E K
has associated data structure: Transient Outward K Current.G to
has associated data structure: Transient Outward K Current.I to
has associated data structure: Transient Outward K Current.V m
has associated data structure: Transient Outward K Current.r to
has associated data structure: Transient Outward K Current.r toss
has associated data structure: Transient Outward K Current.s to
has associated data structure: Transient Outward K Current.s toss
has associated data structure: Transient Outward K Current.ss to
has associated data structure: Transient Outward K Current.tau r to
has associated data structure: Transient Outward K Current.tau s to
has associated data structure: Transient Outward K Current.tau ss to
has associated data structure: Time
has computational component: Transient Outward K Current computation

Transient Outward K Current.E K
type: NamedIndividual
type: Decimal
metadata ID: Transient_Outward_K_Current.E_K
has cell m lpublic interface: in
comment: Potassium nernst potentials
is computational component for: Nernst potential
has unit: UNIT mV
has solution domain: Time

Nernst potential
type: NamedIndividual
has physical definition: Nernst potential
has computational component: Transient Outward K Current.E K

Transient Outward K Current.G to
type: NamedIndividual
type: Decimal
metadata ID: Transient_Outward_K_Current.G_to
has cell m lpublic interface: in
has unit: UNIT mS per uF
has solution domain: Time

Transient Outward K Current.I to
type: NamedIndividual
type: Decimal
metadata ID: Transient_Outward_K_Current.I_to
has cell m lpublic interface: out
comment: Transient Outward K+ current
mapped to: Total Membrane Currents.I to
is computational component for: Charge flow rate
has unit: UNIT uA per uF
has solution domain: Time

Charge flow rate
type: NamedIndividual
has physical definition: Charge flow rate
physical property of: Transient Outward K+ current
has computational component: Transient Outward K Current.I to

Transient Outward K Current.V m
type: NamedIndividual
type: Decimal
metadata ID: Transient_Outward_K_Current.V_m
has cell m lpublic interface: in
comment: Sarcoplasm membrane potential
is computational component for: Chemical potential
has unit: UNIT mV
has solution domain: Time

Chemical potential
type: NamedIndividual
has physical definition: Chemical potential
has computational component: Transient Outward K Current.V m

Transient Outward K Current.r to
type: NamedIndividual
type: Decimal
has cell m linitial value: 1.4e-3
metadata ID: Transient_Outward_K_Current.r_to
has unit: UNIT dimensionless
has solution domain: Time

Transient Outward K Current.r toss
type: NamedIndividual
type: Decimal
metadata ID: Transient_Outward_K_Current.r_toss
has unit: UNIT dimensionless
has solution domain: Time

Transient Outward K Current.s to
type: NamedIndividual
type: Decimal
has cell m linitial value: 1
metadata ID: Transient_Outward_K_Current.s_to
has unit: UNIT dimensionless
has solution domain: Time

Transient Outward K Current.s toss
type: NamedIndividual
type: Decimal
metadata ID: Transient_Outward_K_Current.s_toss
has unit: UNIT dimensionless
has solution domain: Time

Transient Outward K Current.ss to
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.613
metadata ID: Transient_Outward_K_Current.ss_to
has unit: UNIT dimensionless
has solution domain: Time

Transient Outward K Current.tau r to
type: NamedIndividual
type: Decimal
metadata ID: Transient_Outward_K_Current.tau_r_to
has unit: UNIT second
has solution domain: Time

Transient Outward K Current.tau s to
type: NamedIndividual
type: Decimal
metadata ID: Transient_Outward_K_Current.tau_s_to
has unit: UNIT second
has solution domain: Time

Transient Outward K Current.tau ss to
type: NamedIndividual
type: Decimal
metadata ID: Transient_Outward_K_Current.tau_ss_to
has unit: UNIT second
has solution domain: Time

Time
type: NamedIndividual
type: Decimal
metadata ID: Transient_Outward_K_Current.time
has physical definition: https://identifiers.org/opb/OPB_01023
has cell m lpublic interface: in
has unit: UNIT second
has solution domain: Time

Transient Outward K Current computation
type: NamedIndividual
type: Computation
has math ML: <eq /> r_toss <divide /> 1 <plus /> 1 <exp /> <divide /> <plus /> V_m 10.6 <minus /> 11.42 <eq /> s_toss <divide /> 1 <plus /> 1 <exp /> <divide /> <plus /> V_m 43.5 6.8841 <eq /> tau_r_to <divide /> 1 <plus /> <times /> 45.16 <exp /> <times /> 0.03577 <plus /> V_m 50 <times /> 98.9 <exp /> <times /> <minus /> 0.1 <plus /> V_m 38 <eq /> tau_s_to <plus /> <times /> 0.35 <exp /> <times /> <minus /> 1 <power /> <divide /> <plus /> V_m 70 15 2 0.035 <eq /> tau_ss_to <plus /> <times /> 3.7 <exp /> <times /> <minus /> 1 <power /> <divide /> <plus /> V_m 70 30 2 0.035 <eq /> <diff /> time r_to <divide /> <minus /> r_toss r_to tau_r_to <eq /> <diff /> time s_to <divide /> <minus /> s_toss s_to tau_s_to <eq /> <diff /> time ss_to <divide /> <minus /> s_toss ss_to tau_ss_to <eq /> I_to <times /> G_to r_to <plus /> <times /> 0.886 s_to <times /> 0.114 ss_to <minus /> V_m E_K
is computational component for: Transient Outward K Current

UNIT ampere
type: NamedIndividual
type: Unit of measurement
has computational code: ampere
is fundamental unit: true

UNIT cm2
type: NamedIndividual
type: Unit of measurement
has computational code: cm2
unit for: EC Coupling Parameters.A Cap
unit for: Ion Concentrations and Membrane Potential.A Cap
has unit factor: UNIT meter

Axiom
has unit factor exponent: 2.0
has unit factor prefix: centi
annotated property: hasUnitFactor
annotated source: UNIT cm2
annotated target: UNIT meter

UNIT cm per sec
type: NamedIndividual
type: Unit of measurement
has computational code: cm_per_sec
unit for: EC Coupling Parameters.p Ca
unit for: EC Coupling Parameters.p K
unit for: L Type Calcium Current.p Ca
unit for: L Type Calcium Current.p K
has unit factor: UNIT meter
has unit factor: UNIT second

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT cm per sec
annotated target: UNIT second

Axiom
has unit factor prefix: centi
annotated property: hasUnitFactor
annotated source: UNIT cm per sec
annotated target: UNIT meter

UNIT coulomb
type: NamedIndividual
type: Unit of measurement
has computational code: coulomb
is fundamental unit: true

UNIT coulombs per mole
type: NamedIndividual
type: Unit of measurement
has computational code: coulombs_per_mole
unit for: Ion Concentrations and Membrane Potential.Frdy
unit for: L Type Calcium Current.Frdy
unit for: Nernst Potentials.Frdy
has unit factor: UNIT coulomb
has unit factor: UNIT mole

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT coulombs per mole
annotated target: UNIT mole

