keyword electrophysiology vcell 1000 3.14 rad rad L Ageo 2 3.14 rad rad 2 3.14 rad L Acap 2 Ageo vmyo 0.68 vcell vnsr 0.0552 vcell vjsr 0.0048 vcell vss 0.02 vcell Istim amp time time period period time time period period stim_duration 0 vffrt v F F R T vfrt v F R T time v I_SK INa INaL Ito ICaL ICaNa ICaK IKr IKs IK1 INaCa_i INaCa_ss INaK INab IKb IpCa ICab Istim x_SKinf 1 1 K_d cass n tau_SK tau_0 tau_1 1 cass 0.1 time x_SK x_SKinf x_SK tau_SK I_SK G_SK x_SK v EK CaMKb CaMKo 1 CaMKt 1 KmCaM cass CaMKa CaMKb CaMKt CaMKa_HF time CaMKt aCaMK CaMKb CaMKb CaMKt bCaMK CaMKt cmdnmax cmdnmax_b 1.3 celltype 1 cmdnmax_b time nai INa INaL 3 INaCa_i 3 INaK INab Acap cm F vmyo JdiffNa vss vmyo time nass ICaNa 3 INaCa_ss cm Acap F vss JdiffNa time ki Ito IKr IKs IK1 IKb Istim 2 INaK cm Acap F vmyo JdiffK vss vmyo time kss ICaK I_SK cm Acap F vss JdiffK Bcai 1 1 cmdnmax kmcmdn kmcmdn cai 2 trpnmax kmtrpn kmtrpn cai 2 time cai Bcai IpCa ICab 2 INaCa_i cm Acap 2 F vmyo Jup vnsr vmyo Jdiff vss vmyo Bcass 1 1 BSRmax KmBSR KmBSR cass 2 BSLmax KmBSL KmBSL cass 2 time cass Bcass ICaL 2 INaCa_ss cm Acap 2 F vss Jrel vjsr vss Jdiff time cansr Jup Jtr vjsr vnsr Bcajsr 1 1 csqnmax kmcsqn kmcsqn cajsr 2 time cajsr Bcajsr Jtr Jrel ENa R T F nao nai EK R T F ko ki EKs R T F ko PKNa nao ki PKNa nai mss 1 1 v mssV1 mssV3 mssV2 tm 1 mtD1 v mtV1 mtV2 mtD2 v mtV3 mtV4 time m mss m tm hss 1 1 v hssV1 hssV2 thf 1 1.432-5 v 1.196 6.285 6.149 v 0.5096 20.27 ths 1 0.009794 v 17.95 28.05 0.3343 v 5.73 56.66 Ahs 1 Ahf time hf hss hf thf time hs hss hs ths h Ahf hf Ahs hs jss hss tj 2.038 1 0.02136 v 100.6 8.281 0.3052 v 0.9941 38.45 time j jss j tj hssp 1 1 v 78.5 6.2 6.22 thsp 3 ths time hsp hssp hsp thsp hp Ahf hf Ahs hsp tjp 1.46 tj time jp jss jp tjp fINap 1 1 KmCaMK CaMKa INa GNa v ENa m 3 1 fINap h j fINap hp jp mLss 1 1 v 42.85 5.264 tmL tm time mL mLss mL tmL hLss 1 1 v 87.61 7.488 time hL hLss hL thL hLssp 1 1 v 93.81 7.488 thLp 3 thL time hLp hLssp hLp thLp GNaL GNaL_b 0.6 celltype 1 GNaL_b fINaLp 1 1 KmCaMK CaMKa INaL GNaL GNaL_HF v ENa mL 1 fINaLp hL fINaLp hLp ass 1 1 v 14.34 14.82 ta 1.0515 1 1.2089 1 v 18.4099 29.3814 3.5 1 v 100 29.3814 time a ass a ta iss 1 