# K1 module from Tong 2011 # Return kinetic parameters, constraints, and vector of volumes in each # compartment (pL) (1 if gating variable, or in element corresponding to # kappa) # Translated from Pan 2018 cardiac AP import numpy as np def kinetic_parameters(M, include_type2_reactions, dims, V): # Set the kinetic rate constants num_cols = dims['num_cols'] num_rows = dims['num_rows'] # constants are stored in V F = V['F'] N_A = V['N_A'] # from MATLAB PSO for the channel G_GHK = 3.25970736700753e-11 # convert to permeability P = G_GHK / F * 1e12 #Unit pL / s channel_K1 = P kf =[channel_K1] kr =[channel_K1] k_kinetic = kf + kr # CONSTRAINTS N_cT = [] K_C = [] # volume vector # W = list(np.append([1] * num_cols, [V['V_myo']] * num_rows)) W = [1] * num_cols + [V['V_myo'], V['V_o']] return (k_kinetic, N_cT, K_C, W)