UNIT dimensionless
type: NamedIndividual
type: Unit of measurement
has computational code: dimensionless
is fundamental unit: true
unit for: Calcium Induced Calcium Release.ryr off
unit for: Calcium Induced Calcium Release.ryr on
unit for: Cytoplasmic Calcium Buffering.B myo
unit for: Cytoplasmic Calcium Buffering.b cmdn
unit for: Cytoplasmic Calcium Buffering.b indo
unit for: Cytoplasmic Calcium Buffering.b trpn
unit for: EC Coupling Parameters.N lcc
unit for: EC Coupling Parameters.Pns
unit for: EC Coupling Parameters.eta
unit for: EC Coupling Parameters.k sat
unit for: Fast Na Current.h
unit for: Fast Na Current.j
unit for: Fast Na Current.m
unit for: Ion Concentrations and Membrane Potential.B myo
unit for: Ion Concentrations and Membrane Potential.R clamp
unit for: Ion Concentrations and Membrane Potential.protocol
unit for: Ion Concentrations and Membrane Potential.z Ca
unit for: Ion Concentrations and Membrane Potential.z K
unit for: Ion Concentrations and Membrane Potential.z Na
unit for: LCC module.epsilon
unit for: LCC module.frac LCCa p
unit for: LCC module.frac LCCa po
unit for: LCC module.frac LCCb p
unit for: LCC module.frac LCCb po
unit for: LCC parameters.epsilon
unit for: L Type Calcium Current.N lcc
unit for: L Type Calcium Current.f avail
unit for: L Type Calcium Current.f lcc
unit for: L Type Calcium Current.frac LCCa p
unit for: L Type Calcium Current.frac LCCa po
unit for: L Type Calcium Current.frac LCCb p
unit for: L Type Calcium Current.frac LCCb po
unit for: L Type Calcium Current.i bar Ca
unit for: L Type Calcium Current.i bar K
unit for: L Type Calcium Current.v
unit for: L Type Calcium Current.v omega
unit for: L Type Calcium Current.w
unit for: L Type Calcium Current.x
unit for: L Type Calcium Current.y
unit for: L Type Calcium Current.y lcc inf
unit for: L Type Calcium Current.z
unit for: Na Ca Exchanger Current.eta
unit for: Na Ca Exchanger Current.k sat
unit for: Na Ca Exchanger Current.s4
unit for: Na Ca Exchanger Current.s5
unit for: Na K Pump Current.f NaK
unit for: Na K Pump Current.sigma
unit for: Nernst Potentials.z Ca
unit for: Nernst Potentials.z K
unit for: Nernst Potentials.z Na
unit for: Other SR Fluxes and Concentrations.B jsr
unit for: Other SR Fluxes and Concentrations.frac PLB
unit for: Other SR Fluxes and Concentrations.frac PLB o
unit for: PKA module.zed
unit for: PKA module.zed1
unit for: PLB module.frac PLB
unit for: PLB module.frac PLB o
unit for: PLB module.frac PLB p
unit for: Plateau K Current.Kp
unit for: Steady State K Current.r ss
unit for: Steady State K Current.r ss inf
unit for: Steady State K Current.s ss
unit for: Steady State K Current.s ss inf
unit for: Time Independent K Current.Ki ss
unit for: Time Independent K Current.a Ki
unit for: Time Independent K Current.b Ki
unit for: Transient Outward K Current.r to
unit for: Transient Outward K Current.r toss
unit for: Transient Outward K Current.s to
unit for: Transient Outward K Current.s toss
unit for: Transient Outward K Current.ss to
unit for: environment.protocol

UNIT farad
type: NamedIndividual
type: Unit of measurement
has computational code: farad
is fundamental unit: true

UNIT joule
type: NamedIndividual
type: Unit of measurement
has computational code: joule
is fundamental unit: true

UNIT joules per mole kelvin
type: NamedIndividual
type: Unit of measurement
has computational code: joules_per_mole_kelvin
unit for: Nernst Potentials.R
has unit factor: UNIT joule
has unit factor: UNIT kelvin
has unit factor: UNIT mole

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT joules per mole kelvin
annotated target: UNIT kelvin

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT joules per mole kelvin
annotated target: UNIT mole

UNIT kelvin
type: NamedIndividual
type: Unit of measurement
has computational code: kelvin
is fundamental unit: true
unit for: EC Coupling Parameters.Temp
unit for: Nernst Potentials.Temp

UNIT liter
type: NamedIndividual
type: Unit of measurement
has computational code: liter
is fundamental unit: true

UNIT mM
type: NamedIndividual
type: Unit of measurement
has computational code: mM
unit for: Calcium Induced Calcium Release.Ca i
unit for: Calcium Induced Calcium Release.Ca jsr
unit for: Cytoplasmic Calcium Buffering.CMDN bar
unit for: Cytoplasmic Calcium Buffering.Ca i
unit for: Cytoplasmic Calcium Buffering.INDO bar
unit for: Cytoplasmic Calcium Buffering.Km CMDN
unit for: Cytoplasmic Calcium Buffering.Km INDO
unit for: Cytoplasmic Calcium Buffering.Km TRPN
unit for: Cytoplasmic Calcium Buffering.TRPN bar
unit for: EC Coupling Parameters.CMDN bar
unit for: EC Coupling Parameters.CSQN bar
unit for: EC Coupling Parameters.CSQN th
unit for: EC Coupling Parameters.Ca ext
unit for: EC Coupling Parameters.INDO bar
unit for: EC Coupling Parameters.K ext
unit for: EC Coupling Parameters.Km CMDN
unit for: EC Coupling Parameters.Km CSQN
unit for: EC Coupling Parameters.Km Ca
unit for: EC Coupling Parameters.Km INDO
unit for: EC Coupling Parameters.Km Ko
unit for: EC Coupling Parameters.Km NS
unit for: EC Coupling Parameters.Km Na
unit for: EC Coupling Parameters.Km Nai
unit for: EC Coupling Parameters.Km PCa
unit for: EC Coupling Parameters.Km TRPN
unit for: EC Coupling Parameters.Km rel
unit for: EC Coupling Parameters.Km up0
unit for: EC Coupling Parameters.NSR bar
unit for: EC Coupling Parameters.Na ext
unit for: EC Coupling Parameters.TRPN bar
unit for: EC Coupling Parameters.d Cai th
unit for: Ion Concentrations and Membrane Potential.Ca i
unit for: Ion Concentrations and Membrane Potential.K i
unit for: Ion Concentrations and Membrane Potential.Na i
unit for: L Type Calcium Current.Ca ext
unit for: L Type Calcium Current.Ca i
unit for: L Type Calcium Current.K ext
unit for: L Type Calcium Current.K i
unit for: Na Ca Exchanger Current.Ca ext
unit for: Na Ca Exchanger Current.Ca i
unit for: Na Ca Exchanger Current.Km Ca
unit for: Na Ca Exchanger Current.Km Na
unit for: Na Ca Exchanger Current.Na ext
unit for: Na Ca Exchanger Current.Na i
unit for: Na K Pump Current.K ext
unit for: Na K Pump Current.Km Ko
unit for: Na K Pump Current.Km Nai
unit for: Na K Pump Current.Na ext
unit for: Na K Pump Current.Na i
unit for: Nernst Potentials.Ca ext
unit for: Nernst Potentials.Ca i
unit for: Nernst Potentials.K ext
unit for: Nernst Potentials.K i
unit for: Nernst Potentials.Na ext
unit for: Nernst Potentials.Na i
unit for: Other SR Fluxes and Concentrations.CSQN bar
unit for: Other SR Fluxes and Concentrations.Ca i
unit for: Other SR Fluxes and Concentrations.Ca jsr
unit for: Other SR Fluxes and Concentrations.Ca nsr
unit for: Other SR Fluxes and Concentrations.Km CSQN
unit for: Other SR Fluxes and Concentrations.Km up
unit for: Other SR Fluxes and Concentrations.Km up0
unit for: Other SR Fluxes and Concentrations.NSR bar
unit for: Sarcolemmal Ca Pump Current.Ca i
unit for: Sarcolemmal Ca Pump Current.Km PCa
unit for: Time Independent K Current.K ext
has unit factor: UNIT liter
has unit factor: UNIT mole

Axiom
has unit factor prefix: milli
annotated property: hasUnitFactor
annotated source: UNIT mM
annotated target: UNIT mole

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated target: UNIT liter
annotated source: UNIT mM

UNIT mM per sec
type: NamedIndividual
type: Unit of measurement
has computational code: mM_per_sec
unit for: Calcium Induced Calcium Release.G max rel
unit for: Calcium Induced Calcium Release.I rel
unit for: EC Coupling Parameters.G max rel
unit for: EC Coupling Parameters.I up bar
unit for: Ion Concentrations and Membrane Potential.I leak
unit for: Ion Concentrations and Membrane Potential.I rel
unit for: Ion Concentrations and Membrane Potential.I up
unit for: Other SR Fluxes and Concentrations.I leak
unit for: Other SR Fluxes and Concentrations.I rel
unit for: Other SR Fluxes and Concentrations.I tr
unit for: Other SR Fluxes and Concentrations.I up
unit for: Other SR Fluxes and Concentrations.I up bar
has unit factor: UNIT mM
has unit factor: UNIT second

