L type Ca current.K o
is property of: entity 4
is version of: OPB_00340
description: concentration of extracellular potassium

membrane.C sc
description: specific membrane capacitance

L type Ca current.y
description: L-type calcium current activation variable

Na Ca exchanger i NaCa
is version of: OPB_00318
description: sodium-calcium exchanger current

Ca and Mg buffering by ATP.tau xfer CaADP
description: time constant for transfer of calcium-bound ADP from subspace to myoplasm

Ca and Mg buffering by ATP.ADP i
is property of: entity 12
is version of: OPB_00340
description: concentration of free myoplasmic ADP

sarcolemmal calcium pump.MgATP i0
is property of: entity 8
is version of: OPB_00340
description: resting myoplasmic magnesium-bound ATP concentration in normal conditions

SERCA2a pump.Ca NSR
is property of: entity 15
is version of: OPB_00340
description: concentration of calcium in network sarcoplasmic reticulum

Ca and Mg buffering by ATP.k minus MgATP
description: magnesium off-rate constant for ATP

SERCA2a pump.MgATP i
is property of: entity 8
is version of: OPB_00340
description: concentration of magnesium-bound myoplasmic ATP

SERCA2a pump J up
is version of: OPB_00592
description: modified calcium uptake flux into network sarcoplasmic reticulum by SERCA pumps

RyR channel.k a plus
is: OPB_01296
description: ryanodine receptor PC1 - PO1 rate constant

Ca and Mg buffering by ATP.Jxfer MgADP
is version of: OPB_00592
description: magnesium-bound ADP flux from subspace to myoplasm

L type Ca current.k MgATP ss
is property of: entity 9
is version of: OPB_00340
description: calcium half-saturation constant for magnesium-bound subspace ATP

Ca and Mg buffering by ATP.k minus MgADP
description: magnesium off-rate constant for ADP

intracellular ion concentrations.i Na b
is version of: OPB_00318
description: sodium background current

time independent potassium current.g K1
is version of: OPB_01300
description: maximum time-independent potassium current conductance

calcium background current i Ca b
is version of: OPB_00318
description: calcium background current

Ca and Mg buffering by ATP.Jxfer MgATP
is version of: OPB_00592
description: magnesium-bound ATP flux from subspace to myoplasm

Na Ca exchanger.Na o
is property of: entity_0
is version of: OPB_00340
description: concentration of extracellular sodium

rapid activating delayed rectifiyer K current X kr gate.X kr
description: rapid potassium current activation variable

RyR channel.k a minus
is: OPB_01296
description: ryanodine receptor PO1 - PC1 rate constant

Ca and Mg buffering by ATP.tau xfer CaATP
description: time constant for transfer of calcium-bound ATP from subspace to myoplasm

sarcolemmal calcium pump.I pCa
description: maximum sarcolemmal calcium pump current

L type Ca current.P Ca
description: calcium permeability of L-type calcium channel

ATP sensitive potassium current.E K
is version of: OPB_00506
description: potassium reversal potential

intracellular Ca fluxes.Ca ss
is property of: entity 9
is version of: OPB_00340
description: concentration of free subspace calcium

L type Ca current.V
is version of: OPB_00506
description: membrane potential

fast sodium current.E Na
is version of: OPB_00506
description: sodium reversal potential

slow activating delayed rectifiyer K current X ks gate.V
is version of: OPB_00506
description: membrane potential

ATP sensitive potassium current.MgADP i
is property of: entity 12
is version of: OPB_00340
description: concentration of magnesium-bound myoplasmic ADP

rapid activating delayed rectifiyer K current.K o
is property of: entity 4
is version of: OPB_00340
description: concentration of extracellular potassium

intracellular ion concentrations.Ca i
is property of: entity 6
is version of: OPB_00340
description: concentration of free myoplasmic calcium

Na Ca exchanger.K sat
description: saturation factor of sodium-calcium exchanger current

ATP sensitive potassium current.G K ATP
is version of: OPB_01300
description: maximum ATP-sensitive potassium current conductance

