fast sodium current m gate.V
is version of: OPB_00506
description: membrane potential

sodium potassium pump.I NaK
description: maximum sodium-potassium pump current

intracellular ion concentrations.Ca JSR
is property of: entity 11
is version of: OPB_00340
description: concentration of calcium in junctional sarcoplasmic reticulum

SERCA2a pump.K rb
is property of: entity 6
is version of: OPB_00340
description: reverse half-saturation constant for calcium ATPase

plateau potassium current.V
is version of: OPB_00506
description: membrane potential

time independent potassium current K1 gate.T
description: absolute temperature

L type Ca current.P K
description: potassium permeability of L-type calcium channel

L type Ca current.omega
description: L-type calcium channel mode transition parameter

L type Ca current.i Ca max
description: calcium current at maximum potassium permeability of L-type calcium channel

intracellular Ca fluxes.Ca i
is property of: entity 6
is version of: OPB_00340
description: concentration of free myoplasmic calcium

Na Ca exchanger.Na i
is property of: entity 2
is version of: OPB_00340
description: concentration of intracellular sodium

sodium background current.V
is version of: OPB_00506
description: membrane potential

fast sodium current j gate.V
is version of: OPB_00506
description: membrane potential

L type Ca current.O
description: fraction of open L-type calcium channels

slow activating delayed rectifiyer K current X ks gate.V
is version of: OPB_00506
description: membrane potential

membrane.C sc
description: specific membrane capacitance

RyR channel.P O2
description: fraction of ryanodine receptor channels in state PO2

membrane.i Na
is version of: OPB_00318
description: fast sodium current

rapid activating delayed rectifiyer K current.g Kr
is version of: OPB_01300
description: maximum rapid potassium current conductance

intracellular ion concentrations.Na i
is property of: entity 2
is version of: OPB_00340
description: concentration of intracellular sodium

model parameters.V myo
is property of: entity 3
is version of: OPB_00154
description: volume of myoplasm

plateau potassium current i Kp
is version of: OPB_00318
description: plateau potassium current

membrane.i Ca b
is version of: OPB_00318
description: calcium background current

calcium background current i Ca b
is version of: OPB_00318
description: calcium background current

Ca and Mg buffering by ATP.Jxfer MgATP
is version of: OPB_00592
description: magnesium-bound ATP flux from subspace to myoplasm

Ca and Mg buffering by ATP.k minus CaADP
description: calcium off-rate constant for ADP

fast sodium current.Na i
is property of: entity 2
is version of: OPB_00340
description: concentration of intracellular sodium

SERCA2a pump.MgATP i
is property of: entity 8
is version of: OPB_00340
description: concentration of magnesium-bound myoplasmic ATP

intracellular Ca fluxes.tau xfer
description: transfer time constant from subspace to myoplasm

intracellular ion concentrations.CaADP i
is property of: entity 19
is version of: OPB_00340
description: concentration of calcium-bound myoplasmic ADP

time independent potassium current.g K1
is version of: OPB_01300
description: maximum time-independent potassium current conductance

Ca and Mg buffering by ATP.k minus CaATP
description: calcium off-rate constant for ATP

L type Ca current.gprime
is: OPB_01296
description: transition rate out of open state for calcium mode

rapid activating delayed rectifiyer K current X kr gate.K21
description: activation curve of reverse rapid potassium current

RyR channel.k c minus
is: OPB_01296
description: ryanodine receptor PC2 - PO1 rate constant

RyR channel.k b minus
is: OPB_01296
description: ryanodine receptor PO2 - PO1 rate constant

RyR channel.Ca JSR
is property of: entity 11
is version of: OPB_00340
description: concentration of calcium in junctional sarcoplasmic reticulum

Ca and Mg buffering by ATP.Mg i
is property of: entity 23
is version of: OPB_00340
description: concentration of free myoplasmic magnesium

intracellular Ca fluxes.J trpn
is version of: OPB_00592
description: buffering of calcium by troponin C

L type Ca current y gate.y
description: L-type calcium current activation variable

intracellular ion concentrations.i Na b
is version of: OPB_00318
description: sodium background current