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT mM per sec
annotated target: UNIT second

UNIT mS per uF
type: NamedIndividual
type: Unit of measurement
has computational code: mS_per_uF
unit for: EC Coupling Parameters.G Ki bar
unit for: EC Coupling Parameters.G Kp
unit for: EC Coupling Parameters.G Na
unit for: EC Coupling Parameters.G ss
unit for: EC Coupling Parameters.G to
unit for: Fast Na Current.G Na
unit for: Plateau K Current.G Kp
unit for: Steady State K Current.G ss
unit for: Time Independent K Current.G Ki bar
unit for: Transient Outward K Current.G to
has unit factor: UNIT farad
has unit factor: UNIT siemens

Axiom
has unit factor exponent: -1.0
has unit factor prefix: micro
annotated property: hasUnitFactor
annotated target: UNIT farad
annotated source: UNIT mS per uF

Axiom
has unit factor prefix: milli
annotated property: hasUnitFactor
annotated source: UNIT mS per uF
annotated target: UNIT siemens

UNIT mV
type: NamedIndividual
type: Unit of measurement
has computational code: mV
unit for: Ca Background Current.E Ca
unit for: Ca Background Current.V m
unit for: Fast Na Current.E Na
unit for: Fast Na Current.V m
unit for: Ion Concentrations and Membrane Potential.V clamp
unit for: Ion Concentrations and Membrane Potential.V hold
unit for: Ion Concentrations and Membrane Potential.V m
unit for: Ion Concentrations and Membrane Potential.V test
unit for: L Type Calcium Current.V m
unit for: Na Background Current.E Na
unit for: Na Background Current.V m
unit for: Na Ca Exchanger Current.V m
unit for: Na K Pump Current.V m
unit for: Nernst Potentials.E Ca
unit for: Nernst Potentials.E Cl
unit for: Nernst Potentials.E K
unit for: Nernst Potentials.E Na
unit for: Plateau K Current.E K
unit for: Plateau K Current.V m
unit for: Steady State K Current.E K
unit for: Steady State K Current.V m
unit for: Time Independent K Current.E K
unit for: Time Independent K Current.V m
unit for: Transient Outward K Current.E K
unit for: Transient Outward K Current.V m
has unit factor: UNIT volt

Axiom
has unit factor prefix: milli
annotated property: hasUnitFactor
annotated source: UNIT mV
annotated target: UNIT volt

UNIT mV per sec
type: NamedIndividual
type: Unit of measurement
has computational code: mV_per_sec
has unit factor: UNIT second
has unit factor: UNIT volt

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT mV per sec
annotated target: UNIT second

Axiom
has unit factor prefix: milli
annotated property: hasUnitFactor
annotated source: UNIT mV per sec
annotated target: UNIT volt

UNIT meter
type: NamedIndividual
type: Unit of measurement
has computational code: meter
is fundamental unit: true

UNIT millisecond
type: NamedIndividual
type: Unit of measurement
has computational code: millisecond
has unit factor: UNIT second

Axiom
has unit factor prefix: milli
annotated property: hasUnitFactor
annotated source: UNIT millisecond
annotated target: UNIT second

UNIT mole
type: NamedIndividual
type: Unit of measurement
has computational code: mole
is fundamental unit: true

UNIT per mM per sec
type: NamedIndividual
type: Unit of measurement
has computational code: per_mM_per_sec
unit for: EC Coupling Parameters.gamma o
unit for: L Type Calcium Current.gamma
unit for: L Type Calcium Current.gamma o
unit for: L Type Calcium Current.v gamma
has unit factor: UNIT mM
has unit factor: UNIT second

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated target: UNIT mM
annotated source: UNIT per mM per sec

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT per mM per sec
annotated target: UNIT second

UNIT per mV
type: NamedIndividual
type: Unit of measurement
has computational code: per_mV
unit for: L Type Calcium Current.FoRT
unit for: Na Ca Exchanger Current.FoRT
unit for: Na K Pump Current.FoRT
unit for: Nernst Potentials.FoRT
has unit factor: UNIT mV

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated target: UNIT mV
annotated source: UNIT per mV

UNIT per sec
type: NamedIndividual
type: Unit of measurement
has computational code: per_sec
unit for: Calcium Induced Calcium Release.g rel
unit for: EC Coupling Parameters.f
unit for: EC Coupling Parameters.g
unit for: EC Coupling Parameters.omega
unit for: Fast Na Current.ah
unit for: Fast Na Current.aj
unit for: Fast Na Current.am
unit for: Fast Na Current.bh
unit for: Fast Na Current.bj
unit for: Fast Na Current.bm
unit for: LCC module.k pka lcc
unit for: LCC module.k pp1 lcc
unit for: LCC module.k pp2a lcc
unit for: LCC parameters.k pka lcc
unit for: LCC parameters.k pp1 lcc
unit for: LCC parameters.k pp2a lcc
unit for: L Type Calcium Current.a lcc
unit for: L Type Calcium Current.b lcc
unit for: L Type Calcium Current.f
unit for: L Type Calcium Current.g
unit for: L Type Calcium Current.omega
unit for: PLB module.k pka i1
unit for: PLB module.k pka plb
unit for: PLB module.k pp1 plb
unit for: PLB parameters.k pka i1
unit for: PLB parameters.k pka plb
unit for: PLB parameters.k pp1 plb
has unit factor: UNIT second
unit for: b1 AR Gs parameters.k bar km
unit for: b1 AR Gs parameters.k bar kp
unit for: b1 AR Gs parameters.k g act
unit for: b1 AR Gs parameters.k hyd
unit for: b1 AR Gs parameters.k p kam
unit for: b1 AR module.REASSOC
unit for: b1 AR module.k bar km
unit for: b1 AR module.k bar kp
unit for: b1 AR module.k g act
unit for: b1 AR module.k hyd
unit for: b1 AR module.k p kam
unit for: cAMP module.k ac basal
unit for: cAMP module.k ac fsk
unit for: cAMP module.k ac gsa
unit for: cAMP module.k pde
unit for: cAMP parameters.k ac basal
unit for: cAMP parameters.k ac fsk
unit for: cAMP parameters.k ac gsa
unit for: cAMP parameters.k pde

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT per sec
annotated target: UNIT second

UNIT per uM per sec
type: NamedIndividual
type: Unit of measurement
has computational code: per_uM_per_sec
has unit factor: UNIT second
has unit factor: UNIT uM
unit for: b1 AR Gs parameters.k p kap
unit for: b1 AR Gs parameters.k reassoc
unit for: b1 AR module.k p kap
unit for: b1 AR module.k reassoc

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT per uM per sec
annotated target: UNIT second

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT per uM per sec
annotated target: UNIT uM

UNIT second
type: NamedIndividual
type: Unit of measurement
has computational code: second
is fundamental unit: true
unit for: Calcium Induced Calcium Release.t rel
unit for: Calcium Induced Calcium Release.tau off
unit for: Calcium Induced Calcium Release.tau on
unit for: Calcium Induced Calcium Release.trel
unit for: EC Coupling Parameters.tau off
unit for: EC Coupling Parameters.tau on
unit for: EC Coupling Parameters.tau tr
unit for: Time
unit for: Ion Concentrations and Membrane Potential.trel
unit for: L Type Calcium Current.tau y lcc
unit for: Other SR Fluxes and Concentrations.tau tr
unit for: Steady State K Current.tau r ss
unit for: Steady State K Current.tau s ss
unit for: Transient Outward K Current.tau r to
unit for: Transient Outward K Current.tau s to
unit for: Transient Outward K Current.tau ss to

UNIT siemens
type: NamedIndividual
type: Unit of measurement
has computational code: siemens
is fundamental unit: true

