About this model
====================

:Original publication: `Kernik et al. (2019)`_:
  "A computational model of induced pluripotent stem-cell derived cardiomyocytes \
  incorporating experimental variability from multiple data sources" J  Physiol. 2019 Sep 1; 597(17): 4533-4564.

:DOI: https://dx.doi.org/10.1113%2FJP277724

.. _`Kernik et al. (2019)`: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767694/

**********
Figure 04
**********
Calcium current model 
*************************************

Current_Ica.cellml is the main CellML files which contains the formulation for L-type calcium current.
Its associated SED-ML file contains all the simulation settings.

To execute the code, all the files related to this channel need to be downloaded in a same folder:

1. Fig4_CaL.py
2. Current_Ica.cellml
3. Current_Ica.sedml
4. parameter_Ica.cellml
5. parameter.cellml
6. gating_Ica.cellml
7. unit.cellml

To reproduce Figure 4, save all the files to the same folder and 
execute the following script from the command line:

``$ cd [PathToThisFile]``

``$ [PathToOpenCOR]/pythonshell Fig4_CaL.py``


.. figure::  figures/Figure4_CaL.png
   :width: 85%
   :align: center
   :alt: Calcium current model 

A, L-type calcium current (ICaL) steady-state inactivation and activation 
curves with dataset-specific model optimized to experimental data. The L-type calcium 
model used in the baseline cellular model is shown in black. 
B, I-V curves for ICaL, C, time constants of ICaL activation gate. D, time 
constants of ICaL inactivation gate.