L type Ca current.C1
description: fraction of closed L-type calcium channels

Na Ca exchanger.Na o
is property of: entity_0
is version of: OPB_00340
description: concentration of extracellular sodium

rapid activating delayed rectifiyer K current X kr gate.tau X kr
description: activation time constant of rapid potassium current

intracellular ion concentrations.V NSR
is property of: entity 14
is version of: OPB_00154
description: volume of network sarcoplasmic reticulum

sodium potassium pump.K mK o
is property of: entity 4
is version of: OPB_00340
description: potassium half-saturation constant for sodium-potassium pump

intracellular ion concentrations.J rel
is version of: OPB_00592
description: ryanodine receptor channel calcium flux

rapid activating delayed rectifiyer K current.T
description: absolute temperature

fast sodium current h gate.h
description: sodium current inactivation variable

rapid activating delayed rectifiyer K current X kr gate.V
is version of: OPB_00506
description: membrane potential

plateau potassium current Kp gate.Kp V
description: activation potential of plateau potassium current

Ca and Mg buffering by ATP MgATP i
is property of: entity 8
is version of: OPB_00340
description: concentration of magnesium-bound myoplasmic ATP

RyR channel.Ca ss
is property of: entity 9
is version of: OPB_00340
description: concentration of free subspace calcium

sarcolemmal calcium pump.MgATP i0
is property of: entity 8
is version of: OPB_00340
description: resting myoplasmic magnesium-bound ATP concentration in normal conditions

sodium background current i Na b
is version of: OPB_00318
description: sodium background current

L type Ca current.C0
description: fraction of closed L-type calcium channels

intracellular Ca fluxes.k ltrpn minus
is: OPB_01296
description: calcium off-rate for troponin low affinity sites

rapid activating delayed rectifiyer K current.K i
is property of: entity 5
is version of: OPB_00340
description: concentration of intracellular potassium

Ca and Mg buffering by ATP.Ca ss
is property of: entity 9
is version of: OPB_00340
description: concentration of free subspace calcium

intracellular Ca fluxes.k ltrpn plus
is: OPB_01296
description: calcium on-rate for troponin low affinity sites

rapid activating delayed rectifiyer K current.R V
description: activation potential of rapid potassium current

intracellular ion concentrations.i Ca K
is version of: OPB_00318
description: potassium current through L-type calcium channel

Ca and Mg buffering by ATP.ATP ss
is property of: entity 21
is version of: OPB_00340
description: concentration of free subspace ATP

time independent potassium current K1 gate.V
is version of: OPB_00506
description: membrane potential

time independent potassium current.K o
is property of: entity 4
is version of: OPB_00340
description: concentration of extracellular potassium

transient outward potassium current Y to1 gate.Y to1
description: transient outward potassium current inactivation variable

sodium background current.g Nab
is version of: OPB_01300
description: maximum background sodium current conductance

intracellular Ca fluxes.LTRPNCa
is property of: entity 15
is version of: OPB_00340
description: concentration of calcium-bound troponin low-affinity sites

rapid activating delayed rectifiyer K current.V
is version of: OPB_00506
description: membrane potential

L type Ca current.T
description: absolute temperature

fast sodium current.E Na
is version of: OPB_00506
description: sodium reversal potential

extracellular ion concentrations.Ca o
is property of: entity 7
is version of: OPB_00340
description: concentration of extracellular calcium

Ca and Mg buffering by ATP.V myo
is property of: entity 3
is version of: OPB_00154
description: volume of myoplasm

model parameters.V ss
is property of: entity 10
is version of: OPB_00154
description: volume of subspace

plateau potassium current.Kp V
description: activation potential of plateau potassium current

Ca and Mg buffering by ATP.Ca i
is property of: entity 6
is version of: OPB_00340
description: concentration of free myoplasmic calcium

Ca and Mg buffering by ATP.ADP tot
is property of: entity 27
is version of: OPB_00340
description: total ADP concentration

SERCA2a pump.MgATP i0
is property of: entity 8
is version of: OPB_00340
description: resting myoplasmic magnesium-bound ATP concentration in normal conditions

time independent potassium current K1 gate.K1 infinity V
description: steady-state function of time-independent potassium current activation variable

Ca and Mg buffering by ATP.ADP i
is property of: entity 19
is version of: OPB_00340
description: concentration of free myoplasmic ADP

L type Ca current.f
is: OPB_01296
description: transition rate into open state

L type Ca current.O Ca
description: fraction of open L-type calcium channels in calcium mode

