{"identifier":"id","label":"title","items":[{"id":"named_0","type":"root","generated":{"id":"anon_0","tool":"CellMLSimulator","uri":"http://cellml.sourceforge.net/CellMLSimulator","version":"CellMLSimulator 0.3.0-devel-json - revision 211:217 - Thu Jun 11 11:43:39 NZST 2009","date":1246970558000},"uri":"http://models.cellml.org/workspace/a1/@@rawfile/fa41916b2ca31572b372f793380ea141042446ac/tutorial/IUPS-2009-tutorial.xml#reference-description","title":"A series of cardiac cellular electrophysiological modelling case studies in the use of CellML and associated metadata.","created":{"id":"anon_1","creator":{"id":"anon_2","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Auckland Bioengineering Institute, The University of Auckland"},"created":1246795200000},"publisher":"Auckland Bioengingeering Institute, The University of Auckland.","citations":[{"id":"anon_3","subType":"journal-article","pmid":"19380314","doi":"10.1098/rsta.2008.0296","title":"A physiome standards-based model publication paradigm.","journal":"Philos Transact A Math Phys Eng Sci","volume":"367","number":"1895","year":"2009","month":"4","day":"22","startPage":"1823","endPage":"1867","authors":["David P Nickerson","Martin L Buist"]},{"id":"anon_4","subType":"journal-article","pmid":"19163192","doi":"10.1109/IEMBS.2008.4649689","title":"Interactive reference descriptions of cellular electrophysiology models.","journal":"Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference","volume":"2008","year":"2009","month":"1","day":"24","startPage":"2427","endPage":"2457","authors":["David Nickerson","Martin Buist"]},{"id":"anon_5","subType":"journal-article","pmid":"18606438","doi":"10.1016/j.pbiomolbio.2008.05.006","title":"Practical application of CellML 1.1: The integration of new mechanisms into a human ventricular myocyte model.","journal":"Prog. Biophys. Mol. Biol.","volume":"98","number":"1","year":"2008","month":"7","day":"9","startPage":"38","endPage":"51","authors":["David Nickerson","Martin Buist"]},{"id":"anon_6","subType":"journal-article","pmid":"18310619","doi":"10.1093/bioinformatics/btn080","title":"Reference descriptions of cellular electrophysiology models.","journal":"Bioinformatics","volume":"24","number":"8","year":"2008","month":"3","day":"4","startPage":"1112","endPage":"1116","authors":["David P Nickerson","Alberto Corrias","Martin L Buist"]}],"abstract":"This reference description is attempting to document a introductory tutorial for CellML emphasising the modularity, reuse, and exchange features that are available when developing models in a CellML 1.1 framework. The focus of this tutorial is the application of a CellML based modelling framework in the area of cardiac cellular electrophysiology.","description":"

The reference description can be browsed via the tree hierarchy over on the left hand side of the page or by navigating from the list of tasks given below. All you need to do is assume that there is an associated, peer-reviewed article which summarises this reference description and perhaps provides some further analysis of the novel insights mentioned above :)

","modifications":[{"id":"anon_7","modifier":{"id":"anon_8","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Auckland Bioengineering Institute, The University of Auckland"},"modification":"Restructure the reference description to be suitable for the complete IUPS 2009 tutorial.","modified":1246881600000}],"tasks":[{"_reference":"named_1"},{"_reference":"named_2"}]},{"id":"named_1","type":"task","uri":"http://models.cellml.org/workspace/a1/@@rawfile/fa41916b2ca31572b372f793380ea141042446ac/tutorial/IUPS-2009-tutorial.xml#hh-to-n62","title":"Modifying Hodgkin & Huxley toward Noble 1962","created":{"id":"anon_9","creator":{"id":"anon_10","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Auckland Bioengineering Institute, The University of Auckland"},"created":1246881600000},"abstract":"This section of the tutorial illustrates the modularity and resuse aspects of CellML. An accurate representation of the original Hodgkin & Huxley 1952 squid axon model has previously been published and made available on a web server at NUS in Singapore. In this task we first validate this implementation of the model and then modify it through the replacement of the potassium current for a model available in the CellML model repository and the slight modification of some parameters. These modifications are sufficient to turn the short duration nerve action potential into a long lasting action potential similar to the Noble 1962 cardiac Purkinje fibre action potential.","description":"

The basic premise of this example is based on the first biophysical cardiac cellular electrophysiology model, published by Denis Noble in 1962, which defines a modification of the Hodgkin-Huxley 1952 squid axon model capable of reproducing the action and pacemaker potentials observed in Purkinje fibres. In this tutorial we start with a CellML description of the Hodgkin-Huxley model and modify it to reproduce some of the key features of the Noble 1962 model.

","tasks":[{"_reference":"named_3"},{"_reference":"named_4"}]},{"id":"named_3","type":"task","uri":"http://models.cellml.org/workspace/a1/@@rawfile/fa41916b2ca31572b372f793380ea141042446ac/tutorial/IUPS-2009-tutorial.xml#hh-model-validation-task","title":"HH Model Validation","created":{"id":"anon_11","creator":{"id":"anon_12","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Auckland Bioengineering Institute, The University of Auckland"},"created":1246795200000},"abstract":"This is the parent task for the simulation experiments used to validate the base Hodgkin & Huxley model implemented for this tutorial. The model has been previously implemented and is available online from the Computational Bioengineering Laboratory at the National University of Singapore.","description":"

The original source of these models is http://www.bioeng.nus.edu.sg/compbiolab/p3/. All the graphs illustrated here are simulated directly from the data described on the NUS server.

","modifications":[{"id":"anon_13","modifier":{"id":"anon_14","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Auckland Bioengineering Institute, The University of Auckland"},"modification":"Taking the original task description and modifying for this tutorial.","modified":1246795200000}],"tasks":[{"_reference":"named_5"},{"_reference":"named_6"},{"_reference":"named_7"},{"_reference":"named_8"}]},{"id":"named_5","type":"task","uri":"http://models.cellml.org/workspace/a1/@@rawfile/fa41916b2ca31572b372f793380ea141042446ac/tutorial/IUPS-2009-tutorial.xml#INa-gating-kinetics","title":"Sodium Channel Kinetics Validation","created":{"id":"anon_15","creator":{"id":"anon_16","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Auckland Bioengineering Institute, The University of Auckland"},"created":1216123200000},"abstract":"Validation study investigating the kinetics of the sodium channel of the base implementation of the Hodgkin & Huxley model.","modifications":[{"id":"anon_17","modifier":{"id":"anon_18","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Auckland Bioengineering Institute, The University of Auckland"},"modification":"Taking the original task description and modifying for this tutorial - 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namely redirecting graph URIs to the NUS server.","modified":1246795200000}],"graphs":[{"_reference":"named_13"},{"_reference":"named_14"},{"_reference":"named_15"},{"_reference":"named_16"},{"_reference":"named_17"}]},{"id":"named_8","type":"task","uri":"http://models.cellml.org/workspace/a1/@@rawfile/fa41916b2ca31572b372f793380ea141042446ac/tutorial/IUPS-2009-tutorial.xml#applied-stimulus","title":"Action Potential Validation","created":{"id":"anon_27","creator":{"id":"anon_28","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Auckland Bioengineering Institute, The University of Auckland"},"created":1217419200000},"abstract":"Validation study investigating the dynamic response of the base implementation of the Hodgkin & Huxley model to an applied electrical stimulus current.","modifications":[{"id":"anon_29","modifier":{"id":"anon_30","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Auckland Bioengineering Institute, The University of Auckland"},"modification":"Taking the original task description and modifying for this tutorial - 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Physiol. (Lond.)","volume":"160","year":"1962","month":"2","day":"1","startPage":"317","endPage":"369","authors":["D NOBLE"]}],"abstract":"This task defines the modifications made to the base HH implementation in order to approximate the action potential shape of the Noble 1962 model.","description":"

This modified model is defined by: 1) importing the sodium and leakage currents from the base HH model (http://www.bioeng.nus.edu.sg/compbiolab/p3/); 2) importing the stimulus protocol from the base HH model; 3) importing the required units from the base HH model; 4) defining the time component which defines our time variable; 5) ...

","graphs":[{"_reference":"named_24"},{"_reference":"named_25"},{"_reference":"named_26"},{"_reference":"named_27"}]},{"id":"named_2","type":"task","uri":"http://models.cellml.org/workspace/a1/@@rawfile/fa41916b2ca31572b372f793380ea141042446ac/tutorial/IUPS-2009-tutorial.xml#tnnp-stimulus-protocol","title":"TNNP stimuli","created":{"id":"anon_34","creator":{"id":"anon_35","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Auckland Bioengineering Institute, The University of Auckland"},"created":1246881600000},"citations":[{"id":"anon_36","subType":"journal-article","pmid":"18606438","doi":"10.1016/j.pbiomolbio.2008.05.006","title":"Practical application of CellML 1.1: The integration of new mechanisms into a human ventricular myocyte model.","journal":"Prog. Biophys. Mol. Biol.","volume":"98","number":"1","year":"2008","month":"7","day":"9","startPage":"38","endPage":"51","authors":["David Nickerson","Martin Buist"]}],"abstract":"Here we make use of an exisiting encoding of the ten Tusscher et al (2004) human ventricular myocyte model which has a periodic stimulus current applied. We replace this stimulus protocol with one more suited for restitution analysis.","description":"

Nickerson & Buist (2008) published a study investigating the practical application of CellML 1.1 based on the ten Tusscher et al (2004) human ventricular myocyte electrophysiology model. The online supplement for this study is available at: http://www.bioeng.nus.edu.sg/compbiolab/papers/nickerson-PBMB-2008/, which inlcudes all the simulation experiment descriptions presented in that study.

","tasks":[{"_reference":"named_28"},{"_reference":"named_29"}]},{"id":"named_28","type":"task","uri":"http://models.cellml.org/workspace/a1/@@rawfile/fa41916b2ca31572b372f793380ea141042446ac/tutorial/IUPS-2009-tutorial.xml#tnnp-periodic-stimulus","title":"Periodic","created":{"id":"anon_37","creator":{"id":"anon_38","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Auckland Bioengineering Institute, The University of Auckland"},"created":1246881600000},"citations":[{"id":"anon_39","subType":"journal-article","pmid":"18606438","doi":"10.1016/j.pbiomolbio.2008.05.006","title":"Practical application of CellML 1.1: The integration of new mechanisms into a human ventricular myocyte model.","journal":"Prog. Biophys. Mol. Biol.","volume":"98","number":"1","year":"2008","month":"7","day":"9","startPage":"38","endPage":"51","authors":["David Nickerson","Martin Buist"]}],"abstract":"Presentation of the results obtained from the default periodic stimulus simulation experiment from the experiment description provided on the NUS server (http://www.bioeng.nus.edu.sg/compbiolab/papers/nickerson-PBMB-2008/).","graphs":[{"_reference":"named_30"},{"_reference":"named_31"},{"_reference":"named_32"}]},{"id":"named_29","type":"task","uri":"http://models.cellml.org/workspace/a1/@@rawfile/fa41916b2ca31572b372f793380ea141042446ac/tutorial/IUPS-2009-tutorial.xml#tnnp-S1S2-stimulus","title":"S1-S2 restitution","created":{"id":"anon_40","creator":{"id":"anon_41","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Auckland Bioengineering Institute, The University of Auckland"},"created":1246881600000},"citations":[{"id":"anon_42","subType":"journal-article","pmid":"18606438","doi":"10.1016/j.pbiomolbio.2008.05.006","title":"Practical application of CellML 1.1: The integration of new mechanisms into a human ventricular myocyte model.","journal":"Prog. Biophys. Mol. Biol.","volume":"98","number":"1","year":"2008","month":"7","day":"9","startPage":"38","endPage":"51","authors":["David Nickerson","Martin Buist"]}],"abstract":"Apply a S1-S2 restitution stimulus protocol to the base TNNP model. Here we present results for a couple of different values for the S2 interval to illustrate how the complete sequence could be performed in order to obtain the restitution curve.","graphs":[{"_reference":"named_33"}]},{"id":"named_9","type":"graph","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/INa-gating-kinetics-graphs.xml#INa-gating-rates","title":"INa Gating Rates","citations":[{"id":"anon_43","subType":"journal-article","pmid":"12991237","title":"A quantitative description of membrane current and its application to conduction and excitation in nerve.","journal":"J. Physiol. (Lond.)","volume":"117","number":"4","year":"1952","month":"8","day":"1","startPage":"500","endPage":"544","authors":["A L HODGKIN","A F HUXLEY"]}],"bio_entity":"giant nerve fibre","species":"loligo","description":"

This graph matches Figures 7 and 9 of the Hodgkin & Huxley (1952) article.

","modifications":[{"id":"anon_44","modifier":{"id":"anon_45","type":"person","name":"David Nickerson"},"modification":"Adding more comprehensive metadata to the graph.","modified":1205665200000},{"id":"anon_46","modifier":{"id":"anon_47","type":"person","name":"David Nickerson"},"modification":"Updating graph for to account for the splitting out of gating kinetics components to their own model.","modified":1218542400000}],"background":"#ffffff","yLabel":"Rate constant (ms^-1)","xLabel":"V (mV)","csvSource":"INa-gating-rates.csv","traces":[{"type":"trace","id":"anon_48","label":"alpha_m","colour":"#ff0000","xVariable":{"id":"anon_49","simulation":{"_reference":"named_34"},"variable":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/INa-gating-kinetics.xml#V"},"yVariable":{"id":"anon_50","simulation":{"_reference":"named_34"},"variable":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#alpha_m"}},{"type":"trace","id":"anon_51","label":"beta_m","colour":"#0000ff","xVariable":{"id":"anon_52","simulation":{"_reference":"named_34"},"variable":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/INa-gating-kinetics.xml#V","maximum":5},"yVariable":{"id":"anon_53","simulation":{"_reference":"named_34"},"variable":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#beta_m"}},{"type":"trace","id":"anon_54","label":"alpha_h","colour":"#008000","xVariable":{"id":"anon_55","simulation":{"_reference":"named_34"},"variable":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/INa-gating-kinetics.xml#V"},"yVariable":{"id":"anon_56","simulation":{"_reference":"named_34"},"variable":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#alpha_h"}},{"type":"trace","id":"anon_57","label":"beta_h","colour":"#808000","xVariable":{"id":"anon_58","simulation":{"_reference":"named_34"},"variable":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/INa-gating-kinetics.xml#V"},"yVariable":{"id":"anon_59","simulation":{"_reference":"named_34"},"variable":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#beta_h"}}]},{"id":"named_10","type":"graph","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/INa-gating-kinetics-graphs.xml#INa-gating-SS","title":"INa Steady State Gating Kinetics","citations":[{"id":"anon_60","subType":"journal-article","pmid":"12991237","title":"A quantitative description of membrane current and its application to conduction and excitation in nerve.","journal":"J. Physiol. (Lond.)","volume":"117","number":"4","year":"1952","month":"8","day":"1","startPage":"500","endPage":"544","authors":["A L HODGKIN","A F HUXLEY"]}],"bio_entity":"giant nerve fibre","species":"loligo","description":"

This graph matches Figures 8 and 10 of the Hodgkin & Huxley (1952) article.

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This graph matches Figure 4 of the Hodgkin & Huxley (1952) article.

","modifications":[{"id":"anon_70","modifier":{"id":"anon_71","type":"person","name":"David Nickerson"},"modification":"Adding cg:title property to the graph.","modified":1205578800000},{"id":"anon_72","modifier":{"id":"anon_73","type":"person","name":"David Nickerson"},"modification":"Adding more comprehensive metadata to the graph.","modified":1205665200000},{"id":"anon_74","modifier":{"id":"anon_75","type":"person","name":"David Nickerson"},"modification":"Updating graph for to account for the splitting out of alpha_n and beta_n components to their own model.","modified":1218542400000}],"background":"#ffffff","yLabel":"Rate constant (ms^-1)","xLabel":"V (mV)","csvSource":"IK-gating-rates.csv","traces":[{"type":"trace","id":"anon_76","label":"alpha_n","colour":"#ff0000","xVariable":{"id":"anon_77","simulation":{"_reference":"named_35"},"variable":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/IK-gating-kinetics.xml#V"},"yVariable":{"id":"anon_78","simulation":{"_reference":"named_35"},"variable":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#alpha_n"}},{"type":"trace","id":"anon_79","label":"beta_n","colour":"#0000ff","xVariable":{"id":"anon_80","simulation":{"_reference":"named_35"},"variable":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/IK-gating-kinetics.xml#V"},"yVariable":{"id":"anon_81","simulation":{"_reference":"named_35"},"variable":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#beta_n"}}]},{"id":"named_12","type":"graph","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/IK-gating-kinetics-graphs.xml#IK-gating-SS","title":"IK Steady State Gating Kinetics","citations":[{"id":"anon_82","subType":"journal-article","pmid":"12991237","title":"A quantitative description of membrane current and its application to conduction and excitation in nerve.","journal":"J. Physiol. (Lond.)","volume":"117","number":"4","year":"1952","month":"8","day":"1","startPage":"500","endPage":"544","authors":["A L HODGKIN","A F HUXLEY"]}],"bio_entity":"giant nerve fibre","species":"loligo","description":"

This graph matches Figure 5 of the Hodgkin & Huxley (1952) article.

","modifications":[{"id":"anon_83","modifier":{"id":"anon_84","type":"person","name":"David Nickerson"},"modification":"Adding more comprehensive metadata to the graph.","modified":1205665200000}],"background":"#ffffff","yLabel":"Steady state gate ()","xLabel":"V (mV)","csvSource":"IK-gating-SS.csv","traces":[{"type":"trace","id":"anon_85","label":"n_inf","colour":"#ff0000","xVariable":{"id":"anon_86","simulation":{"_reference":"named_35"},"variable":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/IK-gating-kinetics.xml#V"},"yVariable":{"id":"anon_87","simulation":{"_reference":"named_35"},"variable":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/IK-gating-kinetics.xml#n_inf"}}]},{"id":"named_13","type":"graph","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/voltage-clamp-graphs.xml#voltage-clamp-currents-1","title":"Voltage Clamp","citations":[{"id":"anon_88","subType":"journal-article","pmid":"12991237","title":"A quantitative description of membrane current and its application to conduction and excitation in nerve.","journal":"J. Physiol. (Lond.)","volume":"117","number":"4","year":"1952","month":"8","day":"1","startPage":"500","endPage":"544","authors":["A L HODGKIN","A F HUXLEY"]}],"bio_entity":"giant nerve fibre","species":"loligo","description":"

This graph matches Figure 11(a,b) of the Hodgkin & Huxley (1952) article and shows the total membrane current in response to membrane depolarisations of the specified magnitudes.

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This graph matches Figure 11(c) of the Hodgkin & Huxley (1952) article and shows the total membrane current in response to membrane depolarisations of the specified magnitudes.

