26032015152001561m0500
type: Ontology
sem sim version: 0.2
has cell m ldocumentation: <documentation xmlns="http://cellml.org/tmp-documentation"> <articleinfo> Di Francesco-Noble Purkinje Fibre Model 1985 <author> <firstname>Catherine</firstname> <surname>Lloyd</surname> <affiliation> <shortaffil>Bioengineering Institute, University of Auckland</shortaffil> </affiliation> </author> </articleinfo> Model Status This model has been curated and unit-checked by Penny Noble of Oxford University and is known to run in PCEnv and COR and reproduce the results published in the paper it is based on. <sect1 id="sec_structure"> Model Structure During the years that followed the formulation of the McAllister-Noble-Tsien Purkinje fibre model in 1975 and the Beeler-Reuter mammalian ventricular model in 1977, many experiments were performed which provided a greater insight into the working of the ion channels in cardiac tissue. D. Di Francesco and D. Noble (1985) constructed a new model of cardiac electrical activity which sought to incorporate much of this new data (see the figure below). The complete original paper reference is cited below: A Model of the Cardiac Electrical Activity Incorporating Ionic Pumps and Concentration Changes - Simulations of Ionic Currents and Concentration Changes, Di Francesco, D. and Noble, D. Phil. Trans. R. Soc. Lond. , B307, 353-398. (The full text of the article is available to members on the JSTOR website.) PubMed ID: 2578676 <informalfigure float="0" id="fig_cell_diagram"> <mediaobject> <imageobject> <objectinfo> cell diagram of the DFN model showing ionic currents, pumps and exchangers within the sarcolemma and the sarcoplasmic reticulum </objectinfo> <imagedata fileref="difrancesco_noble_1985.png" /> </imageobject> </mediaobject> A schematic diagram describing the current flows across the cell membrane that are captured in the DFN model. </informalfigure> <informalfigure float="0" id="fig_cellml_rendering"> <mediaobject> <imageobject> <objectinfo> the cellml rendering of the DFN model </objectinfo> <imagedata fileref="cellml_ren…
has cell m lrdf markup: <rdf:RDF xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:j.0="http://imc.org/vCard/3.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#"> <rdf:Description rdf:about="http://www.cellml.org/cellml/1.0"> <cmeta:modification> <rdf:Description rdf:about="rdf:#307594d8-70f0-4d35-b5db-81f33862c8ab"> <cmeta:modifier> <rdf:Description rdf:about="rdf:#003be6d0-63f8-497f-88fd-9f5db8146d3d"> <vCard:N> <rdf:Description rdf:about="rdf:#a66d4308-0f4f-4bbd-85c0-2d7200869d2e"> <vCard:Other>J</vCard:Other> <vCard:Family>Noble</vCard:Family> <vCard:Given>Penny</vCard:Given> </rdf:Description> </vCard:N> </rdf:Description> </cmeta:modifier> <rdf:value>Units checked, curated.</rdf:value> <dcterms:modified> <rdf:Description rdf:about="rdf:#67d34689-2a5a-4941-a7fc-f83e7ef55e6c"> <dcterms:W3CDTF>2007-11-28T16:00:36+13:00</dcterms:W3CDTF> </rdf:Description> </dcterms:modified> </rdf:Description> </cmeta:modification> <cmeta:modification> <rdf:Description rdf:about="rdf:#17940d4d-6d26-4c36-bca8-8370616d8722"> <cmeta:modifier> <rdf:Description rdf:about="rdf:#39270657-5af0-4e4c-87af-1ad3b0139171"> <vCard:N> <rdf:Description rdf:about="rdf:#b381ccc4-d23a-415c-b200-14046d56921b"> <vCard:Other>Richard</vCard:Other> <vCard:Family>Lawson</vCard:Family> <vCard:Given>James</vCard:Given> </rdf:Description> </vCard:N> </rdf:Description> </cmeta:modifier> <rdf:value>added cmeta:id's to some variables to allow referencing by PCEnv session file</rdf:value> <dcterms:modified> <rdf:Description rdf:about="rdf:#5998ddc3-fe01-4ae4-89ef-ea09771277f7"> <dcterms:W3CDTF>2007-12-19T14:05:35+13:00</dcterms:W3CDTF> </rdf:Description> </dcterms:modified> </rdf:Description> </cmeta:modification> <dc:creator> <rdf:Description rdf:about="rdf:#08c379a9-2e10-4d2d-8ac4-d1…
model description: A MODEL OF CARDIAC ELECTRICAL A C T I V I T Y INCORPORATING IONIC PUMPS AND CONCENTRATION CHANGES
legacy code URI: C:\Users\thomp_000\Dropbox\Work Related\Annotated Models\Difrancesco_1985\difrancesco_noble_1985.cellml
annotator name: Chris Thompson
model id: difrancesco_noble_1985
model name: difrancesco_noble_1985

Charge flow rate
type: Class
subclass of: Reference physical property
subclass of: Restriction
  on property: refersTo
  has value: Charge flow rate

Chemical concentration
type: Class
subclass of: Reference physical property
subclass of: Restriction
  on property: refersTo
  has value: Chemical concentration

Electrical potential
type: Class
subclass of: Reference physical property
subclass of: Restriction
  on property: refersTo
  has value: Electrical potential

Sodium/calcium exchanger 2 (Na(+)/Ca(2+)-exchange protein 2) (Solute carrier family 8 member 2) (P48768)
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: Sodium/calcium exchanger 2 (Na(+)/Ca(2+)-exchange protein 2) (Solute carrier family 8 member 2) (P48768)

Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-2) (P50993)
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-2) (P50993)

sodium(1+)
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: sodium(1+)

potassium(1+)
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: potassium(1+)

calcium(2+)
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: calcium(2+)

Portion of extracellular matrix
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: Portion of extracellular matrix

Cardiac myocyte
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: Cardiac myocyte

Junctional sarcoplasmic reticulum of cardiac muscle cell
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: Junctional sarcoplasmic reticulum of cardiac muscle cell

Plasma membrane
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: Plasma membrane

Portion of cytosol
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: Portion of cytosol

Composite physical entity
type: Class
subclass of: Physical entity
disjoint with: Custom physical entity
disjoint with: Reference physical entity
comment: A physical entity that is defined by linking multiple physical entity terms with structural relations.

Computation
type: Class
subclass of: Computational model component
disjoint with: Data structure
comment: A mathematical and/or logical expression that determines the value of a data structure.

Computational model component
type: Class
subclass of: SemSim component
disjoint with: Physical model component
comment: An element of a SemSim model that relates to the mathematical or logical representation of physical quantities or qualities.

Custom physical dependency
type: Class
subclass of: Physical dependency
disjoint with: Reference physical dependency
comment: A physical dependency defined in a specific SemSim model.

Custom physical entity
type: Class
subclass of: Physical entity
comment: A physical entity defined in a specific SemSim model.

Custom physical process
type: Class
subclass of: Physical process
comment: A physical process defined in a specific SemSim model.

Custom physical property
type: Class
subclass of: Physical property
disjoint with: Reference physical property
comment: A physical property defined in a specific SemSim model.

Data structure
type: Class
subclass of: Computational model component
comment: A computational element that stores numerical and/or logical information related to the model.

Decimal
type: Class
subclass of: Real
disjoint with: Integer
comment: A data structure whose value is limited to decimals.

Integer
type: Class
subclass of: Real
comment: A data structure whose value is limited to the whole numbers.

MMLchoice
type: Class
subclass of: Real
comment: A data structure unique to JSim's Mathematical Modeling Language (MML) used to set one or more model input values at runtime.

Physical dependency
type: Class
subclass of: Physical model component
disjoint with: Physical entity
disjoint with: Physical process
disjoint with: Physical property
comment: A quantitative relation between values of physical properties that occurs over a span of time and that determines the time-course of a physical process.

Physical entity
type: Class
subclass of: Physical model component
disjoint with: Physical process
disjoint with: Physical property
comment: A physics analytical entity that represents the material, energy, and/or information content of material or immaterial, space-occupying continuants.

Physical model component
type: Class
subclass of: SemSim component
comment: A SemSim model element used to represent, in whole or in part, the physical meaning of a computational element.

Physical process
type: Class
subclass of: Physical model component
disjoint with: Physical property
comment: A physical processural entity that is a flow, or the control of a flow, of energy and/or information amongst physical continuants that are participants in the physical process.

Physical property
type: Class
subclass of: Physical model component
comment: A physical attribute of an instance of a physical entity, an occurrence of a physical process, or a physical dependency that has a quantitative value that is measurable by a physical device or method, or is computable from such values.

Real
type: Class
subclass of: Data structure
comment: A data structure whose value is limited to the real numbers.

Reference physical dependency
type: Class
subclass of: Physical dependency
comment: A physical dependency that is defined using a term in an external knowledge resource.

Reference physical entity
type: Class
subclass of: Physical entity
comment: A physical entity that is defined using a term from an external knowledge resource.

Reference physical process
type: Class
subclass of: Physical process
comment: A physical process that is defined using a term in an external knowledge resource.

Reference physical property
type: Class
subclass of: Physical property
comment: A physical property that is defined using a term in an external knowledge resource.

Relational constraint
type: Class
subclass of: Computational model component
comment: A logical expression that constrains, but does not define, the value of a data structure. Example: x > 0.

SemSim component
type: Class
comment: A computational or physical element of a SemSim model.

Submodel
type: Class
subclass of: Physical model component
comment: A grouping of one or more data structures that comprise a computationally or physically distinct part of a model or submodel.

Unit of measurement
type: Class
subclass of: Computational model component
comment: A physical quantity chosen as a standard in terms of which other physical quantities may be expressed.

sodium(1+)
type: NamedIndividual
refers to: sodium(1+)
is index entity for: CHEBI 29101 part of Portion of cytosol part of Cardiac myocyte
has physical property: Chemical concentration
part of: Portion of cytosol

sodium(1+)
type: NamedIndividual
refers to: sodium(1+)
is index entity for: CHEBI 29101 part of fma9672
has physical property: Chemical concentration
part of: Portion of extracellular matrix

potassium(1+)
type: NamedIndividual
refers to: potassium(1+)
is index entity for: CHEBI 29103 part of Portion of cytosol part of Cardiac myocyte
part of: Portion of cytosol
has physical property: Chemical concentration

potassium(1+)
type: NamedIndividual
refers to: potassium(1+)
is index entity for: CHEBI 29103 part of Intercellular cleft
part of: Intercellular cleft
has physical property: Chemical concentration

potassium(1+)
type: NamedIndividual
refers to: potassium(1+)
is index entity for: CHEBI 29103 part of fma9672
has physical property: Chemical concentration
part of: Portion of extracellular matrix

calcium(2+)
type: NamedIndividual
refers to: calcium(2+)
is index entity for: CHEBI 29108 part of Portion of cytosol part of Cardiac myocyte
has physical property: Chemical concentration
part of: Portion of cytosol

calcium(2+)
type: NamedIndividual
refers to: calcium(2+)
is index entity for: CHEBI 29108 part of fma9672
has physical property: Chemical concentration
part of: Portion of extracellular matrix

calcium(2+)
type: NamedIndividual
refers to: calcium(2+)
is index entity for: CHEBI 29108 part of Junctional sarcoplasmic reticulum of cardiac muscle cell
part of: Junctional sarcoplasmic reticulum of cardiac muscle cell
has physical property: Chemical concentration

calcium(2+)
type: NamedIndividual
refers to: calcium(2+)
is index entity for: CHEBI 29108 part of Sarcoplasmic reticulum uptake store part of Cardiac myocyte
part of: Sarcoplasmic reticulum uptake store
has physical property: Chemical concentration

Ca background current across plasma membrane of cardiac myocyte
type: NamedIndividual
type: Custom physical process
has source: calcium(2+)
has sink: calcium(2+)
has mediator: Plasma membrane
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: calcium(2+)
annotated source: Ca background current across plasma membrane of cardiac myocyte

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: calcium(2+)
annotated source: Ca background current across plasma membrane of cardiac myocyte

Axiom
has multiplier: 1.0
annotated property: hasMediator
annotated source: Ca background current across plasma membrane of cardiac myocyte
annotated target: Plasma membrane

Ca release from sarcoplasmic reticulum into cytosol of cardiac myocyte
type: NamedIndividual
type: Custom physical process
has sink: calcium(2+)
has source: calcium(2+)
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: calcium(2+)
annotated source: Ca release from sarcoplasmic reticulum into cytosol of cardiac myocyte

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: calcium(2+)
annotated source: Ca release from sarcoplasmic reticulum into cytosol of cardiac myocyte

Ca uptake into the sarcoplasmic reticulum
type: NamedIndividual
type: Custom physical process
has source: calcium(2+)
has sink: calcium(2+)
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: calcium(2+)
annotated source: Ca uptake into the sarcoplasmic reticulum

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: calcium(2+)
annotated source: Ca uptake into the sarcoplasmic reticulum

Cardiac myocyte
type: NamedIndividual
refers to: Cardiac myocyte
has part: Plasma membrane
has part: Portion of cytosol
has part: Sarcoplasmic reticulum uptake store

Delayed rectifier K channel current
type: NamedIndividual
type: Custom physical process
has source: sodium(1+)
has sink: sodium(1+)
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: sodium(1+)
annotated source: Delayed rectifier K channel current

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: sodium(1+)
annotated source: Delayed rectifier K channel current

Fast sodium channel current across plasma membrane
type: NamedIndividual
type: Custom physical process
has sink: sodium(1+)
has source: sodium(1+)
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: sodium(1+)
annotated source: Fast sodium channel current across plasma membrane

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: sodium(1+)
annotated source: Fast sodium channel current across plasma membrane

Hyperpolarising activated channel current
type: NamedIndividual
type: Custom physical process
has sink: sodium(1+)
has source: sodium(1+)
has sink: potassium(1+)
has source: potassium(1+)
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: potassium(1+)
annotated source: Hyperpolarising activated channel current

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: potassium(1+)
annotated source: Hyperpolarising activated channel current

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: sodium(1+)
annotated source: Hyperpolarising activated channel current

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: sodium(1+)
annotated source: Hyperpolarising activated channel current

Hyperpolarizing activated K channel current
type: NamedIndividual
type: Custom physical process
has sink: potassium(1+)
has source: potassium(1+)
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: potassium(1+)
annotated source: Hyperpolarizing activated K channel current

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: potassium(1+)
annotated source: Hyperpolarizing activated K channel current

