## kinetic parameters for the LCC channel, adapted from Pan et al ## in the format of the other channels in the BG library ## hardcode the parameters from Pan's optimisation for ionic permeability and gate variables directly import numpy as np def kinetic_parameters(M, include_type2_reactions, dims, V): # Set the kinetic rate constants num_cols = dims['num_cols'] num_rows = dims['num_rows'] # constants are stored in V F = V['F'] N_A = V['N_A'] G_GHK = 5.0759e-09 # from matlab fitting # convert to permeability P_SOC = G_GHK / F * 1e12 #Unit pL / s channel_k = P_SOC #/ x_Cab_channel kf =[channel_k] kr =[channel_k] k_kinetic = kf + kr # CONSTRAINTS N_cT = [] K_C = [] # volume vector # [ outside / inside / ER ] W = [1] * num_cols + [V['V_o'], V['V_myo'], V['V_ER']] return (k_kinetic, N_cT, K_C, W)