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Here we investigate the gating kinetics of the Hodgkin & Huxley sodium current by applying a linear potential ramp. [David Nickerson]

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The actual definition of the time variable.

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Here we define the parameters for the applied voltage ramp.

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The model parameters - in this case we use all default values.

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The initial conditions - using all default values in this case.

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A description of the voltage-dependent activation rate constant for the m gate of the Hodgkin & Huxley (1952) sodium current.

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A description of the voltage-dependent activation rate constant for the h gate of the Hodgkin & Huxley (1952) sodium current.

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The standard definition of a steady state Hodgkin & Huxley gating variable.

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The standard definition of a steady state Hodgkin & Huxley gating variable.

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Here we define a simple linear relationship dy/dt = k, specifying the change in y over time with a slope of k. [David Nickerson (david.nickerson@nus.edu.sg) Division of Bioengineering, National University of Singapore]

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Here we define the complete set of default parameter values.

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Here we define the complete set set of default initial conditions for the model's differental variables.

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Time. Should be zero at the point of change in membrane potential.

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Time. Should be zero at the point of change in membrane potential.

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The membrane potential value at which the activation rate constant for the m gate of the sodium current is desired.

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The membrane potential value at which the inactivation rate constant for the m gate of the sodium current is desired.

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The membrane potential value at which the activation rate constant for the h gate of the sodium current is desired.

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The membrane potential value at which the inactivation rate constant for the h gate of the sodium current is desired.

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The temperature corrected activation rate constant of the m gate for the sodium current.

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The rate of activation of the gating variable.

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The base (non-temperature corrected) value of the activation rate constant for the m gate of the sodium current.

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The Q10 for the temperature dependence of the activation rate constant of the m gate of the sodium current.

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The Q10 for the temperature dependence of the inactivation rate constant of the m gate for the sodium current.

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The Q10 for the temperature dependence of the activation rate constant of the h gate of the sodium current.

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The Q10 for the temperature dependence of the inactivation rate constant of the h gate for the sodium current.

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The actual temperature at which the activation rate constant for the m gate of the sodium current is desired.

","sourceVariable":{"_reference":"named_88"},"units":"K"},{"id":"named_97","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#beta_m_T","name":"T","title":"T","description":"

The actual temperature at which the inactivation rate constant for the m gate of the sodium current is desired.

","sourceVariable":{"_reference":"named_88"},"units":"K"},{"id":"named_104","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#alpha_h_T","name":"T","title":"T","description":"

The actual temperature at which the activation rate constant for the h gate of the sodium current is desired.

","sourceVariable":{"_reference":"named_88"},"units":"K"},{"id":"named_111","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#beta_h_T","name":"T","title":"T","description":"

The actual temperature at which the inactivation rate constant for the h gate of the sodium current is desired.

","sourceVariable":{"_reference":"named_88"},"units":"K"},{"id":"named_90","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#Tref_rates","name":"Tref_rates","title":"Tref_rates","initialValue":"279.45","connectedVariables":[{"_reference":"named_91"},{"_reference":"named_98"},{"_reference":"named_105"},{"_reference":"named_112"}],"units":"K","usedIn":[["named_72","named_91"],["named_73","named_98"],["named_74","named_105"],["named_75","named_112"]]},{"id":"named_91","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#alpha_m_Tref","name":"Tref","title":"Tref","description":"

The reference temperature to use for the Q10 temperature correction of the activation rate constant for the m gate of the sodium current.

","sourceVariable":{"_reference":"named_90"},"units":"K"},{"id":"named_98","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#beta_m_Tref","name":"Tref","title":"Tref","description":"

The reference temperature to use for the Q10 temperature correction of the inactivation rate constant for the m gate of the sodium current.

","sourceVariable":{"_reference":"named_90"},"units":"K"},{"id":"named_105","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#alpha_h_Tref","name":"Tref","title":"Tref","description":"

The reference temperature to use for the Q10 temperature correction of the activation rate constant for the h gate of the sodium current.

","sourceVariable":{"_reference":"named_90"},"units":"K"},{"id":"named_112","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#beta_h_Tref","name":"Tref","title":"Tref","description":"

The reference temperature to use for the Q10 temperature correction of the inactivation rate constant for the h gate of the sodium current.

","sourceVariable":{"_reference":"named_90"},"units":"K"},{"id":"named_95","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#beta_m","name":"beta","title":"beta","description":"

The temperature corrected inactivation rate constant of the m gate for the sodium current.

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The rate of inactivation of the gating variable.

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The base (non-temperature corrected) value of the inactivation rate constant for the m gate of the sodium current.

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The temperature corrected activation rate constant of the h gate for the sodium current.

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The rate of activation of the gating variable.

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The base (non-temperature corrected) value of the activation rate constant for the h gate of the sodium current.

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The temperature corrected inactivation rate constant of the h gate for the sodium current.

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The rate of inactivation of the gating variable.

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The base (non-temperature corrected) value of the inactivation rate constant for the h gate of the sodium current.

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The standard Hodgkin & Huxley steady state gating variable.

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The value of the gating variable at time=0.

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The standard Hodgkin & Huxley steady state gating variable.

","units":"dimensionless","definedIn":"named_77"},{"id":"named_126","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#h_initial","name":"h_initial","title":"h_initial","initialValue":"0.608","connectedVariables":[{"_reference":"named_127"}],"units":"dimensionless","usedIn":[["named_77","named_127"]]},{"id":"named_127","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#gate_initial_steady_state","name":"gate_initial","title":"gate_initial","description":"

The value of the gating variable at time=0.

","sourceVariable":{"_reference":"named_126"},"units":"dimensionless"},{"id":"named_129","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#tau","name":"tau","title":"tau","units":"ms","definedIn":"named_77"},{"id":"named_143","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#VK","name":"VK","title":"VK","initialValue":"12.0","units":"mV"},{"id":"named_144","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#VNa","name":"VNa","title":"VNa","initialValue":"-115.0","units":"mV"},{"id":"named_145","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#Vleak","name":"Vleak","title":"Vleak","initialValue":"-10.613","units":"mV"},{"id":"named_146","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#gK_max","name":"gK_max","title":"gK_max","initialValue":"36.0","units":"mS_per_cmsq"},{"id":"named_147","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#gNa_max","name":"gNa_max","title":"gNa_max","initialValue":"120.0","units":"mS_per_cmsq"},{"id":"named_148","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#gleak_max","name":"gleak_max","title":"gleak_max","initialValue":"0.3","units":"mS_per_cmsq"},{"id":"named_149","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#Cm","name":"Cm","title":"Cm","initialValue":"1.0","units":"uF_per_cmsq"},{"id":"named_150","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#V_initial","name":"V_initial","title":"V_initial","initialValue":"0.0","units":"mV"},{"id":"named_151","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#n_initial","name":"n_initial","title":"n_initial","initialValue":"0.315","units":"dimensionless"},{"id":"named_52","type":"model","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/IK-gating-kinetics.xml#IK_gating_kinetics_model","name":"IK_gating_kinetics","title":"The gating kinetics of the Hodgkin & Huxley (1952) potassium current.","created":{"id":"anon_333","creator":{"id":"anon_334","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205319600000},"description":"

Here we investigate the gating kinetics of the Hodgkin & Huxley potassium current by applying a linear potential ramp. [David Nickerson]

","modifications":[{"id":"anon_335","modifier":{"id":"anon_336","type":"person","name":"David Nickerson"},"modification":"Update to use the new IK gating rates model in order to work around a possible bug in the API implementation (or my understanding of the CellML specification) which doesn't like importing encapsulated children directly.","modified":1218369600000}],"components":[{"_reference":"named_152"},{"_reference":"named_153"},{"_reference":"named_154"},{"_reference":"named_155"},{"_reference":"named_156"},{"_reference":"named_157"},{"_reference":"named_158"},{"_reference":"named_159"},{"_reference":"named_160"},{"_reference":"named_161"}]},{"id":"named_152","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/IK-gating-kinetics.xml#time_component","title":"time","created":{"id":"anon_337","creator":{"id":"anon_338","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205319600000},"description":"

The actual definition of the time variable.

"},{"id":"named_153","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/IK-gating-kinetics.xml#V_parameters","title":"V_parameters","created":{"id":"anon_339","creator":{"id":"anon_340","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205319600000},"description":"

Here we define the parameters for the applied voltage ramp.

"},{"id":"named_154","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/IK-gating-kinetics.xml#parameters","title":"parameters","created":{"id":"anon_341","creator":{"id":"anon_342","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205319600000},"description":"

The model parameters - in this case we use all default values.

"},{"id":"named_155","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/IK-gating-kinetics.xml#initial_conditions","title":"initial_conditions","created":{"id":"anon_343","creator":{"id":"anon_344","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205319600000},"description":"

The initial conditions - using all default values in this case.

"},{"id":"named_156","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#alpha_n_component","title":"Description of the activation rate constant for the n gate.","created":{"id":"anon_345","creator":{"id":"anon_346","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"description":"

A description of the voltage-dependent activation rate constant for the n gate of the Hodgkin & Huxley (1952) potassium current.

","importedAs":{"_reference":"named_162"},"math":"named_156.xml"},{"id":"named_162","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/IK-gating-kinetics.xml#cellmlelement--anonymous-10","title":"alpha_n","created":{"id":"anon_347","creator":{"id":"anon_348","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205319600000}},{"id":"named_157","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#beta_n_component","title":"Description of the inactivation rate constant for the n gate.","created":{"id":"anon_349","creator":{"id":"anon_350","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"description":"

A description of the voltage-dependent inactivation rate constant for the n gate of the Hodgkin & Huxley (1952) potassium current.

","importedAs":{"_reference":"named_173"},"math":"named_157.xml"},{"id":"named_173","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/IK-gating-kinetics.xml#cellmlelement--anonymous-11","title":"beta_n","created":{"id":"anon_351","creator":{"id":"anon_352","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205319600000}},{"id":"named_158","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#hh_gating_variable_steady_state","title":"Standard Hodgkin-Huxley steady state gating kinetics.","created":{"id":"anon_353","creator":{"id":"anon_354","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205146800000},"description":"

The standard definition of a steady state Hodgkin & Huxley gating variable.

","importedAs":{"_reference":"named_180"},"math":"named_158.xml"},{"id":"named_180","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/IK-gating-kinetics.xml#cellmlelement--anonymous-12","title":"gate","created":{"id":"anon_355","creator":{"id":"anon_356","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205319600000}},{"id":"named_159","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/potential-ramp.xml#ramp_component","title":"ramp","created":{"id":"anon_357","creator":{"id":"anon_358","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205319600000},"description":"

Here we define a simple linear relationship dy/dt = k, specifying the change in y over time with a slope of k. [David Nickerson (david.nickerson@nus.edu.sg) Division of Bioengineering, National University of Singapore]

","importedAs":{"_reference":"named_190"},"math":"named_159.xml"},{"id":"named_190","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/IK-gating-kinetics.xml#cellmlelement--anonymous-13","title":"V","created":{"id":"anon_359","creator":{"id":"anon_360","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205319600000}},{"id":"named_160","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#parameters_component","title":"Hodgkin & Huxley default parameters.","created":{"id":"anon_361","creator":{"id":"anon_362","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"description":"

Here we define the complete set of default parameter values.

","importedAs":{"_reference":"named_194"}},{"id":"named_194","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/IK-gating-kinetics.xml#cellmlelement--anonymous-15","title":"default_parameters","created":{"id":"anon_363","creator":{"id":"anon_364","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205319600000}},{"id":"named_161","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#initial_conditions_component","title":"Hodgkin & Huxley default initial conditions.","created":{"id":"anon_365","creator":{"id":"anon_366","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"description":"

Here we define the complete set set of default initial conditions for the model's differental variables.

","importedAs":{"_reference":"named_195"}},{"id":"named_195","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/IK-gating-kinetics.xml#cellmlelement--anonymous-16","title":"default_initial_conditions","created":{"id":"anon_367","creator":{"id":"anon_368","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205319600000}},{"id":"named_185","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/IK-gating-kinetics.xml#time","name":"time","title":"time","initialValue":"0.0","connectedVariables":[{"_reference":"named_186"},{"_reference":"named_191"}],"units":"ms","usedIn":[["named_158","named_186"],["named_159","named_191"]]},{"id":"named_186","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#time_steady_state","name":"time","title":"time","description":"

Time. Should be zero at the point of change in membrane potential.

","sourceVariable":{"_reference":"named_185"},"units":"ms"},{"id":"named_191","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/potential-ramp.xml#time","name":"time","title":"The time variable over which y is to be integrated.","sourceVariable":{"_reference":"named_185"},"units":"ms"},{"id":"named_192","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/IK-gating-kinetics.xml#cellmlelement--anonymous-14","name":"k","title":"k","initialValue":"1.0","connectedVariables":[{"_reference":"named_193"}],"units":"mV_per_ms","usedIn":[["named_159","named_193"]]},{"id":"named_193","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/potential-ramp.xml#k","name":"k","title":"The time slope of the linear relationship.","sourceVariable":{"_reference":"named_192"},"units":"mV_per_ms"},{"id":"named_164","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/potential-ramp.xml#y","name":"y","title":"The ramp variable.","initialValueVariable":{"_reference":"named_196"},"connectedVariables":[{"_reference":"named_197"},{"_reference":"named_165"},{"_reference":"named_175"}],"units":"mV","definedIn":"named_159","usedIn":[["named_156","named_165"],["named_157","named_175"]]},{"id":"named_197","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/IK-gating-kinetics.xml#V","name":"V","title":"V","sourceVariable":{"_reference":"named_164"},"units":"mV"},{"id":"named_165","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#alpha_n_V","name":"V","title":"V","description":"

The membrane potential value at which the activation rate constant for the n gate of the potassium current is desired.

","sourceVariable":{"_reference":"named_164"},"units":"mV"},{"id":"named_175","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#beta_n_V","name":"V","title":"V","description":"

The membrane potential value at which the inactivation rate constant for the n gate of the potassium current is desired.

","sourceVariable":{"_reference":"named_164"},"units":"mV"},{"id":"named_182","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#gate_inf","name":"gate_inf","title":"gate_inf","connectedVariables":[{"_reference":"named_198"}],"units":"dimensionless","definedIn":"named_158"},{"id":"named_198","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/IK-gating-kinetics.xml#n_inf","name":"n_inf","title":"n_inf","sourceVariable":{"_reference":"named_182"},"units":"dimensionless"},{"id":"named_199","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/IK-gating-kinetics.xml#V_initial","name":"V_initial","title":"V_initial","initialValue":"-120.0","connectedVariables":[{"_reference":"named_196"}],"units":"mV"},{"id":"named_196","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/potential-ramp.xml#y_initial","name":"y_initial","title":"The initial value of y.","sourceVariable":{"_reference":"named_199"},"units":"mV"},{"id":"named_166","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#alpha_n","name":"alpha","title":"alpha","description":"

The temperature corrected activation rate constant of the n gate for the potassium current.

","connectedVariables":[{"_reference":"named_188"}],"units":"per_ms","definedIn":"named_156","usedIn":[["named_158","named_188"]]},{"id":"named_188","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#alpha_steady_state","name":"alpha","title":"alpha","description":"

The rate of activation of the gating variable.

","sourceVariable":{"_reference":"named_166"},"units":"per_ms"},{"id":"named_163","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#alpha_n_base","name":"alpha_base","title":"alpha_base","description":"

The base (non-temperature corrected) value of the activation rate constant for the n gate of the potassium current.

","units":"per_ms","definedIn":"named_156"},{"id":"named_167","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#Q10_rates","name":"Q10_rates","title":"Q10_rates","initialValue":"3.0","connectedVariables":[{"_reference":"named_168"},{"_reference":"named_177"}],"units":"dimensionless","usedIn":[["named_156","named_168"],["named_157","named_177"]]},{"id":"named_168","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#alpha_n_Q10","name":"Q10","title":"Q10","description":"

The Q10 for the temperature dependence of the activation rate constant of the n gate of the potassium current.

","sourceVariable":{"_reference":"named_167"},"units":"dimensionless"},{"id":"named_177","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#beta_n_Q10","name":"Q10","title":"Q10","description":"

The Q10 for the temperature dependence of the inactivation rate constant of the n gate for the potassium current.

","sourceVariable":{"_reference":"named_167"},"units":"dimensionless"},{"id":"named_169","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#T","name":"T","title":"T","initialValue":"279.45","connectedVariables":[{"_reference":"named_170"},{"_reference":"named_178"}],"units":"K","usedIn":[["named_156","named_170"],["named_157","named_178"]]},{"id":"named_170","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#alpha_n_T","name":"T","title":"T","description":"

The actual temperature at which the activation rate constant for the n gate of the potassium current is desired.

","sourceVariable":{"_reference":"named_169"},"units":"K"},{"id":"named_178","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#beta_n_T","name":"T","title":"T","description":"

The actual temperature at which the inactivation rate constant for the n gate of the potassium current is desired.

","sourceVariable":{"_reference":"named_169"},"units":"K"},{"id":"named_171","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#Tref_rates","name":"Tref_rates","title":"Tref_rates","initialValue":"279.45","connectedVariables":[{"_reference":"named_172"},{"_reference":"named_179"}],"units":"K","usedIn":[["named_156","named_172"],["named_157","named_179"]]},{"id":"named_172","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#alpha_n_Tref","name":"Tref","title":"Tref","description":"

The reference temperature to use for the Q10 temperature correction of the activation rate constant for the n gate of the potassium current.

","sourceVariable":{"_reference":"named_171"},"units":"K"},{"id":"named_179","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#beta_n_Tref","name":"Tref","title":"Tref","description":"

The reference temperature to use for the Q10 temperature correction of the inactivation rate constant for the n gate of the potassium current.

","sourceVariable":{"_reference":"named_171"},"units":"K"},{"id":"named_176","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#beta_n","name":"beta","title":"beta","description":"

The temperature corrected inactivation rate constant of the n gate for the potassium current.

","connectedVariables":[{"_reference":"named_189"}],"units":"per_ms","definedIn":"named_157","usedIn":[["named_158","named_189"]]},{"id":"named_189","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#beta_steady_state","name":"beta","title":"beta","description":"

The rate of inactivation of the gating variable.

","sourceVariable":{"_reference":"named_176"},"units":"per_ms"},{"id":"named_174","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#beta_n_base","name":"beta_base","title":"beta_base","description":"

The base (non-temperature corrected) value of the inactivation rate constant for the n gate of the potassium current.

","units":"per_ms","definedIn":"named_157"},{"id":"named_181","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#gate_steady_state","name":"gate","title":"gate","description":"

The standard Hodgkin & Huxley steady state gating variable.

","units":"dimensionless","definedIn":"named_158"},{"id":"named_183","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#n_initial","name":"n_initial","title":"n_initial","initialValue":"0.315","connectedVariables":[{"_reference":"named_184"}],"units":"dimensionless","usedIn":[["named_158","named_184"]]},{"id":"named_184","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#gate_initial_steady_state","name":"gate_initial","title":"gate_initial","description":"

The value of the gating variable at time=0.