Hyperpolarizing activated Na channel current
type: NamedIndividual
type: Custom physical process
has sink: sodium(1+)
has source: sodium(1+)
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: sodium(1+)
annotated source: Hyperpolarizing activated Na channel current

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: sodium(1+)
annotated source: Hyperpolarizing activated Na channel current

Intercellular cleft
type: NamedIndividual
type: Custom physical entity
comment: Channel between two tightly packed cell.
has part: potassium(1+)

Junctional sarcoplasmic reticulum of cardiac muscle cell
type: NamedIndividual
refers to: Junctional sarcoplasmic reticulum of cardiac muscle cell
has part: calcium(2+)

K transient outward channel current
type: NamedIndividual
type: Custom physical process
has source: potassium(1+)
has sink: potassium(1+)
has mediator: calcium(2+)
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasMediator
annotated target: calcium(2+)
annotated source: K transient outward channel current

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: potassium(1+)
annotated source: K transient outward channel current

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: potassium(1+)
annotated source: K transient outward channel current

NaCa exchange pump current across plasma membrane
type: NamedIndividual
type: Custom physical process
has sink: sodium(1+)
has source: sodium(1+)
has source: calcium(2+)
has sink: calcium(2+)
has physical property: Charge flow rate
has mediator: Sodium/calcium exchanger 2 (Na(+)/Ca(2+)-exchange protein 2) (Solute carrier family 8 member 2) (P48768)

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: sodium(1+)
annotated source: NaCa exchange pump current across plasma membrane

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: calcium(2+)
annotated source: NaCa exchange pump current across plasma membrane

Axiom
has multiplier: 1.0
annotated property: hasMediator
annotated source: NaCa exchange pump current across plasma membrane
annotated target: Sodium/calcium exchanger 2 (Na(+)/Ca(2+)-exchange protein 2) (Solute carrier family 8 member 2) (P48768)

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: calcium(2+)
annotated source: NaCa exchange pump current across plasma membrane

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: sodium(1+)
annotated source: NaCa exchange pump current across plasma membrane

NaK exchange pump current
type: NamedIndividual
type: Custom physical process
has source: sodium(1+)
has sink: sodium(1+)
has sink: potassium(1+)
has source: potassium(1+)
has mediator: Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-2) (P50993)
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: sodium(1+)
annotated source: NaK exchange pump current

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: potassium(1+)
annotated source: NaK exchange pump current

Axiom
has multiplier: 1.0
annotated property: hasMediator
annotated source: NaK exchange pump current
annotated target: Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-2) (P50993)

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: potassium(1+)
annotated source: NaK exchange pump current

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: sodium(1+)
annotated source: NaK exchange pump current

Na Ca exchanger
type: NamedIndividual
type: Submodel
name: Na_Ca_exchanger
has associated data structure: Na Ca exchanger.Cai
has associated data structure: Na Ca exchanger.Cao
has associated data structure: Na Ca exchanger.E Ca
has associated data structure: Na Ca exchanger.E Na
has associated data structure: Na Ca exchanger.K NaCa
has associated data structure: Na Ca exchanger.Nai
has associated data structure: Na Ca exchanger.Nao
has associated data structure: Na Ca exchanger.RTONF
has associated data structure: Na Ca exchanger.V
has associated data structure: Na Ca exchanger.d NaCa
has associated data structure: Na Ca exchanger.gamma
has associated data structure: Na Ca exchanger.i NaCa
has associated data structure: Na Ca exchanger.n NaCa
has associated data structure: Na Ca exchanger.time
has computational component: Na Ca exchanger computation

Na Ca exchanger.Cai
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Intracellular Ca concentration
is computational component for: Chemical concentration
has unit: UNIT millimolar

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: Na Ca exchanger.Cai

Na Ca exchanger.Cao
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Extracellular calcium concentration
is computational component for: Chemical concentration
has unit: UNIT millimolar

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: Na Ca exchanger.Cao

Na Ca exchanger.E Ca
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Calcium equilibrium potential
is computational component for: Electrical potential
has unit: UNIT millivolt

Electrical potential
type: NamedIndividual
refers to: Electrical potential
has computational component: Na Ca exchanger.E Ca

Na Ca exchanger.E Na
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Sodium equilibrium potential
is computational component for: Na Ca exchanger.E Na property
has unit: UNIT millivolt

Na Ca exchanger.K NaCa
type: NamedIndividual
type: Decimal
has start value: 0.02
is solution domain: false
is discrete: false
is declared: true
comment: scaling factor for i_NaCa
is computational component for: Na Ca exchanger.K NaCa property
has unit: UNIT nanoA

Na Ca exchanger.Nai
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Intracellular Na concentration
is computational component for: Chemical concentration
has unit: UNIT millimolar

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: Na Ca exchanger.Nai

Na Ca exchanger.Nao
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Extracellular sodium concentration
is computational component for: Chemical concentration
has unit: UNIT millimolar

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: Na Ca exchanger.Nao

Na Ca exchanger.RTONF
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
is computational component for: Na Ca exchanger.RTONF property
has unit: UNIT millivolt

Na Ca exchanger.V
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Cardiac myocyte membrane potential
is computational component for: Electrical potential
has unit: UNIT millivolt

Electrical potential
type: NamedIndividual
refers to: Electrical potential
has computational component: Na Ca exchanger.V
physical property of: Plasma membrane

Na Ca exchanger.d NaCa
type: NamedIndividual
type: Decimal
has start value: 0.001
is solution domain: false
is discrete: false
is declared: true
comment: Denominator constant for i_NaCa
is computational component for: Na Ca exchanger.d NaCa property

Na Ca exchanger.gamma
type: NamedIndividual
type: Decimal
has start value: 0.5
is solution domain: false
is discrete: false
is declared: true
comment: Position of energy barrier controlling voltage-dependence of i_NaCa
is computational component for: Na Ca exchanger.gamma property

Na Ca exchanger.i NaCa
type: NamedIndividual
type: Decimal
metadata ID: Na_Ca_exchanger_i_NaCa
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Na-Ca exchange current
is computational component for: Charge flow rate
has unit: UNIT nanoA
mapped to: intracellular calcium concentration.i NaCa
mapped to: intracellular sodium concentration.i NaCa
mapped to: membrane.i NaCa

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: NaCa exchange pump current across plasma membrane
has computational component: Na Ca exchanger.i NaCa

Na Ca exchanger.n NaCa
type: NamedIndividual
type: Decimal
has start value: 3
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Stoichiometry of Na-Ca exchange
is computational component for: Na Ca exchanger.n NaCa property
mapped to: intracellular calcium concentration.n NaCa
mapped to: intracellular sodium concentration.n NaCa

Na Ca exchanger.time
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
is computational component for: Na Ca exchanger.time property
has unit: UNIT second

Na Ca exchanger computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>i_NaCa</ci> <apply> <divide /> <apply> <times /> <ci>K_NaCa</ci> <apply> <minus /> <apply> <times /> <apply> <exp /> <apply> <divide /> <apply> <times /> <ci>gamma</ci> <apply> <minus /> <ci>n_NaCa</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> </apply> <ci>V</ci> </apply> <ci>RTONF</ci> </apply> </apply> <apply> <power /> <ci>Nai</ci> <ci>n_NaCa</ci> </apply> <ci>Cao</ci> </apply> <apply> <times /> <apply> <exp /> <apply> <divide /> <apply> <times /> <apply> <minus /> <ci>gamma</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> </apply> <apply> <minus /> <ci>n_NaCa</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> </apply> <ci>V</ci> </apply> <ci>RTONF</ci> </apply> </apply> <apply> <power /> <ci>Nao</ci> <ci>n_NaCa</ci> </apply> <ci>Cai</ci> </apply> </apply> </apply> <apply> <times /> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar4">1</cn> <apply> <times /> <ci>d_NaCa</ci> <apply> <plus /> <apply> <times /> <ci>Cai</ci> <apply> <power /> <ci>Nao</ci> <ci>n_NaCa</ci> </apply> </apply> <apply> <times /> <ci>Cao</ci> <apply> <power /> <ci>Nai</ci> <ci>n_NaCa</ci> </apply> </apply> </apply> </apply> </apply> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <divide /> <ci>Cai</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.0069</cn> </apply> </apply> </apply> </apply> </apply>
is computational component for: Na Ca exchanger

Na background current across plasma membrane of cardiac myocyte
type: NamedIndividual
type: Custom physical process
has source: sodium(1+)
has sink: sodium(1+)
has mediator: Plasma membrane
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasMediator
annotated source: Na background current across plasma membrane of cardiac myocyte
annotated target: Plasma membrane

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: sodium(1+)
annotated source: Na background current across plasma membrane of cardiac myocyte

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: sodium(1+)
annotated source: Na background current across plasma membrane of cardiac myocyte

Sodium/calcium exchanger 2 (Na(+)/Ca(2+)-exchange protein 2) (Solute carrier family 8 member 2) (P48768)
type: NamedIndividual
refers to: Sodium/calcium exchanger 2 (Na(+)/Ca(2+)-exchange protein 2) (Solute carrier family 8 member 2) (P48768)
is index entity for: P48768 part of Plasma membrane part of Cardiac myocyte
part of: Plasma membrane

Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-2) (P50993)
type: NamedIndividual
refers to: Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-2) (P50993)
is index entity for: P50993 part of Plasma membrane part of Cardiac myocyte
part of: Plasma membrane

Plasma membrane
type: NamedIndividual
refers to: Plasma membrane
part of: Cardiac myocyte
has physical property: Electrical potential
has part: Sodium/calcium exchanger 2 (Na(+)/Ca(2+)-exchange protein 2) (Solute carrier family 8 member 2) (P48768)
has part: Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-2) (P50993)
is index entity for: Plasma membrane part of Cardiac myocyte

Portion of cytosol
type: NamedIndividual
refers to: Portion of cytosol
has part: sodium(1+)
has part: potassium(1+)
has part: calcium(2+)
part of: Cardiac myocyte
is index entity for: Portion of cytosol part of Cardiac myocyte

Sarcoplasmic Ca transfer current
type: NamedIndividual
type: Custom physical process
has sink: calcium(2+)
has source: calcium(2+)
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: calcium(2+)
annotated source: Sarcoplasmic Ca transfer current

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: calcium(2+)
annotated source: Sarcoplasmic Ca transfer current

Sarcoplasmic reticulum uptake store
type: NamedIndividual
type: Custom physical entity
has part: calcium(2+)
part of: Cardiac myocyte
is index entity for: Sarcoplasmic reticulum uptake store part of Cardiac myocyte

Secondary Ca channel inward current
type: NamedIndividual
type: Custom physical process
has sink: calcium(2+)
has source: calcium(2+)
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: calcium(2+)
annotated source: Secondary Ca channel inward current

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: calcium(2+)
annotated source: Secondary Ca channel inward current

Secondary K channel inward current
type: NamedIndividual
type: Custom physical process
has sink: potassium(1+)
has source: potassium(1+)
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: potassium(1+)
annotated source: Secondary K channel inward current

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: potassium(1+)
annotated source: Secondary K channel inward current

Secondary Na channel inward current
type: NamedIndividual
type: Custom physical process
has sink: sodium(1+)
has source: sodium(1+)
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: sodium(1+)
annotated source: Secondary Na channel inward current

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: sodium(1+)
annotated source: Secondary Na channel inward current

Secondary channel inward current
type: NamedIndividual
type: Custom physical process
has sink: sodium(1+)
has source: sodium(1+)
has sink: potassium(1+)
has source: potassium(1+)
has sink: calcium(2+)
has source: calcium(2+)
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: potassium(1+)
annotated source: Secondary channel inward current

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: calcium(2+)
annotated source: Secondary channel inward current

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: potassium(1+)
annotated source: Secondary channel inward current

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: calcium(2+)
annotated source: Secondary channel inward current

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: sodium(1+)
annotated source: Secondary channel inward current

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: sodium(1+)
annotated source: Secondary channel inward current

Time independent K channel current
type: NamedIndividual
type: Custom physical process
has source: potassium(1+)
has sink: potassium(1+)
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: potassium(1+)
annotated source: Time independent K channel current

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: potassium(1+)
annotated source: Time independent K channel current

UNIT ampere
type: NamedIndividual
type: Unit of measurement
has computational code: ampere
is fundamental unit: true
unit factor for: UNIT nanoA

UNIT coulomb
type: NamedIndividual
type: Unit of measurement
has computational code: coulomb
is fundamental unit: true
unit factor for: UNIT coulomb per mole

UNIT coulomb per mole
type: NamedIndividual
type: Unit of measurement
has computational code: coulomb_per_mole
has unit factor: UNIT coulomb
has unit factor: UNIT mole
unit for: extracellular potassium concentration.F
unit for: intracellular calcium concentration.F
unit for: intracellular potassium concentration.F
unit for: intracellular sodium concentration.F
unit for: membrane.F

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT coulomb per mole
annotated target: UNIT mole

UNIT farad
type: NamedIndividual
type: Unit of measurement
has computational code: farad
is fundamental unit: true
unit factor for: UNIT microF

UNIT joule
type: NamedIndividual
type: Unit of measurement
has computational code: joule
is fundamental unit: true
unit factor for: UNIT joule per kilomole kelvin

UNIT joule per kilomole kelvin
type: NamedIndividual
type: Unit of measurement
has computational code: joule_per_kilomole_kelvin
has unit factor: UNIT joule
has unit factor: UNIT kelvin
has unit factor: UNIT mole
unit for: membrane.R

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT joule per kilomole kelvin
annotated target: UNIT kelvin

Axiom
has unit factor exponent: -1.0
has unit factor prefix: kilo
annotated property: hasUnitFactor
annotated source: UNIT joule per kilomole kelvin
annotated target: UNIT mole

UNIT kelvin
type: NamedIndividual
type: Unit of measurement
has computational code: kelvin
is fundamental unit: true
unit factor for: UNIT joule per kilomole kelvin
unit for: membrane.T

UNIT litre
type: NamedIndividual
type: Unit of measurement
has computational code: litre
is fundamental unit: true
unit factor for: UNIT millimolar

UNIT metre
type: NamedIndividual
type: Unit of measurement
has computational code: metre
is fundamental unit: true
unit factor for: UNIT micrometre
unit factor for: UNIT micrometre3

UNIT microF
type: NamedIndividual
type: Unit of measurement
has computational code: microF
has unit factor: UNIT farad
unit for: membrane.C

