# AE1 model based on Weinstein 2000 # Return kinetic parameters, constraints, and vector of volumes in each # compartment (pL) (1 if gating variable, or in element corresponding to # kappa) import numpy as np def kinetic_parameters(M, include_type2_reactions, dims, V): # Set the kinetic rate constants num_cols = dims['num_cols'] num_rows = dims['num_rows'] fkc = 1e6 Kc = 50 # [=] mM Kb = 198 # [=] mM Pc = [562, 61] Pb = [1247, 135] # rxn order # 1 X' + Cl > Cl.X' # 2 Cl.X' > Cl.X'' # 3 Cl.X'' > X'' + Cl # 4 B + X'' > B.X'' # 5 B.X'' > B.X' # 6 B.X' > B + X' # detailed bal is already satisfied in kinetic model kf =[fkc, Pc[0], fkc*Kc, fkc, Pb[1], fkc*Kb] kr =[fkc*Kc, Pc[1], fkc, fkc*Kb, Pb[0], fkc] # kr[5] = np.product(kf)/(np.product(kr[0:4])) k_kinetic = kf + kr # CONSTRAINTS N_cT = [] K_C = [] # volume vector # W = list(np.append([1] * num_cols, [V['V_myo']] * num_rows)) W = [1] * num_cols + [V['V_myo'], V['V_o']]*int(num_rows/2) return (k_kinetic, N_cT, K_C, W)