","sourceVariable":{"_reference":"named_183"},"units":"dimensionless"},{"id":"named_187","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#tau","name":"tau","title":"tau","units":"ms","definedIn":"named_158"},{"id":"named_200","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#VK","name":"VK","title":"VK","initialValue":"12.0","units":"mV"},{"id":"named_201","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#VNa","name":"VNa","title":"VNa","initialValue":"-115.0","units":"mV"},{"id":"named_202","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#Vleak","name":"Vleak","title":"Vleak","initialValue":"-10.613","units":"mV"},{"id":"named_203","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#gK_max","name":"gK_max","title":"gK_max","initialValue":"36.0","units":"mS_per_cmsq"},{"id":"named_204","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#gNa_max","name":"gNa_max","title":"gNa_max","initialValue":"120.0","units":"mS_per_cmsq"},{"id":"named_205","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#gleak_max","name":"gleak_max","title":"gleak_max","initialValue":"0.3","units":"mS_per_cmsq"},{"id":"named_206","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#Cm","name":"Cm","title":"Cm","initialValue":"1.0","units":"uF_per_cmsq"},{"id":"named_207","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#V_initial","name":"V_initial","title":"V_initial","initialValue":"0.0","units":"mV"},{"id":"named_208","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#m_initial","name":"m_initial","title":"m_initial","initialValue":"0.042","units":"dimensionless"},{"id":"named_209","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#h_initial","name":"h_initial","title":"h_initial","initialValue":"0.608","units":"dimensionless"},{"id":"named_53","type":"model","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/voltage-clamp-005.xml#voltage_clamp","name":"voltage_clamp","title":"Hodgkin & Huxley (1952) with voltage clamp of -5 mV applied.","created":{"id":"anon_369","creator":{"id":"anon_370","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205406000000},"description":"

Import the base voltage clamp model and set the clamp potential to -5 mV. [David Nickerson]

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Simply defining the clamp potential variable to connect to the voltage clamp model.

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Here we define an interface to a fully specified voltage clamp model which requires only the new potential value to be set.

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The Hodgkin & Huxley (1952) model assembled such that the total membrane current is calculated for a given step in holding potential.

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The actual definition of the time variable.

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The model parameters which differ from default.

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The initial conditions - using all default values in this case.

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Here we define the complete set of default parameter values.

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Here we define the complete set set of default initial conditions for the model's differental variables.

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A description of the membrane sodium current of the Hodgkin & Huxley (1952) model.

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A description of the membrane potassium current of the Hodgkin & Huxley (1952) model.

","importedAs":{"_reference":"named_259"},"math":"named_219.xml"},{"id":"named_259","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/voltage-clamp.xml#cellmlelement--anonymous-22","title":"IK","created":{"id":"anon_401","creator":{"id":"anon_402","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205406000000}},{"id":"named_220","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/Ileak.xml#Ileak_component","title":"Hodgkin & Huxley leakage current.","created":{"id":"anon_403","creator":{"id":"anon_404","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"description":"

A description of the membrane leakage current of the Hodgkin & Huxley (1952) model.

","importedAs":{"_reference":"named_268"},"math":"named_220.xml"},{"id":"named_268","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/voltage-clamp.xml#cellmlelement--anonymous-23","title":"Ileak","created":{"id":"anon_405","creator":{"id":"anon_406","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205406000000}},{"id":"named_221","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#alpha_m_component","title":"Description of the activation rate constant for the m gate.","created":{"id":"anon_407","creator":{"id":"anon_408","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"description":"

A description of the voltage-dependent activation rate constant for the m gate of the Hodgkin & Huxley (1952) sodium current.

","importedAs":{"_reference":"named_274"},"math":"named_221.xml"},{"id":"named_274","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#alpha_m","title":"alpha_m","created":{"id":"anon_409","creator":{"id":"anon_410","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_222","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#beta_m_component","title":"beta_m","created":{"id":"anon_411","creator":{"id":"anon_412","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"importedAs":{"_reference":"named_284"},"math":"named_222.xml"},{"id":"named_284","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#beta_m","title":"beta_m","created":{"id":"anon_413","creator":{"id":"anon_414","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_223","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#alpha_h_component","title":"Description of the activation rate constant for the h gate.","created":{"id":"anon_415","creator":{"id":"anon_416","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"description":"

A description of the voltage-dependent activation rate constant for the h gate of the Hodgkin & Huxley (1952) sodium current.

","importedAs":{"_reference":"named_291"},"math":"named_223.xml"},{"id":"named_291","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#alpha_h","title":"alpha_h","created":{"id":"anon_417","creator":{"id":"anon_418","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_224","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#beta_h_component","title":"beta_h","created":{"id":"anon_419","creator":{"id":"anon_420","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"importedAs":{"_reference":"named_298"},"math":"named_224.xml"},{"id":"named_298","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#beta_h","title":"beta_h","created":{"id":"anon_421","creator":{"id":"anon_422","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_225","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#hh_gating_variable_dynamic","title":"Standard Hodgkin-Huxley dynamic gating kinetics.","created":{"id":"anon_423","creator":{"id":"anon_424","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205146800000},"description":"

The standard definition of a dynamic Hodgkin & Huxley gating variable.

","importedAs":{"_reference":"named_305"},"math":"named_225.xml"},{"id":"named_305","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#m_gate","title":"Hodgkin-Huxley sodium current's activation gate.","created":{"id":"anon_425","creator":{"id":"anon_426","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"abstract":"We import the standard HH voltage-dependent gating variable description to use as the sodium channel's activation gating variable - 'm'."},{"id":"named_226","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#hh_gating_variable_dynamic","title":"Standard Hodgkin-Huxley dynamic gating kinetics.","created":{"id":"anon_427","creator":{"id":"anon_428","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205146800000},"description":"

The standard definition of a dynamic Hodgkin & Huxley gating variable.

","importedAs":{"_reference":"named_309"},"math":"named_226.xml"},{"id":"named_309","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#h_gate","title":"Hodgkin-Huxley sodium current's inactivation gate.","created":{"id":"anon_429","creator":{"id":"anon_430","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"abstract":"We import the standard HH voltage-dependent gating variable description to use as the sodium channel's inactivation gating variable - 'h'.","modifications":[{"id":"anon_431","modifier":{"id":"anon_432","type":"person","name":"David Nickerson"},"modification":"Splitting out the gating rate equation components to their own model to test out a possible bug in the API implementation which arises when importing encapsulated children directly into other models.","modified":1218369600000}]},{"id":"named_227","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#alpha_n_component","title":"Description of the activation rate constant for the n gate.","created":{"id":"anon_433","creator":{"id":"anon_434","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"description":"

A description of the voltage-dependent activation rate constant for the n gate of the Hodgkin & Huxley (1952) potassium current.

","importedAs":{"_reference":"named_313"},"math":"named_227.xml"},{"id":"named_313","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK.xml#alpha_n_component","title":"alpha_n","created":{"id":"anon_435","creator":{"id":"anon_436","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_228","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#beta_n_component","title":"Description of the inactivation rate constant for the n gate.","created":{"id":"anon_437","creator":{"id":"anon_438","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"description":"

A description of the voltage-dependent inactivation rate constant for the n gate of the Hodgkin & Huxley (1952) potassium current.

","importedAs":{"_reference":"named_320"},"math":"named_228.xml"},{"id":"named_320","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK.xml#beta_n_component","title":"beta_n","created":{"id":"anon_439","creator":{"id":"anon_440","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_229","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#hh_gating_variable_dynamic","title":"Standard Hodgkin-Huxley dynamic gating kinetics.","created":{"id":"anon_441","creator":{"id":"anon_442","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205146800000},"description":"

The standard definition of a dynamic Hodgkin & Huxley gating variable.

","importedAs":{"_reference":"named_327"},"math":"named_229.xml"},{"id":"named_327","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK.xml#cellmlelement--anonymous-24","title":"n_gate","created":{"id":"anon_443","creator":{"id":"anon_444","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_240","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/voltage-clamp-005.xml#clamp_potential","name":"clamp_potential","title":"clamp_potential","initialValue":"-5.0","connectedVariables":[{"_reference":"named_331"},{"_reference":"named_241"}],"units":"mV","usedIn":[["named_212","named_241"]]},{"id":"named_331","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/voltage-clamp.xml#cellmlelement--anonymous-25","name":"Vnew","title":"Vnew","sourceVariable":{"_reference":"named_240"},"units":"mV"},{"id":"named_241","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/voltage-clamp.xml#Vnew","name":"Vnew","title":"Vnew","sourceVariable":{"_reference":"named_240"},"units":"mV"},{"id":"named_244","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#V_initial","name":"V_initial","title":"V_initial","initialValue":"0.0","connectedVariables":[{"_reference":"named_245"}],"units":"mV","usedIn":[["named_212","named_245"]]},{"id":"named_245","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/voltage-clamp.xml#V_initial","name":"V_initial","title":"V_initial","sourceVariable":{"_reference":"named_244"},"units":"mV"},{"id":"named_332","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#n_initial","name":"n_initial","title":"n_initial","initialValue":"0.315","connectedVariables":[{"_reference":"named_333"},{"_reference":"named_334"},{"_reference":"named_335"}],"units":"dimensionless"},{"id":"named_333","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/voltage-clamp.xml#n_initial","name":"n_initial","title":"n_initial","sourceVariable":{"_reference":"named_332"},"units":"dimensionless"},{"id":"named_334","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK.xml#n_initial","name":"n_initial","title":"n_initial","sourceVariable":{"_reference":"named_332"},"units":"dimensionless"},{"id":"named_335","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#gate_initial_dynamic","name":"gate_initial","title":"gate_initial","description":"

The initial value of the dynamic gating variable, must be defined in order to solve the dynamic expression of the gating kinetics.

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The standard Hodgkin & Huxley dynamic gating variable.

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The standard Hodgkin & Huxley dynamic gating variable.

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The standard Hodgkin & Huxley dynamic gating variable.

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The temperature corrected activation rate constant of the m gate for the sodium current.

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The rate of activation of the gating variable.

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The base (non-temperature corrected) value of the activation rate constant for the m gate of the sodium current.

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The temperature corrected inactivation rate constant of the m gate for the sodium current.

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The rate of inactivation of the gating variable.

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The base (non-temperature corrected) value of the inactivation rate constant for the m gate of the sodium current.

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The temperature corrected activation rate constant of the h gate for the sodium current.

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The rate of activation of the gating variable.

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The base (non-temperature corrected) value of the activation rate constant for the h gate of the sodium current.

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The temperature corrected inactivation rate constant of the h gate for the sodium current.

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The rate of inactivation of the gating variable.

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The base (non-temperature corrected) value of the inactivation rate constant for the h gate of the sodium current.

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The temperature corrected activation rate constant of the n gate for the potassium current.

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The rate of activation of the gating variable.

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The base (non-temperature corrected) value of the activation rate constant for the n gate of the potassium current.

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The rate of inactivation of the gating variable.

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The base (non-temperature corrected) value of the inactivation rate constant for the n gate of the potassium current.

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Import the base voltage clamp model and set the clamp potential to -10 mV. [David Nickerson]

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Simply defining the clamp potential variable to connect to the voltage clamp model.

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Here we define an interface to a fully specified voltage clamp model which requires only the new potential value to be set.

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The Hodgkin & Huxley (1952) model assembled such that the total membrane current is calculated for a given step in holding potential.

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The actual definition of the time variable.

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The model parameters which differ from default.

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The initial conditions - using all default values in this case.

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Here we define the complete set of default parameter values.

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Here we define the complete set set of default initial conditions for the model's differental variables.

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A description of the membrane sodium current of the Hodgkin & Huxley (1952) model.

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A description of the membrane potassium current of the Hodgkin & Huxley (1952) model.

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A description of the membrane leakage current of the Hodgkin & Huxley (1952) model.

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A description of the voltage-dependent activation rate constant for the m gate of the Hodgkin & Huxley (1952) sodium current.

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A description of the voltage-dependent activation rate constant for the h gate of the Hodgkin & Huxley (1952) sodium current.

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The standard definition of a dynamic Hodgkin & Huxley gating variable.

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The Q10 for the temperature dependence of the inactivation rate constant of the h gate for the sodium current.

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The Q10 for the temperature dependence of the activation rate constant of the n gate of the potassium current.

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The Q10 for the temperature dependence of the inactivation rate constant of the n gate for the potassium current.

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The independent variable.

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The independent variable.

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The membrane potential value at which the activation rate constant for the m gate of the sodium current is desired.

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The membrane potential value at which the inactivation rate constant for the m gate of the sodium current is desired.

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The membrane potential value at which the activation rate constant for the h gate of the sodium current is desired.

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The membrane potential value at which the inactivation rate constant for the h gate of the sodium current is desired.

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The membrane potential value at which the activation rate constant for the n gate of the potassium current is desired.

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The membrane potential value at which the inactivation rate constant for the n gate of the potassium current is desired.

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The standard Hodgkin & Huxley dynamic gating variable.

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The standard Hodgkin & Huxley dynamic gating variable.

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The standard Hodgkin & Huxley dynamic gating variable.

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The temperature corrected activation rate constant of the m gate for the sodium current.

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The rate of activation of the gating variable.

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The base (non-temperature corrected) value of the activation rate constant for the m gate of the sodium current.

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The rate of inactivation of the gating variable.

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The base (non-temperature corrected) value of the inactivation rate constant for the m gate of the sodium current.

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The temperature corrected activation rate constant of the h gate for the sodium current.

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The base (non-temperature corrected) value of the inactivation rate constant for the n gate of the potassium current.

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Import the base voltage clamp model and set the clamp potential to -20 mV. [David Nickerson]

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Simply defining the clamp potential variable to connect to the voltage clamp model.

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Here we define an interface to a fully specified voltage clamp model which requires only the new potential value to be set.

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The Hodgkin & Huxley (1952) model assembled such that the total membrane current is calculated for a given step in holding potential.

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The actual definition of the time variable.

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The model parameters which differ from default.

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The initial conditions - using all default values in this case.

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Here we define the complete set of default parameter values.

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Here we define the complete set set of default initial conditions for the model's differental variables.

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A description of the membrane sodium current of the Hodgkin & Huxley (1952) model.

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A description of the membrane potassium current of the Hodgkin & Huxley (1952) model.

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The Hodgkin & Huxley (1952) model assembled such that the total membrane current is calculated for a given step in holding potential.

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The actual definition of the time variable.

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The model parameters which differ from default.

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The initial conditions - using all default values in this case.

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Here we define the complete set of default parameter values.

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Here we define the complete set set of default initial conditions for the model's differental variables.

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A description of the membrane sodium current of the Hodgkin & Huxley (1952) model.

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A description of the membrane potassium current of the Hodgkin & Huxley (1952) model.

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A description of the membrane leakage current of the Hodgkin & Huxley (1952) model.

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A description of the voltage-dependent activation rate constant for the m gate of the Hodgkin & Huxley (1952) sodium current.

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A description of the voltage-dependent activation rate constant for the h gate of the Hodgkin & Huxley (1952) sodium current.

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The standard definition of a dynamic Hodgkin & Huxley gating variable.

","importedAs":{"_reference":"named_764"},"math":"named_684.xml"},{"id":"named_764","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#m_gate","title":"Hodgkin-Huxley sodium current's activation gate.","created":{"id":"anon_653","creator":{"id":"anon_654","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"abstract":"We import the standard HH voltage-dependent gating variable description to use as the sodium channel's activation gating variable - 'm'."},{"id":"named_685","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#hh_gating_variable_dynamic","title":"Standard Hodgkin-Huxley dynamic gating kinetics.","created":{"id":"anon_655","creator":{"id":"anon_656","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205146800000},"description":"

The standard definition of a dynamic Hodgkin & Huxley gating variable.

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A description of the voltage-dependent activation rate constant for the n gate of the Hodgkin & Huxley (1952) potassium current.

","importedAs":{"_reference":"named_772"},"math":"named_686.xml"},{"id":"named_772","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK.xml#alpha_n_component","title":"alpha_n","created":{"id":"anon_663","creator":{"id":"anon_664","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_687","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#beta_n_component","title":"Description of the inactivation rate constant for the n gate.","created":{"id":"anon_665","creator":{"id":"anon_666","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"description":"

A description of the voltage-dependent inactivation rate constant for the n gate of the Hodgkin & Huxley (1952) potassium current.

","importedAs":{"_reference":"named_779"},"math":"named_687.xml"},{"id":"named_779","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK.xml#beta_n_component","title":"beta_n","created":{"id":"anon_667","creator":{"id":"anon_668","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_688","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#hh_gating_variable_dynamic","title":"Standard Hodgkin-Huxley dynamic gating kinetics.","created":{"id":"anon_669","creator":{"id":"anon_670","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205146800000},"description":"

The standard definition of a dynamic Hodgkin & Huxley gating variable.

","importedAs":{"_reference":"named_786"},"math":"named_688.xml"},{"id":"named_786","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK.xml#cellmlelement--anonymous-51","title":"n_gate","created":{"id":"anon_671","creator":{"id":"anon_672","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_699","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/voltage-clamp-030.xml#clamp_potential","name":"clamp_potential","title":"clamp_potential","initialValue":"-30.0","connectedVariables":[{"_reference":"named_790"},{"_reference":"named_700"}],"units":"mV","usedIn":[["named_671","named_700"]]},{"id":"named_790","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/voltage-clamp.xml#cellmlelement--anonymous-52","name":"Vnew","title":"Vnew","sourceVariable":{"_reference":"named_699"},"units":"mV"},{"id":"named_700","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/voltage-clamp.xml#Vnew","name":"Vnew","title":"Vnew","sourceVariable":{"_reference":"named_699"},"units":"mV"},{"id":"named_703","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#V_initial","name":"V_initial","title":"V_initial","initialValue":"0.0","connectedVariables":[{"_reference":"named_704"}],"units":"mV","usedIn":[["named_671","named_704"]]},{"id":"named_704","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/voltage-clamp.xml#V_initial","name":"V_initial","title":"V_initial","sourceVariable":{"_reference":"named_703"},"units":"mV"},{"id":"named_791","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#n_initial","name":"n_initial","title":"n_initial","initialValue":"0.315","connectedVariables":[{"_reference":"named_792"},{"_reference":"named_793"},{"_reference":"named_794"}],"units":"dimensionless"},{"id":"named_792","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/voltage-clamp.xml#n_initial","name":"n_initial","title":"n_initial","sourceVariable":{"_reference":"named_791"},"units":"dimensionless"},{"id":"named_793","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK.xml#n_initial","name":"n_initial","title":"n_initial","sourceVariable":{"_reference":"named_791"},"units":"dimensionless"},{"id":"named_794","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#gate_initial_dynamic","name":"gate_initial","title":"gate_initial","description":"

The initial value of the dynamic gating variable, must be defined in order to solve the dynamic expression of the gating kinetics.