Axiom
has unit factor prefix: micro
annotated property: hasUnitFactor
annotated target: UNIT farad
annotated source: UNIT microF

UNIT microS
type: NamedIndividual
type: Unit of measurement
has computational code: microS
unit factor for: UNIT microS per millimolar
has unit factor: UNIT siemens
unit for: calcium background current.g Cab
unit for: fast sodium current.g Na
unit for: hyperpolarising activated current.g f K
unit for: hyperpolarising activated current.g f Na
unit for: sodium background current.g Nab
unit for: time independent potassium current.g K1

Axiom
has unit factor prefix: micro
annotated property: hasUnitFactor
annotated source: UNIT microS
annotated target: UNIT siemens

UNIT microS per millimolar
type: NamedIndividual
type: Unit of measurement
has computational code: microS_per_millimolar
has unit factor: UNIT microS
has unit factor: UNIT millimolar
unit for: transient outward current.g to

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT microS per millimolar
annotated target: UNIT millimolar

UNIT micrometre
type: NamedIndividual
type: Unit of measurement
has computational code: micrometre
has unit factor: UNIT metre
unit for: intracellular sodium concentration.length
unit for: intracellular sodium concentration.radius

Axiom
has unit factor prefix: micro
annotated property: hasUnitFactor
annotated target: UNIT metre
annotated source: UNIT micrometre

UNIT micrometre3
type: NamedIndividual
type: Unit of measurement
has computational code: micrometre3
has unit factor: UNIT metre
unit for: extracellular potassium concentration.Ve
unit for: intracellular calcium concentration.V rel
unit for: intracellular calcium concentration.V up
unit for: intracellular calcium concentration.Vi
unit for: intracellular potassium concentration.Vi
unit for: intracellular sodium concentration.V Cell
unit for: intracellular sodium concentration.Vi

Axiom
has unit factor exponent: 3.0
has unit factor prefix: micro
annotated property: hasUnitFactor
annotated target: UNIT metre
annotated source: UNIT micrometre3

UNIT millimolar
type: NamedIndividual
type: Unit of measurement
has computational code: millimolar
unit for: Na Ca exchanger.Cai
unit for: Na Ca exchanger.Cao
unit for: Na Ca exchanger.Nai
unit for: Na Ca exchanger.Nao
has unit factor: UNIT litre
unit factor for: UNIT microS per millimolar
has unit factor: UNIT mole
unit factor for: UNIT nanoA per millimolar
unit for: calcium background current.Cai
unit for: calcium background current.Cao
unit for: extracellular calcium concentration.Cao
unit for: extracellular potassium concentration.Kb
unit for: extracellular potassium concentration.Kc
unit for: extracellular sodium concentration.Nao
unit for: fast sodium current.Kc
unit for: fast sodium current.Ki
unit for: fast sodium current.Nai
unit for: fast sodium current.Nao
unit for: hyperpolarising activated current.Kc
unit for: hyperpolarising activated current.Ki
unit for: hyperpolarising activated current.Km f
unit for: hyperpolarising activated current.Nai
unit for: hyperpolarising activated current.Nao
unit for: intracellular calcium concentration.Ca rel
unit for: intracellular calcium concentration.Ca up
unit for: intracellular calcium concentration.Ca up max
unit for: intracellular calcium concentration.Cai
unit for: intracellular calcium concentration.K mCa
unit for: intracellular potassium concentration.Ki
unit for: intracellular sodium concentration.Nai
unit for: second inward current.Cai
unit for: second inward current.Cao
unit for: second inward current.Kc
unit for: second inward current.Ki
unit for: second inward current.Nai
unit for: second inward current.Nao
unit for: second inward current f2 gate.Cai
unit for: second inward current f2 gate.K mf2
unit for: sodium potassium pump.K mK
unit for: sodium potassium pump.K mNa
unit for: sodium potassium pump.Kc
unit for: sodium potassium pump.Nai
unit for: time dependent potassium current.Kc
unit for: time dependent potassium current.Ki
unit for: time independent potassium current.Kc
unit for: time independent potassium current.Km K1
unit for: transient outward current.Cai
unit for: transient outward current.Kc
unit for: transient outward current.Ki
unit for: transient outward current.Km Ca
unit for: transient outward current.Km to

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated target: UNIT litre
annotated source: UNIT millimolar

Axiom
has unit factor prefix: milli
annotated property: hasUnitFactor
annotated source: UNIT millimolar
annotated target: UNIT mole

UNIT millivolt
type: NamedIndividual
type: Unit of measurement
has computational code: millivolt
unit for: Na Ca exchanger.E Ca
unit for: Na Ca exchanger.E Na
unit for: Na Ca exchanger.RTONF
unit for: Na Ca exchanger.V
has unit factor: UNIT volt
unit for: calcium background current.E Ca
unit for: calcium background current.RTONF
unit for: calcium background current.V
unit for: fast sodium current.E mh
unit for: fast sodium current.RTONF
unit for: fast sodium current.V
unit for: fast sodium current h gate.V
unit for: fast sodium current m gate.E0 m
unit for: fast sodium current m gate.V
unit for: fast sodium current m gate.delta m
unit for: hyperpolarising activated current.E K
unit for: hyperpolarising activated current.E Na
unit for: hyperpolarising activated current.RTONF
unit for: hyperpolarising activated current.V
unit for: hyperpolarising activated current y gate.E0 y
unit for: hyperpolarising activated current y gate.V
unit for: hyperpolarising activated current y gate.delta y
unit for: intracellular calcium concentration.V
unit for: membrane.RTONF
unit for: membrane.V
unit for: second inward current.RTONF
unit for: second inward current.V
unit for: second inward current d gate.E0 d
unit for: second inward current d gate.V
unit for: second inward current d gate.delta d
unit for: second inward current f2 gate.V
unit for: second inward current f gate.E0 f
unit for: second inward current f gate.V
unit for: second inward current f gate.delta f
unit for: sodium background current.E Na
unit for: sodium background current.V
unit for: sodium potassium pump.V
unit for: time dependent potassium current.RTONF
unit for: time dependent potassium current.V
unit for: time dependent potassium current x gate.V
unit for: time independent potassium current.E K
unit for: time independent potassium current.RTONF
unit for: time independent potassium current.V
unit for: transient outward current.RTONF
unit for: transient outward current.V
unit for: transient outward current s gate.V

Axiom
has unit factor prefix: milli
annotated property: hasUnitFactor
annotated source: UNIT millivolt
annotated target: UNIT volt

UNIT mole
type: NamedIndividual
type: Unit of measurement
has computational code: mole
is fundamental unit: true
unit factor for: UNIT coulomb per mole
unit factor for: UNIT joule per kilomole kelvin
unit factor for: UNIT millimolar

UNIT nanoA
type: NamedIndividual
type: Unit of measurement
has computational code: nanoA
unit for: Na Ca exchanger.K NaCa
unit for: Na Ca exchanger.i NaCa
has unit factor: UNIT ampere
unit factor for: UNIT nanoA per millimolar
unit for: calcium background current.i Ca b
unit for: extracellular potassium concentration.i K
unit for: extracellular potassium concentration.i K1
unit for: extracellular potassium concentration.i fK
unit for: extracellular potassium concentration.i mK
unit for: extracellular potassium concentration.i p
unit for: extracellular potassium concentration.i siK
unit for: extracellular potassium concentration.i to
unit for: fast sodium current.i Na
unit for: hyperpolarising activated current.i f
unit for: hyperpolarising activated current.i fK
unit for: hyperpolarising activated current.i fNa
unit for: intracellular calcium concentration.i Ca b
unit for: intracellular calcium concentration.i NaCa
unit for: intracellular calcium concentration.i rel
unit for: intracellular calcium concentration.i siCa
unit for: intracellular calcium concentration.i tr
unit for: intracellular calcium concentration.i up
unit for: intracellular potassium concentration.i mK
unit for: intracellular sodium concentration.i Na
unit for: intracellular sodium concentration.i NaCa
unit for: intracellular sodium concentration.i Na b
unit for: intracellular sodium concentration.i fNa
unit for: intracellular sodium concentration.i p
unit for: intracellular sodium concentration.i siNa
unit for: membrane.i Ca b
unit for: membrane.i K
unit for: membrane.i K1
unit for: membrane.i Na
unit for: membrane.i NaCa
unit for: membrane.i Na b
unit for: membrane.i f
unit for: membrane.i p
unit for: membrane.i pulse
unit for: membrane.i si
unit for: membrane.i to
unit for: second inward current.i si
unit for: second inward current.i siCa
unit for: second inward current.i siK
unit for: second inward current.i siNa
unit for: sodium background current.i Na b
unit for: sodium potassium pump.I p
unit for: sodium potassium pump.i p
unit for: time dependent potassium current.I K
unit for: time dependent potassium current.i K
unit for: time dependent potassium current.i K max
unit for: time independent potassium current.i K1
unit for: transient outward current.i to

Axiom
has unit factor prefix: nano
annotated property: hasUnitFactor
annotated target: UNIT ampere
annotated source: UNIT nanoA

UNIT nanoA per millimolar
type: NamedIndividual
type: Unit of measurement
has computational code: nanoA_per_millimolar
has unit factor: UNIT millimolar
has unit factor: UNIT nanoA
unit for: second inward current.P si

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated target: UNIT millimolar
annotated source: UNIT nanoA per millimolar

UNIT per second
type: NamedIndividual
type: Unit of measurement
has computational code: per_second
has unit factor: UNIT second
unit for: extracellular potassium concentration.pf
unit for: fast sodium current h gate.alpha h
unit for: fast sodium current h gate.beta h
unit for: fast sodium current m gate.alpha m
unit for: fast sodium current m gate.beta m
unit for: hyperpolarising activated current y gate.alpha y
unit for: hyperpolarising activated current y gate.beta y
unit for: intracellular calcium concentration.alpha p
unit for: intracellular calcium concentration.beta p
unit for: second inward current d gate.alpha d
unit for: second inward current d gate.beta d
unit for: second inward current f2 gate.alpha f2
unit for: second inward current f2 gate.beta f2
unit for: second inward current f gate.alpha f
unit for: second inward current f gate.beta f
unit for: time dependent potassium current x gate.alpha x
unit for: time dependent potassium current x gate.beta x
unit for: transient outward current s gate.alpha s
unit for: transient outward current s gate.beta s

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT per second
annotated target: UNIT second

UNIT second
type: NamedIndividual
type: Unit of measurement
has computational code: second
is fundamental unit: true
unit for: Na Ca exchanger.time
unit factor for: UNIT per second
unit for: calcium background current.time
unit for: environment.time
unit for: extracellular potassium concentration.time
unit for: fast sodium current.time
unit for: fast sodium current h gate.time
unit for: fast sodium current m gate.time
unit for: hyperpolarising activated current.time
unit for: hyperpolarising activated current y gate.time
unit for: intracellular calcium concentration.tau rel
unit for: intracellular calcium concentration.tau rep
unit for: intracellular calcium concentration.tau up
unit for: intracellular calcium concentration.time
unit for: intracellular potassium concentration.time
unit for: intracellular sodium concentration.time
unit for: membrane.time
unit for: second inward current.time
unit for: second inward current d gate.time
unit for: second inward current f2 gate.time
unit for: second inward current f gate.time
unit for: sodium background current.time
unit for: sodium potassium pump.time
unit for: time dependent potassium current.time
unit for: time dependent potassium current x gate.time
unit for: time independent potassium current.time
unit for: transient outward current.time
unit for: transient outward current s gate.time

UNIT siemens
type: NamedIndividual
type: Unit of measurement
has computational code: siemens
is fundamental unit: true
unit factor for: UNIT microS

UNIT volt
type: NamedIndividual
type: Unit of measurement
is fundamental unit: true
has computational code: volt
unit factor for: UNIT millivolt

calcium background current
type: NamedIndividual
type: Submodel
name: calcium_background_current
has associated data structure: calcium background current.Cai
has associated data structure: calcium background current.Cao
has associated data structure: calcium background current.E Ca
has associated data structure: calcium background current.RTONF
has associated data structure: calcium background current.V
has associated data structure: calcium background current.g Cab
has associated data structure: calcium background current.i Ca b
has associated data structure: calcium background current.time
has computational component: calcium background current computation

calcium background current.Cai
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Intracellular Ca concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: calcium background current.Cai

calcium background current.Cao
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Extracellular calcium concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: calcium background current.Cao

calcium background current.E Ca
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Calcium equilibrium potential
mapped to: Na Ca exchanger.E Ca
has unit: UNIT millivolt
is computational component for: calcium background current.E Ca property

calcium background current.RTONF
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
has unit: UNIT millivolt
is computational component for: calcium background current.RTONF property

calcium background current.V
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: calcium background current.V

calcium background current.g Cab
type: NamedIndividual
type: Decimal
has start value: 0.02
is solution domain: false
is discrete: false
is declared: true
comment: Calcium background conductance
has unit: UNIT microS
is computational component for: calcium background current.g Cab property

calcium background current.i Ca b
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Calcium background current
has unit: UNIT nanoA
is computational component for: Charge flow rate
mapped to: intracellular calcium concentration.i Ca b
mapped to: membrane.i Ca b

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Ca background current across plasma membrane of cardiac myocyte
has computational component: calcium background current.i Ca b

calcium background current.time
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: calcium background current.time property

calcium background current computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>E_Ca</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.5</cn> <ci>RTONF</ci> <apply> <ln /> <apply> <divide /> <ci>Cao</ci> <ci>Cai</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>i_Ca_b</ci> <apply> <times /> <ci>g_Cab</ci> <apply> <minus /> <ci>V</ci> <ci>E_Ca</ci> </apply> </apply> </apply>
is computational component for: calcium background current

environment
type: NamedIndividual
type: Submodel
name: environment
has associated data structure: environment.time
has computational component: environment computation

environment.time
type: NamedIndividual
type: Decimal
metadata ID: environment_time
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Time solution domain
mapped to: Na Ca exchanger.time
has unit: UNIT second
mapped to: calcium background current.time
is computational component for: environment.time property
mapped to: extracellular potassium concentration.time
mapped to: fast sodium current.time
mapped to: hyperpolarising activated current.time
mapped to: intracellular calcium concentration.time
mapped to: intracellular potassium concentration.time
mapped to: intracellular sodium concentration.time
mapped to: membrane.time
mapped to: second inward current.time
mapped to: sodium background current.time
mapped to: sodium potassium pump.time
mapped to: time dependent potassium current.time
mapped to: time independent potassium current.time
mapped to: transient outward current.time

extracellular calcium concentration
type: NamedIndividual
type: Submodel
name: extracellular_calcium_concentration
has associated data structure: extracellular calcium concentration.Cao
has computational component: extracellular calcium concentration computation

extracellular calcium concentration.Cao
type: NamedIndividual
type: Decimal
has start value: 2
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Extracellular calcium concentration
mapped to: Na Ca exchanger.Cao
has unit: UNIT millimolar
mapped to: calcium background current.Cao
is computational component for: Chemical concentration
mapped to: second inward current.Cao

