26032015150419070m0500
type: Ontology
sem sim version: 0.2
has cell m ldocumentation: <documentation xmlns="http://cellml.org/tmp-documentation"> <articleinfo> Hilemann-Noble Atrial Cell Model 1987 <author> <firstname>Catherine</firstname> <surname>Lloyd</surname> <affiliation> <shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil> </affiliation> </author> </articleinfo> Model Status This model is known to run in OpenCell and COR and reproduce the published results. <sect1 id="sec_structure"> Model Structure ABSTRACT: Interactions of electrogenic sodium-calcium exchange, calcium channel and sarcoplasmic reticulum in the mammalian heart have been explored by simulation of extracellular calcium transients measured with tetramethylmurexide in rabbit atrium. The approach has been to use the simplest possible formulations of these mechanisms, which together with a minimum number of additional mechanisms allow reconstruction of action potentials, intracellular calcium transients and extracellular calcium transients. A 3:1 sodium-calcium exchange stoichiometry is assumed. Calcium-channel inactivation is assumed to take place by a voltage-dependent mechanism, which is accelerated by a rise in intracellular calcium; intracellular calcium release becomes a major physiological regulator of calcium influx via calcium channels. A calcium release mechanism is assumed, which is both calcium- and voltage-sensitive, and which undergoes prolonged inactivation. 200 microM cytosolic calcium buffer is assumed. For most simulations only instantaneous potassium conductances are simulated so as to study the other mechanisms independently of time- and calcium-dependent outward current. Thus, the model reconstructs extracellular calcium transients and typical action-potential configuration changes during steady-state and non-steady-state stimulation from the mechanisms directly involved in trans-sarcolemmal calcium movements. The model predicts relatively small trans-sarcolemmal calcium movements during regular stimulation (ca. 2 mumol kg-1 fre…
has cell m lrdf markup: <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:j.0="http://imc.org/vCard/3.0#"> <rdf:Description rdf:about="http://www.cellml.org/cellml/1.0"> <cmeta:modification> <rdf:Description rdf:about="rdf:#d134371a-7ca9-4bc9-b15c-8311d6159199"> <cmeta:modifier> <rdf:Description rdf:about="rdf:#b8bd0ccd-2a3d-467d-a4e8-4baeb73e1139"> <vCard:N> <rdf:Description rdf:about="rdf:#53f5e968-5a33-41dc-a08d-abf75f7a4684"> <vCard:Other>Richard</vCard:Other> <vCard:Family>Lawson</vCard:Family> <vCard:Given>James</vCard:Given> </rdf:Description> </vCard:N> </rdf:Description> </cmeta:modifier> <rdf:value>Made 2 new variables - dCaCalmoddt and dCaTropdt in component "intracellular_calcium_concentration," equated these variables to d(CaCalmod)/d(time) and d(CaTrop)/d(time), respectively. This was done to allow PCEnv 0.2 to run the model.</rdf:value> <dcterms:modified> <rdf:Description rdf:about="rdf:#eb2cd150-322c-4782-8f7f-61662395f5f0"> <dcterms:W3CDTF>2007-09-20T12:40:08+12:00</dcterms:W3CDTF> </rdf:Description> </dcterms:modified> </rdf:Description> </cmeta:modification> <cmeta:modification> <rdf:Description rdf:about="rdf:#0a11824d-79bb-4c95-bf67-f2a0c00a1ab1"> <cmeta:modifier> <rdf:Description rdf:about="rdf:#7500468a-4c03-4b44-93f7-84fcc577f8d6"> <vCard:N> <rdf:Description rdf:about="rdf:#9e7662b0-bfb4-4bb5-9d56-3c5f91e06e18"> <vCard:Other>Richard</vCard:Other> <vCard:Family>Lawson</vCard:Family> <vCard:Given>James</vCard:Given> </rdf:Description> </vCard:N> </rdf:Description> </cmeta:modifier> <rdf:value>Added stimulus protocol to allow simulation of trains of action potentials.</rdf:value> <dcterms:modified> <rdf:Description rdf:about="rdf:#eee2dffe-700f-4485-9feb-f7ba7a90a…
legacy code URI: C:\Users\Christopher\Dropbox\Work Related\Annotated Models\Hilgemann_1987\hilgemann_noble_1987.cellml
annotator name: Chris Thompson
model name: hilgemann_noble_1987
model id: hilgemann_noble_1987

Charge flow rate
type: Class
subclass of: Reference physical property
subclass of: Restriction
  on property: refersTo
  has value: Charge flow rate

Chemical concentration
type: Class
subclass of: Reference physical property
subclass of: Restriction
  on property: refersTo
  has value: Chemical concentration

Electrical potential
type: Class
subclass of: Reference physical property
subclass of: Restriction
  on property: refersTo
  has value: Electrical potential

Chemical molar flow rate
type: Class
subclass of: Reference physical property
subclass of: Restriction
  on property: refersTo
  has value: Chemical molar flow rate

Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-2) (P50993)
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-2) (P50993)

Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor) (Q92736)
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor) (Q92736)

sodium(1+)
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: sodium(1+)

potassium(1+)
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: potassium(1+)

calcium(2+)
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: calcium(2+)

Troponin
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: Troponin

Calmodulin
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: Calmodulin

Portion of extracellular matrix
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: Portion of extracellular matrix

Cardiac myocyte
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: Cardiac myocyte

Junctional sarcoplasmic reticulum of cardiac muscle cell
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: Junctional sarcoplasmic reticulum of cardiac muscle cell

Plasma membrane
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: Plasma membrane

Portion of cytosol
type: Class
subclass of: Reference physical entity
subclass of: Restriction
  on property: refersTo
  has value: Portion of cytosol

Composite physical entity
type: Class
subclass of: Physical entity
disjoint with: Custom physical entity
disjoint with: Reference physical entity
comment: A physical entity that is defined by linking multiple physical entity terms with structural relations.

Computation
type: Class
subclass of: Computational model component
disjoint with: Data structure
comment: A mathematical and/or logical expression that determines the value of a data structure.

Computational model component
type: Class
subclass of: SemSim component
disjoint with: Physical model component
comment: An element of a SemSim model that relates to the mathematical or logical representation of physical quantities or qualities.

Custom physical dependency
type: Class
subclass of: Physical dependency
disjoint with: Reference physical dependency
comment: A physical dependency defined in a specific SemSim model.

Custom physical entity
type: Class
subclass of: Physical entity
comment: A physical entity defined in a specific SemSim model.

Custom physical process
type: Class
subclass of: Physical process
comment: A physical process defined in a specific SemSim model.

Custom physical property
type: Class
subclass of: Physical property
disjoint with: Reference physical property
comment: A physical property defined in a specific SemSim model.

Data structure
type: Class
subclass of: Computational model component
comment: A computational element that stores numerical and/or logical information related to the model.

Decimal
type: Class
subclass of: Real
disjoint with: Integer
comment: A data structure whose value is limited to decimals.

Integer
type: Class
subclass of: Real
comment: A data structure whose value is limited to the whole numbers.

MMLchoice
type: Class
subclass of: Real
comment: A data structure unique to JSim's Mathematical Modeling Language (MML) used to set one or more model input values at runtime.

Physical dependency
type: Class
subclass of: Physical model component
disjoint with: Physical entity
disjoint with: Physical process
disjoint with: Physical property
comment: A quantitative relation between values of physical properties that occurs over a span of time and that determines the time-course of a physical process.

Physical entity
type: Class
subclass of: Physical model component
disjoint with: Physical process
disjoint with: Physical property
comment: A physics analytical entity that represents the material, energy, and/or information content of material or immaterial, space-occupying continuants.

Physical model component
type: Class
subclass of: SemSim component
comment: A SemSim model element used to represent, in whole or in part, the physical meaning of a computational element.

Physical process
type: Class
subclass of: Physical model component
disjoint with: Physical property
comment: A physical processural entity that is a flow, or the control of a flow, of energy and/or information amongst physical continuants that are participants in the physical process.

Physical property
type: Class
subclass of: Physical model component
comment: A physical attribute of an instance of a physical entity, an occurrence of a physical process, or a physical dependency that has a quantitative value that is measurable by a physical device or method, or is computable from such values.

Real
type: Class
subclass of: Data structure
comment: A data structure whose value is limited to the real numbers.

Reference physical dependency
type: Class
subclass of: Physical dependency
comment: A physical dependency that is defined using a term in an external knowledge resource.

Reference physical entity
type: Class
subclass of: Physical entity
comment: A physical entity that is defined using a term from an external knowledge resource.

Reference physical process
type: Class
subclass of: Physical process
comment: A physical process that is defined using a term in an external knowledge resource.

Reference physical property
type: Class
subclass of: Physical property
comment: A physical property that is defined using a term in an external knowledge resource.

Relational constraint
type: Class
subclass of: Computational model component
comment: A logical expression that constrains, but does not define, the value of a data structure. Example: x > 0.

SemSim component
type: Class
comment: A computational or physical element of a SemSim model.

Submodel
type: Class
subclass of: Physical model component
comment: A grouping of one or more data structures that comprise a computationally or physically distinct part of a model or submodel.

Unit of measurement
type: Class
subclass of: Computational model component
comment: A physical quantity chosen as a standard in terms of which other physical quantities may be expressed.

sodium(1+)
type: NamedIndividual
refers to: sodium(1+)
is index entity for: CHEBI 29101 part of fma9672
has physical property: Chemical concentration
part of: Portion of extracellular matrix

sodium(1+)
type: NamedIndividual
refers to: sodium(1+)
is index entity for: CHEBI 29101 part of Portion of cytosol part of Cardiac myocyte
has physical property: Chemical concentration
part of: Portion of cytosol

potassium(1+)
type: NamedIndividual
refers to: potassium(1+)
is index entity for: CHEBI 29103 part of Portion of cytosol part of Cardiac myocyte
part of: Portion of cytosol
has physical property: Chemical concentration

potassium(1+)
type: NamedIndividual
refers to: potassium(1+)
is index entity for: CHEBI 29103 part of Intercellular cleft
part of: Intercellular cleft
has physical property: Chemical concentration

calcium(2+)
type: NamedIndividual
refers to: calcium(2+)
is index entity for: CHEBI 29108 part of fma9672
has physical property: Chemical concentration
part of: Portion of extracellular matrix

calcium(2+)
type: NamedIndividual
refers to: calcium(2+)
is index entity for: CHEBI 29108 part of Portion of cytosol part of Cardiac myocyte
has physical property: Chemical concentration
part of: Portion of cytosol

calcium(2+)
type: NamedIndividual
refers to: calcium(2+)
is index entity for: CHEBI 29108 part of Junctional sarcoplasmic reticulum of cardiac muscle cell
part of: Junctional sarcoplasmic reticulum of cardiac muscle cell
has physical property: Chemical concentration

calcium(2+)
type: NamedIndividual
refers to: calcium(2+)
is index entity for: CHEBI 29108 part of Sarcoplasmic reticulum uptake store part of Cardiac myocyte
part of: Sarcoplasmic reticulum uptake store
has physical property: Chemical concentration

calcium(2+)
type: NamedIndividual
refers to: calcium(2+)
is index entity for: CHEBI 29108 part of Muscle Bath
part of: Muscle Bath
has physical property: Chemical concentration

calcium(2+)
type: NamedIndividual
refers to: calcium(2+)
is index entity for: CHEBI 29108 part of fma62338 part of Portion of cytosol part of Cardiac myocyte
part of: Troponin
has physical property: Chemical concentration

calcium(2+)
type: NamedIndividual
refers to: calcium(2+)
is index entity for: CHEBI 29108 part of fma62343 part of Portion of cytosol part of Cardiac myocyte
part of: Calmodulin
has physical property: Chemical concentration

Ca background current across plasma membrane of cardiac myocyte
type: NamedIndividual
type: Custom physical process
has sink: calcium(2+)
has source: calcium(2+)
has mediator: Plasma membrane
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasMediator
annotated source: Ca background current across plasma membrane of cardiac myocyte
annotated target: Plasma membrane

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: calcium(2+)
annotated source: Ca background current across plasma membrane of cardiac myocyte

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: calcium(2+)
annotated source: Ca background current across plasma membrane of cardiac myocyte

Ca release from sarcoplasmic reticulum into cytosol of cardiac myocyte
type: NamedIndividual
type: Custom physical process
has sink: calcium(2+)
has source: calcium(2+)
has mediator: Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor) (Q92736)
has physical property: Chemical molar flow rate

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: calcium(2+)
annotated source: Ca release from sarcoplasmic reticulum into cytosol of cardiac myocyte

Axiom
has multiplier: 1.0
annotated property: hasMediator
annotated source: Ca release from sarcoplasmic reticulum into cytosol of cardiac myocyte
annotated target: Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor) (Q92736)

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: calcium(2+)
annotated source: Ca release from sarcoplasmic reticulum into cytosol of cardiac myocyte

Ca uptake into the sarcoplasmic reticulum
type: NamedIndividual
type: Custom physical process
has source: calcium(2+)
has sink: calcium(2+)
has physical property: Chemical molar flow rate

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: calcium(2+)
annotated source: Ca uptake into the sarcoplasmic reticulum

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: calcium(2+)
annotated source: Ca uptake into the sarcoplasmic reticulum

Cardiac myocyte
type: NamedIndividual
refers to: Cardiac myocyte
has part: Junctional sarcoplasmic reticulum of cardiac muscle cell
has part: Plasma membrane
has part: Portion of cytosol
has part: Sarcoplasmic reticulum uptake store

Fast sodium channel current across plasma membrane
type: NamedIndividual
type: Custom physical process
has source: sodium(1+)
has sink: sodium(1+)
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: sodium(1+)
annotated source: Fast sodium channel current across plasma membrane

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: sodium(1+)
annotated source: Fast sodium channel current across plasma membrane

Intercellular cleft
type: NamedIndividual
type: Custom physical entity
comment: Channel between two tightly packed cell.
has part: potassium(1+)

Junctional sarcoplasmic reticulum of cardiac muscle cell
type: NamedIndividual
refers to: Junctional sarcoplasmic reticulum of cardiac muscle cell
has part: calcium(2+)