UNIT uA per uF
type: NamedIndividual
type: Unit of measurement
has computational code: uA_per_uF
unit for: Ca Background Current.G CaB
unit for: Ca Background Current.I CaB
unit for: Calcium Induced Calcium Release.I Ca tot
unit for: EC Coupling Parameters.G CaB
unit for: EC Coupling Parameters.G NaB
unit for: EC Coupling Parameters.I Ca05
unit for: EC Coupling Parameters.I bar NaK
unit for: EC Coupling Parameters.I bar PCa
unit for: EC Coupling Parameters.k NaCa
unit for: Fast Na Current.I Na
unit for: Ion Concentrations and Membrane Potential.I Ca tot
unit for: Ion Concentrations and Membrane Potential.I K tot
unit for: Ion Concentrations and Membrane Potential.I Na tot
unit for: Ion Concentrations and Membrane Potential.I app
unit for: Ion Concentrations and Membrane Potential.I pace
unit for: L Type Calcium Current.I Ca
unit for: L Type Calcium Current.I Ca05
unit for: L Type Calcium Current.I CaK
unit for: L Type Calcium Current.I Ca tot
unit for: Na Background Current.G NaB
unit for: Na Background Current.I NaB
unit for: Na Ca Exchanger Current.I NCX
unit for: Na Ca Exchanger Current.k NaCa
unit for: Na K Pump Current.I NaK
unit for: Na K Pump Current.I bar NaK
unit for: Pacing.I pace
unit for: Plateau K Current.I Kp
unit for: Sarcolemmal Ca Pump Current.I PCa
unit for: Sarcolemmal Ca Pump Current.I bar PCa
unit for: Steady State K Current.I ss
unit for: Time Independent K Current.I Ki
unit for: Total Membrane Currents.I Ca
unit for: Total Membrane Currents.I CaB
unit for: Total Membrane Currents.I CaK
unit for: Total Membrane Currents.I Ca tot
unit for: Total Membrane Currents.I K tot
unit for: Total Membrane Currents.I Ki
unit for: Total Membrane Currents.I Kp
unit for: Total Membrane Currents.I NCX
unit for: Total Membrane Currents.I Na
unit for: Total Membrane Currents.I NaB
unit for: Total Membrane Currents.I NaK
unit for: Total Membrane Currents.I Na tot
unit for: Total Membrane Currents.I PCa
unit for: Total Membrane Currents.I ss
unit for: Total Membrane Currents.I to
unit for: Transient Outward K Current.I to
has unit factor: UNIT ampere
has unit factor: UNIT farad

Axiom
has unit factor exponent: -1.0
has unit factor prefix: micro
annotated property: hasUnitFactor
annotated target: UNIT farad
annotated source: UNIT uA per uF

Axiom
has unit factor prefix: micro
annotated property: hasUnitFactor
annotated target: UNIT ampere
annotated source: UNIT uA per uF

UNIT uL
type: NamedIndividual
type: Unit of measurement
has computational code: uL
unit for: EC Coupling Parameters.V jsr
unit for: EC Coupling Parameters.V myo
unit for: EC Coupling Parameters.V nsr
unit for: Ion Concentrations and Membrane Potential.V jsr
unit for: Ion Concentrations and Membrane Potential.V myo
unit for: Ion Concentrations and Membrane Potential.V nsr
unit for: Other SR Fluxes and Concentrations.V jsr
unit for: Other SR Fluxes and Concentrations.V myo
unit for: Other SR Fluxes and Concentrations.V nsr
has unit factor: UNIT liter

Axiom
has unit factor prefix: micro
annotated property: hasUnitFactor
annotated target: UNIT liter
annotated source: UNIT uL

UNIT uM
type: NamedIndividual
type: Unit of measurement
has computational code: uM
unit for: LCC module.Km pka lcc
unit for: LCC module.Km pp1 lcc
unit for: LCC module.Km pp2a lcc
unit for: LCC module.LCC tot
unit for: LCC module.LCCa
unit for: LCC module.LCCa p
unit for: LCC module.LCCb
unit for: LCC module.LCCb p
unit for: LCC module.PKAC II
unit for: LCC module.PP1 lcc tot
unit for: LCC module.PP2A lcc tot
unit for: LCC parameters.Km pka lcc
unit for: LCC parameters.Km pp1 lcc
unit for: LCC parameters.Km pp2a lcc
unit for: LCC parameters.LCC tot
unit for: LCC parameters.PP1 lcc tot
unit for: LCC parameters.PP2A lcc tot
unit for: Other SR Fluxes and Concentrations.SR content
unit for: PKA module.A2RC I
unit for: PKA module.A2RC II
unit for: PKA module.A2R I
unit for: PKA module.A2R II
unit for: PKA module.ARC I
unit for: PKA module.ARC II
unit for: PKA module.K a
unit for: PKA module.K b
unit for: PKA module.K d
unit for: PKA module.Ki pki
unit for: PKA module.PKAC I
unit for: PKA module.PKAC II
unit for: PKA module.PKAII tot
unit for: PKA module.PKAI tot
unit for: PKA module.PKA temp
unit for: PKA module.PKI
unit for: PKA module.PKI tot
unit for: PKA module.cAMP
unit for: PKA module.cAMP tot
unit for: PKA parameters.K a
unit for: PKA parameters.K b
unit for: PKA parameters.K d
unit for: PKA parameters.Ki pki
unit for: PKA parameters.PKAII tot
unit for: PKA parameters.PKAI tot
unit for: PKA parameters.PKI tot
unit for: PLB module.Inhib1
unit for: PLB module.Inhib1 tot
unit for: PLB module.Inhib1p
unit for: PLB module.Inhib1p PP1
unit for: PLB module.Inhib1p tot
unit for: PLB module.Ki inhib1
unit for: PLB module.Km pka i1
unit for: PLB module.Km pka plb
unit for: PLB module.Km pp1 plb
unit for: PLB module.Km pp2a i1
unit for: PLB module.PKAC I
unit for: PLB module.PLB
unit for: PLB module.PLB p
unit for: PLB module.PLB tot
unit for: PLB module.PP1
unit for: PLB module.PP1 tot
unit for: PLB parameters.Inhib1 tot
unit for: PLB parameters.Ki inhib1
unit for: PLB parameters.Km pka i1
unit for: PLB parameters.Km pka plb
unit for: PLB parameters.Km pp1 plb
unit for: PLB parameters.Km pp2a i1
unit for: PLB parameters.PLB tot
unit for: PLB parameters.PP1 tot
has unit factor: UNIT liter
has unit factor: UNIT mole
unit for: b1 AR Gs parameters.Gs tot
unit for: b1 AR Gs parameters.Kc
unit for: b1 AR Gs parameters.Kl
unit for: b1 AR Gs parameters.Kr
unit for: b1 AR Gs parameters.L totmax
unit for: b1 AR Gs parameters.sum b1 AR
unit for: b1 AR module.Gs

Axiom
has unit factor prefix: micro
annotated property: hasUnitFactor
annotated target: UNIT mole
annotated source: UNIT uM

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated target: UNIT liter
annotated source: UNIT uM

UNIT uM per sec
type: NamedIndividual
type: Unit of measurement
has computational code: uM_per_sec
unit for: LCC module.LCCa DEPHOSPH
unit for: LCC module.LCCa PHOSPH
unit for: LCC module.LCCb DEPHOSPH
unit for: LCC module.LCCb PHOSPH
unit for: PLB module.Inhib1 DEPHOSPH
unit for: PLB module.Inhib1 PHOSPH
unit for: PLB module.PLB DEPHOSPH
unit for: PLB module.PLB PHOSPH
unit for: PLB module.Vmax pp2a i1
unit for: PLB parameters.Vmax pp2a i1
has unit factor: UNIT second
has unit factor: UNIT uM
unit for: b1 AR module.BARK DESENS
unit for: b1 AR module.BARK RESENS
unit for: b1 AR module.G ACT
unit for: b1 AR module.HYD
unit for: b1 AR module.PKA DESENS
unit for: b1 AR module.PKA RESENS