L type Ca current.omega
description: L-type calcium channel mode transition parameter

intracellular Ca fluxes.k htrpn minus
is: OPB_01296
description: calcium off-rate for troponin high affinity sites

intracellular ion concentrations.CaATP ss
is property of: entity 22
is version of: OPB_00340
description: concentration of calcium-bound subspace ATP

slow activating delayed rectifiyer K current X ks gate.tau X ks
description: activation time constant of slow potassium current

time independent potassium current K1 gate.T
description: absolute temperature

Na Ca exchanger.K mNa
is property of: entity 2
is version of: OPB_00340
description: sodium half-saturation constant for sodium-calcium exchange

fast sodium current h gate.h
description: sodium current inactivation variable

intracellular ion concentrations.J tr
is version of: OPB_00592
description: calcium flux from network sarcoplasmic reticulum to junctional sarcoplasmic reticulum

L type Ca current.Ca ss
is property of: entity 9
is version of: OPB_00340
description: concentration of free subspace calcium

intracellular ion concentrations.i p Ca
is version of: OPB_00318
description: modified sarcolemmal calcium pump current

slow activating delayed rectifiyer K current.K i
is property of: entity 5
is version of: OPB_00340
description: concentration of intracellular potassium

sodium background current.g Nab
is version of: OPB_01300
description: maximum background sodium current conductance

rapid activating delayed rectifiyer K current.V
is version of: OPB_00506
description: membrane potential

SERCA2a pump.K rb
is property of: entity 6
is version of: OPB_00340
description: reverse half-saturation constant for calcium ATPase

Ca and Mg buffering by ATP.Ca ss
is property of: entity 9
is version of: OPB_00340
description: concentration of free subspace calcium

intracellular Ca fluxes.k htrpn plus
is: OPB_01296
description: calcium on-rate for troponin high affinity sites

time independent potassium current K1 gate.V
is version of: OPB_00506
description: membrane potential

sodium background current.V
is version of: OPB_00506
description: membrane potential

Ca and Mg buffering by ATP.CaADP ss
is property of: entity 21
is version of: OPB_00340
description: concentration of calcium-bound subspace ADP

intracellular Ca fluxes.LTRPN tot
description: total concentration of troponin low-affinity sites

calcium background current.Ca o
is property of: entity 7
is version of: OPB_00340
description: concentration of extracellular calcium

rapid activating delayed rectifiyer K current i Kr
is version of: OPB_00318
description: rapid-activating delayed rectifier potassium current

sodium potassium pump.Na i
is property of: entity 2
is version of: OPB_00340
description: concentration of intracellular sodium

intracellular ion concentrations.k minus CaADP
description: calcium off-rate constant for ADP

rapid activating delayed rectifiyer K current.R V
description: activation potential of rapid potassium current

extracellular ion concentrations.Na o
is property of: entity_0
is version of: OPB_00340
description: concentration of extracellular sodium

Na Ca exchanger.K NaCa
description: scale factor of sodium-calcium exchanger

RyR channel.k c plus
is: OPB_01296
description: ryanodine receptor PO1 - PC2 rate constant

rapid activating delayed rectifiyer K current.T
description: absolute temperature

fast sodium current.m
description: sodium current activation variable

plateau potassium current.Kp V
description: activation potential of plateau potassium current

SERCA2a pump.MgATP i0
is property of: entity 8
is version of: OPB_00340
description: resting myoplasmic magnesium-bound ATP concentration in normal conditions

time independent potassium current K1 gate.K1 infinity V
description: steady-state function of time-independent potassium current activation variable

sodium potassium pump i NaK
is version of: OPB_00318
description: modified sodium-potassium current

sodium potassium pump.I NaK
description: maximum sodium-potassium pump current

transient outward potassium current.E K
is version of: OPB_00506
description: potassium reversal potential

slow activating delayed rectifiyer K current.g Ks
is version of: OPB_01300
description: maximum slow potassium current conductance

membrane.i Na
is version of: OPB_00318
description: fast sodium current

intracellular ion concentrations.k minus CaATP
description: calcium off-rate constant for ATP

intracellular ion concentrations.V NSR
is property of: entity 16
is version of: OPB_00154
description: volume of network sarcoplasmic reticulum

intracellular ion concentrations.J up
is version of: OPB_00592
description: modified calcium uptake flux into network sarcoplasmic reticulum by SERCA pumps

intracellular Ca fluxes.Ca i
is property of: entity 6
is version of: OPB_00340
description: concentration of free myoplasmic calcium

intracellular ion concentrations.i K ATP
is version of: OPB_00318
description: ATP-sensitive potassium current

intracellular ion concentrations.i NaK
is version of: OPB_00318
description: modified sodium-potassium current

