Original Paper
==============

:Original publication:  "Quantitative cellular description of gastric slow wave activity"

:DOI: https://doi.org/10.1152/ajpgi.00528.2007


Model status
=============
The original CellML model is divided into twelve modules, with some presenting a modularized version of various ion channels and other presenting a modularized version of various intracellular compartments.

Model Summary
==============
Interstitial cells of Cajal (ICC) are responsible for the spontaneous and
omnipresent electrical activity in the stomach. A quantitative description of
the intracellular processes whose coordinated activity is believed to generate electrical slow waves has been developed and is presented by authors.
In line with recent experimental evidence, the model describes how the interplay
between the mitochondria and the endoplasmic reticulum in cycling intracellular Ca2+ provides the primary regulatory signal for the initiation of the slow wave.

.. image:: ReadMe/corrias_2008.png
   :width: 70%
   :alt: Schematic diagram.



The model is implemented using a Hodgkin-Huxley type formulation. The cell membrane lipid bilayer is represented as a capacitance (Cm),
and the ion channels in the membrane are represented as conductance. The change in the transmembrane potential (Vm) over time depends on
is the sum of the individual ion currents through each class of ion channel in the cell current:


:math:` dVm/dt = - I_{tot}/C_{m}`.


Where there are 9 different ion channels as below:


Ether-a-go-go potassium channels: I-ERG,

Background potassium channels: Ib,

Ca2+/Na+ exchangers(NCX): ICaSR,

L-Type Ca2+ voltage-gated channels (long lasting): ICa-L,

T-Type Ca2+ voltage-gated channel (DHP-Resistant Conductance, VDDR): IVDDR,

Delayed-Rectifying potassium channels: Ikv11,

Non-selective cation channels: INSCC

Sodium channels: INKCC.

The Ca2+-activated Cl− channels (CaCCs): ICaCl.

Also, there are four main intracellular compartments in the model:
Bulk cytoplasm, Mitochondria, ER, and Submembrane space; are represented as individual modules in the current work.

Model Workspace
=======================
1. ReadMe: A ReadMe file that includes all the information about the article and curation (simulations and components).
2. Common: Includes environment, units and parameters files.
3. The modular version of all the components of the primary model; each folder (component) contains two CellML files: one related to the experiment and the other one the main CellML code for the selected component (intracellular compartments or ion channels).