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated target: UNIT second
annotated source: UNIT uM per sec

UNIT unknown
type: NamedIndividual
type: Unit of measurement
has computational code: unknown
has unit factor: UNIT dimensionless

UNIT volt
type: NamedIndividual
type: Unit of measurement
is fundamental unit: true
has computational code: volt

b1 AR Gs parameters
type: NamedIndividual
type: Submodel
name: b1_AR_Gs_parameters
has associated data structure: b1 AR Gs parameters.Gs tot
has associated data structure: b1 AR Gs parameters.Kc
has associated data structure: b1 AR Gs parameters.Kl
has associated data structure: b1 AR Gs parameters.Kr
has associated data structure: b1 AR Gs parameters.L totmax
has associated data structure: b1 AR Gs parameters.k bar km
has associated data structure: b1 AR Gs parameters.k bar kp
has associated data structure: b1 AR Gs parameters.k g act
has associated data structure: b1 AR Gs parameters.k hyd
has associated data structure: b1 AR Gs parameters.k p kam
has associated data structure: b1 AR Gs parameters.k p kap
has associated data structure: b1 AR Gs parameters.k reassoc
has associated data structure: b1 AR Gs parameters.sum b1 AR
has computational component: b1 AR Gs parameters computation

b1 AR Gs parameters.Gs tot
type: NamedIndividual
type: Decimal
has cell m linitial value: 3.83
metadata ID: b1_AR_Gs_parameters.Gs_tot
has cell m lpublic interface: out
has unit: UNIT uM
is computational component for: Chemical concentration
mapped to: b1 AR module.Gs tot
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: b1 AR Gs parameters.Gs tot

b1 AR Gs parameters.Kc
type: NamedIndividual
type: Decimal
has cell m linitial value: 33
metadata ID: b1_AR_Gs_parameters.Kc
has cell m lpublic interface: out
has unit: UNIT uM
is computational component for: Chemical concentration
mapped to: b1 AR module.Kc
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: b1 AR Gs parameters.Kc

b1 AR Gs parameters.Kl
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.285
metadata ID: b1_AR_Gs_parameters.Kl
has cell m lpublic interface: out
has unit: UNIT uM
is computational component for: Chemical concentration
mapped to: b1 AR module.Kl
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: b1 AR Gs parameters.Kl

b1 AR Gs parameters.Kr
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.062
metadata ID: b1_AR_Gs_parameters.Kr
has cell m lpublic interface: out
has unit: UNIT uM
mapped to: b1 AR module.Kr
has solution domain: Time

b1 AR Gs parameters.L totmax
type: NamedIndividual
type: Decimal
has cell m linitial value: 1
metadata ID: b1_AR_Gs_parameters.L_totmax
has cell m lpublic interface: out
has unit: UNIT uM
mapped to: b1 AR module.L totmax
has solution domain: Time

b1 AR Gs parameters.k bar km
type: NamedIndividual
type: Decimal
has cell m linitial value: 2.2e-3
metadata ID: b1_AR_Gs_parameters.k_bar_km
has cell m lpublic interface: out
has unit: UNIT per sec
mapped to: b1 AR module.k bar km
has solution domain: Time

b1 AR Gs parameters.k bar kp
type: NamedIndividual
type: Decimal
has cell m linitial value: 1.1e-3
metadata ID: b1_AR_Gs_parameters.k_bar_kp
has cell m lpublic interface: out
has unit: UNIT per sec
mapped to: b1 AR module.k bar kp
has solution domain: Time

b1 AR Gs parameters.k g act
type: NamedIndividual
type: Decimal
has cell m linitial value: 16
metadata ID: b1_AR_Gs_parameters.k_g_act
has cell m lpublic interface: out
has unit: UNIT per sec
mapped to: b1 AR module.k g act
has solution domain: Time

b1 AR Gs parameters.k hyd
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.8
metadata ID: b1_AR_Gs_parameters.k_hyd
has cell m lpublic interface: out
has unit: UNIT per sec
mapped to: b1 AR module.k hyd
has solution domain: Time

b1 AR Gs parameters.k p kam
type: NamedIndividual
type: Decimal
has cell m linitial value: 2.2e-3
metadata ID: b1_AR_Gs_parameters.k_p_kam
has cell m lpublic interface: out
has unit: UNIT per sec
mapped to: b1 AR module.k p kam
has solution domain: Time

b1 AR Gs parameters.k p kap
type: NamedIndividual
type: Decimal
has cell m linitial value: 3.6e-3
metadata ID: b1_AR_Gs_parameters.k_p_kap
has cell m lpublic interface: out
has unit: UNIT per uM per sec
mapped to: b1 AR module.k p kap
has solution domain: Time

b1 AR Gs parameters.k reassoc
type: NamedIndividual
type: Decimal
has cell m linitial value: 1.21e3
metadata ID: b1_AR_Gs_parameters.k_reassoc
has cell m lpublic interface: out
has unit: UNIT per uM per sec
mapped to: b1 AR module.k reassoc
has solution domain: Time

b1 AR Gs parameters.sum b1 AR
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.0132
metadata ID: b1_AR_Gs_parameters.sum_b1_AR
has cell m lpublic interface: out
has unit: UNIT uM
mapped to: b1 AR module.sum b1 AR
has solution domain: Time

b1 AR module
type: NamedIndividual
type: Submodel
name: b1_AR_module
has associated data structure: b1 AR module.BARK DESENS
has associated data structure: b1 AR module.BARK RESENS
has associated data structure: b1 AR module.G ACT
has associated data structure: b1 AR module.Gs
has associated data structure: b1 AR module.Gs agdp
has associated data structure: b1 AR module.Gs agtp tot
has associated data structure: b1 AR module.Gs bg
has associated data structure: b1 AR module.Gs tot
has associated data structure: b1 AR module.HYD
has associated data structure: b1 AR module.Kc
has associated data structure: b1 AR module.Kl
has associated data structure: b1 AR module.Kr
has associated data structure: b1 AR module.L
has associated data structure: b1 AR module.LR
has associated data structure: b1 AR module.LRG
has associated data structure: b1 AR module.L totmax
has associated data structure: b1 AR module.PKAC I
has associated data structure: b1 AR module.PKA DESENS
has associated data structure: b1 AR module.PKA RESENS
has associated data structure: b1 AR module.R
has associated data structure: b1 AR module.REASSOC
has associated data structure: b1 AR module.RG
has associated data structure: b1 AR module.b1 AR d
has associated data structure: b1 AR module.b1 AR p
has associated data structure: b1 AR module.b1 AR tot
has associated data structure: b1 AR module.k bar km
has associated data structure: b1 AR module.k bar kp
has associated data structure: b1 AR module.k g act
has associated data structure: b1 AR module.k hyd
has associated data structure: b1 AR module.k p kam
has associated data structure: b1 AR module.k p kap
has associated data structure: b1 AR module.k reassoc
has associated data structure: b1 AR module.sum b1 AR
has associated data structure: Time
has computational component: b1 AR module computation

b1 AR module.BARK DESENS
type: NamedIndividual
type: Decimal
metadata ID: BARK_DESENS
has unit: UNIT uM per sec
is computational component for: Chemical concentration flow rate
has solution domain: Time

Chemical concentration flow rate
type: NamedIndividual
has physical definition: Chemical concentration flow rate
has computational component: b1 AR module.BARK DESENS

b1 AR module.BARK RESENS
type: NamedIndividual
type: Decimal
metadata ID: b1_AR_module.BARK_RESENS
has unit: UNIT uM per sec
is computational component for: Chemical concentration flow rate
has solution domain: Time

Chemical concentration flow rate
type: NamedIndividual
has physical definition: Chemical concentration flow rate
has computational component: b1 AR module.BARK RESENS

b1 AR module.G ACT
type: NamedIndividual
type: Decimal
metadata ID: G_ACT
has unit: UNIT uM per sec
is computational component for: Chemical concentration flow rate
has solution domain: Time

