This exposure contains a CellML version of the Noble, Denyer, Brown & DiFrancesco model (1992).

Relevant files
--------------

- ``noble_denyer_brown_difrancesco_1992.cellml``: CellML version of the model.
- ``noble_denyer_brown_difrancesco_1992.sedml``: SED-ML file for simulating the model.
- ``simulation.json``: JSON file for use with Web OpenCOR's interactive mode.
- ``manifest.xml``: manifest file used by PMR to create a crafted COMBINE archive.

Usage
-----

The easiest way to use this model is by:

- switching to the `CellML view <noble_denyer_brown_difrancesco_1992.cellml/view>`_ (alternatively, by clicking on the ``noble_denyer_brown_difrancesco_1992.cellml`` link to the right of this page under the ``Navigation`` section);
- starting `legacy OpenCOR <https://opencor.ws/>`_ or opening `Web OpenCOR <https://opencor.ws/app/>`_;
- right clicking on the ``COMBINE Archive (crafted)`` button (to the right of this page under the ``Downloads`` section);
- selecting ``Copy Link Address`` (or similar, depending on your Web browser); and
- opening the copied link in `legacy OpenCOR <https://opencor.ws/>`_ or `Web OpenCOR <https://opencor.ws/app/>`_ (using the ``File`` | ``Open Remote...`` menu).

.. image:: Screenshot.webp
   :alt: Noble, Denyer, Brown & DiFrancesco model (1992)

Citation
--------

Noble D, Denyer JC, Brown HF, DiFrancesco D. Reciprocal role of the inward currents i\_b,Na and i\_f in controlling and stabilizing pacemaker frequency of rabbit sino-atrial node cells. Proc Biol Sci. 1992 Dec 22;250(1329):199-207. doi: `10.1098/rspb.1992.0150 <https://doi.org/10.1098/rspb.1992.0150>`_. PMID: `1283636 <https://pubmed.ncbi.nlm.nih.gov/1283636/>`_.