Ca and Mg buffering by ATP.CaATP ss
is property of: entity 21
is version of: OPB_00340
description: concentration of calcium-bound subspace ATP

transient outward potassium current X to1 gate.X to1
description: transient outward potassium current activation variable

fast sodium current.V
is version of: OPB_00506
description: membrane potential

L type Ca current.C Ca4
description: fraction of closed L-type calcium channels in calcium mode

intracellular ion concentrations.CMDN tot
is property of: entity 16
is version of: OPB_00340
description: total concentration of myoplasmic calmodulin

intracellular ion concentrations.V myo
is property of: entity 3
is version of: OPB_00154
description: volume of myoplasm

transient outward potassium current.V
is version of: OPB_00506
description: membrane potential

sodium potassium pump.V
is version of: OPB_00506
description: membrane potential

intracellular ion concentrations.ATP i
is property of: entity 8
is version of: OPB_00340
description: concentration of free myoplasmic ATP

L type Ca current.g
is: OPB_01296
description: transition rate out of open state

Ca and Mg buffering by ATP.V ss
is property of: entity 10
is version of: OPB_00154
description: volume of subspace

transient outward potassium current i to1
is version of: OPB_00318
description: transient outward potassium current

fast sodium current.Na o
is property of: entity_0
is version of: OPB_00340
description: concentration of extracellular sodium

slow activating delayed rectifiyer K current X ks gate.X ks infinity
description: steady state function of slow potassium current activation variable

transient outward potassium current X to1 gate.V
is version of: OPB_00506
description: membrane potential

L type Ca current.C Ca3
description: fraction of closed L-type calcium channels in calcium mode

intracellular ion concentrations.K mCSQN
is property of: entity 13
is version of: OPB_00340
description: calcium half-saturation constant for calsequestrin

Ca and Mg buffering by ATP.k plus CaADP
description: calcium on-rate constant for ADP

intracellular Ca fluxes.HTRPN tot
description: total concentration of troponin high-affinity sites

plateau potassium current Kp gate.V
is version of: OPB_00506
description: membrane potential

fast sodium current m gate.m
description: sodium current activation variable

L type Ca current y gate.V
is version of: OPB_00506
description: membrane potential

Ca and Mg buffering by ATP.k plus CaATP
description: calcium on-rate constant for ATP

Na Ca exchanger.K mNa
is property of: entity 2
is version of: OPB_00340
description: sodium half-saturation constant for sodium-calcium exchange

L type Ca current.C Ca2
description: fraction of closed L-type calcium channels in calcium mode

Ca and Mg buffering by ATP.MgATP i0
is property of: entity 8
is version of: OPB_00340
description: resting myoplasmic magnesium-bound ATP concentration in normal conditions

Ca and Mg buffering by ATP Jxfer CaADP
is version of: OPB_00592
description: calcium-bound ADP flux from subspace to myoplasm

slow activating delayed rectifiyer K current.K o
is property of: entity 4
is version of: OPB_00340
description: concentration of extracellular potassium

sodium potassium pump i NaK
is version of: OPB_00318
description: modified sodium-potassium current

sodium potassium pump.T
description: absolute temperature

Na Ca exchanger.K sat
description: saturation factor of sodium-calcium exchanger current

rapid activating delayed rectifiyer K current.K o
is property of: entity 4
is version of: OPB_00340
description: concentration of extracellular potassium

calcium background current.Ca o
is property of: entity 7
is version of: OPB_00340
description: concentration of extracellular calcium

membrane.i NaCa
is version of: OPB_00318
description: sodium-calcium exchanger current

plateau potassium current.E K
is version of: OPB_00506
description: potassium reversal potential

L type Ca current.C Ca1
description: fraction of closed L-type calcium channels in calcium mode

sarcolemmal calcium pump.K mpCa
is property of: entity 6
is version of: OPB_00340
description: half-saturation constant for sarcolemmal calcium pump

intracellular ion concentrations.Ca NSR
is property of: entity 13
is version of: OPB_00340
description: concentration of calcium in network sarcoplasmic reticulum

intracellular ion concentrations.C sc
description: specific membrane capacitance

intracellular ion concentrations.i Ca b
is version of: OPB_00318
description: calcium background current

fast sodium current m gate.E0 m
is version of: OPB_00506
description: fast sodium current M-gate reversal potential

sarcolemmal calcium pump.I pCa
description: maximum sarcolemmal calcium pump current

sarcolemmal calcium pump.MgATP i
is property of: entity 8
is version of: OPB_00340
description: concentration of magnesium-bound myoplasmic ATP

intracellular ion concentrations.K mEGTA
is property of: entity 6
is version of: OPB_00340
description: calcium half-saturation constant for EGTA

