# fast Na module # Return kinetic parameters, constraints, and vector of volumes in each # compartment (pL) (1 if gating variable, or in element corresponding to # kappa) # Translated from Pan 2018 cardiac AP import numpy as np def kinetic_parameters(M, include_type2_reactions, dims, V): # Set the kinetic rate constants num_cols = dims['num_cols'] num_rows = dims['num_rows'] # constants are stored in V # k + = k - = K_leak(on ClancyRudy original model. Params from Kernik19) K_leak = 1.6e-6 kf = K_leak kr = K_leak k_kinetic = [kf, kr] # CONSTRAINTS N_cT = [] K_C = [] # volume vector # W = list(np.append([1] * num_cols, [V['V_myo']] * num_rows)) W = [1, V['V_SR'], V['V_myo']] return (k_kinetic, N_cT, K_C, W)