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: extracellular calcium concentration.Cao

extracellular potassium concentration
type: NamedIndividual
type: Submodel
name: extracellular_potassium_concentration
has associated data structure: extracellular potassium concentration.F
has associated data structure: extracellular potassium concentration.Kb
has associated data structure: extracellular potassium concentration.Kc
has associated data structure: extracellular potassium concentration.Ve
has associated data structure: extracellular potassium concentration.i K
has associated data structure: extracellular potassium concentration.i K1
has associated data structure: extracellular potassium concentration.i fK
has associated data structure: extracellular potassium concentration.i mK
has associated data structure: extracellular potassium concentration.i p
has associated data structure: extracellular potassium concentration.i siK
has associated data structure: extracellular potassium concentration.i to
has associated data structure: extracellular potassium concentration.pf
has associated data structure: extracellular potassium concentration.time
has computational component: extracellular potassium concentration computation

extracellular potassium concentration.F
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Faraday Constant
has unit: UNIT coulomb per mole
is computational component for: extracellular potassium concentration.F property

extracellular potassium concentration.Kb
type: NamedIndividual
type: Decimal
has start value: 4
is solution domain: false
is discrete: false
is declared: true
comment: Bulk extracellular potassium
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: potassium(1+)
has computational component: extracellular potassium concentration.Kb

extracellular potassium concentration.Kc
type: NamedIndividual
type: Decimal
has start value: 4
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Potassium concentration in the extracellular cleft
has unit: UNIT millimolar
is computational component for: Chemical concentration
mapped to: fast sodium current.Kc
mapped to: hyperpolarising activated current.Kc
mapped to: second inward current.Kc
mapped to: sodium potassium pump.Kc
mapped to: time dependent potassium current.Kc
mapped to: time independent potassium current.Kc
mapped to: transient outward current.Kc

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: potassium(1+)
has computational component: extracellular potassium concentration.Kc

extracellular potassium concentration.Ve
type: NamedIndividual
type: Decimal
has start value: 0.00157
is solution domain: false
is discrete: false
is declared: true
comment: Total extracellular volume
has unit: UNIT micrometre3
is computational component for: extracellular potassium concentration.Ve property

extracellular potassium concentration.i K
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Delayed K current
has unit: UNIT nanoA
is computational component for: Charge flow rate

extracellular potassium concentration.i K1
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Time independent K current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Time independent K channel current
has computational component: extracellular potassium concentration.i K1

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Delayed rectifier K channel current
has computational component: extracellular potassium concentration.i K

extracellular potassium concentration.i fK
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: K component of hyperpolarising activated current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Hyperpolarizing activated K channel current
has computational component: extracellular potassium concentration.i fK

extracellular potassium concentration.i mK
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Net membrane potassium flux
has unit: UNIT nanoA
is computational component for: extracellular potassium concentration.i mK property
mapped to: intracellular potassium concentration.i mK

extracellular potassium concentration.i p
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: NaK exchange pump current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: NaK exchange pump current
has computational component: extracellular potassium concentration.i p

extracellular potassium concentration.i siK
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Potassium component of fast Ca current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Secondary K channel inward current
has computational component: extracellular potassium concentration.i siK

extracellular potassium concentration.i to
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Transient outward current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: K transient outward channel current
has computational component: extracellular potassium concentration.i to

extracellular potassium concentration.pf
type: NamedIndividual
type: Decimal
has start value: 0.7
is solution domain: false
is discrete: false
is declared: true
comment: Rate constant for K exchange between bulk and cleft space
has unit: UNIT per second
is computational component for: extracellular potassium concentration.pf property

extracellular potassium concentration.time
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: extracellular potassium concentration.time property

extracellular potassium concentration computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>i_mK</ci> <apply> <minus /> <apply> <plus /> <ci>i_K1</ci> <ci>i_K</ci> <ci>i_fK</ci> <ci>i_siK</ci> <ci>i_to</ci> </apply> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> <ci>i_p</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>Kc</ci> </apply> <apply> <plus /> <apply> <times /> <apply> <minus /> <ci>pf</ci> </apply> <apply> <minus /> <ci>Kc</ci> <ci>Kb</ci> </apply> </apply> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mA_nA">1</cn> <ci>i_mK</ci> </apply> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="litre_micrometre3">1</cn> <ci>Ve</ci> <ci>F</ci> </apply> </apply> </apply> </apply>
is computational component for: extracellular potassium concentration

extracellular sodium concentration
type: NamedIndividual
type: Submodel
name: extracellular_sodium_concentration
has associated data structure: extracellular sodium concentration.Nao
has computational component: extracellular sodium concentration computation

extracellular sodium concentration.Nao
type: NamedIndividual
type: Decimal
has start value: 140
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Extracellular sodium concentration
mapped to: Na Ca exchanger.Nao
has unit: UNIT millimolar
is computational component for: Chemical concentration
mapped to: fast sodium current.Nao
mapped to: hyperpolarising activated current.Nao
mapped to: second inward current.Nao

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: extracellular sodium concentration.Nao

fast sodium current
type: NamedIndividual
type: Submodel
name: fast_sodium_current
has associated data structure: fast sodium current.E mh
has associated data structure: fast sodium current.Kc
has associated data structure: fast sodium current.Ki
has associated data structure: fast sodium current.Nai
has associated data structure: fast sodium current.Nao
has associated data structure: fast sodium current.RTONF
has associated data structure: fast sodium current.V
has associated data structure: fast sodium current.g Na
has associated data structure: fast sodium current.h
has associated data structure: fast sodium current.i Na
has associated data structure: fast sodium current.m
has associated data structure: fast sodium current.time
has computational component: fast sodium current computation
includes submodel: fast sodium current h gate
includes submodel: fast sodium current m gate

Axiom
submodel subsumption type: containment
submodel subsumption type: encapsulation
annotated property: includesSubmodel
annotated source: fast sodium current
annotated target: fast sodium current h gate

Axiom
submodel subsumption type: containment
submodel subsumption type: encapsulation
annotated property: includesSubmodel
annotated source: fast sodium current
annotated target: fast sodium current m gate

fast sodium current.E mh
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
is declared: true
comment: Reversal potential for sodium channel
has unit: UNIT millivolt
is computational component for: fast sodium current.E mh property

fast sodium current.Kc
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Potassium concentration in the extracellular cleft
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: potassium(1+)
has computational component: fast sodium current.Kc

fast sodium current.Ki
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Potassium intracellular concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: potassium(1+)
has computational component: fast sodium current.Ki

fast sodium current.Nai
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Intracellular Na concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: fast sodium current.Nai

fast sodium current.Nao
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Extracellular sodium concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: fast sodium current.Nao

fast sodium current.RTONF
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
has unit: UNIT millivolt
is computational component for: fast sodium current.RTONF property

fast sodium current.V
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
has cell m lprivate interface: out
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential
mapped to: fast sodium current h gate.V
mapped to: fast sodium current m gate.V

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: fast sodium current.V

fast sodium current.g Na
type: NamedIndividual
type: Decimal
has start value: 750
is solution domain: false
is discrete: false
is declared: true
comment: Conductance of fast sodium current channels
has unit: UNIT microS
is computational component for: fast sodium current.g Na property

fast sodium current.h
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lprivate interface: in
is declared: true
comment: Gating variable for h gate
is computational component for: fast sodium current.h property

fast sodium current.i Na
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: TTX sensittive fast Na current
has unit: UNIT nanoA
is computational component for: Charge flow rate
mapped to: intracellular sodium concentration.i Na
mapped to: membrane.i Na

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Fast sodium channel current across plasma membrane
has computational component: fast sodium current.i Na

fast sodium current.m
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lprivate interface: in
is declared: true
comment: Activation gate and rate coefficient
is computational component for: fast sodium current.m property

fast sodium current.time
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
has cell m lprivate interface: out
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: fast sodium current.time property
mapped to: fast sodium current h gate.time
mapped to: fast sodium current m gate.time

fast sodium current computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>E_mh</ci> <apply> <times /> <ci>RTONF</ci> <apply> <ln /> <apply> <divide /> <apply> <plus /> <ci>Nao</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.12</cn> <ci>Kc</ci> </apply> </apply> <apply> <plus /> <ci>Nai</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.12</cn> <ci>Ki</ci> </apply> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>i_Na</ci> <apply> <times /> <ci>g_Na</ci> <apply> <power /> <ci>m</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn> </apply> <ci>h</ci> <apply> <minus /> <ci>V</ci> <ci>E_mh</ci> </apply> </apply> </apply>
is computational component for: fast sodium current

fast sodium current h gate
type: NamedIndividual
type: Submodel
name: fast_sodium_current_h_gate
has associated data structure: fast sodium current h gate.V
has associated data structure: fast sodium current h gate.alpha h
has associated data structure: fast sodium current h gate.beta h
has associated data structure: fast sodium current h gate.h
has associated data structure: fast sodium current h gate.time
has computational component: fast sodium current h gate computation

fast sodium current h gate.V
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: fast sodium current h gate.V

fast sodium current h gate.alpha h
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
is declared: true
comment: Inactivation gate and rate coefficient
has unit: UNIT per second
is computational component for: fast sodium current h gate.alpha h property

fast sodium current h gate.beta h
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Inactivation gate and rate coefficient
has unit: UNIT per second
is computational component for: fast sodium current h gate.beta h property

fast sodium current h gate.h
type: NamedIndividual
type: Decimal
has start value: 0.8
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Gating variable for h gate
mapped to: fast sodium current.h
is computational component for: fast sodium current h gate.h property

fast sodium current h gate.time
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: fast sodium current h gate.time property

fast sodium current h gate computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>alpha_h</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">20</cn> <apply> <exp /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.125</cn> </apply> <apply> <plus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">75</cn> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>beta_h</ci> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">2000</cn> <apply> <plus /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">320</cn> <apply> <exp /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn> </apply> <apply> <plus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">75</cn> </apply> </apply> </apply> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>h</ci> </apply> <apply> <minus /> <apply> <times /> <ci>alpha_h</ci> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <ci>h</ci> </apply> </apply> <apply> <times /> <ci>beta_h</ci> <ci>h</ci> </apply> </apply> </apply>
is computational component for: fast sodium current h gate

fast sodium current m gate
type: NamedIndividual
type: Submodel
name: fast_sodium_current_m_gate
has associated data structure: fast sodium current m gate.E0 m
has associated data structure: fast sodium current m gate.V
has associated data structure: fast sodium current m gate.alpha m
has associated data structure: fast sodium current m gate.beta m
has associated data structure: fast sodium current m gate.delta m
has associated data structure: fast sodium current m gate.m
has associated data structure: fast sodium current m gate.time
has computational component: fast sodium current m gate computation

fast sodium current m gate.E0 m
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
has unit: UNIT millivolt
is computational component for: fast sodium current m gate.E0 m property

fast sodium current m gate.V
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: fast sodium current m gate.V

fast sodium current m gate.alpha m
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Activation gate and rate coefficient
has unit: UNIT per second
is computational component for: fast sodium current m gate.alpha m property

fast sodium current m gate.beta m
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Activation gate and rate coefficient
has unit: UNIT per second
is computational component for: fast sodium current m gate.beta m property

fast sodium current m gate.delta m
type: NamedIndividual
type: Decimal
has start value: 1e-5
is solution domain: false
is discrete: false
is declared: true
has unit: UNIT millivolt
is computational component for: fast sodium current m gate.delta m property

fast sodium current m gate.m
type: NamedIndividual
type: Decimal
has start value: 0.01
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Activation gate and rate coefficient
mapped to: fast sodium current.m
is computational component for: fast sodium current m gate.m property

fast sodium current m gate.time
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: fast sodium current m gate.time property

fast sodium current m gate computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>E0_m</ci> <apply> <plus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">41</cn> </apply> </apply> <apply> <eq /> <ci>alpha_m</ci> <piecewise> <piece> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">2000</cn> <apply> <lt /> <apply> <abs /> <ci>E0_m</ci> </apply> <ci>delta_m</ci> </apply> </piece> <otherwise> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">200</cn> <ci>E0_m</ci> </apply> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <exp /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn> </apply> <ci>E0_m</ci> </apply> </apply> </apply> </apply> </otherwise> </piecewise> </apply> <apply> <eq /> <ci>beta_m</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">8000</cn> <apply> <exp /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.056</cn> </apply> <apply> <plus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">66</cn> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>m</ci> </apply> <apply> <minus /> <apply> <times /> <ci>alpha_m</ci> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <ci>m</ci> </apply> </apply> <apply> <times /> <ci>beta_m</ci> <ci>m</ci> </apply> </apply> </apply>
is computational component for: fast sodium current m gate

Portion of extracellular matrix
type: NamedIndividual
refers to: Portion of extracellular matrix
has part: sodium(1+)
has part: potassium(1+)
has part: calcium(2+)

hyperpolarising activated current
type: NamedIndividual
type: Submodel
name: hyperpolarising_activated_current
has associated data structure: hyperpolarising activated current.E K
has associated data structure: hyperpolarising activated current.E Na
has associated data structure: hyperpolarising activated current.Kc
has associated data structure: hyperpolarising activated current.Ki
has associated data structure: hyperpolarising activated current.Km f
has associated data structure: hyperpolarising activated current.Nai
has associated data structure: hyperpolarising activated current.Nao
has associated data structure: hyperpolarising activated current.RTONF
has associated data structure: hyperpolarising activated current.V
has associated data structure: hyperpolarising activated current.g f K
has associated data structure: hyperpolarising activated current.g f Na
has associated data structure: hyperpolarising activated current.i f
has associated data structure: hyperpolarising activated current.i fK
has associated data structure: hyperpolarising activated current.i fNa
has associated data structure: hyperpolarising activated current.time
has associated data structure: hyperpolarising activated current.y
has computational component: hyperpolarising activated current computation
includes submodel: hyperpolarising activated current y gate