Chemical concentration flow rate
type: NamedIndividual
has physical definition: Chemical concentration flow rate
has computational component: b1 AR module.G ACT

b1 AR module.Gs
type: NamedIndividual
type: Decimal
metadata ID: Gs
has cell m lpublic interface: out
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

b1 AR module.Gs agdp
type: NamedIndividual
type: Decimal
has cell m linitial value: 6.446e-4
metadata ID: b1_AR_module.Gs_agdp
has cell m lpublic interface: out
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: b1 AR module.Gs agdp

b1 AR module.Gs agtp tot
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.02505
metadata ID: b1_AR_module.Gs_agtp_tot
has cell m lpublic interface: out
comment: Concentration of GTP-bound G_s alpha
has unit: UNIT uM
is computational component for: Chemical concentration
mapped to: cAMP module.Gs agtp tot
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: b1 AR module.Gs agtp tot

b1 AR module.Gs bg
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.02569
metadata ID: b1_AR_module.Gs_bg
has cell m lpublic interface: out
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: b1 AR module.Gs bg

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: b1 AR module.Gs

b1 AR module.Gs tot
type: NamedIndividual
type: Decimal
metadata ID: b1_AR_module.Gs_tot
has cell m lpublic interface: in
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: b1 AR module.Gs tot

b1 AR module.HYD
type: NamedIndividual
type: Decimal
metadata ID: b1_AR_module.HYD
has unit: UNIT uM per sec
is computational component for: Chemical concentration flow rate
has solution domain: Time

Chemical concentration flow rate
type: NamedIndividual
has physical definition: Chemical concentration flow rate
has computational component: b1 AR module.HYD

b1 AR module.Kc
type: NamedIndividual
type: Decimal
metadata ID: b1_AR_module.Kc
has cell m lpublic interface: in
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: b1 AR module.Kc

b1 AR module.Kl
type: NamedIndividual
type: Decimal
metadata ID: b1_AR_module.Kl
has cell m lpublic interface: in
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: b1 AR module.Kl

b1 AR module.Kr
type: NamedIndividual
type: Decimal
metadata ID: b1_AR_module.Kr
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

b1 AR module.L
type: NamedIndividual
type: Decimal
metadata ID: L
has cell m lpublic interface: out
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

b1 AR module.LR
type: NamedIndividual
type: Decimal
metadata ID: LR
has cell m lpublic interface: out
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

b1 AR module.LRG
type: NamedIndividual
type: Decimal
metadata ID: LRG
has cell m lpublic interface: out
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: b1 AR module.LRG

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: b1 AR module.LR

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: b1 AR module.L

b1 AR module.L totmax
type: NamedIndividual
type: Decimal
metadata ID: b1_AR_module.L_totmax
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

b1 AR module.PKAC I
type: NamedIndividual
type: Decimal
metadata ID: b1_AR_module.PKAC_I
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

b1 AR module.PKA DESENS
type: NamedIndividual
type: Decimal
metadata ID: PKA_DESENS
has unit: UNIT uM per sec
is computational component for: Chemical concentration flow rate
has solution domain: Time

Chemical concentration flow rate
type: NamedIndividual
has physical definition: Chemical concentration flow rate
has computational component: b1 AR module.PKA DESENS

b1 AR module.PKA RESENS
type: NamedIndividual
type: Decimal
metadata ID: b1_AR_module.PKA_RESENS
has unit: UNIT uM per sec
is computational component for: Chemical concentration flow rate
has solution domain: Time

Chemical concentration flow rate
type: NamedIndividual
has physical definition: Chemical concentration flow rate
has computational component: b1 AR module.PKA RESENS

b1 AR module.R
type: NamedIndividual
type: Decimal
metadata ID: R
has cell m lpublic interface: out
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

b1 AR module.REASSOC
type: NamedIndividual
type: Decimal
metadata ID: b1_AR_module.REASSOC
has unit: UNIT per sec
has solution domain: Time

b1 AR module.RG
type: NamedIndividual
type: Decimal
metadata ID: RG
has cell m lpublic interface: out
has unit: UNIT uM
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: b1 AR module.R

b1 AR module.b1 AR d
type: NamedIndividual
type: Decimal
has cell m linitial value: 0
metadata ID: b1_AR_module.b1_AR_d
has cell m lpublic interface: out
comment: Beta1-specific in activation by phosphorylation at S464 by beta-adrenergic receptor kinase.
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: Beta-1 adrenergic receptor
has computational component: b1 AR module.b1 AR d

b1 AR module.b1 AR p
type: NamedIndividual
type: Decimal
has cell m linitial value: 1.154e-3
metadata ID: b1_AR_module.b1_AR_p
has cell m lpublic interface: out
comment: Beta1-specific in activation by phosphorylation at S301 by beta-adrenergic receptor kinase.
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: Beta-1 adrenergic receptor
has computational component: b1 AR module.b1 AR p

b1 AR module.b1 AR tot
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.01205
metadata ID: b1_AR_module.b1_AR_tot
has cell m lpublic interface: out
comment: Concentration of beta1-adrenergic signaling in the cardiac myocyte
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: Beta-1 adrenergic receptor
has computational component: b1 AR module.b1 AR tot

b1 AR module.k bar km
type: NamedIndividual
type: Decimal
metadata ID: b1_AR_module.k_bar_km
has cell m lpublic interface: in
has unit: UNIT per sec
has solution domain: Time

b1 AR module.k bar kp
type: NamedIndividual
type: Decimal
metadata ID: b1_AR_module.k_bar_kp
has cell m lpublic interface: in
has unit: UNIT per sec
has solution domain: Time

b1 AR module.k g act
type: NamedIndividual
type: Decimal
metadata ID: b1_AR_module.k_g_act
has cell m lpublic interface: in
has unit: UNIT per sec
has solution domain: Time

b1 AR module.k hyd
type: NamedIndividual
type: Decimal
metadata ID: b1_AR_module.k_hyd
has cell m lpublic interface: in
has unit: UNIT per sec
has solution domain: Time

b1 AR module.k p kam
type: NamedIndividual
type: Decimal
metadata ID: b1_AR_module.k_p_kam
has cell m lpublic interface: in
has unit: UNIT per sec
has solution domain: Time

b1 AR module.k p kap
type: NamedIndividual
type: Decimal
metadata ID: b1_AR_module.k_p_kap
has cell m lpublic interface: in
has unit: UNIT per uM per sec
has solution domain: Time

b1 AR module.k reassoc
type: NamedIndividual
type: Decimal
metadata ID: b1_AR_module.k_reassoc
has cell m lpublic interface: in
has unit: UNIT per uM per sec
has solution domain: Time

b1 AR module.sum b1 AR
type: NamedIndividual
type: Decimal
metadata ID: b1_AR_module.sum_b1_AR
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