Ca and Mg buffering by ATP.k plus CaATP
description: calcium on-rate constant for ATP

fast sodium current j gate.V
is version of: OPB_00506
description: membrane potential

membrane.i p Ca
is version of: OPB_00318
description: modified sarcolemmal calcium pump current

calcium background current.Ca i
is property of: entity 6
is version of: OPB_00340
description: concentration of free myoplasmic calcium

Na Ca exchanger.K mCa
is property of: entity 6
is version of: OPB_00340
description: calcium half-saturation constant for sodium-calcium exchange

ATP sensitive potassium current.ATP i
is property of: entity 8
is version of: OPB_00340
description: concentration of free myoplasmic ATP

membrane.i Ca K
is version of: OPB_00318
description: potassium current through L-type calcium channel

Ca and Mg buffering by ATP.k plus CaADP
description: calcium on-rate constant for ADP

intracellular Ca fluxes.HTRPNCa
is property of: entity 17
is version of: OPB_00340
description: concentration of calcium-bound troponin high-affinity sites

RyR channel.Ca ss
is property of: entity 9
is version of: OPB_00340
description: concentration of free subspace calcium

calcium background current.E Ca
is version of: OPB_00506
description: calcium reversal potential

slow activating delayed rectifiyer K current X ks gate.X ks infinity
description: steady state function of slow potassium current activation variable

time independent potassium current.K mK1
is property of: entity 6
is version of: OPB_00340
description: calcium half-saturation constant for time-independent potassium current

intracellular Ca fluxes.HTRPN tot
description: total concentration of troponin high-affinity sites

Ca and Mg buffering by ATP.ATP i
is property of: entity 8
is version of: OPB_00340
description: concentration of free myoplasmic ATP

sarcolemmal calcium pump i p Ca
is version of: OPB_00318
description: modified sarcolemmal calcium pump current

rapid activating delayed rectifiyer K current.E K
is version of: OPB_00506
description: potassium reversal potential

calcium background current.V
is version of: OPB_00506
description: membrane potential

rapid activating delayed rectifiyer K current X kr gate.X kr inf
description: steady state function of rapid potassium current activation variable

SERCA2a pump.Vmaxf
description: maximum SERCA forward pumping rate

transient outward potassium current Y to1 gate.V
is version of: OPB_00506
description: membrane potential

time independent potassium current.E K
is version of: OPB_00506
description: potassium reversal potential

plateau potassium current i Kp
is version of: OPB_00318
description: plateau potassium current

slow activating delayed rectifiyer K current.Na i
is property of: entity 2
is version of: OPB_00340
description: concentration of intracellular sodium

transient outward potassium current Y to1 gate.Y to1
description: transient outward potassium current inactivation variable

ATP sensitive potassium current.K o normal
is property of: entity 4
is version of: OPB_00340
description: concentration of extracellular potassium

Ca and Mg buffering by ATP.MgADP ss
is property of: entity 21
is version of: OPB_00340
description: concentration of magnesium-bound subspace ADP

intracellular ion concentrations.V ss
is property of: entity 10
is version of: OPB_00154
description: volume of subspace

plateau potassium current Kp gate.Kp V
description: activation potential of plateau potassium current

transient outward potassium current.Y to1
description: transient outward potassium current inactivation variable

intracellular Ca fluxes.Ca JSR
is property of: entity 13
is version of: OPB_00340
description: concentration of calcium in junctional sarcoplasmic reticulum

plateau potassium current.E K
is version of: OPB_00506
description: potassium reversal potential

Ca and Mg buffering by ATP.MgADP i
is property of: entity 12
is version of: OPB_00340
description: concentration of magnesium-bound myoplasmic ADP

L type Ca current.T
description: absolute temperature

time independent potassium current.K1 infinity V
description: steady-state function of time-independent potassium current activation variable

RyR channel.P O2
description: fraction of ryanodine receptor channels in state PO2

fast sodium current.V
is version of: OPB_00506
description: membrane potential

sodium background current i Na b
is version of: OPB_00318
description: sodium background current

RyR channel.n
description: ryanodine receptor calcium cooperativity parameter PC1 - PO1

SERCA2a pump.K fb
is property of: entity 6
is version of: OPB_00340
description: forward half-saturation constant for calcium ATPase