Junctional sarcoplasmic reticulum of cardiac muscle cell
type: NamedIndividual
refers to: Junctional sarcoplasmic reticulum of cardiac muscle cell
part of: Cardiac myocyte
is index entity for: Junctional sarcoplasmic reticulum of cardiac muscle cell part of Cardiac myocyte
has part: Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor) (Q92736)

K background current across plasma membrane of the cardiac myocyte
type: NamedIndividual
type: Custom physical process
has sink: calcium(2+)
has source: calcium(2+)
has mediator: Plasma membrane
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: calcium(2+)
annotated source: K background current across plasma membrane of the cardiac myocyte

Axiom
has multiplier: 1.0
annotated property: hasMediator
annotated source: K background current across plasma membrane of the cardiac myocyte
annotated target: Plasma membrane

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: calcium(2+)
annotated source: K background current across plasma membrane of the cardiac myocyte

Muscle Bath
type: NamedIndividual
type: Custom physical entity
has part: calcium(2+)

NaCa exchange pump current across plasma membrane
type: NamedIndividual
type: Custom physical process
has source: sodium(1+)
has sink: sodium(1+)
has sink: calcium(2+)
has source: calcium(2+)
has physical property: Charge flow rate
has mediator: Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-2) (P50993)

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: calcium(2+)
annotated source: NaCa exchange pump current across plasma membrane

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: calcium(2+)
annotated source: NaCa exchange pump current across plasma membrane

Axiom
has multiplier: 1.0
annotated property: hasMediator
annotated source: NaCa exchange pump current across plasma membrane
annotated target: Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-2) (P50993)

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: sodium(1+)
annotated source: NaCa exchange pump current across plasma membrane

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: sodium(1+)
annotated source: NaCa exchange pump current across plasma membrane

Na Ca exchanger
type: NamedIndividual
type: Submodel
name: Na_Ca_exchanger
has associated data structure: Na Ca exchanger.Ca i
has associated data structure: Na Ca exchanger.Ca o
has associated data structure: Na Ca exchanger.Na i
has associated data structure: Na Ca exchanger.Na o
has associated data structure: Na Ca exchanger.RTONF
has associated data structure: Na Ca exchanger.V
has associated data structure: Na Ca exchanger.d NaCa
has associated data structure: Na Ca exchanger.gamma
has associated data structure: Na Ca exchanger.i NaCa
has associated data structure: Na Ca exchanger.k NaCa
has associated data structure: Na Ca exchanger.n NaCa
has associated data structure: Na Ca exchanger.time
has computational component: Na Ca exchanger computation

Na Ca exchanger.Ca i
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Intracellular Ca concentration
is computational component for: Chemical concentration
has unit: UNIT millimolar

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: Na Ca exchanger.Ca i

Na Ca exchanger.Ca o
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Extracellular calcium concentration
is computational component for: Chemical concentration
has unit: UNIT millimolar

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: Na Ca exchanger.Ca o

Na Ca exchanger.Na i
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Intracellular Na concentration
is computational component for: Chemical concentration
has unit: UNIT millimolar

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: Na Ca exchanger.Na i

Na Ca exchanger.Na o
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Extracellular sodium concentration
is computational component for: Chemical concentration
has unit: UNIT millimolar

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: Na Ca exchanger.Na o

Na Ca exchanger.RTONF
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
is computational component for: Na Ca exchanger.RTONF property
has unit: UNIT millivolt

Na Ca exchanger.V
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Cardiac myocyte membrane potential
is computational component for: Electrical potential
has unit: UNIT millivolt

Electrical potential
type: NamedIndividual
refers to: Electrical potential
has computational component: Na Ca exchanger.V
physical property of: Plasma membrane

Na Ca exchanger.d NaCa
type: NamedIndividual
type: Decimal
has start value: 0.0001
is discrete: false
is solution domain: false
is declared: true
comment: Denominator constant for i_NaCa
is computational component for: Na Ca exchanger.d NaCa property

Na Ca exchanger.gamma
type: NamedIndividual
type: Decimal
has start value: 0.5
is discrete: false
is solution domain: false
is declared: true
comment: Position of energy barrier controlling voltage-dependence of i_NaCa
is computational component for: Na Ca exchanger.gamma property

Na Ca exchanger.i NaCa
type: NamedIndividual
type: Decimal
metadata ID: Na_Ca_exchanger_i_NaCa
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Na-Ca exchange current
is computational component for: Charge flow rate
has unit: UNIT nanoA
mapped to: extracellular calcium concentration.i NaCa
mapped to: intracellular calcium concentration.i NaCa
mapped to: intracellular sodium concentration.i NaCa
mapped to: membrane.i NaCa

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: NaCa exchange pump current across plasma membrane
has computational component: Na Ca exchanger.i NaCa

Na Ca exchanger.k NaCa
type: NamedIndividual
type: Decimal
has start value: 0.01
is solution domain: false
is discrete: false
is declared: true
comment: scaling factor for i_NaCa
is computational component for: Na Ca exchanger.k NaCa property
has unit: UNIT nanoA

Na Ca exchanger.n NaCa
type: NamedIndividual
type: Decimal
has start value: 3
is discrete: false
is solution domain: false
is declared: true
comment: Stoichiometry of Na-Ca exchange
is computational component for: Na Ca exchanger.n NaCa property

Na Ca exchanger.time
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
is computational component for: Na Ca exchanger.time property
has unit: UNIT second

Na Ca exchanger computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>i_NaCa</ci> <apply> <divide /> <apply> <times /> <ci>k_NaCa</ci> <apply> <minus /> <apply> <times /> <apply> <exp /> <apply> <divide /> <apply> <times /> <ci>gamma</ci> <apply> <minus /> <ci>n_NaCa</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> </apply> <ci>V</ci> </apply> <ci>RTONF</ci> </apply> </apply> <apply> <power /> <ci>Na_i</ci> <ci>n_NaCa</ci> </apply> <ci>Ca_o</ci> </apply> <apply> <times /> <apply> <exp /> <apply> <divide /> <apply> <times /> <apply> <minus /> <ci>gamma</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> </apply> <apply> <minus /> <ci>n_NaCa</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> </apply> <ci>V</ci> </apply> <ci>RTONF</ci> </apply> </apply> <apply> <power /> <ci>Na_o</ci> <ci>n_NaCa</ci> </apply> <ci>Ca_i</ci> </apply> </apply> </apply> <apply> <times /> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar4">1</cn> <apply> <times /> <ci>d_NaCa</ci> <apply> <plus /> <apply> <times /> <ci>Ca_i</ci> <apply> <power /> <ci>Na_o</ci> <ci>n_NaCa</ci> </apply> </apply> <apply> <times /> <ci>Ca_o</ci> <apply> <power /> <ci>Na_i</ci> <ci>n_NaCa</ci> </apply> </apply> </apply> </apply> </apply> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <divide /> <ci>Ca_i</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.0069</cn> </apply> </apply> </apply> </apply> </apply>
is computational component for: Na Ca exchanger

Na background current across plasma membrane of cardiac myocyte
type: NamedIndividual
type: Custom physical process
has sink: sodium(1+)
has source: sodium(1+)
has mediator: Plasma membrane
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: sodium(1+)
annotated source: Na background current across plasma membrane of cardiac myocyte

Axiom
has multiplier: 1.0
annotated property: hasMediator
annotated source: Na background current across plasma membrane of cardiac myocyte
annotated target: Plasma membrane

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: sodium(1+)
annotated source: Na background current across plasma membrane of cardiac myocyte

Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-2) (P50993)
type: NamedIndividual
refers to: Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-2) (P50993)
is index entity for: P50993 part of Plasma membrane part of Cardiac myocyte
part of: Plasma membrane

Plasma membrane
type: NamedIndividual
refers to: Plasma membrane
part of: Cardiac myocyte
has physical property: Electrical potential
has part: Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-2) (P50993)
is index entity for: Plasma membrane part of Cardiac myocyte

Portion of cytosol
type: NamedIndividual
refers to: Portion of cytosol
has part: sodium(1+)
has part: potassium(1+)
has part: calcium(2+)
part of: Cardiac myocyte
is index entity for: Portion of cytosol part of Cardiac myocyte
has part: Troponin
has part: Calmodulin

Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor) (Q92736)
type: NamedIndividual
refers to: Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor) (Q92736)
part of: Junctional sarcoplasmic reticulum of cardiac muscle cell
is index entity for: Q92736 part of Junctional sarcoplasmic reticulum of cardiac muscle cell part of Cardiac myocyte

Sarcoplasmic Ca transfer current
type: NamedIndividual
type: Custom physical process
has sink: calcium(2+)
has source: calcium(2+)
has physical property: Chemical molar flow rate

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: calcium(2+)
annotated source: Sarcoplasmic Ca transfer current

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: calcium(2+)
annotated source: Sarcoplasmic Ca transfer current

Sarcoplasmic reticulum uptake store
type: NamedIndividual
type: Custom physical entity
has part: calcium(2+)
part of: Cardiac myocyte
is index entity for: Sarcoplasmic reticulum uptake store part of Cardiac myocyte

Secondary Ca channel inward current
type: NamedIndividual
type: Custom physical process
has source: calcium(2+)
has sink: calcium(2+)
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: calcium(2+)
annotated source: Secondary Ca channel inward current

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: calcium(2+)
annotated source: Secondary Ca channel inward current

Secondary K channel inward current
type: NamedIndividual
type: Custom physical process
has sink: potassium(1+)
has source: potassium(1+)
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: potassium(1+)
annotated source: Secondary K channel inward current

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: potassium(1+)
annotated source: Secondary K channel inward current

Secondary Na channel inward current
type: NamedIndividual
type: Custom physical process
has source: sodium(1+)
has sink: sodium(1+)
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: sodium(1+)
annotated source: Secondary Na channel inward current

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: sodium(1+)
annotated source: Secondary Na channel inward current

Secondary channel inward current
type: NamedIndividual
type: Custom physical process
has source: sodium(1+)
has sink: sodium(1+)
has sink: potassium(1+)
has source: potassium(1+)
has source: calcium(2+)
has sink: calcium(2+)
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: calcium(2+)
annotated source: Secondary channel inward current

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: potassium(1+)
annotated source: Secondary channel inward current

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: sodium(1+)
annotated source: Secondary channel inward current

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: sodium(1+)
annotated source: Secondary channel inward current

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: calcium(2+)
annotated source: Secondary channel inward current

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: potassium(1+)
annotated source: Secondary channel inward current

Sodium-Potassium Pump Current
type: NamedIndividual
type: Custom physical process
has sink: sodium(1+)
has source: sodium(1+)
has sink: potassium(1+)
has source: potassium(1+)
has mediator: Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-2) (P50993)
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasMediator
annotated target: Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-2) (P50993)
annotated source: Sodium-Potassium Pump Current

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: sodium(1+)
annotated source: Sodium-Potassium Pump Current

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: potassium(1+)
annotated source: Sodium-Potassium Pump Current

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: sodium(1+)
annotated source: Sodium-Potassium Pump Current

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: potassium(1+)
annotated source: Sodium-Potassium Pump Current

Time independent K channel current
type: NamedIndividual
type: Custom physical process
has source: potassium(1+)
has sink: potassium(1+)
has physical property: Charge flow rate

Axiom
has multiplier: 1.0
annotated property: hasSource
annotated target: potassium(1+)
annotated source: Time independent K channel current

Axiom
has multiplier: 1.0
annotated property: hasSink
annotated target: potassium(1+)
annotated source: Time independent K channel current

UNIT ampere
type: NamedIndividual
type: Unit of measurement
has computational code: ampere
is fundamental unit: true
unit factor for: UNIT nanoA

UNIT coulomb
type: NamedIndividual
type: Unit of measurement
has computational code: coulomb
is fundamental unit: true
unit factor for: UNIT coulomb per mole

UNIT coulomb per mole
type: NamedIndividual
type: Unit of measurement
has computational code: coulomb_per_mole
has unit factor: UNIT coulomb
has unit factor: UNIT mole
unit for: extracellular calcium concentration.F
unit for: intracellular calcium concentration.F
unit for: intracellular potassium concentration.F
unit for: intracellular sodium concentration.F
unit for: membrane.F

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT coulomb per mole
annotated target: UNIT mole

UNIT farad
type: NamedIndividual
type: Unit of measurement
has computational code: farad
is fundamental unit: true
unit factor for: UNIT microF

UNIT joule
type: NamedIndividual
type: Unit of measurement
has computational code: joule
is fundamental unit: true
unit factor for: UNIT joule per kilomole kelvin

UNIT joule per kilomole kelvin
type: NamedIndividual
type: Unit of measurement
has computational code: joule_per_kilomole_kelvin
has unit factor: UNIT joule
has unit factor: UNIT kelvin
has unit factor: UNIT mole
unit for: membrane.R

Axiom
has unit factor exponent: -1.0
has unit factor prefix: kilo
annotated property: hasUnitFactor
annotated source: UNIT joule per kilomole kelvin
annotated target: UNIT mole

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT joule per kilomole kelvin
annotated target: UNIT kelvin

UNIT kelvin
type: NamedIndividual
type: Unit of measurement
has computational code: kelvin
is fundamental unit: true
unit factor for: UNIT joule per kilomole kelvin
unit for: membrane.T

UNIT litre
type: NamedIndividual
type: Unit of measurement
has computational code: litre
is fundamental unit: true
unit factor for: UNIT millimolar

UNIT metre
type: NamedIndividual
type: Unit of measurement
has computational code: metre
is fundamental unit: true
unit factor for: UNIT micrometre
unit factor for: UNIT micrometre3

UNIT microF
type: NamedIndividual
type: Unit of measurement
has computational code: microF
has unit factor: UNIT farad
unit for: membrane.C m

Axiom
has unit factor prefix: micro
annotated property: hasUnitFactor
annotated target: UNIT farad
annotated source: UNIT microF

UNIT microS
type: NamedIndividual
type: Unit of measurement
has computational code: microS
has unit factor: UNIT siemens
unit for: calcium background current.g b Ca
unit for: fast sodium current.g Na
unit for: potassium background current.g b K
unit for: sodium background current.g b Na
unit for: time independent potassium current.g K1

Axiom
has unit factor prefix: micro
annotated property: hasUnitFactor
annotated source: UNIT microS
annotated target: UNIT siemens