","sourceVariable":{"_reference":"named_791"},"units":"dimensionless"},{"id":"named_795","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#m_initial","name":"m_initial","title":"m_initial","initialValue":"0.042","connectedVariables":[{"_reference":"named_796"},{"_reference":"named_797"},{"_reference":"named_798"}],"units":"dimensionless"},{"id":"named_796","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/voltage-clamp.xml#m_initial","name":"m_initial","title":"m_initial","sourceVariable":{"_reference":"named_795"},"units":"dimensionless"},{"id":"named_797","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#m_initial","name":"m_initial","title":"m_initial","sourceVariable":{"_reference":"named_795"},"units":"dimensionless"},{"id":"named_798","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#gate_initial_dynamic","name":"gate_initial","title":"gate_initial","description":"

The initial value of the dynamic gating variable, must be defined in order to solve the dynamic expression of the gating kinetics.

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The standard Hodgkin & Huxley dynamic gating variable.

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The temperature corrected activation rate constant of the m gate for the sodium current.

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The rate of activation of the gating variable.

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The base (non-temperature corrected) value of the activation rate constant for the m gate of the sodium current.

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The temperature corrected inactivation rate constant of the m gate for the sodium current.

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The rate of inactivation of the gating variable.

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The base (non-temperature corrected) value of the inactivation rate constant for the m gate of the sodium current.

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The temperature corrected activation rate constant of the h gate for the sodium current.

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The base (non-temperature corrected) value of the activation rate constant for the h gate of the sodium current.

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The base (non-temperature corrected) value of the inactivation rate constant for the h gate of the sodium current.

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The temperature corrected activation rate constant of the n gate for the potassium current.

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The base (non-temperature corrected) value of the inactivation rate constant for the n gate of the potassium current.

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Import the base voltage clamp model and set the clamp potential to -40 mV. [David Nickerson]

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Simply defining the clamp potential variable to connect to the voltage clamp model.

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Here we define an interface to a fully specified voltage clamp model which requires only the new potential value to be set.

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The Hodgkin & Huxley (1952) model assembled such that the total membrane current is calculated for a given step in holding potential.

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The actual definition of the time variable.

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The model parameters which differ from default.

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The initial conditions - using all default values in this case.

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Here we define the complete set of default parameter values.

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Here we define the complete set set of default initial conditions for the model's differental variables.

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A description of the membrane sodium current of the Hodgkin & Huxley (1952) model.

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A description of the membrane potassium current of the Hodgkin & Huxley (1952) model.

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A description of the membrane leakage current of the Hodgkin & Huxley (1952) model.

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A description of the voltage-dependent activation rate constant for the m gate of the Hodgkin & Huxley (1952) sodium current.

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A description of the voltage-dependent activation rate constant for the h gate of the Hodgkin & Huxley (1952) sodium current.

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The standard definition of a dynamic Hodgkin & Huxley gating variable.

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The standard definition of a dynamic Hodgkin & Huxley gating variable.

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A description of the voltage-dependent activation rate constant for the n gate of the Hodgkin & Huxley (1952) potassium current.

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The independent variable.

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The independent variable.

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The independent variable.

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The membrane potential value at which the activation rate constant for the m gate of the sodium current is desired.

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The membrane potential value at which the inactivation rate constant for the m gate of the sodium current is desired.

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The membrane potential value at which the activation rate constant for the h gate of the sodium current is desired.

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The membrane potential value at which the inactivation rate constant for the h gate of the sodium current is desired.

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The membrane potential value at which the activation rate constant for the n gate of the potassium current is desired.

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The membrane potential value at which the inactivation rate constant for the n gate of the potassium current is desired.

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The standard Hodgkin & Huxley dynamic gating variable.

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The standard Hodgkin & Huxley dynamic gating variable.

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The standard Hodgkin & Huxley dynamic gating variable.

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The temperature corrected activation rate constant of the m gate for the sodium current.

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The rate of activation of the gating variable.

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The base (non-temperature corrected) value of the activation rate constant for the m gate of the sodium current.

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The temperature corrected inactivation rate constant of the m gate for the sodium current.

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The rate of inactivation of the gating variable.

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The base (non-temperature corrected) value of the inactivation rate constant for the m gate of the sodium current.

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The temperature corrected activation rate constant of the h gate for the sodium current.

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The rate of activation of the gating variable.

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The base (non-temperature corrected) value of the activation rate constant for the h gate of the sodium current.

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The temperature corrected inactivation rate constant of the h gate for the sodium current.

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The base (non-temperature corrected) value of the inactivation rate constant for the h gate of the sodium current.

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The temperature corrected activation rate constant of the n gate for the potassium current.

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The rate of activation of the gating variable.

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The base (non-temperature corrected) value of the activation rate constant for the n gate of the potassium current.

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The rate of inactivation of the gating variable.

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The base (non-temperature corrected) value of the inactivation rate constant for the n gate of the potassium current.

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Import the base voltage clamp model and set the clamp potential to -60 mV. [David Nickerson]

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Simply defining the clamp potential variable to connect to the voltage clamp model.

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Here we define an interface to a fully specified voltage clamp model which requires only the new potential value to be set.

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The Hodgkin & Huxley (1952) model assembled such that the total membrane current is calculated for a given step in holding potential.

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The actual definition of the time variable.

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The model parameters which differ from default.

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The initial conditions - using all default values in this case.

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Here we define the complete set of default parameter values.

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Here we define the complete set set of default initial conditions for the model's differental variables.

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A description of the membrane sodium current of the Hodgkin & Huxley (1952) model.

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A description of the membrane potassium current of the Hodgkin & Huxley (1952) model.

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A description of the membrane leakage current of the Hodgkin & Huxley (1952) model.

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The Hodgkin & Huxley (1952) model assembled such that the total membrane current is calculated for a given step in holding potential.

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The actual definition of the time variable.

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The model parameters which differ from default.

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The initial conditions - using all default values in this case.

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Here we define the complete set of default parameter values.

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Here we define the complete set set of default initial conditions for the model's differental variables.

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A description of the membrane sodium current of the Hodgkin & Huxley (1952) model.

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A description of the membrane potassium current of the Hodgkin & Huxley (1952) model.

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A description of the membrane leakage current of the Hodgkin & Huxley (1952) model.

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A description of the voltage-dependent activation rate constant for the m gate of the Hodgkin & Huxley (1952) sodium current.

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A description of the voltage-dependent activation rate constant for the h gate of the Hodgkin & Huxley (1952) sodium current.

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The standard definition of a dynamic Hodgkin & Huxley gating variable.

","importedAs":{"_reference":"named_1223"},"math":"named_1143.xml"},{"id":"named_1223","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#m_gate","title":"Hodgkin-Huxley sodium current's activation gate.","created":{"id":"anon_881","creator":{"id":"anon_882","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"abstract":"We import the standard HH voltage-dependent gating variable description to use as the sodium channel's activation gating variable - 'm'."},{"id":"named_1144","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#hh_gating_variable_dynamic","title":"Standard Hodgkin-Huxley dynamic gating kinetics.","created":{"id":"anon_883","creator":{"id":"anon_884","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205146800000},"description":"

The standard definition of a dynamic Hodgkin & Huxley gating variable.

","importedAs":{"_reference":"named_1227"},"math":"named_1144.xml"},{"id":"named_1227","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#h_gate","title":"Hodgkin-Huxley sodium current's inactivation gate.","created":{"id":"anon_885","creator":{"id":"anon_886","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"abstract":"We import the standard HH voltage-dependent gating variable description to use as the sodium channel's inactivation gating variable - 'h'.","modifications":[{"id":"anon_887","modifier":{"id":"anon_888","type":"person","name":"David Nickerson"},"modification":"Splitting out the gating rate equation components to their own model to test out a possible bug in the API implementation which arises when importing encapsulated children directly into other models.","modified":1218369600000}]},{"id":"named_1145","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#alpha_n_component","title":"Description of the activation rate constant for the n gate.","created":{"id":"anon_889","creator":{"id":"anon_890","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"description":"

A description of the voltage-dependent activation rate constant for the n gate of the Hodgkin & Huxley (1952) potassium current.

","importedAs":{"_reference":"named_1231"},"math":"named_1145.xml"},{"id":"named_1231","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK.xml#alpha_n_component","title":"alpha_n","created":{"id":"anon_891","creator":{"id":"anon_892","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_1146","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#beta_n_component","title":"Description of the inactivation rate constant for the n gate.","created":{"id":"anon_893","creator":{"id":"anon_894","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"description":"

A description of the voltage-dependent inactivation rate constant for the n gate of the Hodgkin & Huxley (1952) potassium current.

","importedAs":{"_reference":"named_1238"},"math":"named_1146.xml"},{"id":"named_1238","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK.xml#beta_n_component","title":"beta_n","created":{"id":"anon_895","creator":{"id":"anon_896","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_1147","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#hh_gating_variable_dynamic","title":"Standard Hodgkin-Huxley dynamic gating kinetics.","created":{"id":"anon_897","creator":{"id":"anon_898","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205146800000},"description":"

The standard definition of a dynamic Hodgkin & Huxley gating variable.

","importedAs":{"_reference":"named_1245"},"math":"named_1147.xml"},{"id":"named_1245","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK.xml#cellmlelement--anonymous-78","title":"n_gate","created":{"id":"anon_899","creator":{"id":"anon_900","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_1158","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/voltage-clamp-080.xml#clamp_potential","name":"clamp_potential","title":"clamp_potential","initialValue":"-80.0","connectedVariables":[{"_reference":"named_1249"},{"_reference":"named_1159"}],"units":"mV","usedIn":[["named_1130","named_1159"]]},{"id":"named_1249","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/voltage-clamp.xml#cellmlelement--anonymous-79","name":"Vnew","title":"Vnew","sourceVariable":{"_reference":"named_1158"},"units":"mV"},{"id":"named_1159","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/voltage-clamp.xml#Vnew","name":"Vnew","title":"Vnew","sourceVariable":{"_reference":"named_1158"},"units":"mV"},{"id":"named_1162","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#V_initial","name":"V_initial","title":"V_initial","initialValue":"0.0","connectedVariables":[{"_reference":"named_1163"}],"units":"mV","usedIn":[["named_1130","named_1163"]]},{"id":"named_1163","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/voltage-clamp.xml#V_initial","name":"V_initial","title":"V_initial","sourceVariable":{"_reference":"named_1162"},"units":"mV"},{"id":"named_1250","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#n_initial","name":"n_initial","title":"n_initial","initialValue":"0.315","connectedVariables":[{"_reference":"named_1251"},{"_reference":"named_1252"},{"_reference":"named_1253"}],"units":"dimensionless"},{"id":"named_1251","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/voltage-clamp.xml#n_initial","name":"n_initial","title":"n_initial","sourceVariable":{"_reference":"named_1250"},"units":"dimensionless"},{"id":"named_1252","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK.xml#n_initial","name":"n_initial","title":"n_initial","sourceVariable":{"_reference":"named_1250"},"units":"dimensionless"},{"id":"named_1253","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#gate_initial_dynamic","name":"gate_initial","title":"gate_initial","description":"

The initial value of the dynamic gating variable, must be defined in order to solve the dynamic expression of the gating kinetics.

","sourceVariable":{"_reference":"named_1250"},"units":"dimensionless"},{"id":"named_1254","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#m_initial","name":"m_initial","title":"m_initial","initialValue":"0.042","connectedVariables":[{"_reference":"named_1255"},{"_reference":"named_1256"},{"_reference":"named_1257"}],"units":"dimensionless"},{"id":"named_1255","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/voltage-clamp.xml#m_initial","name":"m_initial","title":"m_initial","sourceVariable":{"_reference":"named_1254"},"units":"dimensionless"},{"id":"named_1256","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#m_initial","name":"m_initial","title":"m_initial","sourceVariable":{"_reference":"named_1254"},"units":"dimensionless"},{"id":"named_1257","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#gate_initial_dynamic","name":"gate_initial","title":"gate_initial","description":"

The initial value of the dynamic gating variable, must be defined in order to solve the dynamic expression of the gating kinetics.

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The temperature corrected activation rate constant of the m gate for the sodium current.

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The rate of activation of the gating variable.

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The base (non-temperature corrected) value of the activation rate constant for the m gate of the sodium current.

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The temperature corrected inactivation rate constant of the m gate for the sodium current.

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The base (non-temperature corrected) value of the inactivation rate constant for the m gate of the sodium current.

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The temperature corrected activation rate constant of the h gate for the sodium current.

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The base (non-temperature corrected) value of the inactivation rate constant for the h gate of the sodium current.

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The base (non-temperature corrected) value of the inactivation rate constant for the n gate of the potassium current.

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Import the base voltage clamp model and set the clamp potential to -100 mV. [David Nickerson]

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Simply defining the clamp potential variable to connect to the voltage clamp model.

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Here we define an interface to a fully specified voltage clamp model which requires only the new potential value to be set.

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The Hodgkin & Huxley (1952) model assembled such that the total membrane current is calculated for a given step in holding potential.

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The actual definition of the time variable.

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The model parameters which differ from default.

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The initial conditions - using all default values in this case.

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Here we define the complete set of default parameter values.

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Here we define the complete set set of default initial conditions for the model's differental variables.

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A description of the membrane sodium current of the Hodgkin & Huxley (1952) model.

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A description of the membrane potassium current of the Hodgkin & Huxley (1952) model.

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A description of the membrane leakage current of the Hodgkin & Huxley (1952) model.

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A description of the voltage-dependent activation rate constant for the m gate of the Hodgkin & Huxley (1952) sodium current.

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A description of the voltage-dependent activation rate constant for the h gate of the Hodgkin & Huxley (1952) sodium current.

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The standard definition of a dynamic Hodgkin & Huxley gating variable.

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The Q10 for the temperature dependence of the activation rate constant of the m gate of the sodium current.

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The Q10 for the temperature dependence of the inactivation rate constant of the m gate for the sodium current.

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The Q10 for the temperature dependence of the activation rate constant of the h gate of the sodium current.

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The Q10 for the temperature dependence of the inactivation rate constant of the h gate for the sodium current.

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The Q10 for the temperature dependence of the activation rate constant of the n gate of the potassium current.

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The Q10 for the temperature dependence of the inactivation rate constant of the n gate for the potassium current.

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The independent variable.

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The independent variable.

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The independent variable.

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The membrane potential value at which the activation rate constant for the m gate of the sodium current is desired.

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The membrane potential value at which the inactivation rate constant for the m gate of the sodium current is desired.

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The membrane potential value at which the activation rate constant for the h gate of the sodium current is desired.

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The membrane potential value at which the inactivation rate constant for the h gate of the sodium current is desired.

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The membrane potential value at which the activation rate constant for the n gate of the potassium current is desired.

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The membrane potential value at which the inactivation rate constant for the n gate of the potassium current is desired.

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The standard Hodgkin & Huxley dynamic gating variable.

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The standard Hodgkin & Huxley dynamic gating variable.

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The standard Hodgkin & Huxley dynamic gating variable.

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The temperature corrected activation rate constant of the m gate for the sodium current.

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The rate of activation of the gating variable.

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The base (non-temperature corrected) value of the activation rate constant for the m gate of the sodium current.

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The temperature corrected inactivation rate constant of the m gate for the sodium current.

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The rate of inactivation of the gating variable.

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The base (non-temperature corrected) value of the inactivation rate constant for the m gate of the sodium current.

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The temperature corrected activation rate constant of the h gate for the sodium current.

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The rate of activation of the gating variable.

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The base (non-temperature corrected) value of the activation rate constant for the h gate of the sodium current.

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The temperature corrected inactivation rate constant of the h gate for the sodium current.

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The rate of inactivation of the gating variable.

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The base (non-temperature corrected) value of the inactivation rate constant for the h gate of the sodium current.

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The temperature corrected activation rate constant of the n gate for the potassium current.

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The rate of activation of the gating variable.

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The base (non-temperature corrected) value of the activation rate constant for the n gate of the potassium current.

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The temperature corrected inactivation rate constant of the n gate for the potassium current.

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The rate of inactivation of the gating variable.

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The base (non-temperature corrected) value of the inactivation rate constant for the n gate of the potassium current.

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Import the base voltage clamp model and set the clamp potential to -115 mV. [David Nickerson]

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Simply defining the clamp potential variable to connect to the voltage clamp model.

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Here we define an interface to a fully specified voltage clamp model which requires only the new potential value to be set.

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The Hodgkin & Huxley (1952) model assembled such that the total membrane current is calculated for a given step in holding potential.

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The actual definition of the time variable.

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The model parameters which differ from default.

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The initial conditions - using all default values in this case.

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Here we define the complete set of default parameter values.

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Here we define the complete set set of default initial conditions for the model's differental variables.

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The temperature corrected activation rate constant of the m gate for the sodium current.

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The rate of activation of the gating variable.

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The base (non-temperature corrected) value of the activation rate constant for the m gate of the sodium current.

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The temperature corrected inactivation rate constant of the m gate for the sodium current.

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The rate of inactivation of the gating variable.

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The base (non-temperature corrected) value of the inactivation rate constant for the m gate of the sodium current.

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The temperature corrected activation rate constant of the h gate for the sodium current.

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The base (non-temperature corrected) value of the activation rate constant for the h gate of the sodium current.

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The base (non-temperature corrected) value of the inactivation rate constant for the h gate of the sodium current.

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The temperature corrected activation rate constant of the n gate for the potassium current.

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The base (non-temperature corrected) value of the inactivation rate constant for the n gate of the potassium current.

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Import the base voltage clamp model and set the clamp potential to -130 mV. [David Nickerson]

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Simply defining the clamp potential variable to connect to the voltage clamp model.

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Here we define an interface to a fully specified voltage clamp model which requires only the new potential value to be set.

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The Hodgkin & Huxley (1952) model assembled such that the total membrane current is calculated for a given step in holding potential.

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The actual definition of the time variable.

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The model parameters which differ from default.

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The initial conditions - using all default values in this case.

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Here we define the complete set of default parameter values.

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Here we define the complete set set of default initial conditions for the model's differental variables.

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A description of the membrane sodium current of the Hodgkin & Huxley (1952) model.

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A description of the membrane potassium current of the Hodgkin & Huxley (1952) model.

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A description of the membrane leakage current of the Hodgkin & Huxley (1952) model.

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A description of the voltage-dependent activation rate constant for the m gate of the Hodgkin & Huxley (1952) sodium current.

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A description of the voltage-dependent activation rate constant for the h gate of the Hodgkin & Huxley (1952) sodium current.

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The standard definition of a dynamic Hodgkin & Huxley gating variable.

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The standard definition of a dynamic Hodgkin & Huxley gating variable.

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A description of the voltage-dependent activation rate constant for the n gate of the Hodgkin & Huxley (1952) potassium current.

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A description of the voltage-dependent inactivation rate constant for the n gate of the Hodgkin & Huxley (1952) potassium current.