Ca and Mg buffering by ATP.CaADP i
is property of: entity 12
is version of: OPB_00340
description: concentration of calcium-bound myoplasmic ADP

RyR channel.m
description: ryanodine receptor calcium cooperativity parameter PO1 - PO2

rapid activating delayed rectifiyer K current.X kr
description: rapid potassium current activation variable

intracellular ion concentrations.A cap
description: capacitive membrane area

ATP sensitive potassium current i K ATP
is version of: OPB_00318
description: ATP-sensitive potassium current

intracellular Ca fluxes.J LTRPNCa
is version of: OPB_00592
description: calcium flux to low-affinity troponin sites

RyR channel.P O1
description: fraction of ryanodine receptor channels in state PO1

L type Ca current.MgATP ss
is property of: entity 11
is version of: OPB_00340
description: concentration of magnesium-bound subspace ATP

time independent potassium current.T
description: absolute temperature

Ca and Mg buffering by ATP.ADP tot
is property of: entity 26
is version of: OPB_00340
description: total ADP concentration

Ca and Mg buffering by ATP.Jxfer CaADP
is version of: OPB_00592
description: calcium-bound ADP flux from subspace to myoplasm

intracellular ion concentrations.CMDN tot
is property of: entity 18
is version of: OPB_00340
description: total concentration of myoplasmic calmodulin

ATP sensitive potassium current.K o
is property of: entity 4
is version of: OPB_00340
description: concentration of extracellular potassium

intracellular ion concentrations.ATP ss
is property of: entity 22
is version of: OPB_00340
description: concentration of free subspace ATP

Ca and Mg buffering by ATP.Jxfer CaATP
is version of: OPB_00592
description: calcium-bound ATP flux from subspace to myoplasm

fast sodium current.T
description: absolute temperature

intracellular ion concentrations.CaATP i
is property of: entity 8
is version of: OPB_00340
description: concentration of calcium-bound myoplasmic ATP

calcium background current.T
description: absolute temperature

extracellular ion concentrations.K o
is property of: entity 4
is version of: OPB_00340
description: concentration of extracellular potassium

Ca and Mg buffering by ATP.MgATP i0
is property of: entity 8
is version of: OPB_00340
description: resting myoplasmic magnesium-bound ATP concentration in normal conditions

plateau potassium current.V
is version of: OPB_00506
description: membrane potential

intracellular ion concentrations.Ca JSR
is property of: entity 13
is version of: OPB_00340
description: concentration of calcium in junctional sarcoplasmic reticulum

membrane.i NaCa
is version of: OPB_00318
description: sodium-calcium exchanger current

time independent potassium current.V
is version of: OPB_00506
description: membrane potential

sodium potassium pump.Na o
is property of: entity_0
is version of: OPB_00340
description: concentration of extracellular sodium

plateau potassium current Kp gate.V
is version of: OPB_00506
description: membrane potential

Ca and Mg buffering by ATP.Jxfer Mg
is version of: OPB_00592
description: free magnesium flux from subspace to myoplasm

slow activating delayed rectifiyer K current.T
description: absolute temperature

rapid activating delayed rectifiyer K current.g Kr
is version of: OPB_01300
description: maximum rapid potassium current conductance

Ca and Mg buffering by ATP.V ss
is property of: entity 10
is version of: OPB_00154
description: volume of subspace

intracellular ion concentrations.EGTA tot
is property of: entity 19
is version of: OPB_00340
description: total concentration of EGTA

sodium potassium pump.K o
is property of: entity 4
is version of: OPB_00340
description: concentration of extracellular potassium

intracellular Ca fluxes.tau tr
description: transfer time constant from network sarcoplasmic reticulum to junctional sarcoplasmic reticulum

SERCA2a pump.N rb
description: reverse cooperativity constant for SERCA pump

Ca and Mg buffering by ATP.k minus CaADP
description: calcium off-rate constant for ADP

slow activating delayed rectifiyer K current i Ks
is version of: OPB_00318
description: slow-activating delayed rectifier potassium current

Ca and Mg buffering by ATP.tau xfer MgATP
description: time constant for transfer of magnesium-bound ATP from subspace to myoplasm

RyR channel.Ca JSR
is property of: entity 13
is version of: OPB_00340
description: concentration of calcium in junctional sarcoplasmic reticulum