UNIT micrometre
type: NamedIndividual
type: Unit of measurement
has computational code: micrometre
has unit factor: UNIT metre
unit for: intracellular calcium concentration.length
unit for: intracellular calcium concentration.radius

Axiom
has unit factor prefix: micro
annotated property: hasUnitFactor
annotated target: UNIT metre
annotated source: UNIT micrometre

UNIT micrometre3
type: NamedIndividual
type: Unit of measurement
has computational code: micrometre3
has unit factor: UNIT metre
unit for: extracellular calcium concentration.Ve
unit for: intracellular calcium concentration.V Cell
unit for: intracellular calcium concentration.V i
unit for: intracellular calcium concentration.Ve
unit for: intracellular potassium concentration.V i
unit for: intracellular sodium concentration.V i

Axiom
has unit factor exponent: 3.0
has unit factor prefix: micro
annotated property: hasUnitFactor
annotated target: UNIT metre
annotated source: UNIT micrometre3

UNIT millimolar
type: NamedIndividual
type: Unit of measurement
has computational code: millimolar
unit for: Na Ca exchanger.Ca i
unit for: Na Ca exchanger.Ca o
unit for: Na Ca exchanger.Na i
unit for: Na Ca exchanger.Na o
has unit factor: UNIT litre
unit factor for: UNIT millimolar per second
has unit factor: UNIT mole
unit factor for: UNIT nanoA per millimolar
unit factor for: UNIT per millimolar second
unit for: calcium background current.Ca i
unit for: calcium background current.Ca o
unit for: calcium release.Ca i
unit for: calcium release.Ca rel
unit for: calcium translocation.Ca rel
unit for: calcium translocation.Ca up
unit for: extracellular calcium concentration.Ca o
unit for: extracellular calcium concentration.Cab
unit for: extracellular potassium concentration.K c
unit for: extracellular sodium concentration.Na o
unit for: fast sodium current.K c
unit for: fast sodium current.K i
unit for: fast sodium current.Na i
unit for: fast sodium current.Na o
unit for: intracellular calcium concentration.Ca Calmod
unit for: intracellular calcium concentration.Ca Trop
unit for: intracellular calcium concentration.Ca i
unit for: intracellular calcium concentration.Ca rel
unit for: intracellular calcium concentration.Ca up
unit for: intracellular calcium concentration.Calmod
unit for: intracellular calcium concentration.Trop
unit for: intracellular potassium concentration.K i
unit for: intracellular sodium concentration.Na i
unit for: sarcoplasmic reticulum calcium pump.Ca i
unit for: sarcoplasmic reticulum calcium pump.Ca up
unit for: sarcoplasmic reticulum calcium pump.K 2
unit for: sarcoplasmic reticulum calcium pump.K cyca
unit for: sarcoplasmic reticulum calcium pump.K srca
unit for: second inward calcium current.Ca i
unit for: second inward calcium current.Ca o
unit for: second inward calcium current.K c
unit for: second inward calcium current.K i
unit for: second inward calcium current.Na i
unit for: second inward calcium current.Na o
unit for: second inward calcium current f Ca gate.Ca i
unit for: sodium background current.Na i
unit for: sodium background current.Na o
unit for: sodium potassium pump.K c
unit for: sodium potassium pump.K mK
unit for: sodium potassium pump.K mNa
unit for: sodium potassium pump.Na i
unit for: time independent potassium current.K c
unit for: time independent potassium current.K i
unit for: time independent potassium current.K m K1

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated target: UNIT litre
annotated source: UNIT millimolar

Axiom
has unit factor prefix: milli
annotated property: hasUnitFactor
annotated source: UNIT millimolar
annotated target: UNIT mole

UNIT millimolar per second
type: NamedIndividual
type: Unit of measurement
has computational code: millimolar_per_second
has unit factor: UNIT millimolar
has unit factor: UNIT second
unit for: calcium release.i rel
unit for: calcium translocation.i trans
unit for: intracellular calcium concentration.dCaCalmoddt
unit for: intracellular calcium concentration.dCaTropdt
unit for: intracellular calcium concentration.i rel
unit for: intracellular calcium concentration.i trans
unit for: intracellular calcium concentration.i up
unit for: sarcoplasmic reticulum calcium pump.alpha up
unit for: sarcoplasmic reticulum calcium pump.beta up
unit for: sarcoplasmic reticulum calcium pump.i up

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT millimolar per second
annotated target: UNIT second

UNIT millivolt
type: NamedIndividual
type: Unit of measurement
has computational code: millivolt
unit for: Na Ca exchanger.RTONF
unit for: Na Ca exchanger.V
has unit factor: UNIT volt
unit for: calcium background current.E Ca
unit for: calcium background current.RTONF
unit for: calcium background current.V
unit for: calcium release.V
unit for: fast sodium current.E mh
unit for: fast sodium current.RTONF
unit for: fast sodium current.V
unit for: fast sodium current h gate.V
unit for: fast sodium current m gate.E0 m
unit for: fast sodium current m gate.V
unit for: fast sodium current m gate.delta m
unit for: membrane.RTONF
unit for: membrane.V
unit for: potassium background current.E K
unit for: potassium background current.V
unit for: second inward calcium current.RTONF
unit for: second inward calcium current.V
unit for: second inward calcium current d gate.E0 d
unit for: second inward calcium current d gate.V
unit for: second inward calcium current d gate.delta d
unit for: second inward calcium current f Ca gate.E0 f
unit for: second inward calcium current f Ca gate.V
unit for: second inward calcium current f Ca gate.delta f
unit for: sodium background current.E Na
unit for: sodium background current.RTONF
unit for: sodium background current.V
unit for: sodium potassium pump.V
unit for: time independent potassium current.E K
unit for: time independent potassium current.RTONF
unit for: time independent potassium current.V

Axiom
has unit factor prefix: milli
annotated property: hasUnitFactor
annotated source: UNIT millivolt
annotated target: UNIT volt

UNIT mole
type: NamedIndividual
type: Unit of measurement
has computational code: mole
is fundamental unit: true
unit factor for: UNIT coulomb per mole
unit factor for: UNIT joule per kilomole kelvin
unit factor for: UNIT millimolar

UNIT nanoA
type: NamedIndividual
type: Unit of measurement
has computational code: nanoA
unit for: Na Ca exchanger.i NaCa
unit for: Na Ca exchanger.k NaCa
has unit factor: UNIT ampere
unit factor for: UNIT nanoA per millimolar
unit for: calcium background current.i b Ca
unit for: extracellular calcium concentration.i NaCa
unit for: extracellular calcium concentration.i b Ca
unit for: extracellular calcium concentration.i siCa
unit for: fast sodium current.i Na
unit for: intracellular calcium concentration.i NaCa
unit for: intracellular calcium concentration.i b Ca
unit for: intracellular calcium concentration.i siCa
unit for: intracellular potassium concentration.i K1
unit for: intracellular potassium concentration.i NaK
unit for: intracellular potassium concentration.i b K
unit for: intracellular potassium concentration.i siK
unit for: intracellular sodium concentration.i Na
unit for: intracellular sodium concentration.i NaCa
unit for: intracellular sodium concentration.i NaK
unit for: intracellular sodium concentration.i b Na
unit for: intracellular sodium concentration.i siNa
unit for: membrane.i K1
unit for: membrane.i Na
unit for: membrane.i NaCa
unit for: membrane.i NaK
unit for: membrane.i Stim
unit for: membrane.i b Ca
unit for: membrane.i b K
unit for: membrane.i b Na
unit for: membrane.i si
unit for: membrane.stim amplitude
unit for: potassium background current.i b K
unit for: second inward calcium current.i si
unit for: second inward calcium current.i siCa
unit for: second inward calcium current.i siK
unit for: second inward calcium current.i siNa
unit for: sodium background current.i b Na
unit for: sodium potassium pump.i NaK
unit for: sodium potassium pump.i NaK max
unit for: time independent potassium current.i K1

Axiom
has unit factor prefix: nano
annotated property: hasUnitFactor
annotated target: UNIT ampere
annotated source: UNIT nanoA

UNIT nanoA per millimolar
type: NamedIndividual
type: Unit of measurement
has computational code: nanoA_per_millimolar
has unit factor: UNIT millimolar
has unit factor: UNIT nanoA
unit for: second inward calcium current.P si

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated target: UNIT millimolar
annotated source: UNIT nanoA per millimolar

UNIT per millimolar second
type: NamedIndividual
type: Unit of measurement
has computational code: per_millimolar_second
has unit factor: UNIT millimolar
has unit factor: UNIT second
unit for: intracellular calcium concentration.alpha Calmod
unit for: intracellular calcium concentration.alpha Trop

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated target: UNIT millimolar
annotated source: UNIT per millimolar second

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT per millimolar second
annotated target: UNIT second

UNIT per second
type: NamedIndividual
type: Unit of measurement
has computational code: per_second
has unit factor: UNIT second
unit for: calcium release.ActRate
unit for: calcium release.InactRate
unit for: calcium release.K leak rate
unit for: calcium release.K m rel
unit for: calcium translocation.alpha tr
unit for: extracellular calcium concentration.K diff
unit for: fast sodium current h gate.alpha h
unit for: fast sodium current h gate.beta h
unit for: fast sodium current m gate.alpha m
unit for: fast sodium current m gate.beta m
unit for: intracellular calcium concentration.beta Calmod
unit for: intracellular calcium concentration.beta Trop
unit for: second inward calcium current d gate.alpha d
unit for: second inward calcium current d gate.beta d
unit for: second inward calcium current f Ca gate.alpha f Ca
unit for: second inward calcium current f Ca gate.beta f Ca

Axiom
has unit factor exponent: -1.0
annotated property: hasUnitFactor
annotated source: UNIT per second
annotated target: UNIT second

UNIT second
type: NamedIndividual
type: Unit of measurement
has computational code: second
is fundamental unit: true
unit for: Na Ca exchanger.time
unit factor for: UNIT millimolar per second
unit factor for: UNIT per millimolar second
unit factor for: UNIT per second
unit for: calcium background current.time
unit for: calcium release.time
unit for: calcium translocation.time
unit for: environment.time
unit for: extracellular calcium concentration.time
unit for: fast sodium current.time
unit for: fast sodium current h gate.time
unit for: fast sodium current m gate.time
unit for: intracellular calcium concentration.time
unit for: intracellular potassium concentration.time
unit for: intracellular sodium concentration.time
unit for: membrane.stim duration
unit for: membrane.stim end
unit for: membrane.stim period
unit for: membrane.stim start
unit for: membrane.time
unit for: potassium background current.time
unit for: sarcoplasmic reticulum calcium pump.time
unit for: second inward calcium current.time
unit for: second inward calcium current d gate.time
unit for: second inward calcium current f Ca gate.time
unit for: sodium background current.time
unit for: sodium potassium pump.time
unit for: time independent potassium current.time

UNIT siemens
type: NamedIndividual
type: Unit of measurement
has computational code: siemens
is fundamental unit: true
unit factor for: UNIT microS

UNIT volt
type: NamedIndividual
type: Unit of measurement
is fundamental unit: true
has computational code: volt
unit factor for: UNIT millivolt

calcium background current
type: NamedIndividual
type: Submodel
name: calcium_background_current
has associated data structure: calcium background current.Ca i
has associated data structure: calcium background current.Ca o
has associated data structure: calcium background current.E Ca
has associated data structure: calcium background current.RTONF
has associated data structure: calcium background current.V
has associated data structure: calcium background current.g b Ca
has associated data structure: calcium background current.i b Ca
has associated data structure: calcium background current.time
has computational component: calcium background current computation

calcium background current.Ca i
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Intracellular Ca concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: calcium background current.Ca i

calcium background current.Ca o
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Extracellular calcium concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: calcium background current.Ca o

calcium background current.E Ca
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Calcium reversal potential
has unit: UNIT millivolt
is computational component for: calcium background current.E Ca property

calcium background current.RTONF
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
has unit: UNIT millivolt
is computational component for: calcium background current.RTONF property

calcium background current.V
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: calcium background current.V

calcium background current.g b Ca
type: NamedIndividual
type: Decimal
has start value: 0.005
is discrete: false
is solution domain: false
is declared: true
comment: Calcium background conductance
has unit: UNIT microS
is computational component for: calcium background current.g b Ca property

calcium background current.i b Ca
type: NamedIndividual
type: Decimal
metadata ID: calcium_background_current_i_b_Ca
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Calcium background current
has unit: UNIT nanoA
is computational component for: Charge flow rate
mapped to: extracellular calcium concentration.i b Ca
mapped to: intracellular calcium concentration.i b Ca
mapped to: membrane.i b Ca