1 v 43.94 5.711 delta_epi 1 0.95 1 v 70 5 celltype 1 1 tiF_b 4.562 1 0.3933 v 100 100 0.08004 v 50 16.59 tiS_b 23.62 1 0.001416 v 96.52 59.05 1.78-8 v 114.1 8.079 tiF tiF_b delta_epi tiS tiS_b delta_epi AiF 1 1 v 213.6 151.2 AiS 1 AiF time iF iss iF tiF time iS iss iS tiS i AiF iF AiS iS assp 1 1 v 24.34 14.82 time ap assp ap ta dti_develop 1.354 1-4 v 167.4 15.89 v 12.23 0.2154 dti_recover 1 0.5 1 v 70 20 tiFp dti_develop dti_recover tiF tiSp dti_develop dti_recover tiS time iFp iss iFp tiFp time iSp iss iSp tiSp ip AiF iFp AiS iSp Gto Gto_b 4 celltype 1 Gto_b 4 celltype 2 Gto_b fItop 1 1 KmCaMK CaMKa Ito Gto Gto_HF v EK 1 fItop a i fItop ap ip dss 1 1 v 3.94 4.23 td 0.6 1 0.05 v 6 0.09 v 14 time d dss d td fss 1 1 v 19.58 3.696 tff 7 1 0.0045 v 20 10 0.0045 v 20 10 tfs 1000 1 0.000035 v 5 4 0.000035 v 5 6 Aff 0.6 Afs 1 Aff time ff fss ff tff time fs fss fs tfs f Aff ff Afs fs fcass fss tfcaf 7 1 0.04 v 4 7 0.04 v 4 7 tfcas 100 1 0.00012 v 3 0.00012 v 7 Afcaf 0.3 0.6 1 v 10 10 Afcas 1 Afcaf time fcaf fcass fcaf tfcaf time fcas fcass fcas tfcas fca Afcaf fcaf Afcas fcas tjca 75 time jca fcass jca tjca tffp 2.5 tff time ffp fss ffp tffp fp Aff ffp Afs fs tfcafp 2.5 tfcaf time fcafp fcass fcafp tfcafp fcap Afcaf fcafp Afcas fcas km2n jca 1 anca 1 k2n km2n 1 Kmn cass 4 time nca anca k2n nca km2n PhiCaL 4 vffrt cass 2 vfrt 0.341 cao 2 vfrt 1 PhiCaNa 1 vffrt 0.75 nass 1 vfrt 0.75 nao 1 vfrt 1 PhiCaK 1 vffrt 0.75 kss 1 vfrt 0.75 ko 1 vfrt 1 PCa PCa_b 1.2 celltype 1 PCa_b 2.5 celltype 2 PCa_b PCap 1.1 PCa PCaNa 0.00125 PCa PCaK 3.574-4 PCa PCaNap 0.00125 PCap PCaKp 3.574-4 PCap fICaLp 1 1 KmCaMK CaMKa ICaL 1 fICaLp PCa PhiCaL d f 1 nca jca fca nca fICaLp PCap PhiCaL d fp 1 nca jca fcap nca ICaNa 1 fICaLp PCaNa PhiCaNa d f 1 nca jca fca nca fICaLp PCaNap PhiCaNa d fp 1 nca jca fcap nca ICaK 1 fICaLp PCaK PhiCaK d f 1 nca jca fca nca fICaLp PCaKp PhiCaK d fp 1 nca jca fcap nca xrss 1 1 v 8.337 6.789 txrf 12.98 1 0.3652 v 31.66 3.869 4.123-5 v 47.78 20.38 txrs 1.865 1 0.06629 v 34.7 7.355 1.128-5 v 29.74 25.94 Axrf 1 1 v 54.81 38.21 Axrs 1 Axrf time xrf xrss xrf txrf time xrs xrss xrs txrs xr Axrf xrf Axrs xrs rkr 1 1 v 55 75 1 1 v 10 30 GKr GKr_b 