Ca and Mg buffering by ATP.k minus CaATP
description: calcium off-rate constant for ATP

Ca and Mg buffering by ATP.tau xfer MgADP
description: time constant for transfer of magnesium-bound ADP from subspace to myoplasm

intracellular Ca fluxes.J xfer
is version of: OPB_00592
description: free calcium flux from subspace to myoplasm

RyR channel.k c minus
is: OPB_01296
description: ryanodine receptor PC2 - PO1 rate constant

transient outward potassium current.X to1
description: transient outward potassium current activation variable

intracellular ion concentrations.J trpn
is version of: OPB_00592
description: buffering of calcium by troponin C

intracellular ion concentrations.Na i
is property of: entity 2
is version of: OPB_00340
description: concentration of intracellular sodium

RyR channel.v1
description: maximum ryanodine receptor channel calcium flux

Ca and Mg buffering by ATP.tau xfer Mg
description: time constant for transfer of free magnesium from subspace to myoplasm

intracellular ion concentrations.K i
is property of: entity 5
is version of: OPB_00340
description: concentration of intracellular potassium

intracellular ion concentrations.J xfer
is version of: OPB_00592
description: free calcium flux from subspace to myoplasm

L type Ca current.g
is: OPB_01296
description: transition rate out of open state

intracellular ion concentrations.ADP i
is property of: entity 12
is version of: OPB_00340
description: concentration of free myoplasmic ADP

intracellular ion concentrations.Ca ss
is property of: entity 9
is version of: OPB_00340
description: concentration of free subspace calcium

Ca and Mg buffering by ATP.Mg i
is property of: entity 23
is version of: OPB_00340
description: concentration of free myoplasmic magnesium

rapid activating delayed rectifiyer K current X kr gate.K21
description: activation curve of reverse rapid potassium current

rapid activating delayed rectifiyer K current X kr gate.tau X kr
description: activation time constant of rapid potassium current

Ca and Mg buffering by ATP.CaATP ss
is property of: entity 22
is version of: OPB_00340
description: concentration of calcium-bound subspace ATP

intracellular ion concentrations.i to1
is version of: OPB_00318
description: transient outward potassium current

Ca and Mg buffering by ATP.ADP ss
is property of: entity 21
is version of: OPB_00340
description: concentration of free subspace ADP

intracellular ion concentrations.V JSR
is property of: entity 14
is version of: OPB_00154
description: volume of junctional sarcoplasmic reticulum

fast sodium current m gate.m
description: sodium current activation variable

RyR channel.k b plus
is: OPB_01296
description: ryanodine receptor PO1 - PO2 rate constant

rapid activating delayed rectifiyer K current X kr gate.V
is version of: OPB_00506
description: membrane potential

RyR channel.P C2
description: fraction of ryanodine receptor channels in state PC2

model parameters.V myo
is property of: entity 3
is version of: OPB_00154
description: volume of myoplasm

intracellular ion concentrations.ADP ss
is property of: entity 21
is version of: OPB_00340
description: concentration of free subspace ADP

fast sodium current.g Na
is version of: OPB_01300
description: maximum sodium channel conductance

model parameters.V ss
is property of: entity 10
is version of: OPB_00154
description: volume of subspace

intracellular ion concentrations.CaADP i
is property of: entity 12
is version of: OPB_00340
description: concentration of calcium-bound myoplasmic ADP

RyR channel.P C1
description: fraction of ryanodine receptor channels in state PC1

calcium background current.g Cab
is version of: OPB_01300
description: maximum background calcium current conductance

fast sodium current j gate.j
description: sodium current slow inactivation variable

Na Ca exchanger.V
is version of: OPB_00506
description: membrane potential

slow activating delayed rectifiyer K current.Na o
is property of: entity_0
is version of: OPB_00340
description: concentration of extracellular sodium

intracellular Ca fluxes.J HTRPNCa
is version of: OPB_00592
description: calcium flux to high-affinity troponin sites

Ca and Mg buffering by ATP.CaATP i
is property of: entity 8
is version of: OPB_00340
description: concentration of calcium-bound myoplasmic ATP

