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        <changeAttribute target="/cellml:model/cellml:component[@name=&quot;NKE_BG_Env&quot;]/cellml:variable[@name=&quot;c_Nao&quot;]/@initial_value" newValue="140.0"/>
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      <leastSquareObjectiveFunction/>
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          <bounds lowerBound="0.01" upperBound="100000" scale="linear"/>
          <listOfExperimentReferences>
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          </listOfExperimentReferences>
        </adjustableParameter>
        <adjustableParameter id="NKE_BG_param_kappa_r6" initialValue="15" modelReference="NKE_BG_6_state_ATPNaZK_fit_pulseV" target="/cellml:model/cellml:component[@name=&quot;NKE_BG_param&quot;]/cellml:variable[@name=&quot;kappa_r6&quot;]/@initial_value">
          <bounds lowerBound="0.001" upperBound="1000" scale="linear"/>
          <listOfExperimentReferences>
            <experimentReference experimentId="fit_1"/>
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        </adjustableParameter>
        <adjustableParameter id="NKE_BG_param_kappa_r8" initialValue="2.3" modelReference="NKE_BG_6_state_ATPNaZK_fit_pulseV" target="/cellml:model/cellml:component[@name=&quot;NKE_BG_param&quot;]/cellml:variable[@name=&quot;kappa_r8&quot;]/@initial_value">
          <bounds lowerBound="0.01" upperBound="1000" scale="linear"/>
          <listOfExperimentReferences>
            <experimentReference experimentId="fit_1"/>
          </listOfExperimentReferences>
        </adjustableParameter>
        <adjustableParameter id="NKE_BG_param_kappa_r11" initialValue="172042" modelReference="NKE_BG_6_state_ATPNaZK_fit_pulseV" target="/cellml:model/cellml:component[@name=&quot;NKE_BG_param&quot;]/cellml:variable[@name=&quot;kappa_r11&quot;]/@initial_value">
          <bounds lowerBound="0.01" upperBound="1000000" scale="linear"/>
          <listOfExperimentReferences>
            <experimentReference experimentId="fit_1"/>
          </listOfExperimentReferences>
        </adjustableParameter>
        <adjustableParameter id="NKE_BG_param_kappa_r13" initialValue="597" modelReference="NKE_BG_6_state_ATPNaZK_fit_pulseV" target="/cellml:model/cellml:component[@name=&quot;NKE_BG_param&quot;]/cellml:variable[@name=&quot;kappa_r13&quot;]/@initial_value">
          <bounds lowerBound="0.001" upperBound="10000" scale="linear"/>
          <listOfExperimentReferences>
            <experimentReference experimentId="fit_1"/>
          </listOfExperimentReferences>
        </adjustableParameter>
        <adjustableParameter id="NKE_BG_param_K_6" initialValue="92" modelReference="NKE_BG_6_state_ATPNaZK_fit_pulseV" target="/cellml:model/cellml:component[@name=&quot;NKE_BG_param&quot;]/cellml:variable[@name=&quot;K_6&quot;]/@initial_value">
          <bounds lowerBound="0.001" upperBound="1000" scale="linear"/>
          <listOfExperimentReferences>
            <experimentReference experimentId="fit_1"/>
          </listOfExperimentReferences>
        </adjustableParameter>
        <adjustableParameter id="NKE_BG_param_K_13" initialValue="0.32" modelReference="NKE_BG_6_state_ATPNaZK_fit_pulseV" target="/cellml:model/cellml:component[@name=&quot;NKE_BG_param&quot;]/cellml:variable[@name=&quot;K_13&quot;]/@initial_value">
          <bounds lowerBound="0.001" upperBound="100" scale="linear"/>
          <listOfExperimentReferences>
            <experimentReference experimentId="fit_1"/>
          </listOfExperimentReferences>
        </adjustableParameter>
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          <algorithm name="CVODE" kisaoID="KISAO:0000019">
            <listOfAlgorithmParameters>
              <algorithmParameter name="rtol" kisaoID="KISAO:0000209" value="1e-07"/>
              <algorithmParameter name="max_step" kisaoID="KISAO:0000467" value="0.001"/>
              <algorithmParameter name="max_step_number" kisaoID="KISAO:0000415" value="5000"/>
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            <fitMapping dataSource="fid_1_i_Vm" target="dg_fid_1_i_Vm" type="observable" weight="1"/>
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        <dataSet id="dataset_optimal" label="ADJ" dataReference="dg_optimal"/>
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