About this model
====================

:Original publication: `Kernik et al. (2019)`_:
  "A computational model of induced pluripotent stem-cell derived cardiomyocytes
  incorporating experimental variability from multiple data sources" J  Physiol. 2019 Sep 1; 597(17): 4533-4564.

:DOI: https://dx.doi.org/10.1113%2FJP277724

.. _`Kernik et al. (2019)`: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767694/

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Figure 05
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Rapid delayed rectifier potassium current (:math:`I_Kr`) model 
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Current_Ikr.cellml is the main CellML file which contains the formulation for the rapid delayed rectifier potassium current. Its associated SED-ML file contains all the simulation settings.

To execute the code, all the files related to this channel need to be downloaded in a same folder:

1. fig5_Kr.py
2. Current_Ikr.cellml
3. Current_Ikr.sedml
4. parameter_Ikr.cellml
5. parameter.cellml
6. gating_Ikr.cellml
7. unit.cellml

To reproduce Figure 5, save all the files to the same folder and 
execute the following script from the command line:

``$ cd [PathToThisFile]``

``$ [PathToOpenCOR]/pythonshell fig5_Kr.py``

.. figure::  figures/Figure5_Kr.png
   :width: 85%
   :align: center
   :alt: Rapid delayed rectifier potassium current model 

A, optimized activation with dataset-specific model fits. B, I-V curve, C, Time constant of :math:`I_Kr` activation gate. D,
Time constant of :math:`I_Kr` inactivation gate.