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The Q10 for the temperature dependence of the inactivation rate constant of the h gate for the sodium current.

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The Q10 for the temperature dependence of the activation rate constant of the n gate of the potassium current.

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The Q10 for the temperature dependence of the inactivation rate constant of the n gate for the potassium current.

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The independent variable.

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The independent variable.

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The independent variable.

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The membrane potential value at which the activation rate constant for the m gate of the sodium current is desired.

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The membrane potential value at which the inactivation rate constant for the m gate of the sodium current is desired.

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The membrane potential value at which the activation rate constant for the h gate of the sodium current is desired.

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The membrane potential value at which the inactivation rate constant for the h gate of the sodium current is desired.

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The membrane potential value at which the activation rate constant for the n gate of the potassium current is desired.

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The membrane potential value at which the inactivation rate constant for the n gate of the potassium current is desired.

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The standard Hodgkin & Huxley dynamic gating variable.

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The standard Hodgkin & Huxley dynamic gating variable.

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The standard Hodgkin & Huxley dynamic gating variable.

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The temperature corrected activation rate constant of the m gate for the sodium current.

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The rate of activation of the gating variable.

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The base (non-temperature corrected) value of the activation rate constant for the m gate of the sodium current.

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The temperature corrected inactivation rate constant of the m gate for the sodium current.

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The rate of inactivation of the gating variable.

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The base (non-temperature corrected) value of the inactivation rate constant for the m gate of the sodium current.

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The temperature corrected activation rate constant of the h gate for the sodium current.

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The rate of activation of the gating variable.

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The base (non-temperature corrected) value of the activation rate constant for the h gate of the sodium current.

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The temperature corrected inactivation rate constant of the h gate for the sodium current.

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The rate of inactivation of the gating variable.

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The base (non-temperature corrected) value of the inactivation rate constant for the h gate of the sodium current.

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The temperature corrected activation rate constant of the n gate for the potassium current.

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The rate of activation of the gating variable.

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The base (non-temperature corrected) value of the activation rate constant for the n gate of the potassium current.

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The temperature corrected inactivation rate constant of the n gate for the potassium current.

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The rate of inactivation of the gating variable.

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The base (non-temperature corrected) value of the inactivation rate constant for the n gate of the potassium current.

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Defines suitable boundary and initial conditions to the Hodgkin & Huxley (1952) model in order to produce a train of action potentials arising from an applied periodic electrical stimulus. [David Nickerson]

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The actual definition of the time variable.

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Here we define the parameters for the applied periodic stimulus.

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The model parameters - in this case we use all default values.

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The initial conditions - using all default values in this case.

"},{"id":"named_1744","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/stimulated.xml#action_potential","title":"Hodgkin & Huxley with applied electrical stimulus.","created":{"id":"anon_1139","creator":{"id":"anon_1140","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"description":"

The Hodgkin & Huxley (1952) model assembled such that given an electrical stimulus current it will simulate action potential transients.

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Here we define the periodic stimulus protocol.

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Here we define the complete set of default parameter values.

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Here we define the complete set set of default initial conditions for the model's differental variables.

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A description of the membrane sodium current of the Hodgkin & Huxley (1952) model.

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","connectedVariables":[{"_reference":"named_1867"}],"units":"per_ms","definedIn":"named_1758","usedIn":[["named_1759","named_1867"]]},{"id":"named_1867","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#beta_dynamic","name":"beta","title":"beta","description":"

The rate of inactivation of the gating variable.

","sourceVariable":{"_reference":"named_1860"},"units":"per_ms"},{"id":"named_1858","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#beta_n_base","name":"beta_base","title":"beta_base","description":"

The base (non-temperature corrected) value of the inactivation rate constant for the n gate of the potassium current.

","units":"per_ms","definedIn":"named_1758"},{"id":"named_64","type":"model","uri":"http://models.cellml.org/workspace/a1/@@rawfile/fa41916b2ca31572b372f793380ea141042446ac/tutorial/experiment.xml#generic_experiment","name":"generic_experiment","title":"Modified HH with periodic stimulus applied plus default parameter set.","created":{"id":"anon_1205","creator":{"id":"anon_1206","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Auckland Bioengineering Institute, The University of Auckland"},"created":1246881600000},"description":"

Applies the default set of parameters to the modified HH model and leaves some parameters free for customisation. Applies the periodic stimulus protocol from the original HH implementation from http://www.bioeng.nus.edu.sg/compbiolab/p3/. [David Nickerson]

","components":[{"_reference":"named_1899"},{"_reference":"named_1900"},{"_reference":"named_1901"},{"_reference":"named_1902"},{"_reference":"named_1903"},{"_reference":"named_1904"},{"_reference":"named_1905"},{"_reference":"named_1906"},{"_reference":"named_1907"},{"_reference":"named_1908"},{"_reference":"named_1909"},{"_reference":"named_1910"},{"_reference":"named_1911"},{"_reference":"named_1912"},{"_reference":"named_1913"},{"_reference":"named_1914"},{"_reference":"named_1915"},{"_reference":"named_1916"},{"_reference":"named_1917"},{"_reference":"named_1918"}]},{"id":"named_1899","type":"component","uri":"http://models.cellml.org/workspace/a1/@@rawfile/fa41916b2ca31572b372f793380ea141042446ac/tutorial/experiment.xml#time_component","title":"time","created":{"id":"anon_1207","creator":{"id":"anon_1208","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Auckland Bioengineering Institute, The University of Auckland"},"created":1246881600000},"description":"

The actual definition of the time variable.

"},{"id":"named_1900","type":"component","uri":"http://models.cellml.org/workspace/a1/@@rawfile/fa41916b2ca31572b372f793380ea141042446ac/tutorial/experiment.xml#parameters","title":"parameters","created":{"id":"anon_1209","creator":{"id":"anon_1210","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Auckland Bioengineering Institute, The University of Auckland"},"created":1246881600000},"description":"

The model parameters.

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The initial conditions - using all default values in this case.

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The Hodgkin & Huxley (1952) model assembled such that given an electrical stimulus current it will simulate action potential transients.

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Here we define the periodic stimulus protocol.

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Here we define the complete set of default parameter values.

","importedAs":{"_reference":"named_1942"}},{"id":"named_1942","type":"component","uri":"http://models.cellml.org/workspace/a1/@@rawfile/fa41916b2ca31572b372f793380ea141042446ac/tutorial/experiment.xml#cellmlelement--anonymous-132","title":"default_parameters","created":{"id":"anon_1223","creator":{"id":"anon_1224","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Auckland Bioengineering Institute, The University of Auckland"},"created":1246881600000}},{"id":"named_1905","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#initial_conditions_component","title":"Hodgkin & Huxley default initial conditions.","created":{"id":"anon_1225","creator":{"id":"anon_1226","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"description":"

Here we define the complete set set of default initial conditions for the model's differental variables.

","importedAs":{"_reference":"named_1943"}},{"id":"named_1943","type":"component","uri":"http://models.cellml.org/workspace/a1/@@rawfile/fa41916b2ca31572b372f793380ea141042446ac/tutorial/experiment.xml#cellmlelement--anonymous-133","title":"default_initial_conditions","created":{"id":"anon_1227","creator":{"id":"anon_1228","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Auckland Bioengineering Institute, The University of Auckland"},"created":1246881600000}},{"id":"named_1906","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#INa_component","title":"Hodgkin & Huxley sodium current.","created":{"id":"anon_1229","creator":{"id":"anon_1230","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"description":"

A description of the membrane sodium current of the Hodgkin & Huxley (1952) model.

","importedAs":{"_reference":"named_1944"},"math":"named_1906.xml"},{"id":"named_1944","type":"component","uri":"http://models.cellml.org/workspace/a1/@@rawfile/fa41916b2ca31572b372f793380ea141042446ac/tutorial/modified-hh.xml#cellmlelement--anonymous-134","title":"INa","created":{"id":"anon_1231","creator":{"id":"anon_1232","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Auckland Bioengineering Institute, The University of Auckland"},"created":1246881600000}},{"id":"named_1907","type":"component","uri":"http://models.cellml.org/workspace/a1/@@rawfile/fa41916b2ca31572b372f793380ea141042446ac/tutorial/IK.xml#IK_component","title":"Modified Hodgkin & Huxley potassium current.","created":{"id":"anon_1233","creator":{"id":"anon_1234","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Auckland Bioengineering Institute, The University of Auckland"},"created":1246881600000},"description":"

A description of the membrane potassium current of the Hodgkin & Huxley (1952) model with some modifications following Noble 1962. The HH n-gate rate constants are slowed by a factor of 100; a base empirical conductance is introduced as an instanteous function of membrane potential;

","importedAs":{"_reference":"named_1955"},"math":"named_1907.xml"},{"id":"named_1955","type":"component","uri":"http://models.cellml.org/workspace/a1/@@rawfile/fa41916b2ca31572b372f793380ea141042446ac/tutorial/modified-hh.xml#cellmlelement--anonymous-135","title":"IK","created":{"id":"anon_1235","creator":{"id":"anon_1236","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Auckland Bioengineering Institute, The University of Auckland"},"created":1246881600000}},{"id":"named_1908","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/Ileak.xml#Ileak_component","title":"Hodgkin & Huxley leakage current.","created":{"id":"anon_1237","creator":{"id":"anon_1238","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"description":"

A description of the membrane leakage current of the Hodgkin & Huxley (1952) model.

","importedAs":{"_reference":"named_1965"},"math":"named_1908.xml"},{"id":"named_1965","type":"component","uri":"http://models.cellml.org/workspace/a1/@@rawfile/fa41916b2ca31572b372f793380ea141042446ac/tutorial/modified-hh.xml#cellmlelement--anonymous-136","title":"Ileak","created":{"id":"anon_1239","creator":{"id":"anon_1240","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Auckland Bioengineering Institute, The University of Auckland"},"created":1246881600000}},{"id":"named_1909","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#alpha_m_component","title":"Description of the activation rate constant for the m gate.","created":{"id":"anon_1241","creator":{"id":"anon_1242","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"description":"

A description of the voltage-dependent activation rate constant for the m gate of the Hodgkin & Huxley (1952) sodium current.

","importedAs":{"_reference":"named_1971"},"math":"named_1909.xml"},{"id":"named_1971","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#alpha_m","title":"alpha_m","created":{"id":"anon_1243","creator":{"id":"anon_1244","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_1910","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#beta_m_component","title":"beta_m","created":{"id":"anon_1245","creator":{"id":"anon_1246","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"importedAs":{"_reference":"named_1981"},"math":"named_1910.xml"},{"id":"named_1981","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#beta_m","title":"beta_m","created":{"id":"anon_1247","creator":{"id":"anon_1248","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_1911","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#alpha_h_component","title":"Description of the activation rate constant for the h gate.","created":{"id":"anon_1249","creator":{"id":"anon_1250","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"description":"

A description of the voltage-dependent activation rate constant for the h gate of the Hodgkin & Huxley (1952) sodium current.

","importedAs":{"_reference":"named_1988"},"math":"named_1911.xml"},{"id":"named_1988","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#alpha_h","title":"alpha_h","created":{"id":"anon_1251","creator":{"id":"anon_1252","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_1912","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#beta_h_component","title":"beta_h","created":{"id":"anon_1253","creator":{"id":"anon_1254","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"importedAs":{"_reference":"named_1995"},"math":"named_1912.xml"},{"id":"named_1995","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#beta_h","title":"beta_h","created":{"id":"anon_1255","creator":{"id":"anon_1256","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_1913","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#hh_gating_variable_dynamic","title":"Standard Hodgkin-Huxley dynamic gating kinetics.","created":{"id":"anon_1257","creator":{"id":"anon_1258","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205146800000},"description":"

The standard definition of a dynamic Hodgkin & Huxley gating variable.

","importedAs":{"_reference":"named_2002"},"math":"named_1913.xml"},{"id":"named_2002","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#m_gate","title":"Hodgkin-Huxley sodium current's activation gate.","created":{"id":"anon_1259","creator":{"id":"anon_1260","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"abstract":"We import the standard HH voltage-dependent gating variable description to use as the sodium channel's activation gating variable - 'm'."},{"id":"named_1914","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#hh_gating_variable_dynamic","title":"Standard Hodgkin-Huxley dynamic gating kinetics.","created":{"id":"anon_1261","creator":{"id":"anon_1262","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205146800000},"description":"

The standard definition of a dynamic Hodgkin & Huxley gating variable.

","importedAs":{"_reference":"named_2006"},"math":"named_1914.xml"},{"id":"named_2006","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#h_gate","title":"Hodgkin-Huxley sodium current's inactivation gate.","created":{"id":"anon_1263","creator":{"id":"anon_1264","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"abstract":"We import the standard HH voltage-dependent gating variable description to use as the sodium channel's inactivation gating variable - 'h'.","modifications":[{"id":"anon_1265","modifier":{"id":"anon_1266","type":"person","name":"David Nickerson"},"modification":"Splitting out the gating rate equation components to their own model to test out a possible bug in the API implementation which arises when importing encapsulated children directly into other models.","modified":1218369600000}]},{"id":"named_1915","type":"component","uri":"http://models.cellml.org/workspace/a1/@@rawfile/fa41916b2ca31572b372f793380ea141042446ac/tutorial/IK.xml#cellmlelement--anonymous-122","title":"gating_rates","created":{"id":"anon_1267","creator":{"id":"anon_1268","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Auckland Bioengineering Institute, The University of Auckland"},"created":1246881600000},"math":"named_1915.xml"},{"id":"named_1916","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#alpha_n_component","title":"Description of the activation rate constant for the n gate.","created":{"id":"anon_1269","creator":{"id":"anon_1270","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"description":"

A description of the voltage-dependent activation rate constant for the n gate of the Hodgkin & Huxley (1952) potassium current.

","importedAs":{"_reference":"named_2016"},"math":"named_1916.xml"},{"id":"named_2016","type":"component","uri":"http://models.cellml.org/workspace/a1/@@rawfile/fa41916b2ca31572b372f793380ea141042446ac/tutorial/IK.xml#alpha_n_component","title":"HH_alpha_n","created":{"id":"anon_1271","creator":{"id":"anon_1272","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Auckland Bioengineering Institute, The University of Auckland"},"created":1246881600000}},{"id":"named_1917","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#beta_n_component","title":"Description of the inactivation rate constant for the n gate.","created":{"id":"anon_1273","creator":{"id":"anon_1274","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"description":"

A description of the voltage-dependent inactivation rate constant for the n gate of the Hodgkin & Huxley (1952) potassium current.

","importedAs":{"_reference":"named_2022"},"math":"named_1917.xml"},{"id":"named_2022","type":"component","uri":"http://models.cellml.org/workspace/a1/@@rawfile/fa41916b2ca31572b372f793380ea141042446ac/tutorial/IK.xml#beta_n_component","title":"HH_beta_n","created":{"id":"anon_1275","creator":{"id":"anon_1276","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Auckland Bioengineering Institute, The University of Auckland"},"created":1246881600000}},{"id":"named_1918","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#hh_gating_variable_dynamic","title":"Standard Hodgkin-Huxley dynamic gating kinetics.","created":{"id":"anon_1277","creator":{"id":"anon_1278","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205146800000},"description":"

The standard definition of a dynamic Hodgkin & Huxley gating variable.

","importedAs":{"_reference":"named_2028"},"math":"named_1918.xml"},{"id":"named_2028","type":"component","uri":"http://models.cellml.org/workspace/a1/@@rawfile/fa41916b2ca31572b372f793380ea141042446ac/tutorial/IK.xml#cellmlelement--anonymous-141","title":"n_gate","created":{"id":"anon_1279","creator":{"id":"anon_1280","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Auckland Bioengineering Institute, The University of Auckland"},"created":1246881600000}},{"id":"named_1921","type":"variable","uri":"http://models.cellml.org/workspace/a1/@@rawfile/fa41916b2ca31572b372f793380ea141042446ac/tutorial/experiment.xml#time","name":"time","title":"time","initialValue":"0.0","connectedVariables":[{"_reference":"named_1922"},{"_reference":"named_2032"},{"_reference":"named_2003"},{"_reference":"named_2007"},{"_reference":"named_2033"},{"_reference":"named_2029"},{"_reference":"named_1937"}],"units":"ms","usedIn":[["named_1902","named_1922"],["named_1903","named_1937"],["named_1913","named_2003"],["named_1914","named_2007"],["named_1918","named_2029"]]},{"id":"named_1922","type":"variable","uri":"http://models.cellml.org/workspace/a1/@@rawfile/fa41916b2ca31572b372f793380ea141042446ac/tutorial/modified-hh.xml#time","name":"time","title":"time","sourceVariable":{"_reference":"named_1921"},"units":"ms"},{"id":"named_2032","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#time","name":"time","title":"time","sourceVariable":{"_reference":"named_1921"},"units":"ms"},{"id":"named_2003","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#time","name":"time","title":"time","description":"

The independent variable.

","sourceVariable":{"_reference":"named_1921"},"units":"ms"},{"id":"named_2007","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#time","name":"time","title":"time","description":"

The independent variable.

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The actual temperature at which the activation rate constant for the h gate of the sodium current is desired.

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The actual temperature at which the inactivation rate constant for the h gate of the sodium current is desired.

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The actual temperature at which the activation rate constant for the n gate of the potassium current is desired.

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The actual temperature at which the inactivation rate constant for the n gate of the potassium current is desired.

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The Q10 for the temperature dependence of the activation rate constant of the m gate of the sodium current.

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The Q10 for the temperature dependence of the inactivation rate constant of the m gate for the sodium current.

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The Q10 for the temperature dependence of the activation rate constant of the h gate of the sodium current.

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The Q10 for the temperature dependence of the inactivation rate constant of the h gate for the sodium current.

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The Q10 for the temperature dependence of the activation rate constant of the n gate of the potassium current.

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The Q10 for the temperature dependence of the inactivation rate constant of the n gate for the potassium current.

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The standard Hodgkin & Huxley dynamic gating variable.

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The standard Hodgkin & Huxley dynamic gating variable.

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The standard Hodgkin & Huxley dynamic gating variable.

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The temperature corrected activation rate constant of the m gate for the sodium current.

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The rate of activation of the gating variable.

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The base (non-temperature corrected) value of the activation rate constant for the m gate of the sodium current.

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The temperature corrected inactivation rate constant of the m gate for the sodium current.

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The rate of inactivation of the gating variable.

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The base (non-temperature corrected) value of the inactivation rate constant for the m gate of the sodium current.

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The temperature corrected activation rate constant of the h gate for the sodium current.

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The rate of activation of the gating variable.

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The base (non-temperature corrected) value of the activation rate constant for the h gate of the sodium current.

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The temperature corrected inactivation rate constant of the h gate for the sodium current.

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The rate of inactivation of the gating variable.

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The base (non-temperature corrected) value of the inactivation rate constant for the h gate of the sodium current.

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The rate of activation of the gating variable.

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The rate of inactivation of the gating variable.