Time
type: NamedIndividual
type: Decimal
metadata ID: b1_AR_module.time
has physical definition: https://identifiers.org/opb/OPB_01023
has cell m lpublic interface: in
has unit: UNIT second
has solution domain: Time

b1 AR module computation
type: NamedIndividual
type: Computation
has math ML: <eq /> LR <divide /> <times /> L R Kl <eq /> LRG <divide /> <times /> LR Gs Kr <eq /> RG <divide /> <times /> R Gs Kc <eq /> BARK_DESENS <times /> k_bar_kp <plus /> LR LRG <eq /> BARK_RESENS <times /> k_bar_km b1_AR_d <eq /> PKA_DESENS <times /> k_p_kap PKAC_I b1_AR_tot <eq /> PKA_RESENS <times /> k_p_kam b1_AR_p <eq /> G_ACT <times /> k_g_act <plus /> RG LRG <eq /> HYD <times /> k_hyd Gs_agtp_tot <eq /> REASSOC <divide /> <times /> k_reassoc Gs_agdp Gs_bg 1 <eq /> L <minus /> <minus /> L_totmax LR LRG <eq /> R <minus /> <minus /> <minus /> b1_AR_tot LR LRG RG <eq /> Gs <minus /> <minus /> Gs_tot LRG RG <eq /> <diff /> time b1_AR_tot <minus /> <plus /> <minus /> BARK_RESENS BARK_DESENS PKA_RESENS PKA_DESENS <eq /> <diff /> time b1_AR_d <minus /> BARK_DESENS BARK_RESENS <eq /> <diff /> time b1_AR_p <minus /> PKA_DESENS PKA_RESENS <eq /> <diff /> time Gs_agtp_tot <minus /> G_ACT HYD <eq /> <diff /> time Gs_agdp <minus /> HYD <times /> REASSOC 1 <eq /> <diff /> time Gs_bg <minus /> G_ACT <times /> REASSOC 1
is computational component for: b1 AR module

cAMP module
type: NamedIndividual
type: Submodel
name: cAMP_module
has associated data structure: cAMP module.AC
has associated data structure: cAMP module.AC ACT BASAL
has associated data structure: cAMP module.AC ACT FSK
has associated data structure: cAMP module.AC ACT GSA
has associated data structure: cAMP module.AC tot
has associated data structure: cAMP module.ATP
has associated data structure: cAMP module.Fsk
has associated data structure: cAMP module.Fsk AC
has associated data structure: cAMP module.Fsk tot
has associated data structure: cAMP module.Gs agtp tot
has associated data structure: cAMP module.Gsa GTP
has associated data structure: cAMP module.Gsa GTP AC
has associated data structure: cAMP module.IBMX
has associated data structure: cAMP module.IBMX tot
has associated data structure: cAMP module.K fsk
has associated data structure: cAMP module.K gsa
has associated data structure: cAMP module.Ki ibmx
has associated data structure: cAMP module.Km basal
has associated data structure: cAMP module.Km fsk
has associated data structure: cAMP module.Km gsa
has associated data structure: cAMP module.Km pde
has associated data structure: cAMP module.PDE
has associated data structure: cAMP module.PDE ACT
has associated data structure: cAMP module.PDE IBMX
has associated data structure: cAMP module.PDE tot
has associated data structure: cAMP module.cAMP
has associated data structure: cAMP module.cAMP tot
has associated data structure: cAMP module.k ac basal
has associated data structure: cAMP module.k ac fsk
has associated data structure: cAMP module.k ac gsa
has associated data structure: cAMP module.k pde
has associated data structure: Time
has computational component: cAMP module computation

cAMP module.AC
type: NamedIndividual
type: Decimal
metadata ID: AC
comment: Concentration of adenylyl cyclase in the rat ventricular myocyte
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

cAMP module.AC ACT BASAL
type: NamedIndividual
type: Decimal
metadata ID: AC_ACT_BASAL
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: cAMP module.AC ACT BASAL

cAMP module.AC ACT FSK
type: NamedIndividual
type: Decimal
metadata ID: AC_ACT_FSK
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: cAMP module.AC ACT FSK

cAMP module.AC ACT GSA
type: NamedIndividual
type: Decimal
metadata ID: AC_ACT_GSA
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: cAMP module.AC ACT GSA

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: adenylate cyclase
has computational component: cAMP module.AC

cAMP module.AC tot
type: NamedIndividual
type: Decimal
metadata ID: cAMP_module.AC_tot
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

cAMP module.ATP
type: NamedIndividual
type: Decimal
metadata ID: cAMP_module.ATP
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

cAMP module.Fsk
type: NamedIndividual
type: Decimal
metadata ID: FSK
comment: Concentration of forskolin on the sarcolemma
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

cAMP module.Fsk AC
type: NamedIndividual
type: Decimal
metadata ID: Fsk_AC
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: cAMP module.Fsk AC

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: forskolin
has computational component: cAMP module.Fsk

cAMP module.Fsk tot
type: NamedIndividual
type: Decimal
metadata ID: cAMP_module.Fsk_tot
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

cAMP module.Gs agtp tot
type: NamedIndividual
type: Decimal
metadata ID: cAMP_module.Gs_agtp_tot
has cell m lpublic interface: in
comment: Concentration of GTP-bound G_s alpha
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: cAMP module.Gs agtp tot

cAMP module.Gsa GTP
type: NamedIndividual
type: Decimal
metadata ID: Gsa_GTP
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

cAMP module.Gsa GTP AC
type: NamedIndividual
type: Decimal
metadata ID: Gsa_GTP_AC
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: cAMP module.Gsa GTP AC

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: cAMP module.Gsa GTP

cAMP module.IBMX
type: NamedIndividual
type: Decimal
metadata ID: IBMX
comment: Concentration of IBMX (3-isobutyl-1-methylxanthine)
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: 3-isobutyl-1-methylxanthine
has computational component: cAMP module.IBMX

cAMP module.IBMX tot
type: NamedIndividual
type: Decimal
metadata ID: cAMP_module.IBMX_tot
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

cAMP module.K fsk
type: NamedIndividual
type: Decimal
metadata ID: cAMP_module.K_fsk
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

cAMP module.K gsa
type: NamedIndividual
type: Decimal
metadata ID: cAMP_module.K_gsa
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

cAMP module.Ki ibmx
type: NamedIndividual
type: Decimal
metadata ID: cAMP_module.Ki_ibmx
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

cAMP module.Km basal
type: NamedIndividual
type: Decimal
metadata ID: cAMP_module.Km_basal
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

cAMP module.Km fsk
type: NamedIndividual
type: Decimal
metadata ID: cAMP_module.Km_fsk
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

cAMP module.Km gsa
type: NamedIndividual
type: Decimal
metadata ID: cAMP_module.Km_gsa
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

cAMP module.Km pde
type: NamedIndividual
type: Decimal
metadata ID: cAMP_module.Km_pde
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

cAMP module.PDE
type: NamedIndividual
type: Decimal
metadata ID: PDE
comment: Concentration of phosphodiesterase
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

cAMP module.PDE ACT
type: NamedIndividual
type: Decimal
metadata ID: PDE_ACT
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
has computational component: cAMP module.PDE ACT

cAMP module.PDE IBMX
type: NamedIndividual
type: Decimal
metadata ID: cAMP_module.PDE_IBMX
comment: Concentration of nonspecific phosphodiesterase inhibitor IBMX
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: 3-isobutyl-1-methylxanthine
has computational component: cAMP module.PDE IBMX

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: Concentration of phosphodiesterase
has computational component: cAMP module.PDE

cAMP module.PDE tot
type: NamedIndividual
type: Decimal
metadata ID: cAMP_module.PDE_tot
has cell m lpublic interface: in
has unit: UNIT uM
has solution domain: Time

cAMP module.cAMP
type: NamedIndividual
type: Decimal
metadata ID: cAMP_module.cAMP
has cell m lpublic interface: in
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: cAMP biosynthetic process
has computational component: cAMP module.cAMP

cAMP module.cAMP tot
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.8453
metadata ID: cAMP_module.cAMP_tot
has cell m lpublic interface: out
comment: Concentration of cyclic AMP
mapped to: PKA module.cAMP tot
has unit: UNIT uM
is computational component for: Chemical concentration
has solution domain: Time

Chemical concentration
type: NamedIndividual
has physical definition: Chemical concentration
physical property of: cAMP biosynthetic process
has computational component: cAMP module.cAMP tot

cAMP module.k ac basal
type: NamedIndividual
type: Decimal
metadata ID: cAMP_module.k_ac_basal
has cell m lpublic interface: in
has unit: UNIT per sec
has solution domain: Time

cAMP module.k ac fsk
type: NamedIndividual
type: Decimal
metadata ID: cAMP_module.k_ac_fsk
has cell m lpublic interface: in
has unit: UNIT per sec
has solution domain: Time

cAMP module.k ac gsa
type: NamedIndividual
type: Decimal
metadata ID: cAMP_module.k_ac_gsa
has cell m lpublic interface: in
has unit: UNIT per sec
has solution domain: Time

cAMP module.k pde
type: NamedIndividual
type: Decimal
metadata ID: cAMP_module.k_pde
has cell m lpublic interface: in
has unit: UNIT per sec
has solution domain: Time