Ca and Mg buffering by ATP.MgATP i
is property of: entity 8
is version of: OPB_00340
description: concentration of magnesium-bound myoplasmic ATP

membrane.i K ATP
is version of: OPB_00318
description: ATP-sensitive potassium current

intracellular ion concentrations.V myo
is property of: entity 3
is version of: OPB_00154
description: volume of myoplasm

intracellular Ca fluxes.J trpn
is version of: OPB_00592
description: buffering of calcium by troponin C

membrane.i Na b
is version of: OPB_00318
description: sodium background current

intracellular Ca fluxes J tr
is version of: OPB_00592
description: calcium flux from network sarcoplasmic reticulum to junctional sarcoplasmic reticulum

intracellular ion concentrations.CaADP ss
is property of: entity 21
is version of: OPB_00340
description: concentration of calcium-bound subspace ADP

michailova 2005
is described by: 18339738
model name: michailova_2005
unknown: ventricular myocyte@en
has cell m ldocumentation: <documentation xmlns="http://cellml.org/tmp-documentation"> <articleinfo> Modeling regulation of cardiac KATP and L-type Ca2+ currents by ATP, ADP, and Mg2+ <author> <firstname>Catherine</firstname> <surname>Lloyd</surname> <affiliation> <shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil> </affiliation> </author> </articleinfo> Model Status This CellML model runs in both COR and OpenCell to recreate the published results. The units have been checked and they are consistent. We thank the original model author Anushka Michailova for providing us with the MATLAB code for the 2001 model on which this 2005 model is based. Please note when running a simultaion the step size has to be smaller than 0.005 seconds. <sect1 id="sec_structure"> Model Structure ABSTRACT: Changes in cytosolic free Mg(2+) and adenosine nucleotide phosphates affect cardiac excitability and contractility. To investigate how modulation by Mg(2+), ATP, and ADP of K(ATP) and L-type Ca(2+) channels influences excitation-contraction coupling, we incorporated equations for intracellular ATP and MgADP regulation of the K(ATP) current and MgATP regulation of the L-type Ca(2+) current in an ionic-metabolic model of the canine ventricular myocyte. The new model: 1), quantitatively reproduces a dose-response relationship for the effects of changes in ATP on K(ATP) current, 2), simulates effects of ADP in modulating ATP sensitivity of K(ATP) channel, 3), predicts activation of Ca(2+) current during rapid increase in MgATP, and 4), demonstrates that decreased ATP/ADP ratio with normal total Mg(2+) or increased free Mg(2+) with normal ATP and ADP activate K(ATP) current, shorten action potential, and alter ionic currents and intracellular Ca(2+) signals. The model predictions are in agreement with experimental data measured under normal and a variety of pathological conditions. <informalfigure float="0" id="katp_channel_diagram"> <mediaobject> <imageobject> <imagedata fileref="mi…

slow activating delayed rectifiyer K current.V
is version of: OPB_00506
description: membrane potential

intracellular ion concentrations.k plus CaATP
description: calcium on-rate constant for ATP

Ca and Mg buffering by ATP.k plus MgADP
description: magnesium on-rate constant for ADP

Na Ca exchanger.eta
description: voltage dependence factor of sodium-calcium exchange

time independent potassium current.K o
is property of: entity 4
is version of: OPB_00340
description: concentration of extracellular potassium

transient outward potassium current.g to1
is version of: OPB_01300
description: maximum transient outward potassium current conductance

Na Ca exchanger.Ca o
is property of: entity 7
is version of: OPB_00340
description: concentration of extracellular calcium

intracellular ion concentrations.k plus CaADP
description: calcium on-rate constant for ADP

intracellular ion concentrations.i Ca b
is version of: OPB_00318
description: calcium background current

sarcolemmal calcium pump.Ca i
is property of: entity 6
is version of: OPB_00340
description: concentration of free myoplasmic calcium

intracellular ion concentrations.i Na
is version of: OPB_00318
description: fast sodium current

intracellular ion concentrations.i NaCa
is version of: OPB_00318
description: sodium-calcium exchanger current

Na Ca exchanger.T
description: absolute temperature

SERCA2a pump.Ca i
is property of: entity 6
is version of: OPB_00340
description: concentration of free myoplasmic calcium