RyR channel.m
description: ryanodine receptor calcium cooperativity parameter PO1 - PO2

rapid activating delayed rectifiyer K current X kr gate.K12
description: activation curve of forward rapid potassium current

L type Ca current.C Ca0
description: fraction of closed L-type calcium channels in calcium mode

Na Ca exchanger.Ca o
is property of: entity 7
is version of: OPB_00340
description: concentration of extracellular calcium

intracellular Ca fluxes.Ca ss
is property of: entity 9
is version of: OPB_00340
description: concentration of free subspace calcium

intracellular ion concentrations.i Na
is version of: OPB_00318
description: fast sodium current

membrane.i Ca K
is version of: OPB_00318
description: potassium current through L-type calcium channel

slow activating delayed rectifiyer K current.K i
is property of: entity 5
is version of: OPB_00340
description: concentration of intracellular potassium

slow activating delayed rectifiyer K current i Ks
is version of: OPB_00318
description: slow-activating delayed rectifier potassium current

RyR channel.n
description: ryanodine receptor calcium cooperativity parameter PC1 - PO1

SERCA2a pump.Ca i
is property of: entity 6
is version of: OPB_00340
description: concentration of free myoplasmic calcium

SERCA2a pump.N fb
description: forward cooperativity constant for SERCA pump

Ca and Mg buffering by ATP.MgADP ss
is property of: entity 20
is version of: OPB_00340
description: concentration of magnesium-bound subspace ADP

RyR channel.v1
description: maximum ryanodine receptor channel calcium flux

fast sodium current.T
description: absolute temperature

slow activating delayed rectifiyer K current X ks gate.X ks
description: slow potassium current activation variable

rapid activating delayed rectifiyer K current.X kr
description: rapid potassium current activation variable

intracellular Ca fluxes.k htrpn plus
is: OPB_01296
description: calcium on-rate for troponin high affinity sites

SERCA2a pump.Ca NSR
is property of: entity 13
is version of: OPB_00340
description: concentration of calcium in network sarcoplasmic reticulum

L type Ca current.Ca o
is property of: entity 7
is version of: OPB_00340
description: concentration of extracellular calcium

SERCA2a pump.Vmaxf
description: maximum SERCA forward pumping rate

intracellular ion concentrations.k minus CaADP
description: calcium off-rate constant for ADP

Ca and Mg buffering by ATP.k plus MgATP
description: magnesium on-rate constant for ATP

L type Ca current i Ca K
is version of: OPB_00318
description: potassium current through L-type calcium channel

transient outward potassium current.Y to1
description: transient outward potassium current inactivation variable

slow activating delayed rectifiyer K current.V
is version of: OPB_00506
description: membrane potential

intracellular Ca fluxes J tr
is version of: OPB_00592
description: calcium flux from network sarcoplasmic reticulum to junctional sarcoplasmic reticulum

intracellular ion concentrations.k minus CaATP
description: calcium off-rate constant for ATP

intracellular ion concentrations.Ca ss
is property of: entity 9
is version of: OPB_00340
description: concentration of free subspace calcium

Ca and Mg buffering by ATP.k plus MgADP
description: magnesium on-rate constant for ADP

L type Ca current.C sc
description: specific membrane capacitance

rapid activating delayed rectifiyer K current i Kr
is version of: OPB_00318
description: rapid-activating delayed rectifier potassium current

intracellular ion concentrations.CaADP ss
is property of: entity 20
is version of: OPB_00340
description: concentration of calcium-bound subspace ADP

slow activating delayed rectifiyer K current X ks gate.tau X ks
description: activation time constant of slow potassium current