1.3 celltype 1 GKr_b 0.8 celltype 2 GKr_b IKr GKr ko 5.4 xr rkr v EK xs1ss 1 1 v 11.6 8.932 txs1 817.3 1 2.326-4 v 48.28 17.8 0.001292 v 210 230 time xs1 xs1ss xs1 txs1 xs2ss xs1ss txs2 1 0.01 v 50 20 0.0193 v 66.54 31 time xs2 xs2ss xs2 txs2 KsCa 1 0.6 1 3.8-5 cai 1.4 GKs GKs_b 1.4 celltype 1 GKs_b IKs GKs KsCa xs1 xs2 v EKs xk1ss 1 1 v 2.5538 ko 144.59 1.5692 ko 3.8115 txk1 122.2 v 127.2 20.36 v 236.8 69.33 time xk1 xk1ss xk1 txk1 rk1 1 1 v 105.8 2.6 ko 9.493 GK1 GK1_b 1.2 celltype 1 GK1_b 1.3 celltype 2 GK1_b IK1 GK1 GK1_HF ko rk1 xk1 v EK hca qca v F R T hna qna v F R T h1_i 1 nai kna3 1 hna h2_i nai hna kna3 h1_i h3_i 1 h1_i h4_i 1 nai kna1 1 nai kna2 h5_i nai nai h4_i kna1 kna2 h6_i 1 h4_i h7_i 1 nao kna3 1 1 hna h8_i nao kna3 hna h7_i h9_i 1 h7_i h10_i kasymm 1 nao kna1 1 nao kna2 h11_i nao nao h10_i kna1 kna2 h12_i 1 h10_i k1_i h12_i cao kcaon k2_i kcaoff k3p_i h9_i wca k3pp_i h8_i wnaca k3_i k3p_i k3pp_i k4p_i h3_i wca hca k4pp_i h2_i wnaca k4_i k4p_i k4pp_i k5_i kcaoff k6_i h6_i cai kcaon k7_i h5_i h2_i wna k8_i h8_i h11_i wna x1_i k2_i k4_i k7_i k6_i k5_i k7_i k2_i k3_i x2_i k1_i k7_i k4_i k5_i k4_i k6_i k1_i k8_i x3_i k1_i k3_i k7_i k6_i k8_i k6_i k2_i k3_i x4_i k2_i k8_i k4_i k5_i k3_i k5_i k1_i k8_i E1_i x1_i x1_i x2_i x3_i x4_i E2_i x2_i x1_i x2_i x3_i x4_i E3_i x3_i x1_i x2_i x3_i x4_i E4_i x4_i x1_i x2_i x3_i x4_i allo_i 1 1 KmCaAct cai 2 JncxNa_i 1 3 E4_i k7_i E1_i k8_i E3_i k4pp_i E2_i k3pp_i JncxCa_i 1 E2_i k2_i E1_i k1_i Gncx Gncx_b 1.1 celltype 1 Gncx_b 1.4 celltype 2 Gncx_b INaCa_i 0.8 Gncx Gncx_HF allo_i zna JncxNa_i zca JncxCa_i h1_ss 1 nass kna3 1 hna h2_ss nass hna kna3 h1_ss h3_ss 1 h1_ss h4_ss 1 nass kna1 1 nass kna2 h5_ss nass nass h4_ss kna1 kna2 h6_ss 1 h4_ss h7_ss 1 nao kna3 1 1 hna h8_ss nao kna3 hna h7_ss h9_ss 1 h7_ss h10_ss kasymm 1 nao kna1 1 nao kna2 h11_ss nao nao h10_ss kna1 kna2 h12_ss 1 h10_ss k1_ss h12_ss cao kcaon k2_ss kcaoff k3p_ss h9_ss wca k3pp_ss h8_ss wnaca k3_ss k3p_ss k3pp_ss k4p_ss h3_ss wca hca k4pp_ss h2_ss wnaca k4_ss k4p_ss k4pp_ss k5_ss kcaoff k6_ss h6_ss cass kcaon k7_ss h5_ss h2_ss wna k8_ss h8_ss h11_ss wna x1_ss k2_ss k4_ss k7_ss k6_ss k5_ss k7_ss k2_ss k3_ss x2_ss k1_ss