Axiom
submodel subsumption type: containment
submodel subsumption type: encapsulation
annotated property: includesSubmodel
annotated source: hyperpolarising activated current
annotated target: hyperpolarising activated current y gate

hyperpolarising activated current.E K
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Potassium equilibrium potential
has unit: UNIT millivolt
is computational component for: hyperpolarising activated current.E K property
mapped to: time independent potassium current.E K

hyperpolarising activated current.E Na
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Sodium equilibrium potential
mapped to: Na Ca exchanger.E Na
has unit: UNIT millivolt
is computational component for: hyperpolarising activated current.E Na property
mapped to: sodium background current.E Na

hyperpolarising activated current.Kc
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Potassium concentration in the extracellular cleft
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: potassium(1+)
has computational component: hyperpolarising activated current.Kc

hyperpolarising activated current.Ki
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Potassium intracellular concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: potassium(1+)
has computational component: hyperpolarising activated current.Ki

hyperpolarising activated current.Km f
type: NamedIndividual
type: Decimal
has start value: 45
is discrete: false
is solution domain: false
is declared: true
comment: Ionic half-activation concentration for hyperpolarising current
has unit: UNIT millimolar
is computational component for: hyperpolarising activated current.Km f property

hyperpolarising activated current.Nai
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Intracellular Na concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: hyperpolarising activated current.Nai

hyperpolarising activated current.Nao
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Extracellular sodium concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: hyperpolarising activated current.Nao

hyperpolarising activated current.RTONF
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
has unit: UNIT millivolt
is computational component for: hyperpolarising activated current.RTONF property

hyperpolarising activated current.V
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
has cell m lprivate interface: out
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential
mapped to: hyperpolarising activated current y gate.V

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: hyperpolarising activated current.V

hyperpolarising activated current.g f K
type: NamedIndividual
type: Decimal
has start value: 3
is solution domain: false
is discrete: false
is declared: true
comment: K conductance of if channels
has unit: UNIT microS
is computational component for: hyperpolarising activated current.g f K property

hyperpolarising activated current.g f Na
type: NamedIndividual
type: Decimal
has start value: 3
is discrete: false
is solution domain: false
is declared: true
comment: Na conductance of if channels
has unit: UNIT microS
is computational component for: hyperpolarising activated current.g f Na property

hyperpolarising activated current.i f
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
metadata ID: hyperpolarising_activated_current_i_f
has cell m lpublic interface: out
is declared: true
comment: Hyperpolarizing-activated NaK current
has unit: UNIT nanoA
is computational component for: Charge flow rate
mapped to: membrane.i f

hyperpolarising activated current.i fK
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: K component of hyperpolarising activated current
has unit: UNIT nanoA
mapped to: extracellular potassium concentration.i fK
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Hyperpolarizing activated K channel current
has computational component: hyperpolarising activated current.i fK

hyperpolarising activated current.i fNa
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Na component of hyperpolarising activated current
has unit: UNIT nanoA
is computational component for: Charge flow rate
mapped to: intracellular sodium concentration.i fNa

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Hyperpolarizing activated Na channel current
has computational component: hyperpolarising activated current.i fNa

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Hyperpolarising activated channel current
has computational component: hyperpolarising activated current.i f

hyperpolarising activated current.time
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
has cell m lprivate interface: out
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: hyperpolarising activated current.time property
mapped to: hyperpolarising activated current y gate.time

hyperpolarising activated current.y
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lprivate interface: in
is declared: true
comment: Gating variable for Hyperpolarizing-activated NaK current
is computational component for: hyperpolarising activated current.y property

hyperpolarising activated current computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>E_Na</ci> <apply> <times /> <ci>RTONF</ci> <apply> <ln /> <apply> <divide /> <ci>Nao</ci> <ci>Nai</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>E_K</ci> <apply> <times /> <ci>RTONF</ci> <apply> <ln /> <apply> <divide /> <ci>Kc</ci> <ci>Ki</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>i_fNa</ci> <apply> <times /> <apply> <divide /> <apply> <times /> <ci>y</ci> <ci>Kc</ci> </apply> <apply> <plus /> <ci>Kc</ci> <ci>Km_f</ci> </apply> </apply> <ci>g_f_Na</ci> <apply> <minus /> <ci>V</ci> <ci>E_Na</ci> </apply> </apply> </apply> <apply> <eq /> <ci>i_fK</ci> <apply> <times /> <apply> <divide /> <apply> <times /> <ci>y</ci> <ci>Kc</ci> </apply> <apply> <plus /> <ci>Kc</ci> <ci>Km_f</ci> </apply> </apply> <ci>g_f_K</ci> <apply> <minus /> <ci>V</ci> <ci>E_K</ci> </apply> </apply> </apply> <apply> <eq /> <ci>i_f</ci> <apply> <plus /> <ci>i_fNa</ci> <ci>i_fK</ci> </apply> </apply>
is computational component for: hyperpolarising activated current

hyperpolarising activated current y gate
type: NamedIndividual
type: Submodel
name: hyperpolarising_activated_current_y_gate
has associated data structure: hyperpolarising activated current y gate.E0 y
has associated data structure: hyperpolarising activated current y gate.V
has associated data structure: hyperpolarising activated current y gate.alpha y
has associated data structure: hyperpolarising activated current y gate.beta y
has associated data structure: hyperpolarising activated current y gate.delta y
has associated data structure: hyperpolarising activated current y gate.time
has associated data structure: hyperpolarising activated current y gate.y
has computational component: hyperpolarising activated current y gate computation

hyperpolarising activated current y gate.E0 y
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
is declared: true
has unit: UNIT millivolt
is computational component for: hyperpolarising activated current y gate.E0 y property

hyperpolarising activated current y gate.V
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: hyperpolarising activated current y gate.V

hyperpolarising activated current y gate.alpha y
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Rate coefficient for hyperpolarizing-activated NaK current
has unit: UNIT per second
is computational component for: hyperpolarising activated current y gate.alpha y property

hyperpolarising activated current y gate.beta y
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
is declared: true
comment: Rate coefficient for hyperpolarizing-activated NaK current
has unit: UNIT per second
is computational component for: hyperpolarising activated current y gate.beta y property

hyperpolarising activated current y gate.delta y
type: NamedIndividual
type: Decimal
has start value: 1e-5
is solution domain: false
is discrete: false
is declared: true
has unit: UNIT millivolt
is computational component for: hyperpolarising activated current y gate.delta y property

hyperpolarising activated current y gate.time
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: hyperpolarising activated current y gate.time property

hyperpolarising activated current y gate.y
type: NamedIndividual
type: Decimal
has start value: 0.2
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Gating variable for Hyperpolarizing-activated NaK current
mapped to: hyperpolarising activated current.y
is computational component for: hyperpolarising activated current y gate.y property

hyperpolarising activated current y gate computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>alpha_y</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">0.05</cn> <apply> <exp /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.067</cn> </apply> <apply> <minus /> <apply> <plus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">52</cn> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>E0_y</ci> <apply> <minus /> <apply> <plus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">52</cn> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn> </apply> </apply> <apply> <eq /> <ci>beta_y</ci> <piecewise> <piece> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">2.5</cn> <apply> <lt /> <apply> <abs /> <ci>E0_y</ci> </apply> <ci>delta_y</ci> </apply> </piece> <otherwise> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">1</cn> <ci>E0_y</ci> </apply> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <exp /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.2</cn> </apply> <ci>E0_y</ci> </apply> </apply> </apply> </apply> </otherwise> </piecewise> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>y</ci> </apply> <apply> <minus /> <apply> <times /> <ci>alpha_y</ci> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <ci>y</ci> </apply> </apply> <apply> <times /> <ci>beta_y</ci> <ci>y</ci> </apply> </apply> </apply>
is computational component for: hyperpolarising activated current y gate

intracellular calcium concentration
type: NamedIndividual
type: Submodel
name: intracellular_calcium_concentration
has associated data structure: intracellular calcium concentration.Ca rel
has associated data structure: intracellular calcium concentration.Ca up
has associated data structure: intracellular calcium concentration.Ca up max
has associated data structure: intracellular calcium concentration.Cai
has associated data structure: intracellular calcium concentration.F
has associated data structure: intracellular calcium concentration.K mCa
has associated data structure: intracellular calcium concentration.V
has associated data structure: intracellular calcium concentration.V rel
has associated data structure: intracellular calcium concentration.V up
has associated data structure: intracellular calcium concentration.Vi
has associated data structure: intracellular calcium concentration.alpha p
has associated data structure: intracellular calcium concentration.beta p
has associated data structure: intracellular calcium concentration.i Ca b
has associated data structure: intracellular calcium concentration.i NaCa
has associated data structure: intracellular calcium concentration.i rel
has associated data structure: intracellular calcium concentration.i siCa
has associated data structure: intracellular calcium concentration.i tr
has associated data structure: intracellular calcium concentration.i up
has associated data structure: intracellular calcium concentration.n NaCa
has associated data structure: intracellular calcium concentration.p
has associated data structure: intracellular calcium concentration.rCa
has associated data structure: intracellular calcium concentration.tau rel
has associated data structure: intracellular calcium concentration.tau rep
has associated data structure: intracellular calcium concentration.tau up
has associated data structure: intracellular calcium concentration.time
has computational component: intracellular calcium concentration computation

intracellular calcium concentration.Ca rel
type: NamedIndividual
type: Decimal
has start value: 1
is discrete: false
is solution domain: false
is declared: true
comment: Ca concentrations in s.r. release store
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: intracellular calcium concentration.Ca rel

intracellular calcium concentration.Ca up
type: NamedIndividual
type: Decimal
has start value: 2
is discrete: false
is solution domain: false
is declared: true
comment: Ca concentration in s.r. uptake store
has unit: UNIT millimolar
is computational component for: Chemical concentration

intracellular calcium concentration.Ca up max
type: NamedIndividual
type: Decimal
has start value: 5
is discrete: false
is solution domain: false
is declared: true
comment: Maximum Ca concentration in s.r. uptake store
has unit: UNIT millimolar
is computational component for: intracellular calcium concentration.Ca up max property

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: intracellular calcium concentration.Ca up

intracellular calcium concentration.Cai
type: NamedIndividual
type: Decimal
has start value: 5e-5
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Intracellular Ca concentration
mapped to: Na Ca exchanger.Cai
has unit: UNIT millimolar
mapped to: calcium background current.Cai
is computational component for: Chemical concentration
mapped to: second inward current.Cai
mapped to: transient outward current.Cai

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: intracellular calcium concentration.Cai

intracellular calcium concentration.F
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Faraday Constant
has unit: UNIT coulomb per mole
is computational component for: intracellular calcium concentration.F property

intracellular calcium concentration.K mCa
type: NamedIndividual
type: Decimal
has start value: 0.001
is solution domain: false
is discrete: false
is declared: true
comment: Half activation concentration for Ca binding to release site
has unit: UNIT millimolar
is computational component for: intracellular calcium concentration.K mCa property

intracellular calcium concentration.V
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: intracellular calcium concentration.V

intracellular calcium concentration.V rel
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Volume of store of releasable calcium
has unit: UNIT micrometre3
is computational component for: intracellular calcium concentration.V rel property

intracellular calcium concentration.V up
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Volume of sarcoplasmic reticulum (s.r.) uptake store
has unit: UNIT micrometre3
is computational component for: intracellular calcium concentration.V up property

intracellular calcium concentration.Vi
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Total intracellular volume
has unit: UNIT micrometre3
is computational component for: intracellular calcium concentration.Vi property

intracellular calcium concentration.alpha p
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
is declared: true
comment: Rate coefficient of p
has unit: UNIT per second
is computational component for: intracellular calcium concentration.alpha p property

intracellular calcium concentration.beta p
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
is declared: true
comment: Rate coefficient of p
has unit: UNIT per second
is computational component for: intracellular calcium concentration.beta p property

intracellular calcium concentration.i Ca b
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Calcium background current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Ca background current across plasma membrane of cardiac myocyte
has computational component: intracellular calcium concentration.i Ca b

intracellular calcium concentration.i NaCa
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Na-Ca exchange current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: NaCa exchange pump current across plasma membrane
has computational component: intracellular calcium concentration.i NaCa

intracellular calcium concentration.i rel
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Ca release from junctional sarcoplasmic reticulum into cytosol
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Ca release from sarcoplasmic reticulum into cytosol of cardiac myocyte
has computational component: intracellular calcium concentration.i rel

intracellular calcium concentration.i siCa
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Calcium component of fast current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Secondary Ca channel inward current
has computational component: intracellular calcium concentration.i siCa

intracellular calcium concentration.i tr
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Ca transferred into releasable form
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Sarcoplasmic Ca transfer current
has computational component: intracellular calcium concentration.i tr

intracellular calcium concentration.i up
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Ca uptake into s.r. expressed as a current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Ca uptake into the sarcoplasmic reticulum
has computational component: intracellular calcium concentration.i up

intracellular calcium concentration.n NaCa
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Stoichiometry of Na-Ca exchange
is computational component for: intracellular calcium concentration.n NaCa property

intracellular calcium concentration.p
type: NamedIndividual
type: Decimal
has start value: 1
is discrete: false
is solution domain: false
is declared: true
comment: Time- and voltage-dependence of the exchange between storage and release sites.
is computational component for: intracellular calcium concentration.p property

intracellular calcium concentration.rCa
type: NamedIndividual
type: Decimal
has start value: 2
is solution domain: false
is discrete: false
is declared: true
comment: Number of Ca ions required to bind to activate release
is computational component for: intracellular calcium concentration.rCa property

intracellular calcium concentration.tau rel
type: NamedIndividual
type: Decimal
has start value: 0.05
is discrete: false
is solution domain: false
is declared: true
comment: Time constant for Ca release
has unit: UNIT second
is computational component for: intracellular calcium concentration.tau rel property

intracellular calcium concentration.tau rep
type: NamedIndividual
type: Decimal
has start value: 2
is solution domain: false
is discrete: false
is declared: true
comment: Time constant for repriming release store
has unit: UNIT second
is computational component for: intracellular calcium concentration.tau rep property

intracellular calcium concentration.tau up
type: NamedIndividual
type: Decimal
has start value: 0.025
is discrete: false
is solution domain: false
is declared: true
comment: Time constant for s.r. uptake of calcium
has unit: UNIT second
is computational component for: intracellular calcium concentration.tau up property

intracellular calcium concentration.time
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: intracellular calcium concentration.time property

intracellular calcium concentration computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>i_up</ci> <apply> <times /> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="litre_micrometre3">1</cn> <ci>Vi</ci> <ci>F</ci> </apply> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mA_nA">1</cn> <ci>tau_up</ci> <ci>Ca_up_max</ci> </apply> </apply> <ci>Cai</ci> <apply> <minus /> <ci>Ca_up_max</ci> <ci>Ca_up</ci> </apply> </apply> </apply> <apply> <eq /> <ci>i_tr</ci> <apply> <times /> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="litre_micrometre3">1</cn> <ci>V_rel</ci> <ci>F</ci> </apply> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mA_nA">1</cn> <ci>tau_rep</ci> </apply> </apply> <ci>p</ci> <apply> <minus /> <ci>Ca_up</ci> <ci>Ca_rel</ci> </apply> </apply> </apply> <apply> <eq /> <ci>alpha_p</ci> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">0.625</cn> <apply> <plus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">34</cn> </apply> </apply> <apply> <minus /> <apply> <exp /> <apply> <divide /> <apply> <plus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">34</cn> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">4</cn> </apply> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> </apply> </apply> </apply> <apply> <eq /> <ci>beta_p</ci> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">5</cn> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn…
is computational component for: intracellular calcium concentration

intracellular potassium concentration
type: NamedIndividual
type: Submodel
name: intracellular_potassium_concentration
has associated data structure: intracellular potassium concentration.F
has associated data structure: intracellular potassium concentration.Ki
has associated data structure: intracellular potassium concentration.Vi
has associated data structure: intracellular potassium concentration.i mK
has associated data structure: intracellular potassium concentration.time
has computational component: intracellular potassium concentration computation

intracellular potassium concentration.F
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Faraday Constant
has unit: UNIT coulomb per mole
is computational component for: intracellular potassium concentration.F property

intracellular potassium concentration.Ki
type: NamedIndividual
type: Decimal
has start value: 140
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Potassium intracellular concentration
has unit: UNIT millimolar
mapped to: fast sodium current.Ki
mapped to: hyperpolarising activated current.Ki
is computational component for: Chemical concentration
mapped to: second inward current.Ki
mapped to: time dependent potassium current.Ki
mapped to: transient outward current.Ki