L type Ca current.fprime
is: OPB_01296
description: transition rate into open state for calcium mode

intracellular ion concentrations.V JSR
is property of: entity 12
is version of: OPB_00154
description: volume of junctional sarcoplasmic reticulum

intracellular ion concentrations.i to1
is version of: OPB_00318
description: transient outward potassium current

time independent potassium current i K1
is version of: OPB_00318
description: time-independent potassium current

calcium background current.E Ca
is version of: OPB_00506
description: calcium reversal potential

michailova 2001
model name: michailova_2001
is described by: 11463611
unknown: ventricular myocyte@en
unknown: Michailova and McCulloch's mathematical model of ATP and ADP buffering, transport of Ca and Mg, and regulation of ion pumps in ventricular myocytes.@en
has cell m ldocumentation: <documentation xmlns="http://cellml.org/tmp-documentation"> <articleinfo> Model study of ATP and ADP buffering, transport of Ca(2+) and Mg(2+), and regulation of ion pumps in ventricular myocyte <author> <firstname>Catherine</firstname> <surname>Lloyd</surname> <affiliation> <shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil> </affiliation> </author> </articleinfo> Model Status This CellML model runs in both COR and OpenCell to recreate the published results. The units have been checked and they are consistent. We thank the original model author Anushka Michailova for providing us with the MATLAB code for this model. Please note when running a simultaion the step size has to be smaller than 0.005 seconds. <sect1 id="sec_structure"> Model Structure ABSTRACT: We extended the model of the ventricular myocyte by Winslow et al. (Circ. Res 1999, 84:571-586) by incorporating equations for Ca(2+) and Mg(2+) buffering and transport by ATP and ADP and equations for MgATP regulation of ion transporters (Na(+)-K(+) pump, sarcolemmal and sarcoplasmic Ca(2+) pumps). The results indicate that, under normal conditions, Ca(2+) binding by low-affinity ATP and diffusion of CaATP may affect the amplitude and time course of intracellular Ca(2+) signals. The model also suggests that a fall in ATP/ADP ratio significantly reduces sarcoplasmic Ca(2+) content, increases diastolic Ca(2+), lowers systolic Ca(2+), increases Ca(2+) influx through L-type channels, and decreases the efficiency of the Na(+)/Ca(2+) exchanger in extruding Ca(2+) during periodic voltage-clamp stimulation. The analysis suggests that the most important reason for these changes during metabolic inhibition is the down-regulation of the sarcoplasmic Ca(2+)-ATPase pump by reduced diastolic MgATP levels. High Ca(2+) concentrations developed near the membrane might have a greater influence on Mg(2+), ATP, and ADP concentrations than that of the lower Ca(2+) concentrations in the bulk myoplas…
model name: michailova_mcculloch_2001

Ca and Mg buffering by ATP.ADP ss
is property of: entity 20
is version of: OPB_00340
description: concentration of free subspace ADP

intracellular ion concentrations.i Ca
is version of: OPB_00318
description: L-type calcium current

membrane.i to1
is version of: OPB_00318
description: transient outward potassium current

intracellular ion concentrations.J trpn
is version of: OPB_00592
description: buffering of calcium by troponin C

calcium background current.Ca i
is property of: entity 6
is version of: OPB_00340
description: concentration of free myoplasmic calcium

intracellular ion concentrations.A cap
description: capacitive membrane area

Ca and Mg buffering by ATP.tau xfer MgADP
description: time constant for transfer of magnesium-bound ADP from subspace to myoplasm

slow activating delayed rectifiyer K current.T
description: absolute temperature

Ca and Mg buffering by ATP.Jxfer CaATP
is version of: OPB_00592
description: calcium-bound ATP flux from subspace to myoplasm

slow activating delayed rectifiyer K current.Na i
is property of: entity 2
is version of: OPB_00340
description: concentration of intracellular sodium

intracellular ion concentrations.i Kp
is version of: OPB_00318
description: plateau potassium current

Ca and Mg buffering by ATP.tau xfer MgATP
description: time constant for transfer of magnesium-bound ATP from subspace to myoplasm

membrane.T
description: absolute temperature

Na Ca exchanger.V
is version of: OPB_00506
description: membrane potential

intracellular Ca fluxes.k htrpn minus
is: OPB_01296
description: calcium off-rate for troponin high affinity sites

intracellular ion concentrations.K mCMDN
is property of: entity 6
is version of: OPB_00340
description: calcium half-saturation constant for calmodulin

Ca and Mg buffering by ATP.ATP tot
is property of: entity 25
is version of: OPB_00340
description: total ATP concentration

L type Ca current.i Ca half
description: calcium current at half potassium permeability of L-type calcium channel

time independent potassium current.V
is version of: OPB_00506
description: membrane potential

rapid activating delayed rectifiyer K current X kr gate.X kr inf
description: steady state function of rapid potassium current activation variable

transient outward potassium current.X to1
description: transient outward potassium current activation variable