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The temperature corrected activation rate constant of the n gate for the potassium current.

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The temperature corrected inactivation rate constant of the n gate for the potassium current.

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The base (non-temperature corrected) value of the activation rate constant for the n gate of the potassium current.

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The base (non-temperature corrected) value of the inactivation rate constant for the n gate of the potassium current.

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The actual definition of the time variable.

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Here we define the parameters for the applied periodic stimulus.

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Here we define any additional currents for use in the model, in this case\n just the stimulus current as an additional potassium current.

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The interface by which this model can be accessed.

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Here we define the periodic stimulus protocol.

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Here we define the interface to this model, including all boundary\n and initial conditions that we expect to be set for a specific\n simulation. The interface is the root of the encapsulation hierarchy\n for this model.

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The default initial conditions.

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The default model parameters.

","importedAs":{"_reference":"named_2131"}},{"id":"named_2131","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/papers/nickerson-PBMB-2008/experiments/TNNP.xml#cellmlelement--anonymous-156","title":"default_parameters","created":{"id":"anon_1311","creator":{"id":"anon_1312","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1176897600000}},{"id":"named_2073","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Vm.xml#membrane_potential","title":"membrane_potential","created":{"id":"anon_1313","creator":{"id":"anon_1314","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1179057600000},"description":"

The component which defines the membrane potential and specifies\n its kinetics.

","importedAs":{"_reference":"named_2132"},"math":"named_2073.xml"},{"id":"named_2132","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-157","title":"membrane_potential","created":{"id":"anon_1315","creator":{"id":"anon_1316","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2074","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/total_current.xml#total_membrane_current","title":"total_membrane_current","created":{"id":"anon_1317","creator":{"id":"anon_1318","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1179057600000},"importedAs":{"_reference":"named_2139"},"math":"named_2074.xml"},{"id":"named_2139","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-163","title":"total_membrane_current","created":{"id":"anon_1319","creator":{"id":"anon_1320","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2075","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/ion_fluxes.xml#K_flux","title":"K_flux","created":{"id":"anon_1321","creator":{"id":"anon_1322","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1179144000000},"importedAs":{"_reference":"named_2169"},"math":"named_2075.xml"},{"id":"named_2169","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-189","title":"K_flux","created":{"id":"anon_1323","creator":{"id":"anon_1324","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2076","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/ion_fluxes.xml#Na_flux","title":"Na_flux","created":{"id":"anon_1325","creator":{"id":"anon_1326","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1179144000000},"importedAs":{"_reference":"named_2183"},"math":"named_2076.xml"},{"id":"named_2183","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-202","title":"Na_flux","created":{"id":"anon_1327","creator":{"id":"anon_1328","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2077","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/ion_fluxes.xml#Ca_flux","title":"Ca_flux","created":{"id":"anon_1329","creator":{"id":"anon_1330","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1179144000000},"importedAs":{"_reference":"named_2194"},"math":"named_2077.xml"},{"id":"named_2194","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-212","title":"Ca_flux","created":{"id":"anon_1331","creator":{"id":"anon_1332","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2078","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/ion_fluxes.xml#Ca_SR_flux","title":"Ca_SR_flux","created":{"id":"anon_1333","creator":{"id":"anon_1334","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1179144000000},"importedAs":{"_reference":"named_2205"},"math":"named_2078.xml"},{"id":"named_2205","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-222","title":"Ca_SR_flux","created":{"id":"anon_1335","creator":{"id":"anon_1336","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2079","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/INa.xml#INa","title":"INa","created":{"id":"anon_1337","creator":{"id":"anon_1338","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104058800000},"description":"

Here we calculate the fast sodium current. We expect the time, membrane\n potential, reversal potential and conductance to be set externally, and\n we provide access to the gating variables and the calculated current. This\n component encapsulates all others in this model.

","importedAs":{"_reference":"named_2215"},"math":"named_2079.xml"},{"id":"named_2215","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-229","title":"INa","created":{"id":"anon_1339","creator":{"id":"anon_1340","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2080","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IK1.xml#IK1","title":"IK1","created":{"id":"anon_1341","creator":{"id":"anon_1342","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Here we calculate the inward rectifier current. We expect \n the time, membrane potential, reversal potential and conductance \n to be set externally, and we provide access to the gating \n variables and the calculated current. This component encapsulates\n all others in this model.

","importedAs":{"_reference":"named_2227"},"math":"named_2080.xml"},{"id":"named_2227","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-241","title":"IK1","created":{"id":"anon_1343","creator":{"id":"anon_1344","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2081","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Ito-components.xml#current","title":"current","created":{"id":"anon_1345","creator":{"id":"anon_1346","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104231600000},"description":"

Here we specify the current calculation equation as it\n is shared between the versions of the channel.

","importedAs":{"_reference":"named_2237"},"math":"named_2081.xml"},{"id":"named_2237","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Ito-epi.xml#cellmlelement--anonymous-251","title":"Ito","created":{"id":"anon_1347","creator":{"id":"anon_1348","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104231600000},"importedAs":{"_reference":"named_2246"}},{"id":"named_2246","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-260","title":"Ito","created":{"id":"anon_1349","creator":{"id":"anon_1350","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2082","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IKr.xml#IKr","title":"IKr","created":{"id":"anon_1351","creator":{"id":"anon_1352","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Here we calculate the rapid delayed rectifier current. We expect \n the time, membrane potential, reversal potential and conductance \n to be set externally, and we provide access to the gating \n variables and the calculated current. This component encapsulates\n all others in this model.

","importedAs":{"_reference":"named_2247"},"math":"named_2082.xml"},{"id":"named_2247","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-261","title":"IKr","created":{"id":"anon_1353","creator":{"id":"anon_1354","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2083","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IKs.xml#IKs","title":"IKs","created":{"id":"anon_1355","creator":{"id":"anon_1356","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104058800000},"description":"

Here we calculate the slow delayed rectifier current. We expect \n the time, membrane potential, reversal potential and conductance \n to be set externally, and we provide access to the gating \n variables and the calculated current. This component encapsulates\n all others in this model.

","importedAs":{"_reference":"named_2257"},"math":"named_2083.xml"},{"id":"named_2257","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-271","title":"IKs","created":{"id":"anon_1357","creator":{"id":"anon_1358","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2084","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/INaK.xml#INaK","title":"INaK","created":{"id":"anon_1359","creator":{"id":"anon_1360","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Here we calculate the sodium potassium pump current.

","importedAs":{"_reference":"named_2265"},"math":"named_2084.xml"},{"id":"named_2265","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-279","title":"INaK","created":{"id":"anon_1361","creator":{"id":"anon_1362","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2085","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IpK.xml#IpK","title":"IpK","created":{"id":"anon_1363","creator":{"id":"anon_1364","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Here we calculate the plateau potassium current.

","importedAs":{"_reference":"named_2281"},"math":"named_2085.xml"},{"id":"named_2281","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-295","title":"IpK","created":{"id":"anon_1365","creator":{"id":"anon_1366","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2086","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IbNa.xml#IbNa","title":"IbNa","created":{"id":"anon_1367","creator":{"id":"anon_1368","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Here we calculate the background sodium current.

","importedAs":{"_reference":"named_2286"},"math":"named_2086.xml"},{"id":"named_2286","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-300","title":"IbNa","created":{"id":"anon_1369","creator":{"id":"anon_1370","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2087","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/ICaL.xml#ICaL","title":"ICaL","created":{"id":"anon_1371","creator":{"id":"anon_1372","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104231600000},"description":"

Here we calculate the L-type calcium current. We expect the time, membrane\n potential, and conductance to be set externally, and\n we provide access to the gating variables and the calculated current. This\n component encapsulates all others in this model.

","importedAs":{"_reference":"named_2291"},"math":"named_2087.xml"},{"id":"named_2291","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-305","title":"ICaL","created":{"id":"anon_1373","creator":{"id":"anon_1374","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2088","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IpCa.xml#IpCa","title":"IpCa","created":{"id":"anon_1375","creator":{"id":"anon_1376","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Here we calculate the plateau calcium current. Added\n the unit multiplier to get dimensional consistency.

","importedAs":{"_reference":"named_2309"},"math":"named_2088.xml"},{"id":"named_2309","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-323","title":"IpCa","created":{"id":"anon_1377","creator":{"id":"anon_1378","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2089","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/INaCa.xml#INaCa","title":"INaCa","created":{"id":"anon_1379","creator":{"id":"anon_1380","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Here we calculate the sodium calcium exchanger current.

","importedAs":{"_reference":"named_2315"},"math":"named_2089.xml"},{"id":"named_2315","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-329","title":"INaCa","created":{"id":"anon_1381","creator":{"id":"anon_1382","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2090","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IbCa.xml#IbCa","title":"IbCa","created":{"id":"anon_1383","creator":{"id":"anon_1384","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Here we calculate the background calcium current.

","importedAs":{"_reference":"named_2337"},"math":"named_2090.xml"},{"id":"named_2337","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-351","title":"IbCa","created":{"id":"anon_1385","creator":{"id":"anon_1386","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2091","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/common/reversal_potential.xml#one_ion","title":"one_ion","created":{"id":"anon_1387","creator":{"id":"anon_1388","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Bioengineering Institute, The University of Auckland"},"created":1104058800000},"description":"

Calculate the Nernst reversal potential for one ionic specie. We \n expect the temperature, valence and ionic concentrations to be \n defined by the model importing this component. We make the gas \n and Faraday's constants available for others to use.

","importedAs":{"_reference":"named_2343"},"math":"named_2091.xml"},{"id":"named_2343","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-357","title":"ENa","created":{"id":"anon_1389","creator":{"id":"anon_1390","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2092","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/common/reversal_potential.xml#one_ion","title":"one_ion","created":{"id":"anon_1391","creator":{"id":"anon_1392","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Bioengineering Institute, The University of Auckland"},"created":1104058800000},"description":"

Calculate the Nernst reversal potential for one ionic specie. We \n expect the temperature, valence and ionic concentrations to be \n defined by the model importing this component. We make the gas \n and Faraday's constants available for others to use.

","importedAs":{"_reference":"named_2349"},"math":"named_2092.xml"},{"id":"named_2349","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-363","title":"EK","created":{"id":"anon_1393","creator":{"id":"anon_1394","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2093","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/common/reversal_potential.xml#one_ion","title":"one_ion","created":{"id":"anon_1395","creator":{"id":"anon_1396","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Bioengineering Institute, The University of Auckland"},"created":1104058800000},"description":"

Calculate the Nernst reversal potential for one ionic specie. We \n expect the temperature, valence and ionic concentrations to be \n defined by the model importing this component. We make the gas \n and Faraday's constants available for others to use.

","importedAs":{"_reference":"named_2357"},"math":"named_2093.xml"},{"id":"named_2357","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-371","title":"ECa","created":{"id":"anon_1397","creator":{"id":"anon_1398","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2094","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/common/reversal_potential.xml#two_ions","title":"two_ions","created":{"id":"anon_1399","creator":{"id":"anon_1400","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Bioengineering Institute, The University of Auckland"},"created":1104058800000},"description":"

Calculate the Nernst reversal potential for two ionic species,\n not sure how general this is but a few different models use it.\n We expect the temperature, valence, modifiers and ionic \n concentrations to be defined by the model importing this \n component. We make the gas and Faraday's constants available for\n others to use.

","importedAs":{"_reference":"named_2363"},"math":"named_2094.xml"},{"id":"named_2363","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-377","title":"EKs","created":{"id":"anon_1401","creator":{"id":"anon_1402","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2095","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Nai.xml#sodium_dynamics","title":"sodium_dynamics","created":{"id":"anon_1403","creator":{"id":"anon_1404","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

The intracellular sodium dynamics.

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The intracellular potassium dynamics.

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The intracellular calcium dynamics.

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Calculate the calcium leakage flux from the SR.

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Calculate the calcium uptake flux from the SR.

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Calculation of the calcium release flux from the SR.

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The activation gate. Here we specify the standard Hodgkin-Huxley\n type kinetics for the gate and also calculate the steady-state\n m_infinity and tau_m values.

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The fast inactivation gate. Here we specify the standard Hodgkin-Huxley\n type kinetics for the gate and also calculate the steady-state\n h_infinity and tau_h values.

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The slow inactivation gate. Here we specify the standard Hodgkin-Huxley\n type kinetics for the gate and also calculate the steady-state\n j_infinity and tau_j values.

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The activation gate kinetics.

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The activation gate for the transient outward current in the\n ten Tusscher model is common between cell types.

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The epicardial and M cell version of the inactivation gating\n kinetics of the transient outward current.

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The activation gating kinetics.

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The inactivation gating kinetics.

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The activation gating kinetics for the IKs current.

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The voltage dependent activation gate.

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The voltage dependent inactivation gate.

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The calcium dependent inactivation gate.

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The calcium dependent inactivation gate for\n calcium release from the SR.

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The actual definition of the time variable.

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The actual definition of the time variable.

"},{"id":"named_2703","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/papers/nickerson-PBMB-2008/experiments/TNNP-S1S2.xml#stimulus_protocol_params","title":"stimulus_protocol_params","created":{"id":"anon_1467","creator":{"id":"anon_1468","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1177329600000},"description":"

Here we define the parameters for the applied stimulus protocol.

"},{"id":"named_2704","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/protocols/S1S2-restitution.xml#stimulus_protocol","title":"stimulus_protocol","created":{"id":"anon_1469","creator":{"id":"anon_1470","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1177329600000},"description":"

Here we define the S1-S2 stimulus protocol.

","importedAs":{"_reference":"named_2754"},"math":"named_2704.xml"},{"id":"named_2754","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/papers/nickerson-PBMB-2008/experiments/TNNP-S1S2.xml#cellmlelement--anonymous-650","title":"stimulus_protocol","created":{"id":"anon_1471","creator":{"id":"anon_1472","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1177329600000}},{"id":"named_2705","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/papers/nickerson-PBMB-2008/experiments/TNNP-S1S2.xml#additional_currents","title":"additional_currents","created":{"id":"anon_1473","creator":{"id":"anon_1474","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1177329600000},"description":"

Here we define any additional currents for use in the model, in this case\n just the stimulus current as an additional potassium current.

","math":"named_2705.xml"},{"id":"named_2706","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/papers/nickerson-PBMB-2008/experiments/TNNP.xml#interface","title":"interface","created":{"id":"anon_1475","creator":{"id":"anon_1476","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1176897600000},"description":"

The interface by which this model can be accessed.

","importedAs":{"_reference":"named_2772"}},{"id":"named_2772","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/papers/nickerson-PBMB-2008/experiments/TNNP-S1S2.xml#cellmlelement--anonymous-655","title":"base_model","created":{"id":"anon_1477","creator":{"id":"anon_1478","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1177329600000}},{"id":"named_2707","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/protocols/periodic-IStim.xml#stimulus_protocol","title":"stimulus_protocol","created":{"id":"anon_1479","creator":{"id":"anon_1480","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1154260800000},"description":"

Here we define the periodic stimulus protocol.

","importedAs":{"_reference":"named_2773"},"math":"named_2707.xml"},{"id":"named_2773","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/protocols/S1S2-restitution.xml#cellmlelement--anonymous-656","title":"periodicStimulus","created":{"id":"anon_1481","creator":{"id":"anon_1482","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1177329600000}},{"id":"named_2708","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/protocols/single-pulse-IStim.xml#stimulus_protocol","title":"stimulus_protocol","created":{"id":"anon_1483","creator":{"id":"anon_1484","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1154260800000},"description":"

Here we define the single pulse protocol.

","importedAs":{"_reference":"named_2781"},"math":"named_2708.xml"},{"id":"named_2781","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/protocols/S1S2-restitution.xml#cellmlelement--anonymous-664","title":"singlePulseStimulus","created":{"id":"anon_1485","creator":{"id":"anon_1486","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1177329600000}},{"id":"named_2709","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#interface","title":"interface","created":{"id":"anon_1487","creator":{"id":"anon_1488","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000},"description":"

Here we define the interface to this model, including all boundary\n and initial conditions that we expect to be set for a specific\n simulation. The interface is the root of the encapsulation hierarchy\n for this model.

","importedAs":{"_reference":"named_2787"}},{"id":"named_2787","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/papers/nickerson-PBMB-2008/experiments/TNNP.xml#cellmlelement--anonymous-670","title":"model","created":{"id":"anon_1489","creator":{"id":"anon_1490","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1176897600000}},{"id":"named_2710","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/variable_values.xml#initial_conditions","title":"initial_conditions","created":{"id":"anon_1491","creator":{"id":"anon_1492","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1161082800000},"description":"

The default initial conditions.

","importedAs":{"_reference":"named_2788"}},{"id":"named_2788","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/papers/nickerson-PBMB-2008/experiments/TNNP.xml#cellmlelement--anonymous-671","title":"default_initial_conditions","created":{"id":"anon_1493","creator":{"id":"anon_1494","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1176897600000}},{"id":"named_2711","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/variable_values.xml#parameters","title":"parameters","created":{"id":"anon_1495","creator":{"id":"anon_1496","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1161082800000},"description":"

The default model parameters.

","importedAs":{"_reference":"named_2789"}},{"id":"named_2789","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/papers/nickerson-PBMB-2008/experiments/TNNP.xml#cellmlelement--anonymous-672","title":"default_parameters","created":{"id":"anon_1497","creator":{"id":"anon_1498","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1176897600000}},{"id":"named_2712","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Vm.xml#membrane_potential","title":"membrane_potential","created":{"id":"anon_1499","creator":{"id":"anon_1500","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1179057600000},"description":"

The component which defines the membrane potential and specifies\n its kinetics.

","importedAs":{"_reference":"named_2790"},"math":"named_2712.xml"},{"id":"named_2790","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-673","title":"membrane_potential","created":{"id":"anon_1501","creator":{"id":"anon_1502","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2713","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/total_current.xml#total_membrane_current","title":"total_membrane_current","created":{"id":"anon_1503","creator":{"id":"anon_1504","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1179057600000},"importedAs":{"_reference":"named_2797"},"math":"named_2713.xml"},{"id":"named_2797","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-679","title":"total_membrane_current","created":{"id":"anon_1505","creator":{"id":"anon_1506","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2714","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/ion_fluxes.xml#K_flux","title":"K_flux","created":{"id":"anon_1507","creator":{"id":"anon_1508","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1179144000000},"importedAs":{"_reference":"named_2827"},"math":"named_2714.xml"},{"id":"named_2827","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-705","title":"K_flux","created":{"id":"anon_1509","creator":{"id":"anon_1510","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2715","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/ion_fluxes.xml#Na_flux","title":"Na_flux","created":{"id":"anon_1511","creator":{"id":"anon_1512","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1179144000000},"importedAs":{"_reference":"named_2841"},"math":"named_2715.xml"},{"id":"named_2841","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-718","title":"Na_flux","created":{"id":"anon_1513","creator":{"id":"anon_1514","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2716","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/ion_fluxes.xml#Ca_flux","title":"Ca_flux","created":{"id":"anon_1515","creator":{"id":"anon_1516","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1179144000000},"importedAs":{"_reference":"named_2852"},"math":"named_2716.xml"},{"id":"named_2852","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-728","title":"Ca_flux","created":{"id":"anon_1517","creator":{"id":"anon_1518","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2717","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/ion_fluxes.xml#Ca_SR_flux","title":"Ca_SR_flux","created":{"id":"anon_1519","creator":{"id":"anon_1520","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1179144000000},"importedAs":{"_reference":"named_2863"},"math":"named_2717.xml"},{"id":"named_2863","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-738","title":"Ca_SR_flux","created":{"id":"anon_1521","creator":{"id":"anon_1522","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2718","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/INa.xml#INa","title":"INa","created":{"id":"anon_1523","creator":{"id":"anon_1524","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104058800000},"description":"

Here we calculate the fast sodium current. We expect the time, membrane\n potential, reversal potential and conductance to be set externally, and\n we provide access to the gating variables and the calculated current. This\n component encapsulates all others in this model.