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: potassium(1+)
has computational component: intracellular potassium concentration.Ki

intracellular potassium concentration.Vi
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Total intracellular volume
has unit: UNIT micrometre3
is computational component for: intracellular potassium concentration.Vi property

intracellular potassium concentration.i mK
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Net membrane potassium flux
has unit: UNIT nanoA
is computational component for: intracellular potassium concentration.i mK property

intracellular potassium concentration.time
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: intracellular potassium concentration.time property

intracellular potassium concentration computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>Ki</ci> </apply> <apply> <divide /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mA_nA">1</cn> </apply> <ci>i_mK</ci> </apply> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="litre_micrometre3">1</cn> <ci>Vi</ci> <ci>F</ci> </apply> </apply> </apply>
is computational component for: intracellular potassium concentration

intracellular sodium concentration
type: NamedIndividual
type: Submodel
name: intracellular_sodium_concentration
has associated data structure: intracellular sodium concentration.F
has associated data structure: intracellular sodium concentration.Nai
has associated data structure: intracellular sodium concentration.V Cell
has associated data structure: intracellular sodium concentration.V e ratio
has associated data structure: intracellular sodium concentration.Vi
has associated data structure: intracellular sodium concentration.i Na
has associated data structure: intracellular sodium concentration.i NaCa
has associated data structure: intracellular sodium concentration.i Na b
has associated data structure: intracellular sodium concentration.i fNa
has associated data structure: intracellular sodium concentration.i p
has associated data structure: intracellular sodium concentration.i siNa
has associated data structure: intracellular sodium concentration.length
has associated data structure: intracellular sodium concentration.n NaCa
has associated data structure: intracellular sodium concentration.radius
has associated data structure: intracellular sodium concentration.time
has computational component: intracellular sodium concentration computation

intracellular sodium concentration.F
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Faraday Constant
has unit: UNIT coulomb per mole
is computational component for: intracellular sodium concentration.F property

intracellular sodium concentration.Nai
type: NamedIndividual
type: Decimal
has start value: 8
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Intracellular Na concentration
mapped to: Na Ca exchanger.Nai
has unit: UNIT millimolar
mapped to: fast sodium current.Nai
mapped to: hyperpolarising activated current.Nai
is computational component for: Chemical concentration
mapped to: second inward current.Nai
mapped to: sodium potassium pump.Nai

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: intracellular sodium concentration.Nai

intracellular sodium concentration.V Cell
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Total intracellular volume
has unit: UNIT micrometre3
is computational component for: intracellular sodium concentration.V Cell property

intracellular sodium concentration.V e ratio
type: NamedIndividual
type: Decimal
has start value: 0.1
is solution domain: false
is discrete: false
is declared: true
comment: Fraction occupied by extracellular space
is computational component for: intracellular sodium concentration.V e ratio property

intracellular sodium concentration.Vi
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Total intracellular volume
has unit: UNIT micrometre3
mapped to: intracellular calcium concentration.Vi
mapped to: intracellular potassium concentration.Vi
is computational component for: intracellular sodium concentration.Vi property

intracellular sodium concentration.i Na
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: TTX sensittive fast Na current
has unit: UNIT nanoA
is computational component for: Charge flow rate

intracellular sodium concentration.i NaCa
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Na-Ca exchange current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: NaCa exchange pump current across plasma membrane
has computational component: intracellular sodium concentration.i NaCa

intracellular sodium concentration.i Na b
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Sodium background current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Na background current across plasma membrane of cardiac myocyte
has computational component: intracellular sodium concentration.i Na b

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Fast sodium channel current across plasma membrane
has computational component: intracellular sodium concentration.i Na

intracellular sodium concentration.i fNa
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Na component of hyperpolarising activated current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Hyperpolarizing activated Na channel current
has computational component: intracellular sodium concentration.i fNa

intracellular sodium concentration.i p
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: NaK exchange pump current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: NaK exchange pump current
has computational component: intracellular sodium concentration.i p

intracellular sodium concentration.i siNa
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Sodium component of fast Ca current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Secondary Na channel inward current
has computational component: intracellular sodium concentration.i siNa

intracellular sodium concentration.length
type: NamedIndividual
type: Decimal
has start value: 2
is solution domain: false
is discrete: false
is declared: true
comment: Length of preparation
has unit: UNIT micrometre
is computational component for: intracellular sodium concentration.length property

intracellular sodium concentration.n NaCa
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Stoichiometry of Na-Ca exchange
is computational component for: intracellular sodium concentration.n NaCa property

intracellular sodium concentration.radius
type: NamedIndividual
type: Decimal
has start value: 0.05
is solution domain: false
is discrete: false
is declared: true
comment: Radius of preparation
has unit: UNIT micrometre
is computational component for: intracellular sodium concentration.radius property

intracellular sodium concentration.time
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: intracellular sodium concentration.time property

intracellular sodium concentration computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>V_Cell</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.141592654</cn> <apply> <power /> <ci>radius</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> </apply> <ci>length</ci> </apply> </apply> <apply> <eq /> <ci>Vi</ci> <apply> <times /> <ci>V_Cell</ci> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <ci>V_e_ratio</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>Nai</ci> </apply> <apply> <divide /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mA_nA">1</cn> </apply> <apply> <plus /> <ci>i_Na</ci> <ci>i_Na_b</ci> <ci>i_fNa</ci> <ci>i_siNa</ci> <apply> <times /> <ci>i_p</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn> </apply> <apply> <divide /> <apply> <times /> <ci>i_NaCa</ci> <ci>n_NaCa</ci> </apply> <apply> <minus /> <ci>n_NaCa</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> </apply> </apply> </apply> </apply> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="litre_micrometre3">1</cn> <ci>Vi</ci> <ci>F</ci> </apply> </apply> </apply>
is computational component for: intracellular sodium concentration

membrane
type: NamedIndividual
type: Submodel
name: membrane
includes submodel: Na Ca exchanger
includes submodel: calcium background current
includes submodel: extracellular calcium concentration
includes submodel: extracellular potassium concentration
includes submodel: extracellular sodium concentration
includes submodel: fast sodium current
includes submodel: hyperpolarising activated current
includes submodel: intracellular calcium concentration
includes submodel: intracellular potassium concentration
includes submodel: intracellular sodium concentration
has associated data structure: membrane.C
has associated data structure: membrane.F
has associated data structure: membrane.R
has associated data structure: membrane.RTONF
has associated data structure: membrane.T
has associated data structure: membrane.V
has associated data structure: membrane.i Ca b
has associated data structure: membrane.i K
has associated data structure: membrane.i K1
has associated data structure: membrane.i Na
has associated data structure: membrane.i NaCa
has associated data structure: membrane.i Na b
has associated data structure: membrane.i f
has associated data structure: membrane.i p
has associated data structure: membrane.i pulse
has associated data structure: membrane.i si
has associated data structure: membrane.i to
has associated data structure: membrane.time
has computational component: membrane computation
includes submodel: second inward current
includes submodel: sodium background current
includes submodel: sodium potassium pump
includes submodel: time dependent potassium current
includes submodel: time independent potassium current
includes submodel: transient outward current

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated source: membrane
annotated target: sodium potassium pump

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated target: hyperpolarising activated current
annotated source: membrane

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated source: membrane
annotated target: time dependent potassium current

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated target: extracellular potassium concentration
annotated source: membrane

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated target: extracellular calcium concentration
annotated source: membrane

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated target: calcium background current
annotated source: membrane

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated source: membrane
annotated target: sodium background current

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated target: extracellular sodium concentration
annotated source: membrane

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated target: fast sodium current
annotated source: membrane

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated source: membrane
annotated target: transient outward current

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated target: intracellular calcium concentration
annotated source: membrane

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated source: membrane
annotated target: second inward current

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated target: intracellular potassium concentration
annotated source: membrane

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated target: Na Ca exchanger
annotated source: membrane

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated target: intracellular sodium concentration
annotated source: membrane

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated source: membrane
annotated target: time independent potassium current

membrane.C
type: NamedIndividual
type: Decimal
has start value: 0.075
is solution domain: false
is discrete: false
is declared: true
comment: Membrane capacitance
has unit: UNIT microF
is computational component for: membrane.C property

membrane.F
type: NamedIndividual
type: Decimal
has start value: 96485.3415
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Faraday Constant
has unit: UNIT coulomb per mole
mapped to: extracellular potassium concentration.F
mapped to: intracellular calcium concentration.F
mapped to: intracellular potassium concentration.F
mapped to: intracellular sodium concentration.F
is computational component for: membrane.F property

membrane.R
type: NamedIndividual
type: Decimal
has start value: 8314.472
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Boltzmann constant
has unit: UNIT joule per kilomole kelvin
is computational component for: membrane.R property

membrane.RTONF
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
mapped to: Na Ca exchanger.RTONF
has unit: UNIT millivolt
mapped to: calcium background current.RTONF
mapped to: fast sodium current.RTONF
mapped to: hyperpolarising activated current.RTONF
is computational component for: membrane.RTONF property
mapped to: second inward current.RTONF
mapped to: time dependent potassium current.RTONF
mapped to: time independent potassium current.RTONF
mapped to: transient outward current.RTONF

membrane.T
type: NamedIndividual
type: Decimal
has start value: 310
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Temperature
has unit: UNIT kelvin
is computational component for: membrane.T property

membrane.V
type: NamedIndividual
type: Decimal
has start value: -87
is solution domain: false
is discrete: false
metadata ID: membrane_V
has cell m lpublic interface: out
is declared: true
comment: Cardiac myocyte membrane potential
mapped to: Na Ca exchanger.V
has unit: UNIT millivolt
mapped to: calcium background current.V
mapped to: fast sodium current.V
mapped to: hyperpolarising activated current.V
mapped to: intracellular calcium concentration.V
is computational component for: Electrical potential
mapped to: second inward current.V
mapped to: sodium background current.V
mapped to: sodium potassium pump.V
mapped to: time dependent potassium current.V
mapped to: time independent potassium current.V
mapped to: transient outward current.V

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: membrane.V

membrane.i Ca b
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Calcium background current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Ca background current across plasma membrane of cardiac myocyte
has computational component: membrane.i Ca b

membrane.i K
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Delayed K current
has unit: UNIT nanoA
is computational component for: Charge flow rate

membrane.i K1
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Time independent K current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Time independent K channel current
has computational component: membrane.i K1

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Delayed rectifier K channel current
has computational component: membrane.i K

membrane.i Na
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: TTX sensittive fast Na current
has unit: UNIT nanoA
is computational component for: Charge flow rate

membrane.i NaCa
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Na-Ca exchange current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: NaCa exchange pump current across plasma membrane
has computational component: membrane.i NaCa

membrane.i Na b
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Sodium background current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Na background current across plasma membrane of cardiac myocyte
has computational component: membrane.i Na b

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Fast sodium channel current across plasma membrane
has computational component: membrane.i Na

membrane.i f
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Hyperpolarizing-activated NaK current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Hyperpolarising activated channel current
has computational component: membrane.i f

membrane.i p
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: NaK exchange pump current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: NaK exchange pump current
has computational component: membrane.i p

membrane.i pulse
type: NamedIndividual
type: Decimal
has start value: 0
is solution domain: false
is discrete: false
is declared: true
comment: Experimental stimulation current
has unit: UNIT nanoA
is computational component for: membrane.i pulse property

membrane.i si
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Total TTX-insensitive inward current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Secondary channel inward current
has computational component: membrane.i si

membrane.i to
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Transient outward current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: K transient outward channel current
has computational component: membrane.i to

membrane.time
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: membrane.time property

membrane computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>RTONF</ci> <apply> <divide /> <apply> <times /> <ci>R</ci> <ci>T</ci> </apply> <ci>F</ci> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>V</ci> </apply> <apply> <divide /> <apply> <minus /> <apply> <plus /> <ci>i_f</ci> <ci>i_K</ci> <ci>i_K1</ci> <ci>i_to</ci> <ci>i_Na_b</ci> <ci>i_Ca_b</ci> <ci>i_p</ci> <ci>i_NaCa</ci> <ci>i_Na</ci> <ci>i_si</ci> <ci>i_pulse</ci> </apply> </apply> <ci>C</ci> </apply> </apply>
is computational component for: membrane

second inward current
type: NamedIndividual
type: Submodel
name: second_inward_current
has associated data structure: second inward current.Cai
has associated data structure: second inward current.Cao
has associated data structure: second inward current.Kc
has associated data structure: second inward current.Ki
has associated data structure: second inward current.Nai
has associated data structure: second inward current.Nao
has associated data structure: second inward current.P si
has associated data structure: second inward current.RTONF
has associated data structure: second inward current.V
has associated data structure: second inward current.d
has associated data structure: second inward current.f
has associated data structure: second inward current.f2
has associated data structure: second inward current.i si
has associated data structure: second inward current.i siCa
has associated data structure: second inward current.i siK
has associated data structure: second inward current.i siNa
has associated data structure: second inward current.time
has computational component: second inward current computation
includes submodel: second inward current d gate
includes submodel: second inward current f2 gate
includes submodel: second inward current f gate