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Ca background current across plasma membrane of cardiac myocyte
has computational component: calcium background current.i b Ca

calcium background current.time
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: calcium background current.time property

calcium background current computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>E_Ca</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.5</cn> <ci>RTONF</ci> <apply> <ln /> <apply> <divide /> <ci>Ca_o</ci> <ci>Ca_i</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>i_b_Ca</ci> <apply> <times /> <ci>g_b_Ca</ci> <apply> <minus /> <ci>V</ci> <ci>E_Ca</ci> </apply> </apply> </apply>
is computational component for: calcium background current

calcium release
type: NamedIndividual
type: Submodel
name: calcium_release
has associated data structure: calcium release.ActFrac
has associated data structure: calcium release.ActRate
has associated data structure: calcium release.Ca i
has associated data structure: calcium release.Ca rel
has associated data structure: calcium release.InactRate
has associated data structure: calcium release.K leak rate
has associated data structure: calcium release.K m rel
has associated data structure: calcium release.PrecFrac
has associated data structure: calcium release.ProdFrac
has associated data structure: calcium release.RegBindSite
has associated data structure: calcium release.V
has associated data structure: calcium release.VoltDep
has associated data structure: calcium release.i rel
has associated data structure: calcium release.time
has computational component: calcium release computation

calcium release.ActFrac
type: NamedIndividual
type: Decimal
has start value: 0
is discrete: false
is solution domain: false
is declared: true
comment: Activator molecule fraction
is computational component for: calcium release.ActFrac property

calcium release.ActRate
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
is declared: true
comment: Release channel activation rate
has unit: UNIT per second
is computational component for: calcium release.ActRate property

calcium release.Ca i
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Intracellular Ca concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: calcium release.Ca i

calcium release.Ca rel
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Ca concentrations in s.r. release store
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: calcium release.Ca rel

calcium release.InactRate
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Release channel inactivation rate
has unit: UNIT per second
is computational component for: calcium release.InactRate property

calcium release.K leak rate
type: NamedIndividual
type: Decimal
has start value: 0
is discrete: false
is solution domain: false
is declared: true
comment: Release channel Ca leak rate
has unit: UNIT per second
is computational component for: calcium release.K leak rate property

calcium release.K m rel
type: NamedIndividual
type: Decimal
has start value: 250
is discrete: false
is solution domain: false
is declared: true
comment: SR Ca release current maximal release rate
has unit: UNIT per second
is computational component for: calcium release.K m rel property

calcium release.PrecFrac
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
is declared: true
comment: Activator precursor molecule fraction
is computational component for: calcium release.PrecFrac property

calcium release.ProdFrac
type: NamedIndividual
type: Decimal
has start value: 0
is discrete: false
is solution domain: false
is declared: true
comment: Activator molecule inactive product fraction
is computational component for: calcium release.ProdFrac property

calcium release.RegBindSite
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
is declared: true
comment: Regulatory binding sites occupied by Ca.
is computational component for: calcium release.RegBindSite property

calcium release.V
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: calcium release.V

calcium release.VoltDep
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Voltage dependence of release
is computational component for: calcium release.VoltDep property

calcium release.i rel
type: NamedIndividual
type: Decimal
metadata ID: calcium_release_i_rel
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Ca release from junctional sarcoplasmic reticulum into cytosol
has unit: UNIT millimolar per second
is computational component for: Chemical molar flow rate
mapped to: intracellular calcium concentration.i rel

Chemical molar flow rate
type: NamedIndividual
refers to: Chemical molar flow rate
physical property of: Ca release from sarcoplasmic reticulum into cytosol of cardiac myocyte
has computational component: calcium release.i rel

calcium release.time
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Time - Solution Domain
has unit: UNIT second
is computational component for: calcium release.time property

calcium release computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>PrecFrac</ci> <apply> <minus /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <ci>ActFrac</ci> </apply> <ci>ProdFrac</ci> </apply> </apply> <apply> <eq /> <ci>VoltDep</ci> <apply> <exp /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.08</cn> <apply> <minus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>RegBindSite</ci> <apply> <power /> <apply> <divide /> <ci>Ca_i</ci> <apply> <plus /> <ci>Ca_i</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.0005</cn> </apply> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> </apply> </apply> <apply> <eq /> <ci>ActRate</ci> <apply> <plus /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">600</cn> <ci>VoltDep</ci> </apply> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">500</cn> <ci>RegBindSite</ci> </apply> </apply> </apply> <apply> <eq /> <ci>InactRate</ci> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">60</cn> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">500</cn> <ci>RegBindSite</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>ActFrac</ci> </apply> <apply> <minus /> <apply> <times /> <ci>PrecFrac</ci> <ci>ActRate</ci> </apply> <apply> <times /> <ci>ActFrac</ci> <ci>InactRate</ci> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>ProdFrac</ci> </apply> <apply> <minus /> <apply> <times /> <ci>ActFrac</ci> <ci>InactRate</ci> </apply> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_seco…
is computational component for: calcium release

calcium translocation
type: NamedIndividual
type: Submodel
name: calcium_translocation
has associated data structure: calcium translocation.Ca rel
has associated data structure: calcium translocation.Ca up
has associated data structure: calcium translocation.alpha tr
has associated data structure: calcium translocation.i trans
has associated data structure: calcium translocation.time
has computational component: calcium translocation computation

calcium translocation.Ca rel
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Ca concentrations in s.r. release store
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: calcium translocation.Ca rel

calcium translocation.Ca up
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Ca concentration in s.r. uptake store
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: calcium translocation.Ca up

calcium translocation.alpha tr
type: NamedIndividual
type: Decimal
has start value: 50
is solution domain: false
is discrete: false
is declared: true
comment: Rate coefficient for Ca translocation
has unit: UNIT per second
is computational component for: calcium translocation.alpha tr property

calcium translocation.i trans
type: NamedIndividual
type: Decimal
metadata ID: calcium_translocation_i_trans
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Ca transferred into releasable form
has unit: UNIT millimolar per second
is computational component for: Chemical molar flow rate
mapped to: intracellular calcium concentration.i trans

Chemical molar flow rate
type: NamedIndividual
refers to: Chemical molar flow rate
physical property of: Sarcoplasmic Ca transfer current
has computational component: calcium translocation.i trans

calcium translocation.time
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Time - Solution Domain
has unit: UNIT second
is computational component for: calcium translocation.time property

calcium translocation computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>i_trans</ci> <apply> <times /> <apply> <minus /> <ci>Ca_up</ci> <ci>Ca_rel</ci> </apply> <ci>alpha_tr</ci> </apply> </apply>
is computational component for: calcium translocation

environment
type: NamedIndividual
type: Submodel
name: environment
has associated data structure: environment.time
has computational component: environment computation

environment.time
type: NamedIndividual
type: Decimal
metadata ID: environment_time
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Time solution domain
mapped to: Na Ca exchanger.time
has unit: UNIT second
mapped to: calcium background current.time
mapped to: calcium release.time
mapped to: calcium translocation.time
is computational component for: environment.time property
mapped to: extracellular calcium concentration.time
mapped to: fast sodium current.time
mapped to: intracellular calcium concentration.time
mapped to: intracellular potassium concentration.time
mapped to: intracellular sodium concentration.time
mapped to: membrane.time
mapped to: potassium background current.time
mapped to: sarcoplasmic reticulum calcium pump.time
mapped to: second inward calcium current.time
mapped to: sodium background current.time
mapped to: sodium potassium pump.time
mapped to: time independent potassium current.time

extracellular calcium concentration
type: NamedIndividual
type: Submodel
name: extracellular_calcium_concentration
has associated data structure: extracellular calcium concentration.Ca o
has associated data structure: extracellular calcium concentration.Cab
has associated data structure: extracellular calcium concentration.F
has associated data structure: extracellular calcium concentration.K diff
has associated data structure: extracellular calcium concentration.Ve
has associated data structure: extracellular calcium concentration.i NaCa
has associated data structure: extracellular calcium concentration.i b Ca
has associated data structure: extracellular calcium concentration.i siCa
has associated data structure: extracellular calcium concentration.time
has computational component: extracellular calcium concentration computation

extracellular calcium concentration.Ca o
type: NamedIndividual
type: Decimal
has start value: 2
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Extracellular calcium concentration
mapped to: Na Ca exchanger.Ca o
has unit: UNIT millimolar
mapped to: calcium background current.Ca o
is computational component for: Chemical concentration
mapped to: second inward calcium current.Ca o

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: extracellular calcium concentration.Ca o

extracellular calcium concentration.Cab
type: NamedIndividual
type: Decimal
has start value: 2
is discrete: false
is solution domain: false
is declared: true
comment: Ca concentration in the muscle bath
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: extracellular calcium concentration.Cab

extracellular calcium concentration.F
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Faraday Constant
has unit: UNIT coulomb per mole
is computational component for: extracellular calcium concentration.F property

extracellular calcium concentration.K diff
type: NamedIndividual
type: Decimal
has start value: 0.0005
is solution domain: false
is discrete: false
is declared: true
comment: Rate constant of exchange between extracellular space and the muscle bath
has unit: UNIT per second
is computational component for: extracellular calcium concentration.K diff property

extracellular calcium concentration.Ve
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Total extracellular volume
has unit: UNIT micrometre3
is computational component for: extracellular calcium concentration.Ve property

extracellular calcium concentration.i NaCa
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Na-Ca exchange current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: NaCa exchange pump current across plasma membrane
has computational component: extracellular calcium concentration.i NaCa

extracellular calcium concentration.i b Ca
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Calcium background current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Ca background current across plasma membrane of cardiac myocyte
has computational component: extracellular calcium concentration.i b Ca

extracellular calcium concentration.i siCa
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Calcium component of fast Ca current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Secondary Ca channel inward current
has computational component: extracellular calcium concentration.i siCa

extracellular calcium concentration.time
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Time - Solution Domain
has unit: UNIT second
is computational component for: extracellular calcium concentration.time property

extracellular calcium concentration computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>Ca_o</ci> </apply> <apply> <minus /> <apply> <times /> <apply> <minus /> <ci>Cab</ci> <ci>Ca_o</ci> </apply> <ci>K_diff</ci> </apply> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mA_nA">1</cn> <apply> <plus /> <ci>i_siCa</ci> <ci>i_NaCa</ci> <ci>i_b_Ca</ci> </apply> </apply> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="litre_micrometre3">1</cn> <ci>Ve</ci> <ci>F</ci> </apply> </apply> </apply> </apply>
is computational component for: extracellular calcium concentration

extracellular potassium concentration
type: NamedIndividual
type: Submodel
name: extracellular_potassium_concentration
has associated data structure: extracellular potassium concentration.K c
has computational component: extracellular potassium concentration computation

extracellular potassium concentration.K c
type: NamedIndividual
type: Decimal
has start value: 4
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Potassium concentration in the extracellular cleft
has unit: UNIT millimolar
is computational component for: Chemical concentration
mapped to: fast sodium current.K c
mapped to: second inward calcium current.K c
mapped to: sodium potassium pump.K c
mapped to: time independent potassium current.K c

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: potassium(1+)
has computational component: extracellular potassium concentration.K c

extracellular sodium concentration
type: NamedIndividual
type: Submodel
name: extracellular_sodium_concentration
has associated data structure: extracellular sodium concentration.Na o
has computational component: extracellular sodium concentration computation

extracellular sodium concentration.Na o
type: NamedIndividual
type: Decimal
has start value: 140
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Extracellular sodium concentration
mapped to: Na Ca exchanger.Na o
has unit: UNIT millimolar
is computational component for: Chemical concentration
mapped to: fast sodium current.Na o
mapped to: second inward calcium current.Na o
mapped to: sodium background current.Na o

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: extracellular sodium concentration.Na o

fast sodium current
type: NamedIndividual
type: Submodel
name: fast_sodium_current
has associated data structure: fast sodium current.E mh
has associated data structure: fast sodium current.K c
has associated data structure: fast sodium current.K i
has associated data structure: fast sodium current.Na i
has associated data structure: fast sodium current.Na o
has associated data structure: fast sodium current.RTONF
has associated data structure: fast sodium current.V
has associated data structure: fast sodium current.g Na
has associated data structure: fast sodium current.h
has associated data structure: fast sodium current.i Na
has associated data structure: fast sodium current.m
has associated data structure: fast sodium current.time
has computational component: fast sodium current computation
includes submodel: fast sodium current h gate
includes submodel: fast sodium current m gate

Axiom
submodel subsumption type: containment
submodel subsumption type: encapsulation
annotated property: includesSubmodel
annotated source: fast sodium current
annotated target: fast sodium current m gate

Axiom
submodel subsumption type: containment
submodel subsumption type: encapsulation
annotated property: includesSubmodel
annotated source: fast sodium current
annotated target: fast sodium current h gate

fast sodium current.E mh
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Reversal potential for sodium channel
has unit: UNIT millivolt
is computational component for: fast sodium current.E mh property

fast sodium current.K c
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Potassium concentration in the extracellular cleft
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: potassium(1+)
has computational component: fast sodium current.K c

fast sodium current.K i
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Potassium intracellular concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: potassium(1+)
has computational component: fast sodium current.K i

fast sodium current.Na i
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Intracellular Na concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: fast sodium current.Na i

fast sodium current.Na o
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Extracellular sodium concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: fast sodium current.Na o

fast sodium current.RTONF
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
has unit: UNIT millivolt
is computational component for: fast sodium current.RTONF property

fast sodium current.V
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
has cell m lprivate interface: out
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential
mapped to: fast sodium current h gate.V
mapped to: fast sodium current m gate.V

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: fast sodium current.V

fast sodium current.g Na
type: NamedIndividual
type: Decimal
has start value: 50
is solution domain: false
is discrete: false
is declared: true
comment: Conductance of fast sodium current channels
has unit: UNIT microS
is computational component for: fast sodium current.g Na property

fast sodium current.h
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lprivate interface: in
is declared: true
comment: Gating variable for h gate
is computational component for: fast sodium current.h property

fast sodium current.i Na
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
metadata ID: fast_sodium_current_i_Na
has cell m lpublic interface: out
is declared: true
comment: TTX sensittive fast Na current
has unit: UNIT nanoA
is computational component for: Charge flow rate
mapped to: intracellular sodium concentration.i Na
mapped to: membrane.i Na