k7_ss k4_ss k5_ss k4_ss k6_ss k1_ss k8_ss x3_ss k1_ss k3_ss k7_ss k6_ss k8_ss k6_ss k2_ss k3_ss x4_ss k2_ss k8_ss k4_ss k5_ss k3_ss k5_ss k1_ss k8_ss E1_ss x1_ss x1_ss x2_ss x3_ss x4_ss E2_ss x2_ss x1_ss x2_ss x3_ss x4_ss E3_ss x3_ss x1_ss x2_ss x3_ss x4_ss E4_ss x4_ss x1_ss x2_ss x3_ss x4_ss allo_ss 1 1 KmCaAct cass 2 JncxNa_ss 1 3 E4_ss k7_ss E1_ss k8_ss E3_ss k4pp_ss E2_ss k3pp_ss JncxCa_ss 1 E2_ss k2_ss E1_ss k1_ss INaCa_ss 0.2 1 Gncx Gncx_HF allo_ss zna JncxNa_ss zca JncxCa_ss Knai Knai0 delta v F 3 R T Knao Knao0 1 delta v F 3 R T P eP 1 H Khp nai Knap ki Kxkur a1 k1p nai Knai 3 1 nai Knai 3 1 ki Kki 2 1 b1 k1m MgADP a2 k2p b2 k2m nao Knao 3 1 nao Knao 3 1 ko Kko 2 1 a3 k3p ko Kko 2 1 nao Knao 3 1 ko Kko 2 1 b3 k3m P H 1 MgATP Kmgatp a4 k4p MgATP Kmgatp 1 MgATP Kmgatp b4 k4m ki Kki 2 1 nai Knai 3 1 ki Kki 2 1 x1 a4 a1 a2 b2 b4 b3 a2 b4 b3 b3 a1 a2 x2 b2 b1 b4 a1 a2 a3 a3 b1 b4 a2 a3 b4 x3 a2 a3 a4 b3 b2 b1 b2 b1 a4 a3 a4 b1 x4 b4 b3 b2 a3 a4 a1 b2 a4 a1 b3 b2 a1 E1 x1 x1 x2 x3 x4 E2 x2 x1 x2 x3 x4 E3 x3 x1 x2 x3 x4 E4 x4 x1 x2 x3 x4 JnakNa 3 E1 a3 E2 b3 JnakK 2 E4 b1 E3 a1 Pnak Pnak_b 0.9 celltype 1 Pnak_b 0.7 celltype 2 Pnak_b INaK Pnak Pnak_HF zna JnakNa zk JnakK xkb 1 1 v 14.48 18.34 GKb GKb_b 0.6 celltype 1 GKb_b IKb GKb xkb v EK INab PNab vffrt nai vfrt nao vfrt 1 ICab PCab 4 vffrt cai 2 vfrt 0.341 cao 2 vfrt 1 IpCa GpCa cai KmCap cai JdiffNa nass nai 2 JdiffK kss ki 2 Jdiff cass cai 0.2 a_rel 0.5 bt Jrel_inf_temp a_rel ICaL 1 1 1.5 Krel_HF cajsr 8 Jrel_inf Jrel_inf_temp 1.7 celltype 2 Jrel_inf_temp tau_rel_temp bt 1 0.0123 cajsr tau_rel 0.001 tau_rel_temp 0.001 tau_rel_temp time Jrelnp Jrel_inf Jrelnp tau_rel btp 1.25 bt a_relp 0.5 btp Jrel_temp 1 a_relp ICaL 1 1 1.5 Krel_HF cajsr 8 Jrel_infp Jrel_temp 1.7 celltype 2 Jrel_temp tau_relp_temp btp 1 0.0123 cajsr tau_relp 0.001 tau_relp_temp 0.001 tau_relp_temp time Jrelp Jrel_infp Jrelp tau_relp fJrelp 1 1 KmCaMK CaMKa Jrel 1 fJrelp Jrelnp fJrelp Jrelp upScale 1.3 celltype 1 1 Jupnp upScale 0.004375 cai cai 0.00092 Jupp upScale 2.75 0.004375 cai cai 0.00092 0.00017 fJupp 1 1 KmCaMK CaMKa Jleak Jleak_HF 0.0039375 cansr 15 Jup Jup_b 1 fJupp Jupnp fJupp Jupp Jleak Jtr cansr cajsr 100