L type Ca current.Ca o
is property of: entity 7
is version of: OPB_00340
description: concentration of extracellular calcium

intracellular ion concentrations.C sc
description: specific membrane capacitance

L type Ca current y gate.y infinity
description: steady state function of L-type calcium current activation variable

intracellular ion concentrations.K mCSQN
is property of: entity 15
is version of: OPB_00340
description: calcium half-saturation constant for calsequestrin

plateau potassium current.g Kp
is version of: OPB_01300
description: maximum plateau potassium channel conductance

transient outward potassium current X to1 gate.X to1
description: transient outward potassium current activation variable

intracellular Ca fluxes.LTRPNCa
is property of: entity 17
is version of: OPB_00340
description: concentration of calcium-bound troponin low-affinity sites

rapid activating delayed rectifiyer K current.K i
is property of: entity 5
is version of: OPB_00340
description: concentration of intracellular potassium

intracellular Ca fluxes.tau xfer
description: transfer time constant from subspace to myoplasm

intracellular Ca fluxes.k ltrpn minus
is: OPB_01296
description: calcium off-rate for troponin low affinity sites

fast sodium current.Na i
is property of: entity 2
is version of: OPB_00340
description: concentration of intracellular sodium

L type Ca current.a
description: L-type calcium channel mode transition parameter

L type Ca current y gate.y
description: L-type calcium current activation variable

sodium potassium pump.K mNa i
is property of: entity 2
is version of: OPB_00340
description: sodium half-saturation constant for sodium-potassium pump

ATP sensitive potassium current.V
is version of: OPB_00506
description: membrane potential

intracellular ion concentrations.K mEGTA
is property of: entity 6
is version of: OPB_00340
description: calcium half-saturation constant for EGTA

SERCA2a pump.N fb
description: forward cooperativity constant for SERCA pump

intracellular Ca fluxes.k ltrpn plus
is: OPB_01296
description: calcium on-rate for troponin low affinity sites

transient outward potassium current i to1
is version of: OPB_00318
description: transient outward potassium current

sodium potassium pump.K mK o
is property of: entity 4
is version of: OPB_00340
description: potassium half-saturation constant for sodium-potassium pump

fast sodium current m gate.V
is version of: OPB_00506
description: membrane potential

intracellular ion concentrations.J rel
is version of: OPB_00592
description: ryanodine receptor channel calcium flux

Ca and Mg buffering by ATP.Ca i
is property of: entity 6
is version of: OPB_00340
description: concentration of free myoplasmic calcium

Ca and Mg buffering by ATP.k plus MgATP
description: magnesium on-rate constant for ATP

membrane.T
description: absolute temperature

intracellular ion concentrations.CSQN tot
is property of: entity 20
is version of: OPB_00340
description: total concentration of EGTA

time independent potassium current K1 gate.E K
is version of: OPB_00506
description: potassium reversal potential

L type Ca current.K i
is property of: entity 5
is version of: OPB_00340
description: concentration of intracellular potassium

L type Ca current i Ca
is version of: OPB_00318
description: L-type calcium current

slow activating delayed rectifiyer K current.X ks
description: slow potassium current activation variable

transient outward potassium current X to1 gate.V
is version of: OPB_00506
description: membrane potential

L type Ca current y gate.tau y
description: activation time constant of L-type calcium current

sodium potassium pump.T
description: absolute temperature

L type Ca current y gate.V
is version of: OPB_00506
description: membrane potential

Na Ca exchanger.Na i
is property of: entity 2
is version of: OPB_00340
description: concentration of intracellular sodium

sodium potassium pump.V
is version of: OPB_00506
description: membrane potential

intracellular ion concentrations.ATP i
is property of: entity 8
is version of: OPB_00340
description: concentration of free myoplasmic ATP

intracellular ion concentrations.Ca NSR
is property of: entity 15
is version of: OPB_00340
description: concentration of calcium in network sarcoplasmic reticulum

membrane.i NaK
is version of: OPB_00318
description: modified sodium-potassium current

Ca and Mg buffering by ATP.V myo
is property of: entity 3
is version of: OPB_00154
description: volume of myoplasm

ATP sensitive potassium current.k ATP
is property of: entity 6
is version of: OPB_00340
description: calcium half-saturation constant for ATP

membrane V
is version of: OPB_00506
description: membrane potential

ATP sensitive potassium current.k MgADP
is property of: entity 6
is version of: OPB_00340
description: calcium half-saturation constant for magnesium-bound ADP

fast sodium current.j
description: sodium current slow inactivation variable

RyR channel.k b minus
is: OPB_01296
description: ryanodine receptor PO2 - PO1 rate constant

membrane.i Kp
is version of: OPB_00318
description: plateau potassium current

fast sodium current h gate.V
is version of: OPB_00506
description: membrane potential