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Fast sodium channel current across plasma membrane
has computational component: fast sodium current.i Na

fast sodium current.m
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lprivate interface: in
is declared: true
comment: Activation gate and rate coefficient
is computational component for: fast sodium current.m property

fast sodium current.time
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
has cell m lprivate interface: out
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: fast sodium current.time property
mapped to: fast sodium current h gate.time
mapped to: fast sodium current m gate.time

fast sodium current computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>E_mh</ci> <apply> <times /> <ci>RTONF</ci> <apply> <ln /> <apply> <divide /> <apply> <plus /> <ci>Na_o</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.12</cn> <ci>K_c</ci> </apply> </apply> <apply> <plus /> <ci>Na_i</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.12</cn> <ci>K_i</ci> </apply> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>i_Na</ci> <apply> <times /> <ci>g_Na</ci> <apply> <power /> <ci>m</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn> </apply> <ci>h</ci> <apply> <minus /> <ci>V</ci> <ci>E_mh</ci> </apply> </apply> </apply>
is computational component for: fast sodium current

fast sodium current h gate
type: NamedIndividual
type: Submodel
name: fast_sodium_current_h_gate
has associated data structure: fast sodium current h gate.V
has associated data structure: fast sodium current h gate.alpha h
has associated data structure: fast sodium current h gate.beta h
has associated data structure: fast sodium current h gate.h
has associated data structure: fast sodium current h gate.time
has computational component: fast sodium current h gate computation

fast sodium current h gate.V
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: fast sodium current h gate.V

fast sodium current h gate.alpha h
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Inactivation gate and rate coefficient
has unit: UNIT per second
is computational component for: fast sodium current h gate.alpha h property

fast sodium current h gate.beta h
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Inactivation gate and rate coefficient
has unit: UNIT per second
is computational component for: fast sodium current h gate.beta h property

fast sodium current h gate.h
type: NamedIndividual
type: Decimal
has start value: 0.015
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Gating variable for h gate
mapped to: fast sodium current.h
is computational component for: fast sodium current h gate.h property

fast sodium current h gate.time
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: fast sodium current h gate.time property

fast sodium current h gate computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>alpha_h</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">20</cn> <apply> <exp /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.125</cn> </apply> <apply> <plus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">75</cn> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>beta_h</ci> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">2000</cn> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">320</cn> <apply> <exp /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn> </apply> <apply> <plus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">75</cn> </apply> </apply> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>h</ci> </apply> <apply> <minus /> <apply> <times /> <ci>alpha_h</ci> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <ci>h</ci> </apply> </apply> <apply> <times /> <ci>beta_h</ci> <ci>h</ci> </apply> </apply> </apply>
is computational component for: fast sodium current h gate

fast sodium current m gate
type: NamedIndividual
type: Submodel
name: fast_sodium_current_m_gate
has associated data structure: fast sodium current m gate.E0 m
has associated data structure: fast sodium current m gate.V
has associated data structure: fast sodium current m gate.alpha m
has associated data structure: fast sodium current m gate.beta m
has associated data structure: fast sodium current m gate.delta m
has associated data structure: fast sodium current m gate.m
has associated data structure: fast sodium current m gate.time
has computational component: fast sodium current m gate computation

fast sodium current m gate.E0 m
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
is declared: true
has unit: UNIT millivolt
is computational component for: fast sodium current m gate.E0 m property

fast sodium current m gate.V
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: fast sodium current m gate.V

fast sodium current m gate.alpha m
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Activation gate and rate coefficient
has unit: UNIT per second
is computational component for: fast sodium current m gate.alpha m property

fast sodium current m gate.beta m
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Activation gate and rate coefficient
has unit: UNIT per second
is computational component for: fast sodium current m gate.beta m property

fast sodium current m gate.delta m
type: NamedIndividual
type: Decimal
has start value: 1e-5
is discrete: false
is solution domain: false
is declared: true
has unit: UNIT millivolt
is computational component for: fast sodium current m gate.delta m property

fast sodium current m gate.m
type: NamedIndividual
type: Decimal
has start value: 0.076
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Activation gate and rate coefficient
mapped to: fast sodium current.m
is computational component for: fast sodium current m gate.m property

fast sodium current m gate.time
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: fast sodium current m gate.time property

fast sodium current m gate computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>E0_m</ci> <apply> <plus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">41</cn> </apply> </apply> <apply> <eq /> <ci>alpha_m</ci> <piecewise> <piece> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">2000</cn> <apply> <lt /> <apply> <abs /> <ci>E0_m</ci> </apply> <ci>delta_m</ci> </apply> </piece> <otherwise> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">200</cn> <ci>E0_m</ci> </apply> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <exp /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn> </apply> <ci>E0_m</ci> </apply> </apply> </apply> </apply> </otherwise> </piecewise> </apply> <apply> <eq /> <ci>beta_m</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">8000</cn> <apply> <exp /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.056</cn> </apply> <apply> <plus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">66</cn> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>m</ci> </apply> <apply> <minus /> <apply> <times /> <ci>alpha_m</ci> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <ci>m</ci> </apply> </apply> <apply> <times /> <ci>beta_m</ci> <ci>m</ci> </apply> </apply> </apply>
is computational component for: fast sodium current m gate

Troponin
type: NamedIndividual
refers to: Troponin
has part: calcium(2+)
part of: Portion of cytosol
is index entity for: fma62338 part of Portion of cytosol part of Cardiac myocyte
has physical property: Chemical concentration

Calmodulin
type: NamedIndividual
refers to: Calmodulin
has part: calcium(2+)
part of: Portion of cytosol
is index entity for: fma62343 part of Portion of cytosol part of Cardiac myocyte
has physical property: Chemical concentration

Portion of extracellular matrix
type: NamedIndividual
refers to: Portion of extracellular matrix
has part: sodium(1+)
has part: calcium(2+)

intracellular calcium concentration
type: NamedIndividual
type: Submodel
name: intracellular_calcium_concentration
has associated data structure: intracellular calcium concentration.Ca Calmod
has associated data structure: intracellular calcium concentration.Ca Trop
has associated data structure: intracellular calcium concentration.Ca i
has associated data structure: intracellular calcium concentration.Ca rel
has associated data structure: intracellular calcium concentration.Ca up
has associated data structure: intracellular calcium concentration.Calmod
has associated data structure: intracellular calcium concentration.F
has associated data structure: intracellular calcium concentration.Trop
has associated data structure: intracellular calcium concentration.V Cell
has associated data structure: intracellular calcium concentration.V e ratio
has associated data structure: intracellular calcium concentration.V i
has associated data structure: intracellular calcium concentration.V i ratio
has associated data structure: intracellular calcium concentration.V rel ratio
has associated data structure: intracellular calcium concentration.V up ratio
has associated data structure: intracellular calcium concentration.Ve
has associated data structure: intracellular calcium concentration.alpha Calmod
has associated data structure: intracellular calcium concentration.alpha Trop
has associated data structure: intracellular calcium concentration.beta Calmod
has associated data structure: intracellular calcium concentration.beta Trop
has associated data structure: intracellular calcium concentration.dCaCalmoddt
has associated data structure: intracellular calcium concentration.dCaTropdt
has associated data structure: intracellular calcium concentration.i NaCa
has associated data structure: intracellular calcium concentration.i b Ca
has associated data structure: intracellular calcium concentration.i rel
has associated data structure: intracellular calcium concentration.i siCa
has associated data structure: intracellular calcium concentration.i trans
has associated data structure: intracellular calcium concentration.i up
has associated data structure: intracellular calcium concentration.length
has associated data structure: intracellular calcium concentration.radius
has associated data structure: intracellular calcium concentration.time
has computational component: intracellular calcium concentration computation

intracellular calcium concentration.Ca Calmod
type: NamedIndividual
type: Decimal
has start value: 0.0005
is discrete: false
is solution domain: false
is declared: true
comment: Concentration of Ca bound calmodulin in the cytosol
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: intracellular calcium concentration.Ca Calmod

intracellular calcium concentration.Ca Trop
type: NamedIndividual
type: Decimal
has start value: 0.0015
is discrete: false
is solution domain: false
is declared: true
comment: Concentration of Ca bound troponin in the cytosol
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: intracellular calcium concentration.Ca Trop

intracellular calcium concentration.Ca i
type: NamedIndividual
type: Decimal
has start value: 1e-5
is discrete: false
is solution domain: false
metadata ID: intracellular_calcium_concentration_Ca_i
has cell m lpublic interface: out
is declared: true
comment: Intracellular Ca concentration
mapped to: Na Ca exchanger.Ca i
has unit: UNIT millimolar
mapped to: calcium background current.Ca i
mapped to: calcium release.Ca i
is computational component for: Chemical concentration
mapped to: sarcoplasmic reticulum calcium pump.Ca i
mapped to: second inward calcium current.Ca i

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: intracellular calcium concentration.Ca i

intracellular calcium concentration.Ca rel
type: NamedIndividual
type: Decimal
has start value: 0.3
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Ca concentrations in s.r. release store
has unit: UNIT millimolar
mapped to: calcium release.Ca rel
mapped to: calcium translocation.Ca rel
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: intracellular calcium concentration.Ca rel

intracellular calcium concentration.Ca up
type: NamedIndividual
type: Decimal
has start value: 0.3
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Ca concentration in s.r. uptake store
has unit: UNIT millimolar
mapped to: calcium translocation.Ca up
is computational component for: Chemical concentration
mapped to: sarcoplasmic reticulum calcium pump.Ca up

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: intracellular calcium concentration.Ca up

intracellular calcium concentration.Calmod
type: NamedIndividual
type: Decimal
has start value: 0.02
is solution domain: false
is discrete: false
is declared: true
comment: Total calmodulin concentration in the cytosol
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: Calmodulin
has computational component: intracellular calcium concentration.Calmod

intracellular calcium concentration.F
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Faraday Constant
has unit: UNIT coulomb per mole
is computational component for: intracellular calcium concentration.F property

intracellular calcium concentration.Trop
type: NamedIndividual
type: Decimal
has start value: 0.15
is solution domain: false
is discrete: false
is declared: true
comment: Total troponin concentration in the cytosol
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: Troponin
has computational component: intracellular calcium concentration.Trop

intracellular calcium concentration.V Cell
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Cell volume
has unit: UNIT micrometre3
is computational component for: intracellular calcium concentration.V Cell property

intracellular calcium concentration.V e ratio
type: NamedIndividual
type: Decimal
has start value: 0.4
is discrete: false
is solution domain: false
is declared: true
comment: Fraction of volume taken by extracellular space
is computational component for: intracellular calcium concentration.V e ratio property

intracellular calcium concentration.V i
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Total intracellular volume
has unit: UNIT micrometre3
is computational component for: intracellular calcium concentration.V i property
mapped to: intracellular potassium concentration.V i
mapped to: intracellular sodium concentration.V i

intracellular calcium concentration.V i ratio
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
is declared: true
comment: Ratio of intracellular volume and total cell volume
is computational component for: intracellular calcium concentration.V i ratio property

intracellular calcium concentration.V rel ratio
type: NamedIndividual
type: Decimal
has start value: 0.1
is discrete: false
is solution domain: false
is declared: true
comment: Ratio of JSR volume and total cell volume
is computational component for: intracellular calcium concentration.V rel ratio property

intracellular calcium concentration.V up ratio
type: NamedIndividual
type: Decimal
has start value: 0.01
is solution domain: false
is discrete: false
is declared: true
comment: Ratio of SR uptake component volume and total cell volume
is computational component for: intracellular calcium concentration.V up ratio property

intracellular calcium concentration.Ve
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Total extracellular volume
has unit: UNIT micrometre3
mapped to: extracellular calcium concentration.Ve
is computational component for: intracellular calcium concentration.Ve property

intracellular calcium concentration.alpha Calmod
type: NamedIndividual
type: Decimal
has start value: 100000
is discrete: false
is solution domain: false
is declared: true
comment: Ca-calmodulin binding rate constant
has unit: UNIT per millimolar second
is computational component for: intracellular calcium concentration.alpha Calmod property

intracellular calcium concentration.alpha Trop
type: NamedIndividual
type: Decimal
has start value: 100000
is solution domain: false
is discrete: false
is declared: true
comment: Ca-troponin binding rate constant
has unit: UNIT per millimolar second
is computational component for: intracellular calcium concentration.alpha Trop property

intracellular calcium concentration.beta Calmod
type: NamedIndividual
type: Decimal
has start value: 50
is solution domain: false
is discrete: false
is declared: true
comment: Ca-calmodulin dissociation rate constant
has unit: UNIT per second
is computational component for: intracellular calcium concentration.beta Calmod property

intracellular calcium concentration.beta Trop
type: NamedIndividual
type: Decimal
has start value: 200
is solution domain: false
is discrete: false
is declared: true
comment: Ca-troponin dissociation rate constant
has unit: UNIT per second
is computational component for: intracellular calcium concentration.beta Trop property

intracellular calcium concentration.dCaCalmoddt
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Redundant and unused codeword
has unit: UNIT millimolar per second
is computational component for: intracellular calcium concentration.dCaCalmoddt property

intracellular calcium concentration.dCaTropdt
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Redundant and unused codeword
has unit: UNIT millimolar per second
is computational component for: intracellular calcium concentration.dCaTropdt property

intracellular calcium concentration.i NaCa
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Na-Ca exchange current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: NaCa exchange pump current across plasma membrane
has computational component: intracellular calcium concentration.i NaCa

intracellular calcium concentration.i b Ca
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Calcium background current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Ca background current across plasma membrane of cardiac myocyte
has computational component: intracellular calcium concentration.i b Ca

intracellular calcium concentration.i rel
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Ca release from junctional sarcoplasmic reticulum into cytosol
has unit: UNIT millimolar per second
is computational component for: Chemical molar flow rate

Chemical molar flow rate
type: NamedIndividual
refers to: Chemical molar flow rate
physical property of: Ca release from sarcoplasmic reticulum into cytosol of cardiac myocyte
has computational component: intracellular calcium concentration.i rel

intracellular calcium concentration.i siCa
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Calcium component of fast Ca current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Secondary Ca channel inward current
has computational component: intracellular calcium concentration.i siCa

intracellular calcium concentration.i trans
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Ca transferred into releasable form
has unit: UNIT millimolar per second
is computational component for: Chemical molar flow rate

Chemical molar flow rate
type: NamedIndividual
refers to: Chemical molar flow rate
physical property of: Sarcoplasmic Ca transfer current
has computational component: intracellular calcium concentration.i trans

intracellular calcium concentration.i up
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Ca uptake into SR expressed as a current
has unit: UNIT millimolar per second
is computational component for: Chemical molar flow rate