Axiom
submodel subsumption type: containment
submodel subsumption type: encapsulation
annotated property: includesSubmodel
annotated source: second inward current
annotated target: second inward current d gate

Axiom
submodel subsumption type: containment
submodel subsumption type: encapsulation
annotated property: includesSubmodel
annotated source: second inward current
annotated target: second inward current f2 gate

Axiom
submodel subsumption type: containment
submodel subsumption type: encapsulation
annotated property: includesSubmodel
annotated source: second inward current
annotated target: second inward current f gate

second inward current.Cai
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
has cell m lprivate interface: out
is declared: true
comment: Intracellular Ca concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration
mapped to: second inward current f2 gate.Cai

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: second inward current.Cai

second inward current.Cao
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Extracellular calcium concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: second inward current.Cao

second inward current.Kc
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Potassium concentration in the extracellular cleft
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: potassium(1+)
has computational component: second inward current.Kc

second inward current.Ki
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Potassium intracellular concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: potassium(1+)
has computational component: second inward current.Ki

second inward current.Nai
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Intracellular Na concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: second inward current.Nai

second inward current.Nao
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Extracellular sodium concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: second inward current.Nao

second inward current.P si
type: NamedIndividual
type: Decimal
has start value: 15
is solution domain: false
is discrete: false
is declared: true
has unit: UNIT nanoA per millimolar
is computational component for: second inward current.P si property

second inward current.RTONF
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
has unit: UNIT millivolt
is computational component for: second inward current.RTONF property

second inward current.V
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
has cell m lprivate interface: out
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential
mapped to: second inward current d gate.V
mapped to: second inward current f2 gate.V
mapped to: second inward current f gate.V

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: second inward current.V

second inward current.d
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lprivate interface: in
is declared: true
comment: Gating variable for fast Ca current channel d gate
is computational component for: second inward current.d property

second inward current.f
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lprivate interface: in
is declared: true
comment: Gating variable for fast Ca current channel f gate
is computational component for: second inward current.f property

second inward current.f2
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lprivate interface: in
is declared: true
comment: Intracellular Ca dependent inactivation of fast calcium current
is computational component for: second inward current.f2 property

second inward current.i si
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
metadata ID: second_inward_current_i_si
is declared: true
comment: Total TTX-insensitive inward current
has unit: UNIT nanoA
mapped to: membrane.i si
is computational component for: Charge flow rate

second inward current.i siCa
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Calcium component of fast current
has unit: UNIT nanoA
mapped to: intracellular calcium concentration.i siCa
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Secondary Ca channel inward current
has computational component: second inward current.i siCa

second inward current.i siK
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Potassium component of fast Ca current
has unit: UNIT nanoA
mapped to: extracellular potassium concentration.i siK
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Secondary K channel inward current
has computational component: second inward current.i siK

second inward current.i siNa
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Sodium component of fast Ca current
has unit: UNIT nanoA
mapped to: intracellular sodium concentration.i siNa
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Secondary Na channel inward current
has computational component: second inward current.i siNa

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Secondary channel inward current
has computational component: second inward current.i si

second inward current.time
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
has cell m lprivate interface: out
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: second inward current.time property
mapped to: second inward current d gate.time
mapped to: second inward current f2 gate.time
mapped to: second inward current f gate.time

second inward current computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>i_siCa</ci> <apply> <times /> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn> <ci>P_si</ci> <apply> <minus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn> </apply> </apply> <apply> <times /> <ci>RTONF</ci> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <exp /> <apply> <divide /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> </apply> <apply> <minus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> </apply> <ci>RTONF</ci> </apply> </apply> </apply> </apply> </apply> <apply> <minus /> <apply> <times /> <ci>Cai</ci> <apply> <exp /> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">100</cn> <ci>RTONF</ci> </apply> </apply> </apply> <apply> <times /> <ci>Cao</ci> <apply> <exp /> <apply> <divide /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> </apply> <apply> <minus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn> </apply> </apply> <ci>RTONF</ci> </apply> </apply> </apply> </apply> <ci>d</ci> <ci>f</ci> <ci>f2</ci> </apply> </apply> <apply> <eq /> <ci>i_siK</ci> <apply> <times /> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.01</cn> <ci>P_si</ci> <apply> <minus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn> </apply> </apply> <apply> <times /> <ci>RTONF</ci> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:uni…
is computational component for: second inward current

second inward current d gate
type: NamedIndividual
type: Submodel
name: second_inward_current_d_gate
has associated data structure: second inward current d gate.E0 d
has associated data structure: second inward current d gate.V
has associated data structure: second inward current d gate.alpha d
has associated data structure: second inward current d gate.beta d
has associated data structure: second inward current d gate.d
has associated data structure: second inward current d gate.delta d
has associated data structure: second inward current d gate.time
has computational component: second inward current d gate computation

second inward current d gate.E0 d
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
has unit: UNIT millivolt
is computational component for: second inward current d gate.E0 d property

second inward current d gate.V
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: second inward current d gate.V

second inward current d gate.alpha d
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Activation gating and rate coefficient for fast Ca current channel
has unit: UNIT per second
is computational component for: second inward current d gate.alpha d property

second inward current d gate.beta d
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Inactivation gating and rate coefficient for fast Ca current channel d gate
has unit: UNIT per second
is computational component for: second inward current d gate.beta d property

second inward current d gate.d
type: NamedIndividual
type: Decimal
has start value: 0.005
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Gating variable for fast Ca current channel d gate
mapped to: second inward current.d
is computational component for: second inward current d gate.d property

second inward current d gate.delta d
type: NamedIndividual
type: Decimal
has start value: 0.0001
is discrete: false
is solution domain: false
is declared: true
has unit: UNIT millivolt
is computational component for: second inward current d gate.delta d property

second inward current d gate.time
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: second inward current d gate.time property

second inward current d gate computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>E0_d</ci> <apply> <minus /> <apply> <plus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">24</cn> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn> </apply> </apply> <apply> <eq /> <ci>alpha_d</ci> <piecewise> <piece> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">120</cn> <apply> <lt /> <apply> <abs /> <ci>E0_d</ci> </apply> <ci>delta_d</ci> </apply> </piece> <otherwise> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">30</cn> <ci>E0_d</ci> </apply> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <exp /> <apply> <divide /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> </apply> <ci>E0_d</ci> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">4</cn> </apply> </apply> </apply> </apply> </otherwise> </piecewise> </apply> <apply> <eq /> <ci>beta_d</ci> <piecewise> <piece> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">120</cn> <apply> <lt /> <apply> <abs /> <ci>E0_d</ci> </apply> <ci>delta_d</ci> </apply> </piece> <otherwise> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">12</cn> <ci>E0_d</ci> </apply> <apply> <minus /> <apply> <exp /> <apply> <divide /> <ci>E0_d</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn> </apply> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> </apply> </apply> </otherwise> </piecewise> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>d</ci> </apply> <apply> <minus /> <apply> <times /> <ci>alpha_d</ci> <apply> <minus /> <cn xmlns:ce…
is computational component for: second inward current d gate

second inward current f2 gate
type: NamedIndividual
type: Submodel
name: second_inward_current_f2_gate
has associated data structure: second inward current f2 gate.Cai
has associated data structure: second inward current f2 gate.K mf2
has associated data structure: second inward current f2 gate.V
has associated data structure: second inward current f2 gate.alpha f2
has associated data structure: second inward current f2 gate.beta f2
has associated data structure: second inward current f2 gate.f2
has associated data structure: second inward current f2 gate.time
has computational component: second inward current f2 gate computation

second inward current f2 gate.Cai
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Intracellular Ca concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: second inward current f2 gate.Cai

second inward current f2 gate.K mf2
type: NamedIndividual
type: Decimal
has start value: 0.001
is discrete: false
is solution domain: false
is declared: true
comment: Half activation concentration for extracellular K activation of hyperpolarizing-activated NaK current
has unit: UNIT millimolar
is computational component for: second inward current f2 gate.K mf2 property

second inward current f2 gate.V
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: second inward current f2 gate.V

second inward current f2 gate.alpha f2
type: NamedIndividual
type: Decimal
has start value: 5
is solution domain: false
is discrete: false
is declared: true
comment: Intracellular Ca dependent inactivation of fast calcium current
has unit: UNIT per second
is computational component for: second inward current f2 gate.alpha f2 property

second inward current f2 gate.beta f2
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
is declared: true
comment: Intracellular Ca dependent inactivation of fast calcium current
has unit: UNIT per second
is computational component for: second inward current f2 gate.beta f2 property

second inward current f2 gate.f2
type: NamedIndividual
type: Decimal
has start value: 1
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Intracellular Ca dependent inactivation of fast calcium current
mapped to: second inward current.f2
is computational component for: second inward current f2 gate.f2 property

second inward current f2 gate.time
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: second inward current f2 gate.time property

second inward current f2 gate computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>f2</ci> </apply> <apply> <minus /> <ci>alpha_f2</ci> <apply> <times /> <ci>f2</ci> <apply> <plus /> <ci>alpha_f2</ci> <ci>beta_f2</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>beta_f2</ci> <apply> <divide /> <apply> <times /> <ci>Cai</ci> <ci>alpha_f2</ci> </apply> <ci>K_mf2</ci> </apply> </apply>
is computational component for: second inward current f2 gate

second inward current f gate
type: NamedIndividual
type: Submodel
name: second_inward_current_f_gate
has associated data structure: second inward current f gate.E0 f
has associated data structure: second inward current f gate.V
has associated data structure: second inward current f gate.alpha f
has associated data structure: second inward current f gate.beta f
has associated data structure: second inward current f gate.delta f
has associated data structure: second inward current f gate.f
has associated data structure: second inward current f gate.time
has computational component: second inward current f gate computation

second inward current f gate.E0 f
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
has unit: UNIT millivolt
is computational component for: second inward current f gate.E0 f property

second inward current f gate.V
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: second inward current f gate.V

second inward current f gate.alpha f
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
is declared: true
comment: Inactivation gating and rate coefficient for fast Ca current channel
has unit: UNIT per second
is computational component for: second inward current f gate.alpha f property

second inward current f gate.beta f
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
is declared: true
comment: Inactivation gating and rate coefficient for fast Ca current channel
has unit: UNIT per second
is computational component for: second inward current f gate.beta f property

second inward current f gate.delta f
type: NamedIndividual
type: Decimal
has start value: 0.0001
is solution domain: false
is discrete: false
is declared: true
has unit: UNIT millivolt
is computational component for: second inward current f gate.delta f property

second inward current f gate.f
type: NamedIndividual
type: Decimal
has start value: 1
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Gating variable for fast Ca current channel f gate
mapped to: second inward current.f
is computational component for: second inward current f gate.f property

second inward current f gate.time
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: second inward current f gate.time property

second inward current f gate computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>E0_f</ci> <apply> <plus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">34</cn> </apply> </apply> <apply> <eq /> <ci>alpha_f</ci> <piecewise> <piece> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">25</cn> <apply> <lt /> <apply> <abs /> <ci>E0_f</ci> </apply> <ci>delta_f</ci> </apply> </piece> <otherwise> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">6.25</cn> <ci>E0_f</ci> </apply> <apply> <minus /> <apply> <exp /> <apply> <divide /> <ci>E0_f</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">4</cn> </apply> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> </apply> </apply> </otherwise> </piecewise> </apply> <apply> <eq /> <ci>beta_f</ci> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">50</cn> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <exp /> <apply> <divide /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> </apply> <apply> <plus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">34</cn> </apply> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">4</cn> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>f</ci> </apply> <apply> <minus /> <apply> <times /> <ci>alpha_f</ci> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <ci>f</ci> </apply> </apply> <apply> <times /> <ci>beta_f</ci> <ci>f</ci> </apply> </apply> </apply>
is computational component for: second inward current f gate

sodium background current
type: NamedIndividual
type: Submodel
name: sodium_background_current
has associated data structure: sodium background current.E Na
has associated data structure: sodium background current.V
has associated data structure: sodium background current.g Nab
has associated data structure: sodium background current.i Na b
has associated data structure: sodium background current.time
has computational component: sodium background current computation

sodium background current.E Na
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Sodium equilibrium potential
has unit: UNIT millivolt
is computational component for: sodium background current.E Na property

sodium background current.V
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: sodium background current.V

sodium background current.g Nab
type: NamedIndividual
type: Decimal
has start value: 0.18
is discrete: false
is solution domain: false
is declared: true
comment: Sodium background conductance
has unit: UNIT microS
is computational component for: sodium background current.g Nab property

sodium background current.i Na b
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Sodium background current
has unit: UNIT nanoA
mapped to: intracellular sodium concentration.i Na b
mapped to: membrane.i Na b
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Na background current across plasma membrane of cardiac myocyte
has computational component: sodium background current.i Na b

sodium background current.time
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: sodium background current.time property

sodium background current computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>i_Na_b</ci> <apply> <times /> <ci>g_Nab</ci> <apply> <minus /> <ci>V</ci> <ci>E_Na</ci> </apply> </apply> </apply>
is computational component for: sodium background current

sodium potassium pump
type: NamedIndividual
type: Submodel
name: sodium_potassium_pump
has associated data structure: sodium potassium pump.I p
has associated data structure: sodium potassium pump.K mK
has associated data structure: sodium potassium pump.K mNa
has associated data structure: sodium potassium pump.Kc
has associated data structure: sodium potassium pump.Nai
has associated data structure: sodium potassium pump.V
has associated data structure: sodium potassium pump.i p
has associated data structure: sodium potassium pump.time
has computational component: sodium potassium pump computation