","importedAs":{"_reference":"named_2873"},"math":"named_2718.xml"},{"id":"named_2873","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-745","title":"INa","created":{"id":"anon_1525","creator":{"id":"anon_1526","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2719","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IK1.xml#IK1","title":"IK1","created":{"id":"anon_1527","creator":{"id":"anon_1528","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Here we calculate the inward rectifier current. We expect \n the time, membrane potential, reversal potential and conductance \n to be set externally, and we provide access to the gating \n variables and the calculated current. This component encapsulates\n all others in this model.

","importedAs":{"_reference":"named_2885"},"math":"named_2719.xml"},{"id":"named_2885","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-757","title":"IK1","created":{"id":"anon_1529","creator":{"id":"anon_1530","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2720","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Ito-components.xml#current","title":"current","created":{"id":"anon_1531","creator":{"id":"anon_1532","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104231600000},"description":"

Here we specify the current calculation equation as it\n is shared between the versions of the channel.

","importedAs":{"_reference":"named_2895"},"math":"named_2720.xml"},{"id":"named_2895","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Ito-epi.xml#cellmlelement--anonymous-767","title":"Ito","created":{"id":"anon_1533","creator":{"id":"anon_1534","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104231600000},"importedAs":{"_reference":"named_2904"}},{"id":"named_2904","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-776","title":"Ito","created":{"id":"anon_1535","creator":{"id":"anon_1536","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2721","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IKr.xml#IKr","title":"IKr","created":{"id":"anon_1537","creator":{"id":"anon_1538","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Here we calculate the rapid delayed rectifier current. We expect \n the time, membrane potential, reversal potential and conductance \n to be set externally, and we provide access to the gating \n variables and the calculated current. This component encapsulates\n all others in this model.

","importedAs":{"_reference":"named_2905"},"math":"named_2721.xml"},{"id":"named_2905","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-777","title":"IKr","created":{"id":"anon_1539","creator":{"id":"anon_1540","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2722","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IKs.xml#IKs","title":"IKs","created":{"id":"anon_1541","creator":{"id":"anon_1542","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104058800000},"description":"

Here we calculate the slow delayed rectifier current. We expect \n the time, membrane potential, reversal potential and conductance \n to be set externally, and we provide access to the gating \n variables and the calculated current. This component encapsulates\n all others in this model.

","importedAs":{"_reference":"named_2915"},"math":"named_2722.xml"},{"id":"named_2915","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-787","title":"IKs","created":{"id":"anon_1543","creator":{"id":"anon_1544","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2723","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/INaK.xml#INaK","title":"INaK","created":{"id":"anon_1545","creator":{"id":"anon_1546","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Here we calculate the sodium potassium pump current.

","importedAs":{"_reference":"named_2923"},"math":"named_2723.xml"},{"id":"named_2923","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-795","title":"INaK","created":{"id":"anon_1547","creator":{"id":"anon_1548","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2724","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IpK.xml#IpK","title":"IpK","created":{"id":"anon_1549","creator":{"id":"anon_1550","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Here we calculate the plateau potassium current.

","importedAs":{"_reference":"named_2939"},"math":"named_2724.xml"},{"id":"named_2939","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-811","title":"IpK","created":{"id":"anon_1551","creator":{"id":"anon_1552","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2725","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IbNa.xml#IbNa","title":"IbNa","created":{"id":"anon_1553","creator":{"id":"anon_1554","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Here we calculate the background sodium current.

","importedAs":{"_reference":"named_2944"},"math":"named_2725.xml"},{"id":"named_2944","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-816","title":"IbNa","created":{"id":"anon_1555","creator":{"id":"anon_1556","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2726","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/ICaL.xml#ICaL","title":"ICaL","created":{"id":"anon_1557","creator":{"id":"anon_1558","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104231600000},"description":"

Here we calculate the L-type calcium current. We expect the time, membrane\n potential, and conductance to be set externally, and\n we provide access to the gating variables and the calculated current. This\n component encapsulates all others in this model.

","importedAs":{"_reference":"named_2949"},"math":"named_2726.xml"},{"id":"named_2949","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-821","title":"ICaL","created":{"id":"anon_1559","creator":{"id":"anon_1560","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2727","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IpCa.xml#IpCa","title":"IpCa","created":{"id":"anon_1561","creator":{"id":"anon_1562","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Here we calculate the plateau calcium current. Added\n the unit multiplier to get dimensional consistency.

","importedAs":{"_reference":"named_2967"},"math":"named_2727.xml"},{"id":"named_2967","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-839","title":"IpCa","created":{"id":"anon_1563","creator":{"id":"anon_1564","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2728","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/INaCa.xml#INaCa","title":"INaCa","created":{"id":"anon_1565","creator":{"id":"anon_1566","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Here we calculate the sodium calcium exchanger current.

","importedAs":{"_reference":"named_2973"},"math":"named_2728.xml"},{"id":"named_2973","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-845","title":"INaCa","created":{"id":"anon_1567","creator":{"id":"anon_1568","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2729","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IbCa.xml#IbCa","title":"IbCa","created":{"id":"anon_1569","creator":{"id":"anon_1570","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Here we calculate the background calcium current.

","importedAs":{"_reference":"named_2995"},"math":"named_2729.xml"},{"id":"named_2995","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-867","title":"IbCa","created":{"id":"anon_1571","creator":{"id":"anon_1572","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2730","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/common/reversal_potential.xml#one_ion","title":"one_ion","created":{"id":"anon_1573","creator":{"id":"anon_1574","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Bioengineering Institute, The University of Auckland"},"created":1104058800000},"description":"

Calculate the Nernst reversal potential for one ionic specie. We \n expect the temperature, valence and ionic concentrations to be \n defined by the model importing this component. We make the gas \n and Faraday's constants available for others to use.

","importedAs":{"_reference":"named_3001"},"math":"named_2730.xml"},{"id":"named_3001","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-873","title":"ENa","created":{"id":"anon_1575","creator":{"id":"anon_1576","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2731","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/common/reversal_potential.xml#one_ion","title":"one_ion","created":{"id":"anon_1577","creator":{"id":"anon_1578","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Bioengineering Institute, The University of Auckland"},"created":1104058800000},"description":"

Calculate the Nernst reversal potential for one ionic specie. We \n expect the temperature, valence and ionic concentrations to be \n defined by the model importing this component. We make the gas \n and Faraday's constants available for others to use.

","importedAs":{"_reference":"named_3007"},"math":"named_2731.xml"},{"id":"named_3007","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-879","title":"EK","created":{"id":"anon_1579","creator":{"id":"anon_1580","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2732","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/common/reversal_potential.xml#one_ion","title":"one_ion","created":{"id":"anon_1581","creator":{"id":"anon_1582","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Bioengineering Institute, The University of Auckland"},"created":1104058800000},"description":"

Calculate the Nernst reversal potential for one ionic specie. We \n expect the temperature, valence and ionic concentrations to be \n defined by the model importing this component. We make the gas \n and Faraday's constants available for others to use.

","importedAs":{"_reference":"named_3015"},"math":"named_2732.xml"},{"id":"named_3015","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-887","title":"ECa","created":{"id":"anon_1583","creator":{"id":"anon_1584","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2733","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/common/reversal_potential.xml#two_ions","title":"two_ions","created":{"id":"anon_1585","creator":{"id":"anon_1586","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Bioengineering Institute, The University of Auckland"},"created":1104058800000},"description":"

Calculate the Nernst reversal potential for two ionic species,\n not sure how general this is but a few different models use it.\n We expect the temperature, valence, modifiers and ionic \n concentrations to be defined by the model importing this \n component. We make the gas and Faraday's constants available for\n others to use.

","importedAs":{"_reference":"named_3021"},"math":"named_2733.xml"},{"id":"named_3021","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-893","title":"EKs","created":{"id":"anon_1587","creator":{"id":"anon_1588","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2734","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Nai.xml#sodium_dynamics","title":"sodium_dynamics","created":{"id":"anon_1589","creator":{"id":"anon_1590","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

The intracellular sodium dynamics.

","importedAs":{"_reference":"named_3034"},"math":"named_2734.xml"},{"id":"named_3034","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-906","title":"Nai","created":{"id":"anon_1591","creator":{"id":"anon_1592","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2735","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Ki.xml#potassium_dynamics","title":"potassium_dynamics","created":{"id":"anon_1593","creator":{"id":"anon_1594","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

The intracellular potassium dynamics.

","importedAs":{"_reference":"named_3037"},"math":"named_2735.xml"},{"id":"named_3037","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-909","title":"Ki","created":{"id":"anon_1595","creator":{"id":"anon_1596","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2736","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Cai.xml#calcium_dynamics","title":"calcium_dynamics","created":{"id":"anon_1597","creator":{"id":"anon_1598","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

The intracellular calcium dynamics.

","importedAs":{"_reference":"named_3040"},"math":"named_2736.xml"},{"id":"named_3040","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-912","title":"Cai","created":{"id":"anon_1599","creator":{"id":"anon_1600","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2737","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Jleak.xml#Jleak","title":"Jleak","created":{"id":"anon_1601","creator":{"id":"anon_1602","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Calculate the calcium leakage flux from the SR.

","importedAs":{"_reference":"named_3066"},"math":"named_2737.xml"},{"id":"named_3066","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-938","title":"Jleak","created":{"id":"anon_1603","creator":{"id":"anon_1604","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2738","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Jup.xml#Jup","title":"Jup","created":{"id":"anon_1605","creator":{"id":"anon_1606","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Calculate the calcium uptake flux from the SR.

","importedAs":{"_reference":"named_3071"},"math":"named_2738.xml"},{"id":"named_3071","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-943","title":"Jup","created":{"id":"anon_1607","creator":{"id":"anon_1608","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2739","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Jrel.xml#Jrel","title":"Jrel","created":{"id":"anon_1609","creator":{"id":"anon_1610","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Calculation of the calcium release flux from the SR.

","importedAs":{"_reference":"named_3077"},"math":"named_2739.xml"},{"id":"named_3077","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-949","title":"Jrel","created":{"id":"anon_1611","creator":{"id":"anon_1612","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_2740","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/INa.xml#m_gate","title":"m_gate","created":{"id":"anon_1613","creator":{"id":"anon_1614","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104058800000},"description":"

The activation gate. Here we specify the standard Hodgkin-Huxley\n type kinetics for the gate and also calculate the steady-state\n m_infinity and tau_m values.

","math":"named_2740.xml"},{"id":"named_2741","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/INa.xml#h_gate","title":"h_gate","created":{"id":"anon_1615","creator":{"id":"anon_1616","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104058800000},"description":"

The fast inactivation gate. Here we specify the standard Hodgkin-Huxley\n type kinetics for the gate and also calculate the steady-state\n h_infinity and tau_h values.

","math":"named_2741.xml"},{"id":"named_2742","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/INa.xml#j_gate","title":"j_gate","created":{"id":"anon_1617","creator":{"id":"anon_1618","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104058800000},"description":"

The slow inactivation gate. Here we specify the standard Hodgkin-Huxley\n type kinetics for the gate and also calculate the steady-state\n j_infinity and tau_j values.

","math":"named_2742.xml"},{"id":"named_2743","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IK1.xml#K1_gate","title":"K1_gate","created":{"id":"anon_1619","creator":{"id":"anon_1620","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

The activation gate kinetics.

","math":"named_2743.xml"},{"id":"named_2744","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Ito-components.xml#r_gate","title":"r_gate","created":{"id":"anon_1621","creator":{"id":"anon_1622","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104231600000},"description":"

The activation gate for the transient outward current in the\n ten Tusscher model is common between cell types.

","importedAs":{"_reference":"named_3110"},"math":"named_2744.xml"},{"id":"named_3110","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Ito-epi.xml#cellmlelement--anonymous-982","title":"r_gate","created":{"id":"anon_1623","creator":{"id":"anon_1624","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104231600000}},{"id":"named_2745","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Ito-components.xml#epi_M_s_gate","title":"epi_M_s_gate","created":{"id":"anon_1625","creator":{"id":"anon_1626","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104231600000},"description":"

The epicardial and M cell version of the inactivation gating\n kinetics of the transient outward current.

","importedAs":{"_reference":"named_3115"},"math":"named_2745.xml"},{"id":"named_3115","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Ito-epi.xml#cellmlelement--anonymous-987","title":"s_gate","created":{"id":"anon_1627","creator":{"id":"anon_1628","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104231600000}},{"id":"named_2746","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IKr.xml#Xr1_gate","title":"Xr1_gate","created":{"id":"anon_1629","creator":{"id":"anon_1630","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

The activation gating kinetics.

","math":"named_2746.xml"},{"id":"named_2747","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IKr.xml#Xr2_gate","title":"Xr2_gate","created":{"id":"anon_1631","creator":{"id":"anon_1632","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

The inactivation gating kinetics.

","math":"named_2747.xml"},{"id":"named_2748","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IKs.xml#Xs_gate","title":"Xs_gate","created":{"id":"anon_1633","creator":{"id":"anon_1634","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104058800000},"description":"

The activation gating kinetics for the IKs current.

","math":"named_2748.xml"},{"id":"named_2749","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/ICaL.xml#d_gate","title":"d_gate","created":{"id":"anon_1635","creator":{"id":"anon_1636","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104231600000},"description":"

The voltage dependent activation gate.

","math":"named_2749.xml"},{"id":"named_2750","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/ICaL.xml#f_gate","title":"f_gate","created":{"id":"anon_1637","creator":{"id":"anon_1638","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104231600000},"description":"

The voltage dependent inactivation gate.

","math":"named_2750.xml"},{"id":"named_2751","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/ICaL.xml#fCa_gate","title":"fCa_gate","created":{"id":"anon_1639","creator":{"id":"anon_1640","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104231600000},"description":"

The calcium dependent inactivation gate.

","math":"named_2751.xml"},{"id":"named_2752","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Jrel.xml#g_gate","title":"g_gate","created":{"id":"anon_1641","creator":{"id":"anon_1642","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

The calcium dependent inactivation gate for\n calcium release from the SR.

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The actual definition of the time variable.

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University of Singapore"},"created":1177329600000}},{"id":"named_3364","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/papers/nickerson-PBMB-2008/experiments/TNNP-S1S2.xml#time","title":"time","created":{"id":"anon_1651","creator":{"id":"anon_1652","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1177329600000},"description":"

The actual definition of the time variable.

"},{"id":"named_3365","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/papers/nickerson-PBMB-2008/experiments/TNNP-S1S2.xml#stimulus_protocol_params","title":"stimulus_protocol_params","created":{"id":"anon_1653","creator":{"id":"anon_1654","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1177329600000},"description":"

Here we define the parameters for the applied stimulus protocol.

"},{"id":"named_3366","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/protocols/S1S2-restitution.xml#stimulus_protocol","title":"stimulus_protocol","created":{"id":"anon_1655","creator":{"id":"anon_1656","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1177329600000},"description":"

Here we define the S1-S2 stimulus protocol.

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Here we define any additional currents for use in the model, in this case\n just the stimulus current as an additional potassium current.

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The interface by which this model can be accessed.

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Here we define the periodic stimulus protocol.

","importedAs":{"_reference":"named_3435"},"math":"named_3369.xml"},{"id":"named_3435","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/protocols/S1S2-restitution.xml#cellmlelement--anonymous-1172","title":"periodicStimulus","created":{"id":"anon_1667","creator":{"id":"anon_1668","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1177329600000}},{"id":"named_3370","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/protocols/single-pulse-IStim.xml#stimulus_protocol","title":"stimulus_protocol","created":{"id":"anon_1669","creator":{"id":"anon_1670","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1154260800000},"description":"

Here we define the single pulse protocol.

","importedAs":{"_reference":"named_3443"},"math":"named_3370.xml"},{"id":"named_3443","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/protocols/S1S2-restitution.xml#cellmlelement--anonymous-1180","title":"singlePulseStimulus","created":{"id":"anon_1671","creator":{"id":"anon_1672","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1177329600000}},{"id":"named_3371","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#interface","title":"interface","created":{"id":"anon_1673","creator":{"id":"anon_1674","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000},"description":"

Here we define the interface to this model, including all boundary\n and initial conditions that we expect to be set for a specific\n simulation. The interface is the root of the encapsulation hierarchy\n for this model.

","importedAs":{"_reference":"named_3449"}},{"id":"named_3449","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/papers/nickerson-PBMB-2008/experiments/TNNP.xml#cellmlelement--anonymous-1186","title":"model","created":{"id":"anon_1675","creator":{"id":"anon_1676","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1176897600000}},{"id":"named_3372","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/variable_values.xml#initial_conditions","title":"initial_conditions","created":{"id":"anon_1677","creator":{"id":"anon_1678","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1161082800000},"description":"

The default initial conditions.

","importedAs":{"_reference":"named_3450"}},{"id":"named_3450","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/papers/nickerson-PBMB-2008/experiments/TNNP.xml#cellmlelement--anonymous-1187","title":"default_initial_conditions","created":{"id":"anon_1679","creator":{"id":"anon_1680","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1176897600000}},{"id":"named_3373","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/variable_values.xml#parameters","title":"parameters","created":{"id":"anon_1681","creator":{"id":"anon_1682","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1161082800000},"description":"

The default model parameters.

","importedAs":{"_reference":"named_3451"}},{"id":"named_3451","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/papers/nickerson-PBMB-2008/experiments/TNNP.xml#cellmlelement--anonymous-1188","title":"default_parameters","created":{"id":"anon_1683","creator":{"id":"anon_1684","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1176897600000}},{"id":"named_3374","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Vm.xml#membrane_potential","title":"membrane_potential","created":{"id":"anon_1685","creator":{"id":"anon_1686","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1179057600000},"description":"

The component which defines the membrane potential and specifies\n its kinetics.

