# with the following commands at the prompt in the OpenCOR Python console:
#
#     In [1]: cd path/to/folder_this_file_is_in
#     In [2]: run Fig2_sim.py
import opencor as oc
import matplotlib.pyplot as plt
import numpy as np
# The prefix of the saved output file name
V_var = 0;
if V_var:
    prefilename = 'Fig2'
    # Load the simulation file
    from pathlib import Path
    simfile = 'C:/Users/lnor300/Documents/CellML/12_Labors/Tong_2011_V1/Simulations/Tong_2011.sedml'

    simulation = oc.open_simulation(simfile)
    data = simulation.data()

    # Reset states variables and parameters
    simulation.reset(True)
    # Set constant values
    start = 0
    end = 5000
    pointInterval = 0.1
    data.set_starting_point(start)
    data.set_ending_point(end)
    data.set_point_interval(pointInterval)
    data.constants()['interface/membrane_potential/v_init'] = -90
    data.constants() [ 'interface/parameters/kmca' ] = 0.001
    simulation.run()
    # Access simulation results
    results = simulation.results()
    # Data to save
    varName = np.array(["Time", "hss", "mss", "htc", "mtc", "ina", "v"])
    vars = np.reshape(varName, (1,7))
    rows = end * 10 + 1
    print(rows)

    # Access simulation results
    results = simulation.results()
    # Grab a some algebraic variable results
    r = np.zeros((rows, len(varName)))
    r [ :, 0 ] = results.voi().values()
    r [ :, 1 ] = results.algebraic()['interface/I_Na/hss'].values()
    r [ :, 2 ] = results.algebraic()['interface/I_Na/mss'].values()
    r [ :, 3 ] = results.algebraic() [ 'interface/I_Na/htc' ].values()
    r [ :, 4 ] = results.algebraic() [ 'interface/I_Na/mtc' ].values()
    r [ :, 5 ] = results.algebraic() [ 'interface/I_Na/ina' ].values()
    r [ :, 6 ] = results.states() [ 'interface/membrane_potential/v' ].values()
    filename = '%s.csv' % (prefilename)
    np.savetxt(filename, vars, fmt='%s', delimiter=",")
    with open(filename, "ab") as f:
        np.savetxt(f, r, delimiter=",")
    f.close
else:
    prefilename = 'Fig2_3'
    # Load the simulation file

    simfile = 'C:/Users/lnor300/Documents/CellML/12_Labors/Tong_2011_V1/Simulations/VoltageVAR_Tong_2011.sedml'
    simulation = oc.open_simulation(simfile)
    data = simulation.data()

    # Reset states variables and parameters
    simulation.reset(True)
    # Set constant values
    start = 0
    end = 50
    pointInterval = 0.001
    data.set_starting_point(start)
    data.set_ending_point(end)
    data.set_point_interval(pointInterval)
    v_clamp =[50, 40, 30, 20, 10, 0, -10, -20, -30, -40, -50]
    for i in range(11):
        simulation.reset(True)
        data.constants()['interface/membrane_potential/v_hold'] = -90
        data.constants() [ 'interface/parameters/kmca' ] = 0.001
        data.constants() [ 'interface/membrane_potential/v_var' ] = 0
        data.constants() [ 'interface/membrane_potential/v_clamp'] = v_clamp[i]
        data.constants() [ 'interface/membrane_potential/time_clamp_end'] = end
        data.constants() [ 'interface/membrane_potential/time_clamp_sta'] = 10
        simulation.run()
    # Access simulation results
        results = simulation.results()
    # Data to save
        varName = np.array([ "Time", "ina", "v" ])
        vars = np.reshape(varName, (1,3))
        rows = end * 1000 + 1
    # Access simulation results
        results = simulation.results()
    # Grab some algebraic variable results
        r = np.zeros((rows, len(varName)))
        r [ :, 0 ] = results.voi().values()
        r [ :, 1 ] = results.algebraic() [ 'interface/I_Na/ina'].values()
        r [ :, 2 ] = results.algebraic() [ 'interface/membrane_potential/v' ].values()
    # Save the simulation result of the last run
        filename = '%s_%s.csv' % (prefilename, i)
        np.savetxt(filename, vars, fmt='%s', delimiter=",")
        with open(filename, "ab") as f:
            np.savetxt(f, r, delimiter=",")
        f.close