L type Ca current.K i
is property of: entity 5
is version of: OPB_00340
description: concentration of intracellular potassium

plateau potassium current.g Kp
is version of: OPB_01300
description: maximum plateau potassium channel conductance

intracellular Ca fluxes.Ca JSR
is property of: entity 11
is version of: OPB_00340
description: concentration of calcium in junctional sarcoplasmic reticulum

Na Ca exchanger i NaCa
is version of: OPB_00318
description: sodium-calcium exchanger current

L type Ca current y gate.tau y
description: activation time constant of L-type calcium current

time independent potassium current.K1 infinity V
description: steady-state function of time-independent potassium current activation variable

intracellular ion concentrations.Ca i
is property of: entity 6
is version of: OPB_00340
description: concentration of free myoplasmic calcium

Na Ca exchanger.Ca i
is property of: entity 6
is version of: OPB_00340
description: concentration of free myoplasmic calcium

Ca and Mg buffering by ATP.CaADP ss
is property of: entity 20
is version of: OPB_00340
description: concentration of calcium-bound subspace ADP

intracellular Ca fluxes J xfer
is version of: OPB_00592
description: free calcium flux from subspace to myoplasm

L type Ca current.a
description: L-type calcium channel mode transition parameter

transient outward potassium current.g to1
is version of: OPB_01300
description: maximum transient outward potassium current conductance

intracellular ion concentrations.i NaK
is version of: OPB_00318
description: modified sodium-potassium current

Ca and Mg buffering by ATP.Mg ss
is property of: entity 22
is version of: OPB_00340
description: concentration of free subspace magnesium

Na Ca exchanger.K mCa
is property of: entity 6
is version of: OPB_00340
description: calcium half-saturation constant for sodium-calcium exchange

time independent potassium current.T
description: absolute temperature

L type Ca current.b
description: L-type calcium channel mode transition parameter

calcium background current.T
description: absolute temperature

RyR channel.P C1
description: fraction of ryanodine receptor channels in state PC1

intracellular ion concentrations.ATP ss
is property of: entity 21
is version of: OPB_00340
description: concentration of free subspace ATP

L type Ca current.P Ca
description: calcium permeability of L-type calcium channel

time independent potassium current.K mK1
is property of: entity 6
is version of: OPB_00340
description: calcium half-saturation constant for time-independent potassium current

rapid activating delayed rectifiyer K current.E K
is version of: OPB_00506
description: potassium reversal potential

fast sodium current i Na
is version of: OPB_00318
description: fast sodium current

calcium background current.g Cab
is version of: OPB_01300
description: maximum background calcium current conductance

rapid activating delayed rectifiyer K current X kr gate.X kr
description: rapid potassium current activation variable

fast sodium current h gate.V
is version of: OPB_00506
description: membrane potential

RyR channel.P C2
description: fraction of ryanodine receptor channels in state PC2

membrane.i p Ca
is version of: OPB_00318
description: modified sarcolemmal calcium pump current

sarcolemmal calcium pump.Ca i
is property of: entity 6
is version of: OPB_00340
description: concentration of free myoplasmic calcium

fast sodium current.m
description: sodium current activation variable

sodium potassium pump.Na i
is property of: entity 2
is version of: OPB_00340
description: concentration of intracellular sodium

calcium background current.V
is version of: OPB_00506
description: membrane potential

SERCA2a pump.N rb
description: reverse cooperativity constant for SERCA pump

slow activating delayed rectifiyer K current.g Ks
is version of: OPB_01300
description: maximum slow potassium current conductance

intracellular ion concentrations.i K1
is version of: OPB_00318
description: time-independent potassium current

intracellular ion concentrations.i Ks
is version of: OPB_00318
description: slow-activating delayed rectifier potassium current

Ca and Mg buffering by ATP Jxfer Mg
is version of: OPB_00592
description: free magnesium flux from subspace to myoplasm

intracellular ion concentrations.K i
is property of: entity 5
is version of: OPB_00340
description: concentration of intracellular potassium

Ca and Mg buffering by ATP.MgATP ss
is property of: entity 21
is version of: OPB_00340
description: concentration of magnesium-bound subspace ATP

