About
====================

Landing page for the channels contributing to the plateau potassium current (**Kp**).
   
This channel transports potassium ions across the plasma membrane according to the concentration gradient.

Model
===================
The below image shows the bond graph diagram of the channel operating under normal physiological conditions.

.. figure:: exposure/BG_Kp.png
   :width: 55%
   :align: center
   :alt: BG_Kp
   
   
Subfamilies
===================
The following list contains the known proteins which form the Kp current.

.. csv-table:: Variants within the human species
   :header: "Name", "Alias", Gene, Structure
   :widths: 7,7,7, 7

   KCNK2, TREK-1, "`Uniprot 2 <https://www.uniprot.org/uniprotkb/O95069/entry>`_", "`EBI 2 <https://www.ebi.ac.uk/pdbe-srv/view/entry/4TWK>`_"
   KCNK3, TASK-1, "`Uniprot 3 <https://www.uniprot.org/uniprotkb/O14649/entry>`_", "`EBI 3 <https://www.ebi.ac.uk/pdbe-srv/view/entry/6RV2>`_"


Literature
===================

.. csv-table:: For further reading
   :header: "Title", "Author"
   :widths: 30, 15   
   
   "`Potassium channels in the heart: structure, function and regulation <https://doi.org/10.1113%2FJP272864>`_", "Grandi et al."


Existing models 
===================

.. csv-table:: Link to other PMR workspaces or exposures
   :header: "Title", "Author"
   :widths: 30, 15
   
   "`BG_Kp <https://models.physiomeproject.org/workspace/825>`_", "S Fong" 
   "`Bond graph modelling of the cardiac action potential: Implications for drift and non-unique steady states^ <https://github.com/uomsystemsbiology/bond_graph_cardiac_AP>`_", "Pan et al."

   
Models denoted by [*] are not in bond graph form.
Models denoted by [^] are part of a whole cell model.