sodium potassium pump.I p
type: NamedIndividual
type: Decimal
has start value: 125
is solution domain: false
is discrete: false
is declared: true
comment: Maximum NaK exchane pump current
has unit: UNIT nanoA
is computational component for: sodium potassium pump.I p property

sodium potassium pump.K mK
type: NamedIndividual
type: Decimal
has start value: 1
is discrete: false
is solution domain: false
is declared: true
comment: NaK pump K half activation concentration
has unit: UNIT millimolar
is computational component for: sodium potassium pump.K mK property

sodium potassium pump.K mNa
type: NamedIndividual
type: Decimal
has start value: 40
is solution domain: false
is discrete: false
is declared: true
comment: NaK pump Na half activation concentration
has unit: UNIT millimolar
is computational component for: sodium potassium pump.K mNa property

sodium potassium pump.Kc
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Potassium concentration in the extracellular cleft
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: potassium(1+)
has computational component: sodium potassium pump.Kc

sodium potassium pump.Nai
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Intracellular Na concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: sodium potassium pump.Nai

sodium potassium pump.V
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: sodium potassium pump.V

sodium potassium pump.i p
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: NaK exchange pump current
has unit: UNIT nanoA
mapped to: extracellular potassium concentration.i p
mapped to: intracellular sodium concentration.i p
mapped to: membrane.i p
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: NaK exchange pump current
has computational component: sodium potassium pump.i p

sodium potassium pump.time
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: sodium potassium pump.time property

sodium potassium pump computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>i_p</ci> <apply> <divide /> <apply> <times /> <apply> <divide /> <apply> <times /> <ci>I_p</ci> <ci>Kc</ci> </apply> <apply> <plus /> <ci>K_mK</ci> <ci>Kc</ci> </apply> </apply> <ci>Nai</ci> </apply> <apply> <plus /> <ci>K_mNa</ci> <ci>Nai</ci> </apply> </apply> </apply>
is computational component for: sodium potassium pump

time dependent potassium current
type: NamedIndividual
type: Submodel
name: time_dependent_potassium_current
has associated data structure: time dependent potassium current.I K
has associated data structure: time dependent potassium current.Kc
has associated data structure: time dependent potassium current.Ki
has associated data structure: time dependent potassium current.RTONF
has associated data structure: time dependent potassium current.V
has associated data structure: time dependent potassium current.i K
has associated data structure: time dependent potassium current.i K max
has associated data structure: time dependent potassium current.time
has associated data structure: time dependent potassium current.x
has computational component: time dependent potassium current computation
includes submodel: time dependent potassium current x gate

Axiom
submodel subsumption type: containment
submodel subsumption type: encapsulation
annotated property: includesSubmodel
annotated source: time dependent potassium current
annotated target: time dependent potassium current x gate

time dependent potassium current.I K
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
is declared: true
comment: Fully activated value of delayed K current
has unit: UNIT nanoA
is computational component for: time dependent potassium current.I K property

time dependent potassium current.Kc
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Potassium concentration in the extracellular cleft
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: potassium(1+)
has computational component: time dependent potassium current.Kc

time dependent potassium current.Ki
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Potassium intracellular concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: potassium(1+)
has computational component: time dependent potassium current.Ki

time dependent potassium current.RTONF
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
has unit: UNIT millivolt
is computational component for: time dependent potassium current.RTONF property

time dependent potassium current.V
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
has cell m lprivate interface: out
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential
mapped to: time dependent potassium current x gate.V

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: time dependent potassium current.V

time dependent potassium current.i K
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Delayed K current
has unit: UNIT nanoA
mapped to: extracellular potassium concentration.i K
mapped to: membrane.i K
is computational component for: Charge flow rate

time dependent potassium current.i K max
type: NamedIndividual
type: Decimal
has start value: 180
is solution domain: false
is discrete: false
is declared: true
comment: Maximum outward potassium current
has unit: UNIT nanoA
is computational component for: time dependent potassium current.i K max property

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Delayed rectifier K channel current
has computational component: time dependent potassium current.i K

time dependent potassium current.time
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
has cell m lprivate interface: out
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: time dependent potassium current.time property
mapped to: time dependent potassium current x gate.time

time dependent potassium current.x
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lprivate interface: in
is declared: true
comment: Delayed K current gating variable
is computational component for: time dependent potassium current.x property

time dependent potassium current computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>I_K</ci> <apply> <divide /> <apply> <times /> <ci>i_K_max</ci> <apply> <minus /> <ci>Ki</ci> <apply> <times /> <ci>Kc</ci> <apply> <exp /> <apply> <divide /> <apply> <minus /> <ci>V</ci> </apply> <ci>RTONF</ci> </apply> </apply> </apply> </apply> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">140</cn> </apply> </apply> <apply> <eq /> <ci>i_K</ci> <apply> <times /> <ci>x</ci> <ci>I_K</ci> </apply> </apply>
is computational component for: time dependent potassium current

time dependent potassium current x gate
type: NamedIndividual
type: Submodel
name: time_dependent_potassium_current_x_gate
has associated data structure: time dependent potassium current x gate.V
has associated data structure: time dependent potassium current x gate.alpha x
has associated data structure: time dependent potassium current x gate.beta x
has associated data structure: time dependent potassium current x gate.time
has associated data structure: time dependent potassium current x gate.x
has computational component: time dependent potassium current x gate computation

time dependent potassium current x gate.V
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: time dependent potassium current x gate.V

time dependent potassium current x gate.alpha x
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
is declared: true
comment: Delayed K rate coefficient
has unit: UNIT per second
is computational component for: time dependent potassium current x gate.alpha x property

time dependent potassium current x gate.beta x
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Delayed K rate coefficient
has unit: UNIT per second
is computational component for: time dependent potassium current x gate.beta x property

time dependent potassium current x gate.time
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: time dependent potassium current x gate.time property

time dependent potassium current x gate.x
type: NamedIndividual
type: Decimal
has start value: 0.01
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Delayed K current gating variable
mapped to: time dependent potassium current.x
is computational component for: time dependent potassium current x gate.x property

time dependent potassium current x gate computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>alpha_x</ci> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">0.5</cn> <apply> <exp /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0826</cn> <apply> <plus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn> </apply> </apply> </apply> </apply> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <exp /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.057</cn> <apply> <plus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn> </apply> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>beta_x</ci> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">1.3</cn> <apply> <exp /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.06</cn> </apply> <apply> <plus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn> </apply> </apply> </apply> </apply> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <exp /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.04</cn> </apply> <apply> <plus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn> </apply> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>x</ci> </apply> <apply> <minus /> <apply> <times /> <ci>alpha_x</ci> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <ci>x</ci> </apply> </apply> <apply> …
is computational component for: time dependent potassium current x gate

time independent potassium current
type: NamedIndividual
type: Submodel
name: time_independent_potassium_current
has associated data structure: time independent potassium current.E K
has associated data structure: time independent potassium current.Kc
has associated data structure: time independent potassium current.Km K1
has associated data structure: time independent potassium current.RTONF
has associated data structure: time independent potassium current.V
has associated data structure: time independent potassium current.g K1
has associated data structure: time independent potassium current.i K1
has associated data structure: time independent potassium current.time
has computational component: time independent potassium current computation

time independent potassium current.E K
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Potassium equilibrium potential
has unit: UNIT millivolt
is computational component for: time independent potassium current.E K property

time independent potassium current.Kc
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Potassium concentration in the extracellular cleft
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: potassium(1+)
has computational component: time independent potassium current.Kc

time independent potassium current.Km K1
type: NamedIndividual
type: Decimal
has start value: 210
is solution domain: false
is discrete: false
is declared: true
comment: K half-activation concentration for inward K rectifier
has unit: UNIT millimolar
is computational component for: time independent potassium current.Km K1 property

time independent potassium current.RTONF
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
has unit: UNIT millivolt
is computational component for: time independent potassium current.RTONF property

time independent potassium current.V
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: time independent potassium current.V

time independent potassium current.g K1
type: NamedIndividual
type: Decimal
has start value: 920
is discrete: false
is solution domain: false
is declared: true
comment: Inward K rectifier conductance
has unit: UNIT microS
is computational component for: time independent potassium current.g K1 property

time independent potassium current.i K1
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
metadata ID: time_independent_potassium_current_i_K1
is declared: true
comment: Time independent K current
has unit: UNIT nanoA
mapped to: extracellular potassium concentration.i K1
mapped to: membrane.i K1
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Time independent K channel current
has computational component: time independent potassium current.i K1

time independent potassium current.time
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: time independent potassium current.time property

time independent potassium current computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>i_K1</ci> <apply> <divide /> <apply> <times /> <apply> <divide /> <apply> <times /> <ci>g_K1</ci> <ci>Kc</ci> </apply> <apply> <plus /> <ci>Kc</ci> <ci>Km_K1</ci> </apply> </apply> <apply> <minus /> <ci>V</ci> <ci>E_K</ci> </apply> </apply> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <exp /> <apply> <divide /> <apply> <times /> <apply> <minus /> <apply> <plus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn> </apply> <ci>E_K</ci> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> </apply> <ci>RTONF</ci> </apply> </apply> </apply> </apply> </apply>
is computational component for: time independent potassium current

transient outward current
type: NamedIndividual
type: Submodel
name: transient_outward_current
has associated data structure: transient outward current.Cai
has associated data structure: transient outward current.Kc
has associated data structure: transient outward current.Ki
has associated data structure: transient outward current.Km Ca
has associated data structure: transient outward current.Km to
has associated data structure: transient outward current.RTONF
has associated data structure: transient outward current.V
has associated data structure: transient outward current.g to
has associated data structure: transient outward current.i to
has associated data structure: transient outward current.s
has associated data structure: transient outward current.time
has computational component: transient outward current computation
includes submodel: transient outward current s gate

Axiom
submodel subsumption type: containment
submodel subsumption type: encapsulation
annotated property: includesSubmodel
annotated source: transient outward current
annotated target: transient outward current s gate

transient outward current.Cai
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Intracellular Ca concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: transient outward current.Cai

transient outward current.Kc
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Potassium concentration in the extracellular cleft
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: potassium(1+)
has computational component: transient outward current.Kc

transient outward current.Ki
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Potassium intracellular concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: potassium(1+)
has computational component: transient outward current.Ki

transient outward current.Km Ca
type: NamedIndividual
type: Decimal
has start value: 0.0005
is discrete: false
is solution domain: false
is declared: true
comment: Ca half activation concentration for transient outward current
has unit: UNIT millimolar
is computational component for: transient outward current.Km Ca property

transient outward current.Km to
type: NamedIndividual
type: Decimal
has start value: 10
is solution domain: false
is discrete: false
is declared: true
comment: K half activation concentration for transient outward current
has unit: UNIT millimolar
is computational component for: transient outward current.Km to property

transient outward current.RTONF
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
has unit: UNIT millivolt
is computational component for: transient outward current.RTONF property

transient outward current.V
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
has cell m lprivate interface: out
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential
mapped to: transient outward current s gate.V

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: transient outward current.V

transient outward current.g to
type: NamedIndividual
type: Decimal
has start value: 0.28
is solution domain: false
is discrete: false
is declared: true
comment: Conductance for transient outward K rectification
has unit: UNIT microS per millimolar
is computational component for: transient outward current.g to property

transient outward current.i to
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
metadata ID: transient_outward_current_i_to
is declared: true
comment: Transient outward current
has unit: UNIT nanoA
mapped to: extracellular potassium concentration.i to
mapped to: membrane.i to
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: K transient outward channel current
has computational component: transient outward current.i to

transient outward current.s
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lprivate interface: in
is declared: true
comment: Gating variable for transient outward current
is computational component for: transient outward current.s property

transient outward current.time
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
has cell m lprivate interface: out
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: transient outward current.time property
mapped to: transient outward current s gate.time

transient outward current computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>i_to</ci> <apply> <times /> <apply> <divide /> <apply> <times /> <apply> <divide /> <apply> <times /> <ci>s</ci> <ci>g_to</ci> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn> <apply> <divide /> <ci>Kc</ci> <apply> <plus /> <ci>Km_to</ci> <ci>Kc</ci> </apply> </apply> </apply> <ci>Cai</ci> </apply> <apply> <plus /> <ci>Km_Ca</ci> <ci>Cai</ci> </apply> </apply> <apply> <plus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn> </apply> </apply> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <exp /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.2</cn> </apply> <apply> <plus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn> </apply> </apply> </apply> </apply> </apply> <apply> <minus /> <apply> <times /> <ci>Ki</ci> <apply> <exp /> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.5</cn> <ci>V</ci> </apply> <ci>RTONF</ci> </apply> </apply> </apply> <apply> <times /> <ci>Kc</ci> <apply> <exp /> <apply> <divide /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.5</cn> </apply> <ci>V</ci> </apply> <ci>RTONF</ci> </apply> </apply> </apply> </apply> </apply> </apply>
is computational component for: transient outward current

transient outward current s gate
type: NamedIndividual
type: Submodel
name: transient_outward_current_s_gate
has associated data structure: transient outward current s gate.V
has associated data structure: transient outward current s gate.alpha s
has associated data structure: transient outward current s gate.beta s
has associated data structure: transient outward current s gate.s
has associated data structure: transient outward current s gate.time
has computational component: transient outward current s gate computation

transient outward current s gate.V
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: transient outward current s gate.V

transient outward current s gate.alpha s
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Rate coefficient for transient outward current
has unit: UNIT per second
is computational component for: transient outward current s gate.alpha s property

transient outward current s gate.beta s
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Rate coefficient for transient outward current
has unit: UNIT per second
is computational component for: transient outward current s gate.beta s property

transient outward current s gate.s
type: NamedIndividual
type: Decimal
has start value: 1
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Gating variable for transient outward current
mapped to: transient outward current.s
is computational component for: transient outward current s gate.s property

transient outward current s gate.time
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: transient outward current s gate.time property

transient outward current s gate computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>alpha_s</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">0.033</cn> <apply> <exp /> <apply> <divide /> <apply> <minus /> <ci>V</ci> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">17</cn> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>beta_s</ci> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">33</cn> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <exp /> <apply> <divide /> <apply> <minus /> <apply> <plus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn> </apply> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">8</cn> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>s</ci> </apply> <apply> <minus /> <apply> <times /> <ci>alpha_s</ci> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <ci>s</ci> </apply> </apply> <apply> <times /> <ci>beta_s</ci> <ci>s</ci> </apply> </apply> </apply>
is computational component for: transient outward current s gate