RyR channel J rel
is version of: OPB_00592
description: ryanodine receptor channel calcium flux

membrane V
is version of: OPB_00506
description: membrane potential

Ca and Mg buffering by ATP.tau xfer Mg
description: time constant for transfer of free magnesium from subspace to myoplasm

intracellular ion concentrations.i Kr
is version of: OPB_00318
description: rapid-activating delayed rectifier potassium current

intracellular ion concentrations.k plus CaATP
description: calcium on-rate constant for ATP

membrane.i Kr
is version of: OPB_00318
description: rapid-activating delayed rectifier potassium current

intracellular ion concentrations.V ss
is property of: entity 10
is version of: OPB_00154
description: volume of subspace

intracellular Ca fluxes.J LTRPNCa
is version of: OPB_00592
description: calcium flux to low-affinity troponin sites

SERCA2a pump.K fb
is property of: entity 6
is version of: OPB_00340
description: forward half-saturation constant for calcium ATPase

extracellular ion concentrations.K o
is property of: entity 4
is version of: OPB_00340
description: concentration of extracellular potassium

L type Ca current.V
is version of: OPB_00506
description: membrane potential

intracellular ion concentrations.ADP ss
is property of: entity 20
is version of: OPB_00340
description: concentration of free subspace ADP

sodium background current.E Na
is version of: OPB_00506
description: sodium reversal potential

intracellular Ca fluxes.J HTRPNCa
is version of: OPB_00592
description: calcium flux to high-affinity troponin sites

RyR channel.k b plus
is: OPB_01296
description: ryanodine receptor PO1 - PO2 rate constant

sodium potassium pump.MgATP i0
is property of: entity 8
is version of: OPB_00340
description: resting myoplasmic magnesium-bound ATP concentration in normal conditions

fast sodium current.h
description: sodium current inactivation variable

intracellular Ca fluxes.tau tr
description: transfer time constant from network sarcoplasmic reticulum to junctional sarcoplasmic reticulum

transient outward potassium current Y to1 gate.V
is version of: OPB_00506
description: membrane potential

membrane.i K1
is version of: OPB_00318
description: time-independent potassium current

membrane.i Ks
is version of: OPB_00318
description: slow-activating delayed rectifier potassium current

L type Ca current y gate.y infinity
description: steady state function of L-type calcium current activation variable

intracellular ion concentrations.k plus CaADP
description: calcium on-rate constant for ADP

intracellular ion concentrations.J tr
is version of: OPB_00592
description: calcium flux from network sarcoplasmic reticulum to junctional sarcoplasmic reticulum

L type Ca current.C4
description: fraction of closed L-type calcium channels

time independent potassium current K1 gate.E K
is version of: OPB_00506
description: potassium reversal potential

sodium potassium pump.K o
is property of: entity 4
is version of: OPB_00340
description: concentration of extracellular potassium

L type Ca current.y
description: L-type calcium current activation variable

fast sodium current.j
description: sodium current slow inactivation variable

intracellular ion concentrations.CaATP i
is property of: entity 8
is version of: OPB_00340
description: concentration of calcium-bound myoplasmic ATP

Ca and Mg buffering by ATP CaADP i
is property of: entity 19
is version of: OPB_00340
description: concentration of calcium-bound myoplasmic ADP

SERCA2a pump.Vmaxr
description: maximum SERCA reverse pumping rate

L type Ca current.C3
description: fraction of closed L-type calcium channels

Ca and Mg buffering by ATP.MgADP i
is property of: entity 24
is version of: OPB_00340
description: concentration of magnesium-bound myoplasmic ADP

slow activating delayed rectifiyer K current.Na o
is property of: entity_0
is version of: OPB_00340
description: concentration of extracellular sodium

L type Ca current.C2
description: fraction of closed L-type calcium channels

L type Ca current.Ca ss
is property of: entity 9
is version of: OPB_00340
description: concentration of free subspace calcium

sodium potassium pump.MgATP i
is property of: entity 8
is version of: OPB_00340
description: concentration of magnesium-bound myoplasmic ATP

sodium potassium pump.K mNa i
is property of: entity 2
is version of: OPB_00340
description: sodium half-saturation constant for sodium-potassium pump

Ca and Mg buffering by ATP.CaATP i
is property of: entity 8
is version of: OPB_00340
description: concentration of calcium-bound myoplasmic ATP