Chemical molar flow rate
type: NamedIndividual
refers to: Chemical molar flow rate
physical property of: Ca uptake into the sarcoplasmic reticulum
has computational component: intracellular calcium concentration.i up

intracellular calcium concentration.length
type: NamedIndividual
type: Decimal
has start value: 0.08
is solution domain: false
is discrete: false
is declared: true
comment: length of preparation
has unit: UNIT micrometre
is computational component for: intracellular calcium concentration.length property

intracellular calcium concentration.radius
type: NamedIndividual
type: Decimal
has start value: 0.08
is discrete: false
is solution domain: false
is declared: true
comment: radius of preparation
has unit: UNIT micrometre
is computational component for: intracellular calcium concentration.radius property

intracellular calcium concentration.time
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: intracellular calcium concentration.time property

intracellular calcium concentration computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>V_Cell</ci> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.141592654</cn> <apply> <power /> <ci>radius</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> </apply> <ci>length</ci> </apply> </apply> <apply> <eq /> <ci>V_i_ratio</ci> <apply> <minus /> <apply> <minus /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <ci>V_e_ratio</ci> </apply> <ci>V_up_ratio</ci> </apply> <ci>V_rel_ratio</ci> </apply> </apply> <apply> <eq /> <ci>V_i</ci> <apply> <times /> <ci>V_Cell</ci> <ci>V_i_ratio</ci> </apply> </apply> <apply> <eq /> <ci>Ve</ci> <apply> <times /> <ci>V_Cell</ci> <ci>V_e_ratio</ci> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>Ca_i</ci> </apply> <apply> <minus /> <apply> <minus /> <apply> <minus /> <apply> <plus /> <apply> <times /> <apply> <divide /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mA_nA">1</cn> </apply> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="litre_micrometre3">1</cn> <ci>V_i</ci> <ci>F</ci> </apply> </apply> <apply> <minus /> <apply> <plus /> <ci>i_siCa</ci> <ci>i_b_Ca</ci> </apply> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> <ci>i_NaCa</ci> </apply> </apply> </apply> <apply> <divide /> <apply> <times /> <ci>i_rel</ci> <ci>V_rel_ratio</ci> </apply> <ci>V_i_ratio</ci> </apply> </apply> <ci>dCaCalmoddt</ci> </apply> <ci>dCaTropdt</ci> </apply> <ci>i_up</ci> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>Ca_up</ci> </apply> <apply> <minus /> <apply> <times /> <apply> <divide /> <ci>V_i_ratio</ci> <ci>V_up_ratio</ci> </apply> <ci>i_up</ci> </apply> <ci>i_trans</ci> </apply> </…
is computational component for: intracellular calcium concentration

intracellular potassium concentration
type: NamedIndividual
type: Submodel
name: intracellular_potassium_concentration
has associated data structure: intracellular potassium concentration.F
has associated data structure: intracellular potassium concentration.K i
has associated data structure: intracellular potassium concentration.V i
has associated data structure: intracellular potassium concentration.i K1
has associated data structure: intracellular potassium concentration.i NaK
has associated data structure: intracellular potassium concentration.i b K
has associated data structure: intracellular potassium concentration.i siK
has associated data structure: intracellular potassium concentration.time
has computational component: intracellular potassium concentration computation

intracellular potassium concentration.F
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Faraday Constant
has unit: UNIT coulomb per mole
is computational component for: intracellular potassium concentration.F property

intracellular potassium concentration.K i
type: NamedIndividual
type: Decimal
has start value: 140
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Potassium intracellular concentration
has unit: UNIT millimolar
mapped to: fast sodium current.K i
is computational component for: Chemical concentration
mapped to: second inward calcium current.K i
mapped to: time independent potassium current.K i

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: potassium(1+)
has computational component: intracellular potassium concentration.K i

intracellular potassium concentration.V i
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Total intracellular volume
has unit: UNIT micrometre3
is computational component for: intracellular potassium concentration.V i property

intracellular potassium concentration.i K1
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Time independent K current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Time independent K channel current
has computational component: intracellular potassium concentration.i K1

intracellular potassium concentration.i NaK
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: NaK exchange pump current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: NaCa exchange pump current across plasma membrane
has computational component: intracellular potassium concentration.i NaK

intracellular potassium concentration.i b K
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Background K current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: K background current across plasma membrane of the cardiac myocyte
has computational component: intracellular potassium concentration.i b K

intracellular potassium concentration.i siK
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Potassium component of fast Ca current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Secondary K channel inward current
has computational component: intracellular potassium concentration.i siK

intracellular potassium concentration.time
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: intracellular potassium concentration.time property

intracellular potassium concentration computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>K_i</ci> </apply> <apply> <times /> <apply> <divide /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mA_nA">1</cn> </apply> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="litre_micrometre3">1</cn> <ci>V_i</ci> <ci>F</ci> </apply> </apply> <apply> <minus /> <apply> <plus /> <ci>i_K1</ci> <ci>i_siK</ci> <ci>i_b_K</ci> </apply> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> <ci>i_NaK</ci> </apply> </apply> </apply> </apply>
is computational component for: intracellular potassium concentration

intracellular sodium concentration
type: NamedIndividual
type: Submodel
name: intracellular_sodium_concentration
has associated data structure: intracellular sodium concentration.F
has associated data structure: intracellular sodium concentration.Na i
has associated data structure: intracellular sodium concentration.V i
has associated data structure: intracellular sodium concentration.i Na
has associated data structure: intracellular sodium concentration.i NaCa
has associated data structure: intracellular sodium concentration.i NaK
has associated data structure: intracellular sodium concentration.i b Na
has associated data structure: intracellular sodium concentration.i siNa
has associated data structure: intracellular sodium concentration.time
has computational component: intracellular sodium concentration computation

intracellular sodium concentration.F
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Faraday Constant
has unit: UNIT coulomb per mole
is computational component for: intracellular sodium concentration.F property

intracellular sodium concentration.Na i
type: NamedIndividual
type: Decimal
has start value: 6.5
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Intracellular Na concentration
mapped to: Na Ca exchanger.Na i
has unit: UNIT millimolar
mapped to: fast sodium current.Na i
is computational component for: Chemical concentration
mapped to: second inward calcium current.Na i
mapped to: sodium background current.Na i
mapped to: sodium potassium pump.Na i

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: intracellular sodium concentration.Na i

intracellular sodium concentration.V i
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Total intracellular volume
has unit: UNIT micrometre3
is computational component for: intracellular sodium concentration.V i property

intracellular sodium concentration.i Na
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: TTX sensittive fast Na current
has unit: UNIT nanoA
is computational component for: Charge flow rate

intracellular sodium concentration.i NaCa
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Na-Ca exchange current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: NaCa exchange pump current across plasma membrane
has computational component: intracellular sodium concentration.i NaCa

intracellular sodium concentration.i NaK
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: NaK exchange pump current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: NaCa exchange pump current across plasma membrane
has computational component: intracellular sodium concentration.i NaK

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Fast sodium channel current across plasma membrane
has computational component: intracellular sodium concentration.i Na

intracellular sodium concentration.i b Na
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Sodium background current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Na background current across plasma membrane of cardiac myocyte
has computational component: intracellular sodium concentration.i b Na

intracellular sodium concentration.i siNa
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Sodium component of fast Ca current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Secondary Na channel inward current
has computational component: intracellular sodium concentration.i siNa

intracellular sodium concentration.time
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: intracellular sodium concentration.time property

intracellular sodium concentration computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>Na_i</ci> </apply> <apply> <times /> <apply> <divide /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mA_nA">1</cn> </apply> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="litre_micrometre3">1</cn> <ci>V_i</ci> <ci>F</ci> </apply> </apply> <apply> <plus /> <ci>i_Na</ci> <ci>i_b_Na</ci> <apply> <times /> <ci>i_NaK</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn> </apply> <apply> <times /> <ci>i_NaCa</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn> </apply> <ci>i_siNa</ci> </apply> </apply> </apply>
is computational component for: intracellular sodium concentration

membrane
type: NamedIndividual
type: Submodel
name: membrane
includes submodel: Na Ca exchanger
includes submodel: calcium background current
includes submodel: calcium release
includes submodel: calcium translocation
includes submodel: extracellular calcium concentration
includes submodel: extracellular potassium concentration
includes submodel: extracellular sodium concentration
includes submodel: fast sodium current
includes submodel: intracellular calcium concentration
includes submodel: intracellular potassium concentration
includes submodel: intracellular sodium concentration
has associated data structure: membrane.C m
has associated data structure: membrane.F
has associated data structure: membrane.R
has associated data structure: membrane.RTONF
has associated data structure: membrane.T
has associated data structure: membrane.V
has associated data structure: membrane.i K1
has associated data structure: membrane.i Na
has associated data structure: membrane.i NaCa
has associated data structure: membrane.i NaK
has associated data structure: membrane.i Stim
has associated data structure: membrane.i b Ca
has associated data structure: membrane.i b K
has associated data structure: membrane.i b Na
has associated data structure: membrane.i si
has associated data structure: membrane.stim amplitude
has associated data structure: membrane.stim duration
has associated data structure: membrane.stim end
has associated data structure: membrane.stim period
has associated data structure: membrane.stim start
has associated data structure: membrane.time
has computational component: membrane computation
includes submodel: potassium background current
includes submodel: sarcoplasmic reticulum calcium pump
includes submodel: second inward calcium current
includes submodel: sodium background current
includes submodel: sodium potassium pump
includes submodel: time independent potassium current

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated target: fast sodium current
annotated source: membrane

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated target: calcium background current
annotated source: membrane

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated target: intracellular calcium concentration
annotated source: membrane

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated source: membrane
annotated target: potassium background current

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated source: membrane
annotated target: second inward calcium current

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated source: membrane
annotated target: sarcoplasmic reticulum calcium pump

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated target: extracellular potassium concentration
annotated source: membrane

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated target: Na Ca exchanger
annotated source: membrane

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated target: extracellular sodium concentration
annotated source: membrane

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated target: calcium release
annotated source: membrane

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated source: membrane
annotated target: sodium background current

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated source: membrane
annotated target: time independent potassium current

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated source: membrane
annotated target: sodium potassium pump

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated target: calcium translocation
annotated source: membrane

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated target: extracellular calcium concentration
annotated source: membrane

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated target: intracellular sodium concentration
annotated source: membrane

Axiom
submodel subsumption type: containment
annotated property: includesSubmodel
annotated target: intracellular potassium concentration
annotated source: membrane

membrane.C m
type: NamedIndividual
type: Decimal
has start value: 0.006
is solution domain: false
is discrete: false
is declared: true
comment: Membrane capacitance
has unit: UNIT microF
is computational component for: membrane.C m property

membrane.F
type: NamedIndividual
type: Decimal
has start value: 96485.3415
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Faraday Constant
has unit: UNIT coulomb per mole
mapped to: extracellular calcium concentration.F
mapped to: intracellular calcium concentration.F
mapped to: intracellular potassium concentration.F
mapped to: intracellular sodium concentration.F
is computational component for: membrane.F property

membrane.R
type: NamedIndividual
type: Decimal
has start value: 8314.472
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Boltzmann constant
has unit: UNIT joule per kilomole kelvin
is computational component for: membrane.R property

membrane.RTONF
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
mapped to: Na Ca exchanger.RTONF
has unit: UNIT millivolt
mapped to: calcium background current.RTONF
mapped to: fast sodium current.RTONF
is computational component for: membrane.RTONF property
mapped to: second inward calcium current.RTONF
mapped to: sodium background current.RTONF
mapped to: time independent potassium current.RTONF

membrane.T
type: NamedIndividual
type: Decimal
has start value: 310
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Temperature
has unit: UNIT kelvin
is computational component for: membrane.T property

membrane.V
type: NamedIndividual
type: Decimal
has start value: -88
is solution domain: false
is discrete: false
metadata ID: membrane_V
has cell m lpublic interface: out
is declared: true
comment: Cardiac myocyte membrane potential
mapped to: Na Ca exchanger.V
has unit: UNIT millivolt
mapped to: calcium background current.V
mapped to: calcium release.V
mapped to: fast sodium current.V
is computational component for: Electrical potential
mapped to: potassium background current.V
mapped to: second inward calcium current.V
mapped to: sodium background current.V
mapped to: sodium potassium pump.V
mapped to: time independent potassium current.V

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: membrane.V

membrane.i K1
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Time independent K current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Time independent K channel current
has computational component: membrane.i K1

membrane.i Na
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: TTX sensittive fast Na current
has unit: UNIT nanoA
is computational component for: Charge flow rate

membrane.i NaCa
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Na-Ca exchange current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: NaCa exchange pump current across plasma membrane
has computational component: membrane.i NaCa

membrane.i NaK
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: NaK exchange pump current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: NaCa exchange pump current across plasma membrane
has computational component: membrane.i NaK

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Fast sodium channel current across plasma membrane
has computational component: membrane.i Na

membrane.i Stim
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Experimental stimulation current
has unit: UNIT nanoA
is computational component for: membrane.i Stim property

membrane.i b Ca
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Calcium background current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Ca background current across plasma membrane of cardiac myocyte
has computational component: membrane.i b Ca

membrane.i b K
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Background K current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: K background current across plasma membrane of the cardiac myocyte
has computational component: membrane.i b K

membrane.i b Na
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Sodium background current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Na background current across plasma membrane of cardiac myocyte
has computational component: membrane.i b Na

membrane.i si
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Total TTX-insensitive inward current
has unit: UNIT nanoA
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Secondary channel inward current
has computational component: membrane.i si

membrane.stim amplitude
type: NamedIndividual
type: Decimal
has start value: -200
is solution domain: false
is discrete: false
is declared: true
has unit: UNIT nanoA
is computational component for: membrane.stim amplitude property

membrane.stim duration
type: NamedIndividual
type: Decimal
has start value: 0.002
is discrete: false
is solution domain: false
is declared: true
has unit: UNIT second
is computational component for: membrane.stim duration property

membrane.stim end
type: NamedIndividual
type: Decimal
has start value: 10000
is discrete: false
is solution domain: false
is declared: true
has unit: UNIT second
is computational component for: membrane.stim end property

membrane.stim period
type: NamedIndividual
type: Decimal
has start value: 1
is discrete: false
is solution domain: false
is declared: true
has unit: UNIT second
is computational component for: membrane.stim period property

membrane.stim start
type: NamedIndividual
type: Decimal
has start value: 0.1
is solution domain: false
is discrete: false
is declared: true
has unit: UNIT second
is computational component for: membrane.stim start property

membrane.time
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: membrane.time property

