About this model
====================

:Original publication: `Kernik et al. (2019)`_:
  "A computational model of induced pluripotent stem-cell derived cardiomyocytes
  incorporating experimental variability from multiple data sources" J  Physiol. 2019 Sep 1; 597(17): 4533-4564.

:DOI: https://dx.doi.org/10.1113%2FJP277724

.. _`Kernik et al. (2019)`: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767694/

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Figure 06
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Transient outward potassium current (:math:`I_to`) model 
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Current_Ito.cellml is the main CellML file which contains the formulation for the transient outward current. Its associated SED-ML file contains all the simulation settings.

To execute the code, all the files related to this channel need to be downloaded in a same folder:

1. fig6_to.py
2. Current_Ito.cellml
3. Current_Ito.sedml
4. parameter_Ito.cellml
5. parameter.cellml
6. gating_Ito.cellml
7. unit.cellml

To reproduce Figure 6, save all the files to the same folder and 
execute the following script from the command line:

``$ cd [PathToThisFile]``

``$ [PathToOpenCOR]/pythonshell fig6_to.py``

.. figure::  figures/Figure6_to.png
   :width: 85%
   :align: center
   :alt: Transient outward potassium current model 

A, optimized activation with dataset-specific model fits. B. I-V curves, C, Time constant of :math:`I_to` activation gate. D,
Time constant of :math:`I_to` inactivation gate.