L type Ca current.i Ca K
is version of: OPB_00318
description: potassium current through L-type calcium channel

ATP sensitive potassium current.g K ATP
is version of: OPB_01300
description: ATP-sensitive potassium current conductance

Na Ca exchanger.Ca i
is property of: entity 6
is version of: OPB_00340
description: concentration of free myoplasmic calcium

intracellular ion concentrations.i Ca K
is version of: OPB_00318
description: potassium current through L-type calcium channel

intracellular ion concentrations.i Kp
is version of: OPB_00318
description: plateau potassium current

fast sodium current m gate.E0 m
is version of: OPB_00506
description: fast sodium current M-gate reversal potential

time independent potassium current i K1
is version of: OPB_00318
description: time-independent potassium current

membrane.i Ca
is version of: OPB_00318
description: L-type calcium current

transient outward potassium current.V
is version of: OPB_00506
description: membrane potential

intracellular ion concentrations.i Ca
is version of: OPB_00318
description: L-type calcium current

Ca and Mg buffering by ATP.ATP tot
is property of: entity 24
is version of: OPB_00340
description: total ATP concentration

RyR channel J rel
is version of: OPB_00592
description: ryanodine receptor channel calcium flux

Ca and Mg buffering by ATP.ATP ss
is property of: entity 22
is version of: OPB_00340
description: concentration of free subspace ATP

fast sodium current.h
description: sodium current inactivation variable

Ca and Mg buffering by ATP.Mg ss
is property of: entity 11
is version of: OPB_00340
description: concentration of free subspace magnesium

Ca and Mg buffering by ATP.MgATP ss
is property of: entity 11
is version of: OPB_00340
description: concentration of magnesium-bound subspace ATP

L type Ca current.f
is: OPB_01296
description: transition rate into open state

L type Ca current.b
description: L-type calcium channel mode transition parameter

membrane.i Ca b
is version of: OPB_00318
description: calcium background current

SERCA2a pump.Vmaxr
description: maximum SERCA reverse pumping rate

rapid activating delayed rectifiyer K current X kr gate.K12
description: activation curve of forward rapid potassium current

sodium background current.E Na
is version of: OPB_00506
description: sodium reversal potential

membrane.i Kr
is version of: OPB_00318
description: rapid-activating delayed rectifier potassium current

L type Ca current.C sc
description: specific membrane capacitance

slow activating delayed rectifiyer K current.K o
is property of: entity 4
is version of: OPB_00340
description: concentration of extracellular potassium

fast sodium current i Na
is version of: OPB_00318
description: fast sodium current

intracellular ion concentrations.i Kr
is version of: OPB_00318
description: rapid-activating delayed rectifier potassium current

membrane.i to1
is version of: OPB_00318
description: transient outward potassium current

slow activating delayed rectifiyer K current X ks gate.X ks
description: slow potassium current activation variable

intracellular ion concentrations.K mCMDN
is property of: entity 6
is version of: OPB_00340
description: calcium half-saturation constant for calmodulin

sarcolemmal calcium pump.K mpCa
is property of: entity 6
is version of: OPB_00340
description: half-saturation constant for sarcolemmal calcium pump

intracellular Ca fluxes.Ca NSR
is property of: entity 15
is version of: OPB_00340
description: concentration of calcium in network sarcoplasmic reticulum

fast sodium current.Na o
is property of: entity_0
is version of: OPB_00340
description: concentration of extracellular sodium

membrane.i Ks
is version of: OPB_00318
description: slow-activating delayed rectifier potassium current

extracellular ion concentrations.Ca o
is property of: entity 7
is version of: OPB_00340
description: concentration of extracellular calcium

membrane.i K1
is version of: OPB_00318
description: time-independent potassium current

slow activating delayed rectifiyer K current.E Ks
is version of: OPB_00506
description: slow delayed rectifier current reversal potential

sarcolemmal calcium pump.MgATP i
is property of: entity 8
is version of: OPB_00340
description: concentration of magnesium-bound myoplasmic ATP

intracellular ion concentrations.i K1
is version of: OPB_00318
description: time-independent potassium current

intracellular ion concentrations.i Ks
is version of: OPB_00318
description: slow-activating delayed rectifier potassium current