membrane computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>RTONF</ci> <apply> <divide /> <apply> <times /> <ci>R</ci> <ci>T</ci> </apply> <ci>F</ci> </apply> </apply> <apply> <eq /> <ci>i_Stim</ci> <piecewise> <piece> <ci>stim_amplitude</ci> <apply> <and /> <apply> <geq /> <ci>time</ci> <ci>stim_start</ci> </apply> <apply> <leq /> <ci>time</ci> <ci>stim_end</ci> </apply> <apply> <leq /> <apply> <minus /> <apply> <minus /> <ci>time</ci> <ci>stim_start</ci> </apply> <apply> <times /> <apply> <floor /> <apply> <divide /> <apply> <minus /> <ci>time</ci> <ci>stim_start</ci> </apply> <ci>stim_period</ci> </apply> </apply> <ci>stim_period</ci> </apply> </apply> <ci>stim_duration</ci> </apply> </apply> </piece> <otherwise> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="nanoA">0</cn> </otherwise> </piecewise> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>V</ci> </apply> <apply> <divide /> <apply> <minus /> <apply> <plus /> <ci>i_Stim</ci> <ci>i_K1</ci> <ci>i_b_Na</ci> <ci>i_b_Ca</ci> <ci>i_b_K</ci> <ci>i_NaK</ci> <ci>i_NaCa</ci> <ci>i_Na</ci> <ci>i_si</ci> </apply> </apply> <ci>C_m</ci> </apply> </apply>
is computational component for: membrane

potassium background current
type: NamedIndividual
type: Submodel
name: potassium_background_current
has associated data structure: potassium background current.E K
has associated data structure: potassium background current.V
has associated data structure: potassium background current.g b K
has associated data structure: potassium background current.i b K
has associated data structure: potassium background current.time
has computational component: potassium background current computation

potassium background current.E K
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Potassium reversal potential
has unit: UNIT millivolt
is computational component for: potassium background current.E K property

potassium background current.V
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: potassium background current.V

potassium background current.g b K
type: NamedIndividual
type: Decimal
has start value: 0.17
is solution domain: false
is discrete: false
is declared: true
comment: Potassium background conductance
has unit: UNIT microS
is computational component for: potassium background current.g b K property

potassium background current.i b K
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Background K current
has unit: UNIT nanoA
mapped to: intracellular potassium concentration.i b K
mapped to: membrane.i b K
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: K background current across plasma membrane of the cardiac myocyte
has computational component: potassium background current.i b K

potassium background current.time
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Time - Solution Domain
has unit: UNIT second
is computational component for: potassium background current.time property

potassium background current computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>i_b_K</ci> <apply> <times /> <ci>g_b_K</ci> <apply> <minus /> <ci>V</ci> <ci>E_K</ci> </apply> </apply> </apply>
is computational component for: potassium background current

sarcoplasmic reticulum calcium pump
type: NamedIndividual
type: Submodel
name: sarcoplasmic_reticulum_calcium_pump
has associated data structure: sarcoplasmic reticulum calcium pump.Ca i
has associated data structure: sarcoplasmic reticulum calcium pump.Ca up
has associated data structure: sarcoplasmic reticulum calcium pump.K 1
has associated data structure: sarcoplasmic reticulum calcium pump.K 2
has associated data structure: sarcoplasmic reticulum calcium pump.K cyca
has associated data structure: sarcoplasmic reticulum calcium pump.K srca
has associated data structure: sarcoplasmic reticulum calcium pump.K xcs
has associated data structure: sarcoplasmic reticulum calcium pump.alpha up
has associated data structure: sarcoplasmic reticulum calcium pump.beta up
has associated data structure: sarcoplasmic reticulum calcium pump.i up
has associated data structure: sarcoplasmic reticulum calcium pump.time
has computational component: sarcoplasmic reticulum calcium pump computation

sarcoplasmic reticulum calcium pump.Ca i
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Intracellular Ca concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: sarcoplasmic reticulum calcium pump.Ca i

sarcoplasmic reticulum calcium pump.Ca up
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Ca concentration in s.r. uptake store
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: sarcoplasmic reticulum calcium pump.Ca up

sarcoplasmic reticulum calcium pump.K 1
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
is computational component for: sarcoplasmic reticulum calcium pump.K 1 property

sarcoplasmic reticulum calcium pump.K 2
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
has unit: UNIT millimolar
is computational component for: sarcoplasmic reticulum calcium pump.K 2 property

sarcoplasmic reticulum calcium pump.K cyca
type: NamedIndividual
type: Decimal
has start value: 0.0003
is discrete: false
is solution domain: false
is declared: true
comment: Cytosolic Ca/enzyme reaction rate
has unit: UNIT millimolar
is computational component for: sarcoplasmic reticulum calcium pump.K cyca property

sarcoplasmic reticulum calcium pump.K srca
type: NamedIndividual
type: Decimal
has start value: 0.5
is solution domain: false
is discrete: false
is declared: true
comment: SR Ca/enzyme reaction rate
has unit: UNIT millimolar
is computational component for: sarcoplasmic reticulum calcium pump.K srca property

sarcoplasmic reticulum calcium pump.K xcs
type: NamedIndividual
type: Decimal
has start value: 0.4
is solution domain: false
is discrete: false
is declared: true
is computational component for: sarcoplasmic reticulum calcium pump.K xcs property

sarcoplasmic reticulum calcium pump.alpha up
type: NamedIndividual
type: Decimal
has start value: 3
is solution domain: false
is discrete: false
is declared: true
comment: SR Ca uptake forward reaction rate constant
has unit: UNIT millimolar per second
is computational component for: sarcoplasmic reticulum calcium pump.alpha up property

sarcoplasmic reticulum calcium pump.beta up
type: NamedIndividual
type: Decimal
has start value: 0.23
is solution domain: false
is discrete: false
is declared: true
comment: SR Ca uptake back ard reaction rate constant
has unit: UNIT millimolar per second
is computational component for: sarcoplasmic reticulum calcium pump.beta up property

sarcoplasmic reticulum calcium pump.i up
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Ca uptake into SR expressed as a current
has unit: UNIT millimolar per second
mapped to: intracellular calcium concentration.i up
is computational component for: Chemical molar flow rate

Chemical molar flow rate
type: NamedIndividual
refers to: Chemical molar flow rate
physical property of: Ca uptake into the sarcoplasmic reticulum
has computational component: sarcoplasmic reticulum calcium pump.i up

sarcoplasmic reticulum calcium pump.time
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Time - Solution Domain
has unit: UNIT second
is computational component for: sarcoplasmic reticulum calcium pump.time property

sarcoplasmic reticulum calcium pump computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>K_1</ci> <apply> <divide /> <apply> <times /> <ci>K_cyca</ci> <ci>K_xcs</ci> </apply> <ci>K_srca</ci> </apply> </apply> <apply> <eq /> <ci>K_2</ci> <apply> <plus /> <ci>Ca_i</ci> <apply> <times /> <ci>Ca_up</ci> <ci>K_1</ci> </apply> <apply> <times /> <ci>K_cyca</ci> <ci>K_xcs</ci> </apply> <ci>K_cyca</ci> </apply> </apply> <apply> <eq /> <ci>i_up</ci> <apply> <minus /> <apply> <times /> <apply> <divide /> <ci>Ca_i</ci> <ci>K_2</ci> </apply> <ci>alpha_up</ci> </apply> <apply> <times /> <apply> <divide /> <apply> <times /> <ci>Ca_up</ci> <ci>K_1</ci> </apply> <ci>K_2</ci> </apply> <ci>beta_up</ci> </apply> </apply> </apply>
is computational component for: sarcoplasmic reticulum calcium pump

second inward calcium current
type: NamedIndividual
type: Submodel
name: second_inward_calcium_current
has associated data structure: second inward calcium current.CaChon
has associated data structure: second inward calcium current.Ca i
has associated data structure: second inward calcium current.Ca o
has associated data structure: second inward calcium current.K c
has associated data structure: second inward calcium current.K i
has associated data structure: second inward calcium current.Na i
has associated data structure: second inward calcium current.Na o
has associated data structure: second inward calcium current.P si
has associated data structure: second inward calcium current.RTONF
has associated data structure: second inward calcium current.V
has associated data structure: second inward calcium current.d
has associated data structure: second inward calcium current.f Ca
has associated data structure: second inward calcium current.i si
has associated data structure: second inward calcium current.i siCa
has associated data structure: second inward calcium current.i siK
has associated data structure: second inward calcium current.i siNa
has associated data structure: second inward calcium current.time
has computational component: second inward calcium current computation
includes submodel: second inward calcium current d gate
includes submodel: second inward calcium current f Ca gate

Axiom
submodel subsumption type: containment
submodel subsumption type: encapsulation
annotated property: includesSubmodel
annotated source: second inward calcium current
annotated target: second inward calcium current f Ca gate

Axiom
submodel subsumption type: containment
submodel subsumption type: encapsulation
annotated property: includesSubmodel
annotated source: second inward calcium current
annotated target: second inward calcium current d gate

second inward calcium current.CaChon
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lprivate interface: in
is declared: true
comment: Active, unbound regulatory states
is computational component for: second inward calcium current.CaChon property

second inward calcium current.Ca i
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
has cell m lprivate interface: out
is declared: true
comment: Intracellular Ca concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration
mapped to: second inward calcium current f Ca gate.Ca i

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: second inward calcium current.Ca i

second inward calcium current.Ca o
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Extracellular calcium concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: second inward calcium current.Ca o

second inward calcium current.K c
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Potassium concentration in the extracellular cleft
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: potassium(1+)
has computational component: second inward calcium current.K c

second inward calcium current.K i
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Potassium intracellular concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: potassium(1+)
has computational component: second inward calcium current.K i

second inward calcium current.Na i
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Intracellular Na concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: second inward calcium current.Na i

second inward calcium current.Na o
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Extracellular sodium concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: second inward calcium current.Na o

second inward calcium current.P si
type: NamedIndividual
type: Decimal
has start value: 5
is discrete: false
is solution domain: false
is declared: true
has unit: UNIT nanoA per millimolar
is computational component for: second inward calcium current.P si property

second inward calcium current.RTONF
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
has unit: UNIT millivolt
is computational component for: second inward calcium current.RTONF property

second inward calcium current.V
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
has cell m lprivate interface: out
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential
mapped to: second inward calcium current d gate.V
mapped to: second inward calcium current f Ca gate.V

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: second inward calcium current.V

second inward calcium current.d
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lprivate interface: in
is declared: true
comment: Activation gating and rate coefficient for fast Ca current channel
is computational component for: second inward calcium current.d property

second inward calcium current.f Ca
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lprivate interface: in
is declared: true
comment: Fraction of channels inactivated by voltage-dependent process.
is computational component for: second inward calcium current.f Ca property

second inward calcium current.i si
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Total TTX-insensitive inward current
has unit: UNIT nanoA
mapped to: membrane.i si
is computational component for: Charge flow rate

second inward calcium current.i siCa
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Calcium component of fast Ca current
has unit: UNIT nanoA
mapped to: extracellular calcium concentration.i siCa
mapped to: intracellular calcium concentration.i siCa
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Secondary Ca channel inward current
has computational component: second inward calcium current.i siCa

second inward calcium current.i siK
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Potassium component of fast Ca current
has unit: UNIT nanoA
mapped to: intracellular potassium concentration.i siK
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Secondary K channel inward current
has computational component: second inward calcium current.i siK

second inward calcium current.i siNa
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Sodium component of fast Ca current
has unit: UNIT nanoA
mapped to: intracellular sodium concentration.i siNa
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Secondary Na channel inward current
has computational component: second inward calcium current.i siNa

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Secondary channel inward current
has computational component: second inward calcium current.i si

second inward calcium current.time
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
has cell m lprivate interface: out
is declared: true
comment: Time - Solution Domain
has unit: UNIT second
is computational component for: second inward calcium current.time property
mapped to: second inward calcium current d gate.time
mapped to: second inward calcium current f Ca gate.time

second inward calcium current computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>i_si</ci> <apply> <plus /> <ci>i_siCa</ci> <ci>i_siK</ci> <ci>i_siNa</ci> </apply> </apply> <apply> <eq /> <ci>i_siCa</ci> <apply> <times /> <apply> <divide /> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn> <ci>P_si</ci> <ci>d</ci> <ci>CaChon</ci> <apply> <minus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn> </apply> </apply> <ci>RTONF</ci> </apply> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <exp /> <apply> <divide /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> </apply> <apply> <minus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> </apply> <ci>RTONF</ci> </apply> </apply> </apply> </apply> <apply> <minus /> <apply> <times /> <ci>Ca_i</ci> <apply> <exp /> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">100</cn> <ci>RTONF</ci> </apply> </apply> </apply> <apply> <times /> <ci>Ca_o</ci> <apply> <exp /> <apply> <divide /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> </apply> <apply> <minus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn> </apply> </apply> <ci>RTONF</ci> </apply> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>i_siK</ci> <apply> <times /> <apply> <divide /> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.002</cn> <ci>P_si</ci> <ci>d</ci> <ci>CaChon</ci> <apply> <minus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:unit…
is computational component for: second inward calcium current

second inward calcium current d gate
type: NamedIndividual
type: Submodel
name: second_inward_calcium_current_d_gate
has associated data structure: second inward calcium current d gate.E0 d
has associated data structure: second inward calcium current d gate.V
has associated data structure: second inward calcium current d gate.alpha d
has associated data structure: second inward calcium current d gate.beta d
has associated data structure: second inward calcium current d gate.d
has associated data structure: second inward calcium current d gate.delta d
has associated data structure: second inward calcium current d gate.time
has computational component: second inward calcium current d gate computation

second inward calcium current d gate.E0 d
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
has unit: UNIT millivolt
is computational component for: second inward calcium current d gate.E0 d property

second inward calcium current d gate.V
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: second inward calcium current d gate.V

second inward calcium current d gate.alpha d
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Activation gating and rate coefficient for fast Ca current channel
has unit: UNIT per second
is computational component for: second inward calcium current d gate.alpha d property

second inward calcium current d gate.beta d
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
is declared: true
comment: Activation gating and rate coefficient for fast Ca current channel
has unit: UNIT per second
is computational component for: second inward calcium current d gate.beta d property

second inward calcium current d gate.d
type: NamedIndividual
type: Decimal
has start value: 0.0011
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Activation gating and rate coefficient for fast Ca current channel
mapped to: second inward calcium current.d
is computational component for: second inward calcium current d gate.d property