Na Ca exchanger.T
description: absolute temperature

RyR channel.k a minus
is: OPB_01296
description: ryanodine receptor PO1 - PC1 rate constant

intracellular ion concentrations.CSQN tot
is property of: entity 18
is version of: OPB_00340
description: total concentration of EGTA

slow activating delayed rectifiyer K current.E Ks
is version of: OPB_00506
description: slow delayed rectifier current reversal potential

Ca and Mg buffering by ATP.Jxfer MgADP
is version of: OPB_00592
description: magnesium-bound ADP flux from subspace to myoplasm

L type Ca current.K o
is property of: entity 4
is version of: OPB_00340
description: concentration of extracellular potassium

Na Ca exchanger.eta
description: voltage dependence factor of sodium-calcium exchange

L type Ca current i Ca
is version of: OPB_00318
description: L-type calcium current

intracellular ion concentrations.CaATP ss
is property of: entity 21
is version of: OPB_00340
description: concentration of calcium-bound subspace ATP

RyR channel.P O1
description: fraction of ryanodine receptor channels in state PO1

RyR channel.k c plus
is: OPB_01296
description: ryanodine receptor PO1 - PC2 rate constant

membrane.i Na b
is version of: OPB_00318
description: sodium background current

sodium potassium pump.Na o
is property of: entity_0
is version of: OPB_00340
description: concentration of extracellular sodium

intracellular ion concentrations.ADP i
is property of: entity 19
is version of: OPB_00340
description: concentration of free myoplasmic ADP

transient outward potassium current.E K
is version of: OPB_00506
description: potassium reversal potential

Ca and Mg buffering by ATP.k minus MgATP
description: magnesium off-rate constant for ATP

intracellular ion concentrations.EGTA tot
is property of: entity 17
is version of: OPB_00340
description: total concentration of EGTA

time independent potassium current.E K
is version of: OPB_00506
description: potassium reversal potential

intracellular ion concentrations.i NaCa
is version of: OPB_00318
description: sodium-calcium exchanger current

slow activating delayed rectifiyer K current.X ks
description: slow potassium current activation variable

intracellular ion concentrations.J up
is version of: OPB_00592
description: modified calcium uptake flux into network sarcoplasmic reticulum by SERCA pumps

Ca and Mg buffering by ATP.tau xfer CaADP
description: time constant for transfer of calcium-bound ADP from subspace to myoplasm

membrane.i Kp
is version of: OPB_00318
description: plateau potassium current

Ca and Mg buffering by ATP.k minus MgADP
description: magnesium off-rate constant for ADP

intracellular Ca fluxes.HTRPNCa
is property of: entity 15
is version of: OPB_00340
description: concentration of calcium-bound troponin high-affinity sites

fast sodium current j gate.j
description: sodium current slow inactivation variable

SERCA2a pump J up
is version of: OPB_00592
description: modified calcium uptake flux into network sarcoplasmic reticulum by SERCA pumps

extracellular ion concentrations.Na o
is property of: entity_0
is version of: OPB_00340
description: concentration of extracellular sodium

membrane.i NaK
is version of: OPB_00318
description: modified sodium-potassium current

intracellular ion concentrations.i p Ca
is version of: OPB_00318
description: modified sarcolemmal calcium pump current

Ca and Mg buffering by ATP.tau xfer CaATP
description: time constant for transfer of calcium-bound ATP from subspace to myoplasm

intracellular Ca fluxes.Ca NSR
is property of: entity 13
is version of: OPB_00340
description: concentration of calcium in network sarcoplasmic reticulum

sarcolemmal calcium pump i p Ca
is version of: OPB_00318
description: modified sarcolemmal calcium pump current

intracellular ion concentrations.J xfer
is version of: OPB_00592
description: free calcium flux from subspace to myoplasm

membrane.i Ca
is version of: OPB_00318
description: L-type calcium current

intracellular Ca fluxes.LTRPN tot
description: total concentration of troponin low-affinity sites

RyR channel.k a plus
is: OPB_01296
description: ryanodine receptor PC1 - PO1 rate constant

Ca and Mg buffering by ATP.ATP i
is property of: entity 8
is version of: OPB_00340
description: concentration of free myoplasmic ATP

Na Ca exchanger.K NaCa
description: scale factor of sodium-calcium exchanger

fast sodium current.g Na
is version of: OPB_01300
description: maximum sodium channel conductance