","importedAs":{"_reference":"named_3452"},"math":"named_3374.xml"},{"id":"named_3452","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1189","title":"membrane_potential","created":{"id":"anon_1687","creator":{"id":"anon_1688","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3375","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/total_current.xml#total_membrane_current","title":"total_membrane_current","created":{"id":"anon_1689","creator":{"id":"anon_1690","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1179057600000},"importedAs":{"_reference":"named_3459"},"math":"named_3375.xml"},{"id":"named_3459","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1195","title":"total_membrane_current","created":{"id":"anon_1691","creator":{"id":"anon_1692","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3376","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/ion_fluxes.xml#K_flux","title":"K_flux","created":{"id":"anon_1693","creator":{"id":"anon_1694","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1179144000000},"importedAs":{"_reference":"named_3489"},"math":"named_3376.xml"},{"id":"named_3489","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1221","title":"K_flux","created":{"id":"anon_1695","creator":{"id":"anon_1696","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3377","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/ion_fluxes.xml#Na_flux","title":"Na_flux","created":{"id":"anon_1697","creator":{"id":"anon_1698","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1179144000000},"importedAs":{"_reference":"named_3503"},"math":"named_3377.xml"},{"id":"named_3503","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1234","title":"Na_flux","created":{"id":"anon_1699","creator":{"id":"anon_1700","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3378","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/ion_fluxes.xml#Ca_flux","title":"Ca_flux","created":{"id":"anon_1701","creator":{"id":"anon_1702","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1179144000000},"importedAs":{"_reference":"named_3514"},"math":"named_3378.xml"},{"id":"named_3514","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1244","title":"Ca_flux","created":{"id":"anon_1703","creator":{"id":"anon_1704","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3379","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/ion_fluxes.xml#Ca_SR_flux","title":"Ca_SR_flux","created":{"id":"anon_1705","creator":{"id":"anon_1706","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1179144000000},"importedAs":{"_reference":"named_3525"},"math":"named_3379.xml"},{"id":"named_3525","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1254","title":"Ca_SR_flux","created":{"id":"anon_1707","creator":{"id":"anon_1708","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3380","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/INa.xml#INa","title":"INa","created":{"id":"anon_1709","creator":{"id":"anon_1710","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104058800000},"description":"

Here we calculate the fast sodium current. We expect the time, membrane\n potential, reversal potential and conductance to be set externally, and\n we provide access to the gating variables and the calculated current. This\n component encapsulates all others in this model.

","importedAs":{"_reference":"named_3535"},"math":"named_3380.xml"},{"id":"named_3535","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1261","title":"INa","created":{"id":"anon_1711","creator":{"id":"anon_1712","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3381","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IK1.xml#IK1","title":"IK1","created":{"id":"anon_1713","creator":{"id":"anon_1714","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Here we calculate the inward rectifier current. We expect \n the time, membrane potential, reversal potential and conductance \n to be set externally, and we provide access to the gating \n variables and the calculated current. This component encapsulates\n all others in this model.

","importedAs":{"_reference":"named_3547"},"math":"named_3381.xml"},{"id":"named_3547","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1273","title":"IK1","created":{"id":"anon_1715","creator":{"id":"anon_1716","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3382","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Ito-components.xml#current","title":"current","created":{"id":"anon_1717","creator":{"id":"anon_1718","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104231600000},"description":"

Here we specify the current calculation equation as it\n is shared between the versions of the channel.

","importedAs":{"_reference":"named_3557"},"math":"named_3382.xml"},{"id":"named_3557","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Ito-epi.xml#cellmlelement--anonymous-1283","title":"Ito","created":{"id":"anon_1719","creator":{"id":"anon_1720","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104231600000},"importedAs":{"_reference":"named_3566"}},{"id":"named_3566","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1292","title":"Ito","created":{"id":"anon_1721","creator":{"id":"anon_1722","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3383","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IKr.xml#IKr","title":"IKr","created":{"id":"anon_1723","creator":{"id":"anon_1724","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Here we calculate the rapid delayed rectifier current. We expect \n the time, membrane potential, reversal potential and conductance \n to be set externally, and we provide access to the gating \n variables and the calculated current. This component encapsulates\n all others in this model.

","importedAs":{"_reference":"named_3567"},"math":"named_3383.xml"},{"id":"named_3567","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1293","title":"IKr","created":{"id":"anon_1725","creator":{"id":"anon_1726","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3384","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IKs.xml#IKs","title":"IKs","created":{"id":"anon_1727","creator":{"id":"anon_1728","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104058800000},"description":"

Here we calculate the slow delayed rectifier current. We expect \n the time, membrane potential, reversal potential and conductance \n to be set externally, and we provide access to the gating \n variables and the calculated current. This component encapsulates\n all others in this model.

","importedAs":{"_reference":"named_3577"},"math":"named_3384.xml"},{"id":"named_3577","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1303","title":"IKs","created":{"id":"anon_1729","creator":{"id":"anon_1730","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3385","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/INaK.xml#INaK","title":"INaK","created":{"id":"anon_1731","creator":{"id":"anon_1732","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Here we calculate the sodium potassium pump current.

","importedAs":{"_reference":"named_3585"},"math":"named_3385.xml"},{"id":"named_3585","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1311","title":"INaK","created":{"id":"anon_1733","creator":{"id":"anon_1734","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3386","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IpK.xml#IpK","title":"IpK","created":{"id":"anon_1735","creator":{"id":"anon_1736","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Here we calculate the plateau potassium current.

","importedAs":{"_reference":"named_3601"},"math":"named_3386.xml"},{"id":"named_3601","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1327","title":"IpK","created":{"id":"anon_1737","creator":{"id":"anon_1738","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3387","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IbNa.xml#IbNa","title":"IbNa","created":{"id":"anon_1739","creator":{"id":"anon_1740","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Here we calculate the background sodium current.

","importedAs":{"_reference":"named_3606"},"math":"named_3387.xml"},{"id":"named_3606","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1332","title":"IbNa","created":{"id":"anon_1741","creator":{"id":"anon_1742","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3388","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/ICaL.xml#ICaL","title":"ICaL","created":{"id":"anon_1743","creator":{"id":"anon_1744","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104231600000},"description":"

Here we calculate the L-type calcium current. We expect the time, membrane\n potential, and conductance to be set externally, and\n we provide access to the gating variables and the calculated current. This\n component encapsulates all others in this model.

","importedAs":{"_reference":"named_3611"},"math":"named_3388.xml"},{"id":"named_3611","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1337","title":"ICaL","created":{"id":"anon_1745","creator":{"id":"anon_1746","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3389","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IpCa.xml#IpCa","title":"IpCa","created":{"id":"anon_1747","creator":{"id":"anon_1748","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Here we calculate the plateau calcium current. Added\n the unit multiplier to get dimensional consistency.

","importedAs":{"_reference":"named_3629"},"math":"named_3389.xml"},{"id":"named_3629","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1355","title":"IpCa","created":{"id":"anon_1749","creator":{"id":"anon_1750","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3390","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/INaCa.xml#INaCa","title":"INaCa","created":{"id":"anon_1751","creator":{"id":"anon_1752","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Here we calculate the sodium calcium exchanger current.

","importedAs":{"_reference":"named_3635"},"math":"named_3390.xml"},{"id":"named_3635","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1361","title":"INaCa","created":{"id":"anon_1753","creator":{"id":"anon_1754","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3391","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IbCa.xml#IbCa","title":"IbCa","created":{"id":"anon_1755","creator":{"id":"anon_1756","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Here we calculate the background calcium current.

","importedAs":{"_reference":"named_3657"},"math":"named_3391.xml"},{"id":"named_3657","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1383","title":"IbCa","created":{"id":"anon_1757","creator":{"id":"anon_1758","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3392","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/common/reversal_potential.xml#one_ion","title":"one_ion","created":{"id":"anon_1759","creator":{"id":"anon_1760","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Bioengineering Institute, The University of Auckland"},"created":1104058800000},"description":"

Calculate the Nernst reversal potential for one ionic specie. We \n expect the temperature, valence and ionic concentrations to be \n defined by the model importing this component. We make the gas \n and Faraday's constants available for others to use.

","importedAs":{"_reference":"named_3663"},"math":"named_3392.xml"},{"id":"named_3663","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1389","title":"ENa","created":{"id":"anon_1761","creator":{"id":"anon_1762","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3393","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/common/reversal_potential.xml#one_ion","title":"one_ion","created":{"id":"anon_1763","creator":{"id":"anon_1764","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Bioengineering Institute, The University of Auckland"},"created":1104058800000},"description":"

Calculate the Nernst reversal potential for one ionic specie. We \n expect the temperature, valence and ionic concentrations to be \n defined by the model importing this component. We make the gas \n and Faraday's constants available for others to use.

","importedAs":{"_reference":"named_3669"},"math":"named_3393.xml"},{"id":"named_3669","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1395","title":"EK","created":{"id":"anon_1765","creator":{"id":"anon_1766","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3394","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/common/reversal_potential.xml#one_ion","title":"one_ion","created":{"id":"anon_1767","creator":{"id":"anon_1768","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Bioengineering Institute, The University of Auckland"},"created":1104058800000},"description":"

Calculate the Nernst reversal potential for one ionic specie. We \n expect the temperature, valence and ionic concentrations to be \n defined by the model importing this component. We make the gas \n and Faraday's constants available for others to use.

","importedAs":{"_reference":"named_3677"},"math":"named_3394.xml"},{"id":"named_3677","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1403","title":"ECa","created":{"id":"anon_1769","creator":{"id":"anon_1770","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3395","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/common/reversal_potential.xml#two_ions","title":"two_ions","created":{"id":"anon_1771","creator":{"id":"anon_1772","type":"person","name":"David Nickerson","email":"d.nickerson@auckland.ac.nz","organisation":"Bioengineering Institute, The University of Auckland"},"created":1104058800000},"description":"

Calculate the Nernst reversal potential for two ionic species,\n not sure how general this is but a few different models use it.\n We expect the temperature, valence, modifiers and ionic \n concentrations to be defined by the model importing this \n component. We make the gas and Faraday's constants available for\n others to use.

","importedAs":{"_reference":"named_3683"},"math":"named_3395.xml"},{"id":"named_3683","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1409","title":"EKs","created":{"id":"anon_1773","creator":{"id":"anon_1774","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3396","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Nai.xml#sodium_dynamics","title":"sodium_dynamics","created":{"id":"anon_1775","creator":{"id":"anon_1776","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

The intracellular sodium dynamics.

","importedAs":{"_reference":"named_3696"},"math":"named_3396.xml"},{"id":"named_3696","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1422","title":"Nai","created":{"id":"anon_1777","creator":{"id":"anon_1778","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3397","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Ki.xml#potassium_dynamics","title":"potassium_dynamics","created":{"id":"anon_1779","creator":{"id":"anon_1780","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

The intracellular potassium dynamics.

","importedAs":{"_reference":"named_3699"},"math":"named_3397.xml"},{"id":"named_3699","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1425","title":"Ki","created":{"id":"anon_1781","creator":{"id":"anon_1782","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3398","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Cai.xml#calcium_dynamics","title":"calcium_dynamics","created":{"id":"anon_1783","creator":{"id":"anon_1784","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

The intracellular calcium dynamics.

","importedAs":{"_reference":"named_3702"},"math":"named_3398.xml"},{"id":"named_3702","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1428","title":"Cai","created":{"id":"anon_1785","creator":{"id":"anon_1786","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3399","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Jleak.xml#Jleak","title":"Jleak","created":{"id":"anon_1787","creator":{"id":"anon_1788","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Calculate the calcium leakage flux from the SR.

","importedAs":{"_reference":"named_3728"},"math":"named_3399.xml"},{"id":"named_3728","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1454","title":"Jleak","created":{"id":"anon_1789","creator":{"id":"anon_1790","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3400","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Jup.xml#Jup","title":"Jup","created":{"id":"anon_1791","creator":{"id":"anon_1792","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Calculate the calcium uptake flux from the SR.

","importedAs":{"_reference":"named_3733"},"math":"named_3400.xml"},{"id":"named_3733","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1459","title":"Jup","created":{"id":"anon_1793","creator":{"id":"anon_1794","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3401","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Jrel.xml#Jrel","title":"Jrel","created":{"id":"anon_1795","creator":{"id":"anon_1796","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

Calculation of the calcium release flux from the SR.

","importedAs":{"_reference":"named_3739"},"math":"named_3401.xml"},{"id":"named_3739","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/2004_tenTusscher_noble_noble_panfilov-epi.xml#cellmlelement--anonymous-1465","title":"Jrel","created":{"id":"anon_1797","creator":{"id":"anon_1798","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104404400000}},{"id":"named_3402","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/INa.xml#m_gate","title":"m_gate","created":{"id":"anon_1799","creator":{"id":"anon_1800","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104058800000},"description":"

The activation gate. Here we specify the standard Hodgkin-Huxley\n type kinetics for the gate and also calculate the steady-state\n m_infinity and tau_m values.

","math":"named_3402.xml"},{"id":"named_3403","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/INa.xml#h_gate","title":"h_gate","created":{"id":"anon_1801","creator":{"id":"anon_1802","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104058800000},"description":"

The fast inactivation gate. Here we specify the standard Hodgkin-Huxley\n type kinetics for the gate and also calculate the steady-state\n h_infinity and tau_h values.

","math":"named_3403.xml"},{"id":"named_3404","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/INa.xml#j_gate","title":"j_gate","created":{"id":"anon_1803","creator":{"id":"anon_1804","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104058800000},"description":"

The slow inactivation gate. Here we specify the standard Hodgkin-Huxley\n type kinetics for the gate and also calculate the steady-state\n j_infinity and tau_j values.

","math":"named_3404.xml"},{"id":"named_3405","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IK1.xml#K1_gate","title":"K1_gate","created":{"id":"anon_1805","creator":{"id":"anon_1806","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

The activation gate kinetics.

","math":"named_3405.xml"},{"id":"named_3406","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Ito-components.xml#r_gate","title":"r_gate","created":{"id":"anon_1807","creator":{"id":"anon_1808","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104231600000},"description":"

The activation gate for the transient outward current in the\n ten Tusscher model is common between cell types.

","importedAs":{"_reference":"named_3772"},"math":"named_3406.xml"},{"id":"named_3772","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Ito-epi.xml#cellmlelement--anonymous-1498","title":"r_gate","created":{"id":"anon_1809","creator":{"id":"anon_1810","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104231600000}},{"id":"named_3407","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Ito-components.xml#epi_M_s_gate","title":"epi_M_s_gate","created":{"id":"anon_1811","creator":{"id":"anon_1812","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104231600000},"description":"

The epicardial and M cell version of the inactivation gating\n kinetics of the transient outward current.

","importedAs":{"_reference":"named_3777"},"math":"named_3407.xml"},{"id":"named_3777","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Ito-epi.xml#cellmlelement--anonymous-1503","title":"s_gate","created":{"id":"anon_1813","creator":{"id":"anon_1814","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104231600000}},{"id":"named_3408","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IKr.xml#Xr1_gate","title":"Xr1_gate","created":{"id":"anon_1815","creator":{"id":"anon_1816","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

The activation gating kinetics.

","math":"named_3408.xml"},{"id":"named_3409","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IKr.xml#Xr2_gate","title":"Xr2_gate","created":{"id":"anon_1817","creator":{"id":"anon_1818","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

The inactivation gating kinetics.

","math":"named_3409.xml"},{"id":"named_3410","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/IKs.xml#Xs_gate","title":"Xs_gate","created":{"id":"anon_1819","creator":{"id":"anon_1820","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104058800000},"description":"

The activation gating kinetics for the IKs current.

","math":"named_3410.xml"},{"id":"named_3411","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/ICaL.xml#d_gate","title":"d_gate","created":{"id":"anon_1821","creator":{"id":"anon_1822","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104231600000},"description":"

The voltage dependent activation gate.

","math":"named_3411.xml"},{"id":"named_3412","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/ICaL.xml#f_gate","title":"f_gate","created":{"id":"anon_1823","creator":{"id":"anon_1824","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104231600000},"description":"

The voltage dependent inactivation gate.

","math":"named_3412.xml"},{"id":"named_3413","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/ICaL.xml#fCa_gate","title":"fCa_gate","created":{"id":"anon_1825","creator":{"id":"anon_1826","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104231600000},"description":"

The calcium dependent inactivation gate.

","math":"named_3413.xml"},{"id":"named_3414","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/models/2004_tenTusscher-version-2/components/Jrel.xml#g_gate","title":"g_gate","created":{"id":"anon_1827","creator":{"id":"anon_1828","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1104318000000},"description":"

The calcium dependent inactivation gate for\n calcium release from the SR.

","math":"named_3414.xml"},{"id":"named_3418","type":"variable","uri":"http://models.cellml.org/workspace/a1/@@rawfile/fa41916b2ca31572b372f793380ea141042446ac/tutorial/TNNP-S1S2-600.xml#cellmlelement--anonymous-1167","name":"basicCycleLength","title":"basicCycleLength","initialValue":"1000","connectedVariables":[{"_reference":"named_3825"},{"_reference":"named_3419"},{"_reference":"named_3441"}],"units":"ms","usedIn":[["named_3366","named_3419"],["named_3369","named_3441"]]},{"id":"named_3825","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/papers/nickerson-PBMB-2008/experiments/TNNP-S1S2.xml#basicCycleLength","name":"basicCycleLength","title":"basicCycleLength","sourceVariable":{"_reference":"named_3418"},"units":"ms"},{"id":"named_3419","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/protocols/S1S2-restitution.xml#basicCycleLength","name":"basicCycleLength","title":"basicCycleLength","sourceVariable":{"_reference":"named_3418"},"units":"ms"},{"id":"named_3441","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/protocols/periodic-IStim.xml#cellmlelement--anonymous-1178","name":"stimPeriod","title":"stimPeriod","sourceVariable":{"_reference":"named_3418"},"units":"ms"},{"id":"named_3423","type":"variable","uri":"http://models.cellml.org/workspace/a1/@@rawfile/fa41916b2ca31572b372f793380ea141042446ac/tutorial/TNNP-S1S2-600.xml#cellmlelement--anonymous-1169","name":"S2Interval","title":"S2Interval","initialValue":"600","connectedVariables":[{"_reference":"named_3826"},{"_reference":"named_3424"}],"units":"ms","usedIn":[["named_3366","named_3424"]]},{"id":"named_3826","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/papers/nickerson-PBMB-2008/experiments/TNNP-S1S2.xml#S2Interval","name":"S2Interval","title":"S2Interval","sourceVariable":{"_reference":"named_3423"},"units":"ms"},{"id":"named_3424","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/cellml/protocols/S1S2-restitution.xml#S2Interval","name":"S2Interval","title":"S2Interval","sourceVariable":{"_reference":"named_3423"},"units":"ms"},{"id":"named_3428","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/papers/nickerson-PBMB-2008/experiments/TNNP-S1S2.xml#time","name":"time","title":"time","description":"

The actual definition of the time variable.

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The model importing this model is expected to define the time variable.

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