Time
type: NamedIndividual
type: Decimal
metadata ID: cAMP_module.time
has physical definition: https://identifiers.org/opb/OPB_01023
has cell m lpublic interface: in
has unit: UNIT second
has solution domain: Time

cAMP module computation
type: NamedIndividual
type: Computation
has math ML: <eq /> Gsa_GTP_AC <divide /> <times /> Gsa_GTP AC K_gsa <eq /> Fsk_AC <divide /> <times /> Fsk AC K_fsk <eq /> AC_ACT_BASAL <divide /> <times /> k_ac_basal AC ATP <plus /> Km_basal ATP <eq /> AC_ACT_GSA <divide /> <times /> k_ac_gsa Gsa_GTP_AC ATP <plus /> Km_gsa ATP <eq /> AC_ACT_FSK <divide /> <times /> k_ac_fsk Fsk_AC ATP <plus /> Km_fsk ATP <eq /> PDE_ACT <divide /> <times /> k_pde PDE cAMP <plus /> Km_pde cAMP <eq /> PDE_IBMX <divide /> <times /> PDE IBMX Ki_ibmx <eq /> Gsa_GTP <minus /> Gs_agtp_tot Gsa_GTP_AC <eq /> Fsk <minus /> Fsk_tot Fsk_AC <eq /> AC <minus /> AC_tot Gsa_GTP_AC <eq /> PDE <minus /> PDE_tot PDE_IBMX <eq /> IBMX <minus /> IBMX_tot PDE_IBMX <eq /> <diff /> time cAMP_tot <plus /> <minus /> <plus /> AC_ACT_BASAL AC_ACT_GSA PDE_ACT AC_ACT_FSK
is computational component for: cAMP module

cAMP parameters
type: NamedIndividual
type: Submodel
name: cAMP_parameters
has associated data structure: cAMP parameters.AC tot
has associated data structure: cAMP parameters.ATP
has associated data structure: cAMP parameters.Fsk tot
has associated data structure: cAMP parameters.IBMX tot
has associated data structure: cAMP parameters.K fsk
has associated data structure: cAMP parameters.K gsa
has associated data structure: cAMP parameters.Ki ibmx
has associated data structure: cAMP parameters.Km basal
has associated data structure: cAMP parameters.Km fsk
has associated data structure: cAMP parameters.Km gsa
has associated data structure: cAMP parameters.Km pde
has associated data structure: cAMP parameters.PDE tot
has associated data structure: cAMP parameters.k ac basal
has associated data structure: cAMP parameters.k ac fsk
has associated data structure: cAMP parameters.k ac gsa
has associated data structure: cAMP parameters.k pde
has computational component: cAMP parameters computation

cAMP parameters.AC tot
type: NamedIndividual
type: Decimal
has cell m linitial value: 49.7e-3
metadata ID: cAMP_parameters.AC_tot
has cell m lpublic interface: out
has unit: UNIT uM
mapped to: cAMP module.AC tot
has solution domain: Time

cAMP parameters.ATP
type: NamedIndividual
type: Decimal
has cell m linitial value: 5e3
metadata ID: cAMP_parameters.ATP
has cell m lpublic interface: out
has unit: UNIT uM
mapped to: cAMP module.ATP
has solution domain: Time

cAMP parameters.Fsk tot
type: NamedIndividual
type: Decimal
has cell m linitial value: 0
metadata ID: cAMP_parameters.Fsk_tot
has cell m lpublic interface: out
has unit: UNIT uM
mapped to: cAMP module.Fsk tot
has solution domain: Time

cAMP parameters.IBMX tot
type: NamedIndividual
type: Decimal
has cell m linitial value: 1
metadata ID: cAMP_parameters.IBMX_tot
has cell m lpublic interface: out
has unit: UNIT uM
mapped to: cAMP module.IBMX tot
has solution domain: Time

cAMP parameters.K fsk
type: NamedIndividual
type: Decimal
has cell m linitial value: 44
metadata ID: cAMP_parameters.K_fsk
has cell m lpublic interface: out
has unit: UNIT uM
mapped to: cAMP module.K fsk
has solution domain: Time

cAMP parameters.K gsa
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.4
metadata ID: cAMP_parameters.K_gsa
has cell m lpublic interface: out
has unit: UNIT uM
mapped to: cAMP module.K gsa
has solution domain: Time

cAMP parameters.Ki ibmx
type: NamedIndividual
type: Decimal
has cell m linitial value: 30
metadata ID: cAMP_parameters.Ki_ibmx
has cell m lpublic interface: out
has unit: UNIT uM
mapped to: cAMP module.Ki ibmx
has solution domain: Time

cAMP parameters.Km basal
type: NamedIndividual
type: Decimal
has cell m linitial value: 1.03e3
metadata ID: cAMP_parameters.Km_basal
has cell m lpublic interface: out
has unit: UNIT uM
mapped to: cAMP module.Km basal
has solution domain: Time

cAMP parameters.Km fsk
type: NamedIndividual
type: Decimal
has cell m linitial value: 860
metadata ID: cAMP_parameters.Km_fsk
has cell m lpublic interface: out
has unit: UNIT uM
mapped to: cAMP module.Km fsk
has solution domain: Time

cAMP parameters.Km gsa
type: NamedIndividual
type: Decimal
has cell m linitial value: 315
metadata ID: cAMP_parameters.Km_gsa
has cell m lpublic interface: out
has unit: UNIT uM
mapped to: cAMP module.Km gsa
has solution domain: Time

cAMP parameters.Km pde
type: NamedIndividual
type: Decimal
has cell m linitial value: 1.3
metadata ID: cAMP_parameters.Km_pde
has cell m lpublic interface: out
has unit: UNIT uM
mapped to: cAMP module.Km pde
has solution domain: Time

cAMP parameters.PDE tot
type: NamedIndividual
type: Decimal
has cell m linitial value: 39e-3
metadata ID: cAMP_parameters.PDE_tot
has cell m lpublic interface: out
has unit: UNIT uM
mapped to: cAMP module.PDE tot
has solution domain: Time

cAMP parameters.k ac basal
type: NamedIndividual
type: Decimal
has cell m linitial value: 0.2
metadata ID: cAMP_parameters.k_ac_basal
has cell m lpublic interface: out
has unit: UNIT per sec
mapped to: cAMP module.k ac basal
has solution domain: Time

cAMP parameters.k ac fsk
type: NamedIndividual
type: Decimal
has cell m linitial value: 0
metadata ID: cAMP_parameters.k_ac_fsk
has cell m lpublic interface: out
has unit: UNIT per sec
mapped to: cAMP module.k ac fsk
has solution domain: Time

cAMP parameters.k ac gsa
type: NamedIndividual
type: Decimal
has cell m linitial value: 8.5
metadata ID: cAMP_parameters.k_ac_gsa
has cell m lpublic interface: out
has unit: UNIT per sec
mapped to: cAMP module.k ac gsa
has solution domain: Time

cAMP parameters.k pde
type: NamedIndividual
type: Decimal
has cell m linitial value: 5
metadata ID: cAMP_parameters.k_pde
has cell m lpublic interface: out
has unit: UNIT per sec
mapped to: cAMP module.k pde
has solution domain: Time

environment
type: NamedIndividual
type: Submodel
name: environment
has associated data structure: environment.protocol
has associated data structure: Time
has computational component: environment computation

environment.protocol
type: NamedIndividual
type: Decimal
has cell m linitial value: 0
metadata ID: environment.protocol
has cell m lpublic interface: out
mapped to: Ion Concentrations and Membrane Potential.protocol
has unit: UNIT dimensionless
has solution domain: Time

Time
type: NamedIndividual
type: Decimal
metadata ID: environment.time
has physical definition: https://identifiers.org/opb/OPB_01023
has cell m lpublic interface: out
is solution domain: true
mapped to: Time
has unit: UNIT second