# diffusion of Calcium from diadic space to myoplasm (From Greenstein and Winslow 2002) # Return kinetic parameters, constraints, and vector of volumes in each # compartment (pL) (1 if gating variable, or in element corresponding to # kappa) # Translated from Pan 2018 cardiac AP import numpy as np def kinetic_parameters(M, include_type2_reactions, dims, V): # Set the kinetic rate constants num_cols = dims['num_cols'] num_rows = dims['num_rows'] # constants are stored in V # k+ = k- = r_xfer r_xfer = 0.2 # [=] 1/s kf = r_xfer kr = r_xfer k_kinetic = [kf, kr] # CONSTRAINTS N_cT = [] K_C = [] # volume vector # W = list(np.append([1] * num_cols, [V['V_myo']] * num_rows)) W = [1, V['V_di'], V['V_myo']] return (k_kinetic, N_cT, K_C, W)