def model FCU_AP_and_FCU_EC as def import using "units_and_constants/units_BG.cellml" for unit mM using unit mM; unit fmol using unit fmol; unit per_fmol using unit per_fmol; unit J_per_mol using unit J_per_mol; unit fmol_per_sec using unit fmol_per_sec; unit C_per_mol using unit C_per_mol; unit J_per_C using unit J_per_C; unit microm3 using unit microm3; unit fF using unit fF; unit fC using unit fC; unit fA using unit fA; unit per_second using unit per_second; unit millivolt using unit millivolt; unit per_sec using unit per_sec; unit J_per_K_per_mol using unit J_per_K_per_mol; unit fmol_per_L using unit fmol_per_L; unit fmol_per_L_per_sec using unit fmol_per_L_per_sec; unit per_sec_per_fmol_per_L using unit per_sec_per_fmol_per_L; unit uM using unit uM; unit mM_per_sec using unit mM_per_sec; unit uM_per_sec using unit uM_per_sec; unit pL using unit pL; unit m_to_u using unit m_to_u; enddef; def import using "units_and_constants/constants_BG.cellml" for comp constants using comp constants; enddef; def import using "FCU_AP/CaB/BG_CaB.cellml" for comp CaB using comp CaB; enddef; def import using "FCU_EC/crossbridge_TRPN/BG_crossbridge_TRPN.cellml" for comp crossbridge_TRPN using comp crossbridge_TRPN; enddef; def comp BG_parameters as var kappa_CaB: fmol_per_sec {init: 0.000469987, pub: out}; var kappa_R_TRPNCa: fmol_per_sec {init: 82.4067, pub: out}; var kappa_R_BU: fmol_per_sec {init: 8.82154, pub: out}; var kappa_R_UW: fmol_per_sec {init: 0.283765, pub: out}; var kappa_R_WS: fmol_per_sec {init: 0.00667683, pub: out}; var kappa_R_SU: fmol_per_sec {init: 120183, pub: out}; var K_Ca_i: per_fmol {init: 0.624848, pub: out}; var K_Ca_o: per_fmol {init: 3.1158, pub: out}; var K_TRPN: per_fmol {init: 28.8225, pub: out}; var K_Ca_TRPN: per_fmol {init: 0.0469618, pub: out}; var K_B_XB: per_fmol {init: 9.45563, pub: out}; var K_U_XB: per_fmol {init: 3.54586, pub: out}; var K_W_XB: per_fmol {init: 23.1845, pub: out}; var K_S_XB: per_fmol {init: 5.79612e-06, pub: out}; enddef; def comp environment as var time: second {pub: out}; var vol_myo: pL {init: 34.4, pub: out}; var freq: dimensionless {init: 500}; var q_Ca_i: fmol {init: 1e-888, pub: out}; var q_Ca_o: fmol {init: 1e-888, pub: out}; var q_TRPN: fmol {init: 1e-888, pub: out}; var q_Ca_TRPN: fmol {init: 1e-888, pub: out}; var q_B_XB: fmol {init: 1e-888, pub: out}; var q_U_XB: fmol {init: 1e-888, pub: out}; var q_W_XB: fmol {init: 1e-888, pub: out}; var q_S_XB: fmol {init: 1e-888, pub: out}; // CaB imports var v_CaB: fmol_per_sec {pub: in}; // crossbridge_TRPN imports var v_R_TRPNCa: fmol_per_sec {pub: in}; var v_R_BU: fmol_per_sec {pub: in}; var v_R_UW: fmol_per_sec {pub: in}; var v_R_WS: fmol_per_sec {pub: in}; var v_R_SU: fmol_per_sec {pub: in}; ode(q_Ca_i, time) = + v_mCaB + v_mcrossbridge_TRPN ; ode(q_Ca_o, time) = + v_mCaB ; ode(q_TRPN, time) = + v_mcrossbridge_TRPN ; ode(q_Ca_TRPN, time) = + v_mcrossbridge_TRPN ; ode(q_B_XB, time) = + v_mcrossbridge_TRPN ; ode(q_U_XB, time) = + v_mcrossbridge_TRPN ; ode(q_W_XB, time) = + v_mcrossbridge_TRPN ; ode(q_S_XB, time) = + v_mcrossbridge_TRPN ; enddef; def map between environment and CaB for vars time and time; vars q_Ca_i and q_Ca_i; vars q_Ca_o and q_Ca_o; vars v_CaB and v_CaB; enddef; def map between environment and crossbridge_TRPN for vars time and time; vars q_TRPN and q_TRPN; vars q_Ca_i and q_Ca_i; vars q_Ca_TRPN and q_Ca_TRPN; vars q_B_XB and q_B_XB; vars q_U_XB and q_U_XB; vars q_W_XB and q_W_XB; vars q_S_XB and q_S_XB; vars v_R_TRPNCa and v_R_TRPNCa; vars v_R_BU and v_R_BU; vars v_R_UW and v_R_UW; vars v_R_WS and v_R_WS; vars v_R_SU and v_R_SU; enddef; def map between BG_parameters and CaB for vars kappa_CaB and kappa_CaB; vars K_Ca_i and K_Ca_i; vars K_Ca_o and K_Ca_o; enddef; def map between BG_parameters and crossbridge_TRPN for vars kappa_R_TRPNCa and kappa_R_TRPNCa; vars kappa_R_BU and kappa_R_BU; vars kappa_R_UW and kappa_R_UW; vars kappa_R_WS and kappa_R_WS; vars kappa_R_SU and kappa_R_SU; vars K_TRPN and K_TRPN; vars K_Ca_i and K_Ca_i; vars K_Ca_TRPN and K_Ca_TRPN; vars K_B_XB and K_B_XB; vars K_U_XB and K_U_XB; vars K_W_XB and K_W_XB; vars K_S_XB and K_S_XB; enddef; def map between constants and CaB for vars R and R; vars T and T; enddef; def map between constants and crossbridge_TRPN for vars R and R; vars T and T; enddef; enddef;