second inward calcium current d gate.delta d
type: NamedIndividual
type: Decimal
has start value: 0.0001
is discrete: false
is solution domain: false
is declared: true
has unit: UNIT millivolt
is computational component for: second inward calcium current d gate.delta d property

second inward calcium current d gate.time
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Time - Solution Domain
has unit: UNIT second
is computational component for: second inward calcium current d gate.time property

second inward calcium current d gate computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>E0_d</ci> <apply> <minus /> <apply> <plus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">24</cn> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn> </apply> </apply> <apply> <eq /> <ci>alpha_d</ci> <piecewise> <piece> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">120</cn> <apply> <lt /> <apply> <abs /> <ci>E0_d</ci> </apply> <ci>delta_d</ci> </apply> </piece> <otherwise> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">30</cn> <ci>E0_d</ci> </apply> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <exp /> <apply> <divide /> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> </apply> <ci>E0_d</ci> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">4</cn> </apply> </apply> </apply> </apply> </otherwise> </piecewise> </apply> <apply> <eq /> <ci>beta_d</ci> <piecewise> <piece> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">120</cn> <apply> <lt /> <apply> <abs /> <ci>E0_d</ci> </apply> <ci>delta_d</ci> </apply> </piece> <otherwise> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">12</cn> <ci>E0_d</ci> </apply> <apply> <minus /> <apply> <exp /> <apply> <divide /> <ci>E0_d</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn> </apply> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> </apply> </apply> </otherwise> </piecewise> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>d</ci> </apply> <apply> <minus /> <apply> <times /> <ci>alpha_d</ci> <apply> <minus /> <cn xmlns:ce…
is computational component for: second inward calcium current d gate

second inward calcium current f Ca gate
type: NamedIndividual
type: Submodel
name: second_inward_calcium_current_f_Ca_gate
has associated data structure: second inward calcium current f Ca gate.CaChoff
has associated data structure: second inward calcium current f Ca gate.CaChon
has associated data structure: second inward calcium current f Ca gate.Ca i
has associated data structure: second inward calcium current f Ca gate.E0 f
has associated data structure: second inward calcium current f Ca gate.V
has associated data structure: second inward calcium current f Ca gate.alpha f Ca
has associated data structure: second inward calcium current f Ca gate.beta f Ca
has associated data structure: second inward calcium current f Ca gate.delta f
has associated data structure: second inward calcium current f Ca gate.f Ca
has associated data structure: second inward calcium current f Ca gate.time
has computational component: second inward calcium current f Ca gate computation

second inward calcium current f Ca gate.CaChoff
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
is declared: true
comment: Fraction of regulatory sites occupied by Ca
is computational component for: second inward calcium current f Ca gate.CaChoff property

second inward calcium current f Ca gate.CaChon
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Active, unbound regulatory states
mapped to: second inward calcium current.CaChon
is computational component for: second inward calcium current f Ca gate.CaChon property

second inward calcium current f Ca gate.Ca i
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Intracellular Ca concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: calcium(2+)
has computational component: second inward calcium current f Ca gate.Ca i

second inward calcium current f Ca gate.E0 f
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
is declared: true
has unit: UNIT millivolt
is computational component for: second inward calcium current f Ca gate.E0 f property

second inward calcium current f Ca gate.V
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: second inward calcium current f Ca gate.V

second inward calcium current f Ca gate.alpha f Ca
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
is declared: true
comment: Inactivation gating and rate coefficient for fast Ca current channel
has unit: UNIT per second
is computational component for: second inward calcium current f Ca gate.alpha f Ca property

second inward calcium current f Ca gate.beta f Ca
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
is declared: true
comment: Inactivation gating and rate coefficient for fast Ca current channel
has unit: UNIT per second
is computational component for: second inward calcium current f Ca gate.beta f Ca property

second inward calcium current f Ca gate.delta f
type: NamedIndividual
type: Decimal
has start value: 0.0001
is discrete: false
is solution domain: false
is declared: true
has unit: UNIT millivolt
is computational component for: second inward calcium current f Ca gate.delta f property

second inward calcium current f Ca gate.f Ca
type: NamedIndividual
type: Decimal
has start value: 0.785
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Fraction of channels inactivated by voltage-dependent process.
mapped to: second inward calcium current.f Ca
is computational component for: second inward calcium current f Ca gate.f Ca property

second inward calcium current f Ca gate.time
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Time - Solution Domain
has unit: UNIT second
is computational component for: second inward calcium current f Ca gate.time property

second inward calcium current f Ca gate computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>E0_f</ci> <apply> <plus /> <ci>V</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">34</cn> </apply> </apply> <apply> <eq /> <ci>alpha_f_Ca</ci> <piecewise> <piece> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">25</cn> <apply> <lt /> <apply> <abs /> <ci>E0_f</ci> </apply> <ci>delta_f</ci> </apply> </piece> <otherwise> <apply> <divide /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">6.25</cn> <ci>E0_f</ci> </apply> <apply> <minus /> <apply> <exp /> <apply> <divide /> <ci>E0_f</ci> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">4</cn> </apply> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> </apply> </apply> </otherwise> </piecewise> </apply> <apply> <eq /> <ci>beta_f_Ca</ci> <apply> <divide /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">12</cn> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <exp /> <apply> <divide /> <apply> <minus /> <ci>E0_f</ci> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">4</cn> </apply> </apply> </apply> </apply> </apply> <apply> <eq /> <apply> <diff /> <bvar> <ci>time</ci> </bvar> <ci>f_Ca</ci> </apply> <apply> <minus /> <apply> <times /> <apply> <plus /> <apply> <times /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">120</cn> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <ci>f_Ca</ci> </apply> <ci>CaChoff</ci> </apply> <apply> <times /> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <ci>f_Ca</ci> </apply> <apply> <minus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <ci>CaChoff</ci>…
is computational component for: second inward calcium current f Ca gate

sodium background current
type: NamedIndividual
type: Submodel
name: sodium_background_current
has associated data structure: sodium background current.E Na
has associated data structure: sodium background current.Na i
has associated data structure: sodium background current.Na o
has associated data structure: sodium background current.RTONF
has associated data structure: sodium background current.V
has associated data structure: sodium background current.g b Na
has associated data structure: sodium background current.i b Na
has associated data structure: sodium background current.time
has computational component: sodium background current computation

sodium background current.E Na
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: out
is declared: true
comment: Sodium reversal potential
has unit: UNIT millivolt
is computational component for: sodium background current.E Na property

sodium background current.Na i
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Intracellular Na concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: sodium background current.Na i

sodium background current.Na o
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Extracellular sodium concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: sodium background current.Na o

sodium background current.RTONF
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
has unit: UNIT millivolt
is computational component for: sodium background current.RTONF property

sodium background current.V
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: sodium background current.V

sodium background current.g b Na
type: NamedIndividual
type: Decimal
has start value: 0.012
is solution domain: false
is discrete: false
is declared: true
comment: Sodium background conductance
has unit: UNIT microS
is computational component for: sodium background current.g b Na property

sodium background current.i b Na
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
metadata ID: sodium_background_current_i_b_Na
is declared: true
comment: Sodium background current
has unit: UNIT nanoA
mapped to: intracellular sodium concentration.i b Na
mapped to: membrane.i b Na
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Na background current across plasma membrane of cardiac myocyte
has computational component: sodium background current.i b Na

sodium background current.time
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: sodium background current.time property

sodium background current computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>E_Na</ci> <apply> <times /> <ci>RTONF</ci> <apply> <ln /> <apply> <divide /> <ci>Na_o</ci> <ci>Na_i</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>i_b_Na</ci> <apply> <times /> <ci>g_b_Na</ci> <apply> <minus /> <ci>V</ci> <ci>E_Na</ci> </apply> </apply> </apply>
is computational component for: sodium background current

sodium potassium pump
type: NamedIndividual
type: Submodel
name: sodium_potassium_pump
has associated data structure: sodium potassium pump.K c
has associated data structure: sodium potassium pump.K mK
has associated data structure: sodium potassium pump.K mNa
has associated data structure: sodium potassium pump.Na i
has associated data structure: sodium potassium pump.V
has associated data structure: sodium potassium pump.i NaK
has associated data structure: sodium potassium pump.i NaK max
has associated data structure: sodium potassium pump.time
has computational component: sodium potassium pump computation

sodium potassium pump.K c
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Potassium concentration in the extracellular cleft
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: potassium(1+)
has computational component: sodium potassium pump.K c

sodium potassium pump.K mK
type: NamedIndividual
type: Decimal
has start value: 1
is solution domain: false
is discrete: false
is declared: true
comment: NaK pump K half activation concentration
has unit: UNIT millimolar
is computational component for: sodium potassium pump.K mK property

sodium potassium pump.K mNa
type: NamedIndividual
type: Decimal
has start value: 40
is discrete: false
is solution domain: false
is declared: true
comment: NaK pump Na half activation concentration
has unit: UNIT millimolar
is computational component for: sodium potassium pump.K mNa property

sodium potassium pump.Na i
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Intracellular Na concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: sodium(1+)
has computational component: sodium potassium pump.Na i

sodium potassium pump.V
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: sodium potassium pump.V

sodium potassium pump.i NaK
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
metadata ID: sodium_potassium_pump_i_NaK
is declared: true
comment: NaK exchange pump current
has unit: UNIT nanoA
mapped to: intracellular potassium concentration.i NaK
mapped to: intracellular sodium concentration.i NaK
mapped to: membrane.i NaK
is computational component for: Charge flow rate

sodium potassium pump.i NaK max
type: NamedIndividual
type: Decimal
has start value: 14
is discrete: false
is solution domain: false
is declared: true
comment: Maximum NaK exchane pump current
has unit: UNIT nanoA
is computational component for: sodium potassium pump.i NaK max property

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Sodium-Potassium Pump Current
has computational component: sodium potassium pump.i NaK

sodium potassium pump.time
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: sodium potassium pump.time property

sodium potassium pump computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>i_NaK</ci> <apply> <divide /> <apply> <times /> <apply> <divide /> <apply> <times /> <ci>i_NaK_max</ci> <ci>K_c</ci> </apply> <apply> <plus /> <ci>K_mK</ci> <ci>K_c</ci> </apply> </apply> <ci>Na_i</ci> </apply> <apply> <plus /> <ci>K_mNa</ci> <ci>Na_i</ci> </apply> </apply> </apply>
is computational component for: sodium potassium pump

time independent potassium current
type: NamedIndividual
type: Submodel
name: time_independent_potassium_current
has associated data structure: time independent potassium current.E K
has associated data structure: time independent potassium current.K c
has associated data structure: time independent potassium current.K i
has associated data structure: time independent potassium current.K m K1
has associated data structure: time independent potassium current.RTONF
has associated data structure: time independent potassium current.V
has associated data structure: time independent potassium current.g K1
has associated data structure: time independent potassium current.i K1
has associated data structure: time independent potassium current.time
has computational component: time independent potassium current computation

time independent potassium current.E K
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
is declared: true
comment: Potassium reversal potential
has unit: UNIT millivolt
mapped to: potassium background current.E K
is computational component for: time independent potassium current.E K property

time independent potassium current.K c
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Potassium concentration in the extracellular cleft
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: potassium(1+)
has computational component: time independent potassium current.K c

time independent potassium current.K i
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Potassium intracellular concentration
has unit: UNIT millimolar
is computational component for: Chemical concentration

Chemical concentration
type: NamedIndividual
refers to: Chemical concentration
physical property of: potassium(1+)
has computational component: time independent potassium current.K i

time independent potassium current.K m K1
type: NamedIndividual
type: Decimal
has start value: 10
is discrete: false
is solution domain: false
is declared: true
comment: K half-activation concentration for inward K rectifier
has unit: UNIT millimolar
is computational component for: time independent potassium current.K m K1 property

time independent potassium current.RTONF
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
has unit: UNIT millivolt
is computational component for: time independent potassium current.RTONF property

time independent potassium current.V
type: NamedIndividual
type: Decimal
is discrete: false
is solution domain: false
has cell m lpublic interface: in
is declared: true
comment: Cardiac myocyte membrane potential
has unit: UNIT millivolt
is computational component for: Electrical potential

Electrical potential
type: NamedIndividual
refers to: Electrical potential
physical property of: Plasma membrane
has computational component: time independent potassium current.V

time independent potassium current.g K1
type: NamedIndividual
type: Decimal
has start value: 1.7
is discrete: false
is solution domain: false
is declared: true
comment: Inward K rectifier conductance
has unit: UNIT microS
is computational component for: time independent potassium current.g K1 property

time independent potassium current.i K1
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: out
metadata ID: time_independent_potassium_current_i_K1
is declared: true
comment: Time independent K current
has unit: UNIT nanoA
mapped to: intracellular potassium concentration.i K1
mapped to: membrane.i K1
is computational component for: Charge flow rate

Charge flow rate
type: NamedIndividual
refers to: Charge flow rate
physical property of: Time independent K channel current
has computational component: time independent potassium current.i K1

time independent potassium current.time
type: NamedIndividual
type: Decimal
is solution domain: false
is discrete: false
has cell m lpublic interface: in
is declared: true
comment: Time solution domain
has unit: UNIT second
is computational component for: time independent potassium current.time property

time independent potassium current computation
type: NamedIndividual
type: Computation
has math ML: <apply> <eq /> <ci>E_K</ci> <apply> <times /> <ci>RTONF</ci> <apply> <ln /> <apply> <divide /> <ci>K_c</ci> <ci>K_i</ci> </apply> </apply> </apply> </apply> <apply> <eq /> <ci>i_K1</ci> <apply> <divide /> <apply> <times /> <apply> <divide /> <apply> <times /> <ci>g_K1</ci> <ci>K_c</ci> </apply> <apply> <plus /> <ci>K_c</ci> <ci>K_m_K1</ci> </apply> </apply> <apply> <minus /> <ci>V</ci> <ci>E_K</ci> </apply> </apply> <apply> <plus /> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn> <apply> <exp /> <apply> <divide /> <apply> <times /> <apply> <minus /> <apply> <minus /> <ci>V</ci> <ci>E_K</ci> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn> </apply> <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn> </apply> <ci>RTONF</ci> </apply> </apply> </apply> </apply> </apply>
is computational component for: time independent potassium current